SK284161B6 - Spôsob in vitro skríningu na neuropatológiu - Google Patents

Spôsob in vitro skríningu na neuropatológiu Download PDF

Info

Publication number
SK284161B6
SK284161B6 SK165-97A SK16597A SK284161B6 SK 284161 B6 SK284161 B6 SK 284161B6 SK 16597 A SK16597 A SK 16597A SK 284161 B6 SK284161 B6 SK 284161B6
Authority
SK
Slovakia
Prior art keywords
icam
ala
gly
leu
ser
Prior art date
Application number
SK165-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK16597A3 (en
Inventor
Patrick D. Kilgannon
W. Michael Gallatin
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of SK16597A3 publication Critical patent/SK16597A3/sk
Publication of SK284161B6 publication Critical patent/SK284161B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Memories (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Glass Compositions (AREA)
SK165-97A 1995-06-07 1996-06-06 Spôsob in vitro skríningu na neuropatológiu SK284161B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/481,130 US5702917A (en) 1992-01-27 1995-06-07 Polynucleotides encoding human ICAM-4
PCT/US1996/009146 WO1996040916A1 (en) 1995-06-07 1996-06-06 Icam-4 materials and methods

Publications (2)

Publication Number Publication Date
SK16597A3 SK16597A3 (en) 1998-02-04
SK284161B6 true SK284161B6 (sk) 2004-10-05

Family

ID=23910735

Family Applications (1)

Application Number Title Priority Date Filing Date
SK165-97A SK284161B6 (sk) 1995-06-07 1996-06-06 Spôsob in vitro skríningu na neuropatológiu

Country Status (21)

Country Link
US (1) US5702917A (fi)
EP (2) EP1308514A3 (fi)
JP (2) JP3349514B2 (fi)
CN (2) CN1152960C (fi)
AT (1) ATE224448T1 (fi)
AU (1) AU721316B2 (fi)
BR (1) BR9606440A (fi)
CA (2) CA2288401A1 (fi)
CZ (1) CZ291974B6 (fi)
DE (1) DE69623746T2 (fi)
DK (1) DK0789763T3 (fi)
ES (1) ES2183961T3 (fi)
FI (1) FI970503A (fi)
HU (1) HUP9901123A3 (fi)
IL (2) IL120095A0 (fi)
MX (1) MX9700941A (fi)
NO (1) NO317150B1 (fi)
PL (2) PL188612B1 (fi)
RU (2) RU2155345C2 (fi)
SK (1) SK284161B6 (fi)
WO (1) WO1996040916A1 (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
GB9715164D0 (en) * 1997-07-19 1997-09-24 Medical Res Council Improvements in or relating to expression of nucleic acid sequences in cerebellar cells
RU2208230C2 (ru) * 1997-10-02 2003-07-10 Айкос Корпорейшн Icam-4 и его диагностическое использование
WO1999020762A1 (en) * 1997-10-22 1999-04-29 Icos Corporation Icam-6 materials and methods
EP1146837A4 (en) * 1998-11-30 2002-10-31 Ivf Sciences Colorado Inc ARRANGEMENT AND SEQUENTIAL CULTURAL MEDIA FOR IN-VITRO FERTILISATION

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2080044T3 (es) * 1987-05-04 1996-02-01 Dana Farber Cancer Inst Inc Moleculas de adhesion intercelular y sus ligandos de fijacion.
NZ226414A (en) * 1987-10-02 1992-07-28 Genentech Inc Cd4 peptide adhesion variants and their preparation and use
US5272263A (en) * 1989-04-28 1993-12-21 Biogen, Inc. DNA sequences encoding vascular cell adhesion molecules (VCAMS)
US5264554A (en) * 1990-01-19 1993-11-23 The Blood Center Of Southeastern Wisconsin, Inc. Platelet cell adhesion molecule and variants thereof
GB9009548D0 (en) * 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
EP0468257B1 (en) * 1990-07-20 1999-09-01 Bayer Corporation Multimeric form of human rhinovirus receptor protein
ES2115618T3 (es) * 1990-08-31 1998-07-01 Boehringer Ingelheim Pharma Uso de anticuerpos anti-icam en la preparacion de un medicamento para el tratamiento del choque por endotoxinas.
NZ243114A (en) * 1991-06-11 1995-03-28 Blood Res Center Icam-3; dna encoding it; antibodies; hybridomas; pharmaceuticals containing icam-3, a derivative or antagonist, anti-icam-3 or fragment; and in vivo and in vitro diagnosis
JP3616090B2 (ja) * 1992-01-27 2005-02-02 イコス コーポレイション 細胞間接着分子関連タンパク質
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4

Also Published As

Publication number Publication date
EP0789763A1 (en) 1997-08-20
RU2000111744A (ru) 2002-09-10
CN1164870A (zh) 1997-11-12
JP3349514B2 (ja) 2002-11-25
AU721316B2 (en) 2000-06-29
HUP9901123A2 (hu) 1999-07-28
BR9606440A (pt) 1997-09-30
CA2196431A1 (en) 1996-12-19
ES2183961T3 (es) 2003-04-01
FI970503A (fi) 1997-04-04
EP1308514A2 (en) 2003-05-07
PL318545A1 (en) 1997-06-23
NO970546D0 (no) 1997-02-06
CZ291974B6 (cs) 2003-06-18
JPH10505508A (ja) 1998-06-02
NO317150B1 (no) 2004-08-30
CA2196431C (en) 2000-08-15
CN1597950A (zh) 2005-03-23
MX9700941A (es) 1998-01-31
HUP9901123A3 (en) 2001-10-29
DE69623746T2 (de) 2003-05-08
RU2155345C2 (ru) 2000-08-27
WO1996040916A1 (en) 1996-12-19
CN1152960C (zh) 2004-06-09
US5702917A (en) 1997-12-30
DE69623746D1 (de) 2002-10-24
EP1308514A3 (en) 2004-01-02
SK16597A3 (en) 1998-02-04
EP0789763B1 (en) 2002-09-18
JP2003047493A (ja) 2003-02-18
FI970503A0 (fi) 1997-02-06
IL146447A0 (en) 2002-07-25
CA2288401A1 (en) 1996-12-19
IL120095A0 (en) 1997-04-15
ATE224448T1 (de) 2002-10-15
NO970546L (no) 1997-04-07
PL188612B1 (pl) 2005-03-31
DK0789763T3 (da) 2003-01-27
PL188878B1 (pl) 2005-05-31
AU6256096A (en) 1996-12-30
CZ29297A3 (en) 1997-10-15

Similar Documents

Publication Publication Date Title
US5869262A (en) Method for monitoring an inflammatory disease state by detecting circulating ICAM-R
US5837822A (en) Humanized antibodies specific for ICAM related protein
US20010029293A1 (en) Icam-related protein
WO1993014776A1 (en) Icam-related protein
US5753502A (en) Neuron-specific ICAM-4 promoter
US6040176A (en) Antibodies to ICAM-related protein
SK284161B6 (sk) Spôsob in vitro skríningu na neuropatológiu
EP0643728A1 (en) Icam-related protein
US6153395A (en) ICAM-related protein
US5773293A (en) Anti-ICAM-4 antibodies and hybridomas
US5989843A (en) Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US20030068659A1 (en) ICAM-4 materials and methods
US5852170A (en) ICAM-4 materials and methods
EP0956508B1 (en) Icam-4 and diagnostic uses thereof
WO1999018441A1 (en) Icam-4 and diagnostic uses thereof