SK34296A3 - Assembled particles of plant virus, manufacture process and a vaccine on their base, a fragment of cdna, a vector containing this fragment and their rna transcripts - Google Patents
Assembled particles of plant virus, manufacture process and a vaccine on their base, a fragment of cdna, a vector containing this fragment and their rna transcripts Download PDFInfo
- Publication number
- SK34296A3 SK34296A3 SK342-96A SK34296A SK34296A3 SK 34296 A3 SK34296 A3 SK 34296A3 SK 34296 A SK34296 A SK 34296A SK 34296 A3 SK34296 A3 SK 34296A3
- Authority
- SK
- Slovakia
- Prior art keywords
- virus
- plant virus
- assembled
- plant
- sequence
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32711—Rhinovirus
- C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9414118A GB9414118D0 (en) | 1994-07-13 | 1994-07-13 | Modified plant viruses as vectors of heterologous peptides |
| PCT/GB1995/001618 WO1996002649A1 (en) | 1994-07-13 | 1995-07-10 | Modified plant viruses as vectors of heterologous peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK34296A3 true SK34296A3 (en) | 1996-07-03 |
Family
ID=10758254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK342-96A SK34296A3 (en) | 1994-07-13 | 1995-07-10 | Assembled particles of plant virus, manufacture process and a vaccine on their base, a fragment of cdna, a vector containing this fragment and their rna transcripts |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5958422A (de) |
| EP (1) | EP0719336B1 (de) |
| JP (1) | JP3681753B2 (de) |
| KR (1) | KR100379803B1 (de) |
| CN (1) | CN1211488C (de) |
| AT (1) | ATE346934T1 (de) |
| AU (1) | AU697867B2 (de) |
| BR (1) | BR9506047A (de) |
| CA (1) | CA2170412C (de) |
| CZ (1) | CZ290484B6 (de) |
| DE (1) | DE69535314T2 (de) |
| GB (1) | GB9414118D0 (de) |
| HU (1) | HU223078B1 (de) |
| NZ (1) | NZ289170A (de) |
| SK (1) | SK34296A3 (de) |
| WO (1) | WO1996002649A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6846968B1 (en) | 1988-02-26 | 2005-01-25 | Large Scale Biology Corporation | Production of lysosomal enzymes in plants by transient expression |
| US6660500B2 (en) | 1988-02-26 | 2003-12-09 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
| US7033835B1 (en) | 1988-02-26 | 2006-04-25 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
| US5977438A (en) * | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| GB9108386D0 (en) * | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
| US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
| US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
| US5484719A (en) | 1991-08-26 | 1996-01-16 | Edible Vaccines, Inc. | Vaccines produced and administered through edible plants |
| AU6976296A (en) * | 1995-09-15 | 1997-04-01 | John A Howard | Expression cassettes and methods for delivery of animal vaccines |
| GB9712282D0 (en) * | 1997-06-12 | 1997-08-13 | Innes John Centre Innov Ltd | Epitope presentation system |
| US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| GB9921337D0 (en) | 1999-09-09 | 1999-11-10 | Axis Genetics Plc | Modified plant viruses |
| GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| US7135282B1 (en) | 1999-10-14 | 2006-11-14 | The Dow Chemical Company | Viral particles with exogenous internal epitopes |
| WO2001098335A2 (en) * | 2000-06-20 | 2001-12-27 | Phycotransgenics, Llc | Transgenic algae for delivering antigens to an animal |
| US6932980B1 (en) * | 2001-01-18 | 2005-08-23 | Richard Sayre | Method of making microalgal-based animal foodstuff supplements, microalgal-supplemented animal foodstuffs and method of animal nutrition |
| IL151882A0 (en) * | 2001-01-24 | 2003-04-10 | Virogene Ltd | Vectors capable of imparting herbicide resistance and viral cross protection |
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
| US8101189B2 (en) * | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| EP1720990A4 (de) * | 2004-02-27 | 2008-04-30 | Dow Global Technologies Inc | Hocheffiziente peptidproduktion in pflanzenzellen |
| WO2006124044A2 (en) * | 2004-07-30 | 2006-11-23 | George Mason University | Protein scaffolds and viral particles for detecting analytes |
| US20060216238A1 (en) * | 2005-02-28 | 2006-09-28 | Marianne Manchester | Compositions and methods for targeting or imaging a tissue in a vertebrate subject |
| EP1885394A4 (de) * | 2005-06-01 | 2009-10-21 | Dow Global Technologies Inc | Herstellung multivalenter, virusartiger partikeln |
| CN101227920A (zh) * | 2005-07-19 | 2008-07-23 | 陶氏环球技术公司 | 重组流感疫苗 |
| JP2010508860A (ja) * | 2006-11-15 | 2010-03-25 | フォリア バイオテック インコーポレイテッド | パパイヤモザイクウイルスに基づくインフルエンザ用ワクチン |
