SK69799A3 - Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists - Google Patents
Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists Download PDFInfo
- Publication number
- SK69799A3 SK69799A3 SK697-99A SK69799A SK69799A3 SK 69799 A3 SK69799 A3 SK 69799A3 SK 69799 A SK69799 A SK 69799A SK 69799 A3 SK69799 A3 SK 69799A3
- Authority
- SK
- Slovakia
- Prior art keywords
- gndnl
- nothing
- compounds
- guanidine
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3202396P | 1996-11-25 | 1996-11-25 | |
PCT/US1997/020802 WO1998023596A1 (en) | 1996-11-25 | 1997-11-21 | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
SK69799A3 true SK69799A3 (en) | 2000-06-12 |
Family
ID=21862692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK697-99A SK69799A3 (en) | 1996-11-25 | 1997-11-21 | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists |
Country Status (25)
Country | Link |
---|---|
US (3) | US6225331B1 (de) |
EP (1) | EP0944604B1 (de) |
JP (1) | JP2001506600A (de) |
KR (1) | KR20000069131A (de) |
CN (1) | CN1104422C (de) |
AR (1) | AR009145A1 (de) |
AT (1) | ATE286885T1 (de) |
AU (1) | AU730369B2 (de) |
BR (1) | BR9713536A (de) |
CA (1) | CA2272640C (de) |
CO (1) | CO4910148A1 (de) |
CZ (1) | CZ184099A3 (de) |
DE (1) | DE69732244T2 (de) |
ES (1) | ES2236833T3 (de) |
HU (1) | HUP0000312A3 (de) |
ID (1) | ID23857A (de) |
IL (1) | IL130077A0 (de) |
NO (1) | NO313912B1 (de) |
NZ (1) | NZ336010A (de) |
PE (1) | PE16399A1 (de) |
RU (1) | RU2194700C2 (de) |
SK (1) | SK69799A3 (de) |
TR (1) | TR199901468T2 (de) |
WO (1) | WO1998023596A1 (de) |
ZA (1) | ZA9710578B (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE286885T1 (de) | 1996-11-25 | 2005-01-15 | Procter & Gamble | Guanidyl-heterocyclische verbindungen als alpha-2 adrenoceptor agonisten |
US6291514B1 (en) * | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
DZ3415A1 (fr) * | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
JP2004508324A (ja) * | 2000-09-08 | 2004-03-18 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 急性副鼻腔炎及び洞発作の予防 |
ES2278016T3 (es) * | 2001-04-09 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r). |
US20030195187A1 (en) * | 2002-02-04 | 2003-10-16 | Chiron Corporation | Guanidino compounds |
US20050124652A1 (en) * | 2002-02-04 | 2005-06-09 | Rustum Boyce | Guanidino compounds |
US20030207814A1 (en) * | 2002-02-04 | 2003-11-06 | Chiron Corporation | Novel guanidinyl derivatives |
JP2005524649A (ja) * | 2002-02-25 | 2005-08-18 | カイロン コーポレーション | Mc4−rアゴニストの鼻腔内投与 |
WO2003099818A1 (en) * | 2002-05-23 | 2003-12-04 | Chiron Corporation | Substituted quinazolinone compounds |
EP1651229A1 (de) * | 2003-05-23 | 2006-05-03 | Chiron Corporation | Guanidino-substituierte chinazolinon-verbindungen als mc4-r agonisten |
US7368453B2 (en) * | 2003-11-19 | 2008-05-06 | Chiron Corporation | Quinazolinone compounds with reduced bioaccumulation |
JP5833804B2 (ja) * | 2005-04-13 | 2015-12-16 | ニューラクソン,インコーポレーテッド | Nos阻害活性を有する置換インドール化合物 |
RU2008122978A (ru) | 2005-11-09 | 2009-12-20 | Комбинаторкс, Инкорпорейтед (Us) | Способы, композиции и наборы для лечения медицинских состояний |
CL2008000838A1 (es) * | 2007-03-23 | 2008-10-10 | Neuraxon Inc | Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios |
US20090131503A1 (en) * | 2007-11-16 | 2009-05-21 | Annedi Subhash C | 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity |
US20100196286A1 (en) * | 2008-12-01 | 2010-08-05 | Armer Thomas A | Inhalation delivery methods and devices |
WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
GB0919889D0 (en) * | 2009-11-13 | 2009-12-30 | Biocopea Ltd | Drug composition and its use in therapy |
EP2668177B1 (de) * | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituierte pyridinyl-pyrimidine und ihre verwendung als arzneimittel |
CN112047947A (zh) * | 2020-10-13 | 2020-12-08 | 石药集团新诺威制药股份有限公司 | 一种茶碱的合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3908013A (en) | 1970-09-17 | 1975-09-23 | Armour Pharma | Pharmaceutical aromatic guanidine compositions and methods of using same |
BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US3947455A (en) | 1974-04-15 | 1976-03-30 | Armour Pharmaceutical Company | 5'-(8'-Hydroxyquinolyl)guanidine compounds |
US4000279A (en) | 1974-10-29 | 1976-12-28 | Armour Pharmaceutical Company | Pharmaceutical preparations containing 5'-(8'-hydroxyquinolyl)guanidine compounds and methods of using same |
US5091528A (en) | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
ATE194771T1 (de) * | 1993-12-17 | 2000-08-15 | Procter & Gamble | 6-(2-imidazolinylamino) chinoxalin-verbindungen als alpha-2-adrenorezeptoragonisten |
ATE286885T1 (de) | 1996-11-25 | 2005-01-15 | Procter & Gamble | Guanidyl-heterocyclische verbindungen als alpha-2 adrenoceptor agonisten |
US6057329A (en) * | 1996-12-23 | 2000-05-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives |
-
1997
- 1997-11-21 AT AT97948290T patent/ATE286885T1/de not_active IP Right Cessation
- 1997-11-21 ES ES97948290T patent/ES2236833T3/es not_active Expired - Lifetime
- 1997-11-21 CA CA002272640A patent/CA2272640C/en not_active Expired - Fee Related
- 1997-11-21 CZ CZ991840A patent/CZ184099A3/cs unknown
- 1997-11-21 TR TR1999/01468T patent/TR199901468T2/xx unknown
- 1997-11-21 BR BR9713536-4A patent/BR9713536A/pt not_active IP Right Cessation
- 1997-11-21 NZ NZ336010A patent/NZ336010A/en unknown
- 1997-11-21 ID IDW990410A patent/ID23857A/id unknown
- 1997-11-21 US US09/308,788 patent/US6225331B1/en not_active Expired - Lifetime
- 1997-11-21 AU AU54381/98A patent/AU730369B2/en not_active Ceased
- 1997-11-21 WO PCT/US1997/020802 patent/WO1998023596A1/en active IP Right Grant
- 1997-11-21 JP JP52469498A patent/JP2001506600A/ja active Pending
- 1997-11-21 IL IL13007797A patent/IL130077A0/xx unknown
- 1997-11-21 SK SK697-99A patent/SK69799A3/sk unknown
- 1997-11-21 DE DE69732244T patent/DE69732244T2/de not_active Expired - Lifetime
- 1997-11-21 HU HU0000312A patent/HUP0000312A3/hu unknown
- 1997-11-21 RU RU99113446/04A patent/RU2194700C2/ru not_active IP Right Cessation
- 1997-11-21 CN CN97181078A patent/CN1104422C/zh not_active Expired - Fee Related
- 1997-11-21 KR KR1019997004619A patent/KR20000069131A/ko not_active Application Discontinuation
- 1997-11-21 EP EP97948290A patent/EP0944604B1/de not_active Expired - Lifetime
- 1997-11-24 CO CO97068606A patent/CO4910148A1/es unknown
- 1997-11-25 PE PE1997001070A patent/PE16399A1/es not_active Application Discontinuation
- 1997-11-25 AR ARP970105530A patent/AR009145A1/es unknown
- 1997-11-25 ZA ZA9710578A patent/ZA9710578B/xx unknown
-
1999
- 1999-05-25 NO NO19992498A patent/NO313912B1/no unknown
-
2000
- 2000-12-01 US US09/727,900 patent/US6391878B2/en not_active Expired - Lifetime
-
2002
- 2002-02-08 US US10/071,284 patent/US20020128481A1/en not_active Abandoned
Also Published As
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