SK281932B6 - Použitie kombinácie tricyklického antidepresíva alebo inhibítora monoaminooxidázy s aminokyselinovou zlúčeninou indukujúcou neurotransmiter - Google Patents
Použitie kombinácie tricyklického antidepresíva alebo inhibítora monoaminooxidázy s aminokyselinovou zlúčeninou indukujúcou neurotransmiter Download PDFInfo
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- SK281932B6 SK281932B6 SK438-97A SK43897A SK281932B6 SK 281932 B6 SK281932 B6 SK 281932B6 SK 43897 A SK43897 A SK 43897A SK 281932 B6 SK281932 B6 SK 281932B6
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- phenylalanine
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- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims abstract description 7
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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GB9420116A GB9420116D0 (en) | 1994-10-05 | 1994-10-05 | A therapeutic drug treatment for compensating for the effects of nerve damage caused by multiple sclerosis and other demyelinating conditions |
GBGB9508482.8A GB9508482D0 (en) | 1995-04-26 | 1995-04-26 | A therapeutic drug treatment for compensating for the effects of nerve damage caused by multiple sclerosis and other demyelinating conditions, and the product |
PCT/GB1995/002361 WO1996011009A1 (en) | 1994-10-05 | 1995-10-05 | Treatment of multiple sclerosis (ms) and other demyelinating conditions using lofepramine in combination with l-phenylalanine, tyrosine or tryptophan and possibly a vitamin b12 compound |
Publications (2)
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SK43897A3 SK43897A3 (en) | 1998-08-05 |
SK281932B6 true SK281932B6 (sk) | 2001-09-11 |
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Family Applications (1)
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SK438-97A SK281932B6 (sk) | 1994-10-05 | 1995-10-05 | Použitie kombinácie tricyklického antidepresíva alebo inhibítora monoaminooxidázy s aminokyselinovou zlúčeninou indukujúcou neurotransmiter |
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US (2) | US6096737A (cs) |
EP (1) | EP0784476B1 (cs) |
JP (1) | JPH10508583A (cs) |
AT (1) | ATE227124T1 (cs) |
AU (1) | AU710339B2 (cs) |
CA (1) | CA2200761C (cs) |
CZ (1) | CZ293873B6 (cs) |
DE (1) | DE69528773T2 (cs) |
DK (1) | DK0784476T3 (cs) |
ES (1) | ES2184808T3 (cs) |
FI (1) | FI116659B (cs) |
HU (1) | HU225493B1 (cs) |
IS (1) | IS1956B (cs) |
NO (1) | NO314486B1 (cs) |
NZ (1) | NZ293642A (cs) |
PL (1) | PL181802B1 (cs) |
PT (1) | PT784476E (cs) |
SK (1) | SK281932B6 (cs) |
WO (1) | WO1996011009A1 (cs) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE224733T1 (de) * | 1996-07-05 | 2002-10-15 | Wwk Trust | Zusammensetzungen zur behandlung der peripheren neuropathie, die antidepressiven verbindungen und/oder monoamino-oxidaseinhibitoren und/oder vitamin b12 und/oder neurotransmitter-vorläufer oder induktoren enthalten |
GB9617990D0 (en) | 1996-08-29 | 1996-10-09 | Scotia Holdings Plc | Treatment of pain |
EP0835660A1 (en) * | 1996-10-14 | 1998-04-15 | Gaston Edmond Filomena Merckx | Products containing methylcobalamin for the treatment of multiple sclerosis or other demyelinating conditions |
US7232830B2 (en) * | 1998-06-26 | 2007-06-19 | Elaine A Delack | Method for treatment of neurodegenerative diseases and effects of aging |
GB9904252D0 (en) * | 1999-02-24 | 1999-04-21 | Worsley Andrew P | Composition for the treatment of pain |
GB9906808D0 (en) * | 1999-03-24 | 1999-05-19 | Kilgowan Limited | Formulation for treatment of pain |
GB2355191A (en) * | 1999-10-12 | 2001-04-18 | Laxdale Ltd | Combination formulations for fatigue, head injury and strokes |
ES2381775T3 (es) | 2000-08-04 | 2012-05-31 | Dmi Biosciences, Inc. | Procedimiento del uso de dicetopiperazinas y composición que las contiene |
US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
US20020147206A1 (en) * | 2001-04-05 | 2002-10-10 | Pfizer Inc. | Combination treatment of multiple sclerosis (MS), other demyelinating conditions and peripheral neuropathy, especially painful neuropathies and diabetic neuropathy |
