SK282496B6 - Imidazolové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents
Imidazolové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie Download PDFInfo
- Publication number
- SK282496B6 SK282496B6 SK435-98A SK43598A SK282496B6 SK 282496 B6 SK282496 B6 SK 282496B6 SK 43598 A SK43598 A SK 43598A SK 282496 B6 SK282496 B6 SK 282496B6
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- SK
- Slovakia
- Prior art keywords
- alkyl
- carbon atoms
- moiety
- cycloalkyl
- aryl
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- 150000002460 imidazoles Chemical class 0.000 title claims description 26
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title claims description 17
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 134
- 125000003118 aryl group Chemical group 0.000 claims abstract description 124
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 30
- 201000010099 disease Diseases 0.000 claims abstract description 29
- 102000004127 Cytokines Human genes 0.000 claims abstract description 27
- 108090000695 Cytokines Proteins 0.000 claims abstract description 27
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 19
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 17
- 125000004429 atom Chemical group 0.000 claims abstract description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
- 201000011510 cancer Diseases 0.000 claims abstract description 13
- 230000001404 mediated effect Effects 0.000 claims abstract description 10
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 10
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 9
- 125000004434 sulfur atom Chemical group 0.000 claims abstract description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 450
- 125000004432 carbon atom Chemical group C* 0.000 claims description 449
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 121
- 229910052739 hydrogen Inorganic materials 0.000 claims description 92
- -1 aromatic heterocyclic radical Chemical class 0.000 claims description 88
- 125000001072 heteroaryl group Chemical group 0.000 claims description 63
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 57
- 125000003342 alkenyl group Chemical group 0.000 claims description 53
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- 239000001257 hydrogen Substances 0.000 claims description 47
- 125000000304 alkynyl group Chemical group 0.000 claims description 45
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 44
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 43
- 125000000623 heterocyclic group Chemical group 0.000 claims description 31
- 239000000126 substance Substances 0.000 claims description 30
- 229910052736 halogen Inorganic materials 0.000 claims description 28
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- 150000002367 halogens Chemical class 0.000 claims description 25
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 20
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 19
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 19
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- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 5
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- QQDDWRLYAVFTDR-UHFFFAOYSA-N 1-[4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1h-imidazol-2-yl]piperidin-1-yl]ethanone Chemical compound C1CN(C(=O)C)CCC1C1=NC(C=2C=CN=CC=2)=C(C=2C=CC(F)=CC=2)N1 QQDDWRLYAVFTDR-UHFFFAOYSA-N 0.000 claims description 4
- UWQNZECDJJWEBU-UHFFFAOYSA-N 4-[2-(1,4-dimethylpiperidin-4-yl)-4-(4-fluorophenyl)-1h-imidazol-5-yl]pyridine Chemical compound C1CN(C)CCC1(C)C1=NC(C=2C=CN=CC=2)=C(C=2C=CC(F)=CC=2)N1 UWQNZECDJJWEBU-UHFFFAOYSA-N 0.000 claims description 4
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- XLKVTNJFFBUUOU-UHFFFAOYSA-N 4-[2-(1-ethylpiperidin-4-yl)-4-(4-fluorophenyl)-1h-imidazol-5-yl]pyridine Chemical compound C1CN(CC)CCC1C1=NC(C=2C=CN=CC=2)=C(C=2C=CC(F)=CC=2)N1 XLKVTNJFFBUUOU-UHFFFAOYSA-N 0.000 claims description 3
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- 125000001424 substituent group Chemical group 0.000 claims description 3
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- IVYSQXWBIOQKAZ-UHFFFAOYSA-N 4-[5-(2-fluoropyridin-4-yl)-1-hydroxy-4-[3-(trifluoromethyl)phenyl]imidazol-2-yl]piperidine-1-carboxylic acid Chemical compound ON1C(=NC(=C1C1=CC(=NC=C1)F)C1=CC(=CC=C1)C(F)(F)F)C1CCN(CC1)C(=O)O IVYSQXWBIOQKAZ-UHFFFAOYSA-N 0.000 claims 1
