SK40895A3 - 17-beta-substituted 4-azaandrostane derivatives, pharmaceutical compositions containing them and process for preparing same - Google Patents

17-beta-substituted 4-azaandrostane derivatives, pharmaceutical compositions containing them and process for preparing same Download PDF

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Publication number
SK40895A3
SK40895A3 SK408-95A SK40895A SK40895A3 SK 40895 A3 SK40895 A3 SK 40895A3 SK 40895 A SK40895 A SK 40895A SK 40895 A3 SK40895 A3 SK 40895A3
Authority
SK
Slovakia
Prior art keywords
aza
oxo
atoms
formula
androst
Prior art date
Application number
SK408-95A
Other languages
English (en)
Slovak (sk)
Inventor
Zoltan Tuba
Judit Horvath
Laszlo Kollar
Marsai M Lovasne
Gabor Balogh
Attila Csehi
Andras Javor
Gyorgy Hajos
Laszlo Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SK40895A3 publication Critical patent/SK40895A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK408-95A 1992-10-02 1993-10-01 17-beta-substituted 4-azaandrostane derivatives, pharmaceutical compositions containing them and process for preparing same SK40895A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9203135A HU212459B (en) 1992-10-02 1992-10-02 Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
PCT/HU1993/000058 WO1994007909A1 (en) 1992-10-02 1993-10-01 NOVEL 17β-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME

Publications (1)

Publication Number Publication Date
SK40895A3 true SK40895A3 (en) 1995-07-11

Family

ID=10982391

Family Applications (1)

Application Number Title Priority Date Filing Date
SK408-95A SK40895A3 (en) 1992-10-02 1993-10-01 17-beta-substituted 4-azaandrostane derivatives, pharmaceutical compositions containing them and process for preparing same

Country Status (13)

Country Link
US (1) US5583138A (ja)
EP (1) EP0662977A1 (ja)
JP (1) JPH08502059A (ja)
KR (1) KR950703577A (ja)
AU (1) AU672046B2 (ja)
CA (1) CA2146164A1 (ja)
CZ (1) CZ282170B6 (ja)
FI (1) FI951561A0 (ja)
HU (1) HU212459B (ja)
RU (1) RU95110751A (ja)
SK (1) SK40895A3 (ja)
WO (1) WO1994007909A1 (ja)
ZA (1) ZA936774B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
EP1622567B1 (en) * 2003-05-07 2013-07-24 Merck Sharp & Dohme Corp. Androgen receptor modulators and methods of use thereof
BRPI0920681A2 (pt) * 2008-10-28 2015-12-29 Biomarin Pharm Inc inibidores de decahidro-1h-indenoquinolinona e decahidro-3h-ciclopentafenantridinona de cyp17
CN103554213A (zh) * 2012-01-05 2014-02-05 中国药科大学 4-氧杂-雄甾-3-酮-17β-酰胺类衍生物、其制备方法及其医药用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
US4885289A (en) * 1983-12-12 1989-12-05 Breuer Miklos M Alteration of character of male beard growth
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US5312984A (en) * 1984-12-19 1994-05-17 The B. F. Goodrich Company Amidation of vinyl chloride with dimethylamine using a supported palladium catalyst
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
HU195972B (en) * 1985-07-01 1988-08-29 Richter Gedeon Vegyeszet Process for producing new diamino-androstane derivatives and pharmaceutical compositions containing them
DE3607651A1 (de) * 1986-03-06 1987-09-10 Schering Ag Kombination von aromatasehemmer und testosteron-5(alpha)-reduktase-hemmer
US4845104A (en) * 1986-11-20 1989-07-04 Merck & Co., Inc. Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
US4888336A (en) * 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
DE3888994T2 (de) * 1987-04-03 1994-11-03 Merck & Co Inc Behandlung von androgener Alopecia mit 17-beta-n-mono-substituierten-carbamoyl-4-aza-5-alpha-androst-1-en-3-onen.
EP0285383B1 (en) * 1987-04-03 1994-03-16 Merck & Co. Inc. Treatment of prostatic carcinoma with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
EP0462662A3 (en) * 1990-06-20 1992-08-19 Merck & Co. Inc. 17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
CA2166089C (en) * 1993-06-24 2004-01-27 Zoltan Tuba 17-halogeno-4-azaandrostene derivatives and process for the preparation thereof
DE69331763T2 (de) * 1993-06-24 2002-10-02 Richter Gedeon Vegyeszet Neues verfahren zum herstellen von 17 beta-substituierten 4-azaandrostan-derivaten

Also Published As

Publication number Publication date
CZ78095A3 (en) 1995-11-15
CZ282170B6 (cs) 1997-05-14
FI951561A (fi) 1995-03-31
EP0662977A1 (en) 1995-07-19
RU95110751A (ru) 1996-11-20
JPH08502059A (ja) 1996-03-05
WO1994007909A1 (en) 1994-04-14
AU672046B2 (en) 1996-09-19
CA2146164A1 (en) 1994-04-14
HUT65768A (en) 1994-07-28
ZA936774B (en) 1994-04-14
KR950703577A (ko) 1995-09-20
HU9203135D0 (en) 1992-12-28
FI951561A0 (fi) 1995-03-31
HU212459B (en) 1996-06-28
AU5118393A (en) 1994-04-26
US5583138A (en) 1996-12-10

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