| DE602007003944D1 (de) * | 2007-01-03 | 2010-02-04 | Academia Sinica | Rekombinante virale Proteine und Partikel |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| DK2610345T3 (en) | 2007-11-27 | 2015-12-07 | Medicago Inc | RECOMBINANT INFLUENZA VIRUS SIMULAR PARTICULARS (VLPS) MADE IN TRANSGENE PLANTS THAT EXPRESS HEMAGGLUTININ |
| CN102165062B (zh) | 2008-07-18 | 2017-09-08 | 麦迪卡格公司 | 新的流感病毒免疫表位 |
| WO2010012069A1 (en) * | 2008-07-30 | 2010-02-04 | Folio Biotech Inc. | Multivalent vaccines based on papaya mosaic virus and uses thereof |
| US20100183523A1 (en) | 2009-01-22 | 2010-07-22 | Wagner Richard E | Dental composition and method |
| WO2010148511A1 (en) | 2009-06-24 | 2010-12-29 | Medicago, Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| SG178947A1 (en) | 2009-09-22 | 2012-04-27 | Medicago Inc | Method of preparing plant-derived proteins |
| ES2625406T3 (es) | 2010-03-25 | 2017-07-19 | Oregon Health & Science University | Glicoproteínas de CMV y vectores recombinantes |
| SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| EP2679596B1 (de) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 Env-proteinvariante |
| EP2848937A1 (de) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Verfahren zur Identifizierung neuartiger HIV-1-Immunogene |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| CN105980561B (zh) | 2014-01-10 | 2020-06-02 | 莫迪卡戈公司 | Cpmv增强子元件 |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US10617751B2 (en) | 2017-07-13 | 2020-04-14 | VisionTech International Limited | Edible vaccines expressed in yeast for preventing and treating infectious diseases in animals and humans |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8421282D0 (en) * | 1984-08-22 | 1984-09-26 | Connaught Lab | Multispecific antigenic proteins |
| AU638411B2 (en) * | 1988-02-26 | 1993-07-01 | Large Scale Biology Corporation | Non-nuclear chromosomal transformation |
| WO1991013994A1 (en) * | 1990-03-13 | 1991-09-19 | Commonwealth Scientific And Industrial Research Organisation | Gene expression |
| EP0527767A4 (en) * | 1990-04-06 | 1993-05-05 | Commonwealth Scientific And Industrial Research Organisation | Self-polymerising expression system based on modified potyvirus coat proteins |
| WO1993003161A1 (en) * | 1990-10-22 | 1993-02-18 | Biosource Genetics Corporation | Recombinant plant viral nucleic acids |
| GB9108386D0 (en) * | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
| AU1838495A (en) * | 1994-02-03 | 1995-08-21 | Scripps Research Institute, The | Method for using tobacco mosaic virus to overproduce peptides and proteins |
-
1994
- 1994-07-13 GB GB9414118A patent/GB9414118D0/en active Pending
-
1995
- 1995-07-10 HU HU9600586A patent/HU223078B1/hu not_active IP Right Cessation
- 1995-07-10 WO PCT/GB1995/001618 patent/WO1996002649A1/en active IP Right Grant
- 1995-07-10 CA CA002170412A patent/CA2170412C/en not_active Expired - Fee Related
- 1995-07-10 DE DE69535314T patent/DE69535314T2/de not_active Expired - Lifetime
- 1995-07-10 SK SK342-96A patent/SK34296A3/sk unknown
- 1995-07-10 JP JP50478996A patent/JP3681753B2/ja not_active Expired - Fee Related
- 1995-07-10 US US08/612,858 patent/US5958422A/en not_active Expired - Fee Related
- 1995-07-10 CN CNB951907956A patent/CN1211488C/zh not_active Expired - Fee Related
- 1995-07-10 AT AT95924436T patent/ATE346934T1/de not_active IP Right Cessation
- 1995-07-10 NZ NZ289170A patent/NZ289170A/en not_active IP Right Cessation
- 1995-07-10 KR KR1019960701197A patent/KR100379803B1/ko not_active IP Right Cessation
- 1995-07-10 EP EP95924436A patent/EP0719336B1/de not_active Expired - Lifetime
- 1995-07-10 CZ CZ1996723A patent/CZ290484B6/cs not_active IP Right Cessation
- 1995-07-10 BR BR9506047A patent/BR9506047A/pt not_active Application Discontinuation
- 1995-07-10 AU AU28934/95A patent/AU697867B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US5958422A (en) | 1999-09-28 |
| CZ72396A3 (en) | 1996-06-12 |
| AU697867B2 (en) | 1998-10-22 |
| DE69535314T2 (de) | 2007-03-08 |
| CA2170412A1 (en) | 1996-02-01 |
| CN1211488C (zh) | 2005-07-20 |
| HU223078B1 (hu) | 2004-03-29 |
| EP0719336A1 (de) | 1996-07-03 |
| HUP9600586D0 (en) | 1996-05-28 |
| HUT75088A (en) | 1997-04-28 |
| WO1996002649A1 (en) | 1996-02-01 |
| DE69535314D1 (de) | 2007-01-11 |
| AU2893495A (en) | 1996-02-16 |
| NZ289170A (en) | 1997-11-24 |
| EP0719336B1 (de) | 2006-11-29 |
| GB9414118D0 (en) | 1994-08-31 |
| JP3681753B2 (ja) | 2005-08-10 |
| JPH09504961A (ja) | 1997-05-20 |
| BR9506047A (pt) | 1997-08-05 |
| KR100379803B1 (ko) | 2003-10-04 |
| CZ290484B6 (cs) | 2002-08-14 |
| ATE346934T1 (de) | 2006-12-15 |
| CN1134174A (zh) | 1996-10-23 |
| CA2170412C (en) | 2010-01-12 |
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