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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- UUNZNAIKWSUTED-UHFFFAOYSA-N tert-butyl 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1h-imidazol-2-yl]-4-methylpiperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1(C)C1=NC(C=2C=CN=CC=2)=C(C=2C=CC(F)=CC=2)N1 UUNZNAIKWSUTED-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US506395P | 1995-10-06 | 1995-10-06 | |
| US505995P | 1995-10-06 | 1995-10-06 | |
| GBGB9602907.9A GB9602907D0 (en) | 1996-02-13 | 1996-02-13 | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| GBGB9602975.6A GB9602975D0 (en) | 1996-02-13 | 1996-02-13 | Acyl heterocylcic substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| PCT/US1996/015880 WO1997012876A1 (en) | 1995-10-06 | 1996-10-02 | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK43598A3 SK43598A3 (en) | 1998-11-04 |
| SK282496B6 true SK282496B6 (sk) | 2002-02-05 |
Family
ID=27451400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK435-98A SK282496B6 (sk) | 1995-10-06 | 1996-10-02 | Imidazolové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0854870B1 (cs) |
| JP (1) | JP3382951B2 (cs) |
| KR (1) | KR19990064117A (cs) |
| CN (1) | CN1117082C (cs) |
| AT (1) | ATE433446T1 (cs) |
| AU (1) | AU702146B2 (cs) |
| CA (1) | CA2234066C (cs) |
| CZ (1) | CZ292707B6 (cs) |
| DE (1) | DE69637948D1 (cs) |
| EA (1) | EA001203B1 (cs) |
| EE (1) | EE03681B1 (cs) |
| IL (1) | IL123950A (cs) |
| NO (1) | NO981528L (cs) |
| NZ (1) | NZ321738A (cs) |
| PL (1) | PL184819B1 (cs) |
| SK (1) | SK282496B6 (cs) |
| WO (1) | WO1997012876A1 (cs) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
| US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| JP2000504023A (ja) * | 1996-04-03 | 2000-04-04 | メルク エンド カンパニー インコーポレーテッド | 癌治療方法 |
| US6410729B1 (en) | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
| US6096753A (en) * | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
| EP1314732A3 (en) * | 1996-12-05 | 2004-01-02 | Amgen Inc. | Substituted pyrimidine compounds and their use |
| AU735901C (en) * | 1996-12-05 | 2004-02-12 | Amgen, Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
| JP2002514195A (ja) * | 1996-12-05 | 2002-05-14 | アムジエン・インコーポレーテツド | 置換ピリミジン化合物およびそれの使用 |
| US6608060B1 (en) | 1996-12-18 | 2003-08-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US5945418A (en) * | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| ATE335735T1 (de) | 1997-06-12 | 2006-09-15 | Aventis Pharma Ltd | Imidazolyl-cyclische acetale |
| AU7966198A (en) | 1997-06-13 | 1998-12-30 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
| CA2294137A1 (en) | 1997-06-19 | 1998-12-23 | Smithkline Beecham Corporation | Novel aryloxy substituted pyrimidine imidazole compounds |
| GB9713726D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| CA2295762A1 (en) | 1997-07-02 | 1999-01-14 | Ravi Shanker Garigipati | Novel cycloalkyl substituted imidazoles |
| WO1999017776A1 (en) | 1997-10-08 | 1999-04-15 | Smithkline Beecham Corporation | Novel cycloalkenyl substituted compounds |
| EP1037639A4 (en) | 1997-12-19 | 2002-04-17 | Smithkline Beecham Corp | HETEROARYL-SUBSTITUTED IMIDAZOLE COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES |
| NZ508180A (en) | 1998-05-22 | 2003-09-26 | Smithkline Beecham Corp | 2(alkyl)-, 5(4-pyridinyl)- substituted imidazole derivatives and pharmaceuticals thereof |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| WO2000019824A1 (en) | 1998-10-07 | 2000-04-13 | Smithkline Beecham Corporation | Novel treatment for stroke management |
| ES2212657T3 (es) | 1998-11-04 | 2004-07-16 | Smithkline Beecham Corporation | Pirazinas sustituidas piridin-4-il o pirimidin-4-il. |
| PT1180518E (pt) * | 1999-04-23 | 2007-02-28 | Takeda Pharmaceutical | Compostos de 5-piridil-1, 3-azole, processo para a sua produção e sua utilização |
| US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
| AU6471300A (en) | 1999-08-06 | 2001-03-05 | Takeda Chemical Industries Ltd. | P38map kinase inhibitors |
| AU1783201A (en) | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors |
| AU1782301A (en) | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors |
| US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| GB0005357D0 (en) * | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
| EP1263753B1 (en) * | 2000-03-06 | 2004-05-06 | SmithKline Beecham plc | Imidazol derivatives as raf kinase inhibitors |
| US7495018B2 (en) | 2000-03-30 | 2009-02-24 | Takeda Pharmaceutical Company Limited | Substituted 1,3-thiazole compounds, their production and use |
| WO2001098268A2 (en) | 2000-06-21 | 2001-12-27 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
| FR2818978B1 (fr) * | 2000-12-28 | 2003-02-28 | Sod Conseils Rech Applic | Modulateurs de canaux sodiques derives de 2-piperidylimidazoles |
| GB0112348D0 (en) | 2001-05-19 | 2001-07-11 | Smithkline Beecham Plc | Compounds |
| JP2005538066A (ja) | 2002-07-09 | 2005-12-15 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 新規な抗コリン作用薬及びｐ３８キナーゼ阻害剤を用いた新規な医薬組成物 |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP1606283B1 (en) | 2003-03-03 | 2008-10-08 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| WO2005063716A1 (en) | 2003-12-22 | 2005-07-14 | Janssen Pharmaceutica, N.V. | Imidazoles and their use cck-1 receptor modulators |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| HRP20120256T1 (hr) | 2006-01-31 | 2012-04-30 | Array Biopharma | Inhibitori kinaza i postupci njihove upotrebe |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| EA201001456A1 (ru) * | 2008-03-21 | 2011-06-30 | Новартис Аг | Новые гетероциклические соединения и их применение |
| US20240043399A1 (en) * | 2021-03-04 | 2024-02-08 | Industry-University Cooperation Foundation Hanyang University Erica Campus | Pyridinyl pyrazole derivative or pharmaceutically acceptable salt thereof, and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL104369A0 (en) * | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
| AU7629594A (en) * | 1993-07-21 | 1995-02-20 | Smithkline Beecham Corporation | Imidazoles for treating cytokine mediated disease |
-
1996
- 1996-10-02 EA EA199800268A patent/EA001203B1/ru not_active IP Right Cessation
- 1996-10-02 CN CN96198718A patent/CN1117082C/zh not_active Expired - Fee Related
- 1996-10-02 KR KR1019980702598A patent/KR19990064117A/ko not_active Ceased
- 1996-10-02 AU AU75143/96A patent/AU702146B2/en not_active Ceased
- 1996-10-02 AT AT96937654T patent/ATE433446T1/de not_active IP Right Cessation
- 1996-10-02 CZ CZ19981043A patent/CZ292707B6/cs not_active IP Right Cessation
- 1996-10-02 NZ NZ321738A patent/NZ321738A/xx unknown
- 1996-10-02 DE DE69637948T patent/DE69637948D1/de not_active Expired - Fee Related
- 1996-10-02 SK SK435-98A patent/SK282496B6/sk unknown
- 1996-10-02 PL PL96326025A patent/PL184819B1/pl unknown
- 1996-10-02 WO PCT/US1996/015880 patent/WO1997012876A1/en not_active Ceased
- 1996-10-02 EE EE9800083A patent/EE03681B1/xx not_active IP Right Cessation
- 1996-10-02 EP EP96937654A patent/EP0854870B1/en not_active Expired - Lifetime
- 1996-10-02 JP JP51442897A patent/JP3382951B2/ja not_active Expired - Fee Related
- 1996-10-02 IL IL12395096A patent/IL123950A/en not_active IP Right Cessation
- 1996-10-02 CA CA002234066A patent/CA2234066C/en not_active Expired - Fee Related
-
1998
- 1998-04-03 NO NO981528A patent/NO981528L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK43598A3 (en) | 1998-11-04 |
| EP0854870A1 (en) | 1998-07-29 |
| AU7514396A (en) | 1997-04-28 |
| KR19990064117A (ko) | 1999-07-26 |
| IL123950A (en) | 2001-04-30 |
| EP0854870A4 (en) | 1999-01-07 |
| PL184819B1 (pl) | 2002-12-31 |
| CA2234066A1 (en) | 1997-04-10 |
| PL326025A1 (en) | 1998-08-17 |
| EA001203B1 (ru) | 2000-12-25 |
| NO981528D0 (no) | 1998-04-03 |
| ATE433446T1 (de) | 2009-06-15 |
| WO1997012876A1 (en) | 1997-04-10 |
| NO981528L (no) | 1998-06-05 |
| JPH11514353A (ja) | 1999-12-07 |
| DE69637948D1 (de) | 2009-07-23 |
| CA2234066C (en) | 2005-12-13 |
| CZ104398A3 (cs) | 1998-07-15 |
| CN1203590A (zh) | 1998-12-30 |
| EE03681B1 (et) | 2002-04-15 |
| EA199800268A1 (ru) | 1998-12-24 |
| EP0854870B1 (en) | 2009-06-10 |
| JP3382951B2 (ja) | 2003-03-04 |
| EE9800083A (et) | 1998-10-15 |
| CZ292707B6 (cs) | 2003-11-12 |
| CN1117082C (zh) | 2003-08-06 |
| AU702146B2 (en) | 1999-02-11 |
| NZ321738A (en) | 1999-11-29 |
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