GB0216027D0 (en) | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US6833142B2 (en) * | 2002-03-14 | 2004-12-21 | Duane Bennett | Formulation for the prevention and treatment of multiple sclerosis and other demyelinating conditions |
NZ539735A (en) | 2002-10-02 | 2009-07-31 | Dmi Biosciences Inc | Diagnosis and monitoring of diseases using markers, such as diketopiperazines |
CA2514061A1 (en) * | 2003-02-14 | 2004-09-02 | Combinatorx, Incorporated | Combination therapy for the treatment of immunoinflammatory disorders |
CN101947306B (zh) | 2003-05-15 | 2014-06-18 | 安皮奥制药股份有限公司 | T-细胞介导的疾病的治疗 |
GB0313630D0 (en) * | 2003-06-12 | 2003-07-16 | Wwk Trust The | Compositions for the enhanced treatment of depression |
US20050192261A1 (en) * | 2003-09-15 | 2005-09-01 | Jost-Price Edward R. | Methods and reagents for the treatment of immunoinflammatory disorders |
ATE552832T1 (de) | 2006-02-24 | 2012-04-15 | Shire Llc | Antidepressivum-propharmaka |
EP2300011A4 (en) * | 2008-05-27 | 2012-06-20 | Dmi Life Sciences Inc | THERAPEUTIC PROCESSES AND COMPOUNDS |
WO2011011594A2 (en) * | 2009-07-23 | 2011-01-27 | Shriners Hospitals For Children | Intracellular toll-like receptors pathways and axonal degeneration |
CA2810844C (en) | 2010-09-07 | 2017-03-21 | Dmi Acquisition Corp. | Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions |
EP2766029B1 (en) | 2011-10-10 | 2020-03-25 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
EP3701921A1 (en) | 2011-10-10 | 2020-09-02 | Ampio Pharmaceuticals, Inc. | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
SG11201400283RA (en) | 2011-10-28 | 2014-03-28 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
NZ712630A (en) | 2013-03-15 | 2021-07-30 | Ampio Pharmaceuticals Inc | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
WO2016028790A1 (en) | 2014-08-18 | 2016-02-25 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
HK1246669A1 (zh) | 2015-06-22 | 2018-09-14 | Ampio Pharmaceuticals, Inc. | 人血清白蛋白低分子量组分在疾病治疗中的应用 |
WO2017085437A1 (en) | 2015-11-19 | 2017-05-26 | The Wwk Trust | Combinations for the treatment of dementia, and the enhancement of cognitive function |
US20190262353A1 (en) * | 2016-10-25 | 2019-08-29 | Uti Limited Partnership | Treatment for progressive multiple sclerosis |
AU2018260628A1 (en) | 2017-04-25 | 2019-12-12 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
EP3431491A1 (en) * | 2017-07-18 | 2019-01-23 | Centre National De La Recherche Scientifique | Methods for purifying proteins having a tubulin carboxypeptidase activity and peptidic based inhibitors thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1497306A (en) * | 1975-07-03 | 1978-01-05 | Leo Ab | Preparation of lofepramine and its hydrochloride |
GB2082910A (en) * | 1980-08-28 | 1982-03-17 | Berk Pharmaceuticals Ltd | Anti-depressant compositions |
US4409243A (en) * | 1981-11-09 | 1983-10-11 | Julian Lieb | Treatment of auto-immune and inflammatory diseases |
GB2129299A (en) * | 1982-11-09 | 1984-05-16 | Alec James Coppen | Pharmaceutical compositions |
DE3519687A1 (de) * | 1985-06-01 | 1986-12-04 | Veit Arend | Aminosaeuren enthaltendes arzneimittel |
US4650789A (en) * | 1985-10-15 | 1987-03-17 | Commonwealth Medical Corporation Of America | Method and composition for increasing production of serotonin |
US4843071A (en) * | 1986-12-05 | 1989-06-27 | Serotonin Industries Of Charleston | Method and composition for treating obesity, drug abuse, and narcolepsy |
DE4204102C2 (de) * | 1992-02-12 | 1998-09-24 | Kragler Peter | Arzneimittel zur Behandlung und/oder Prophylaxe von AIDS und anderen verwandten Erkrankungen |
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1995
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- 1995-10-05 JP JP8512415A patent/JPH10508583A/ja active Pending
- 1995-10-05 HU HU9702373A patent/HU225493B1/hu not_active IP Right Cessation
- 1995-10-05 CA CA002200761A patent/CA2200761C/en not_active Expired - Fee Related
- 1995-10-05 SK SK438-97A patent/SK281932B6/sk not_active IP Right Cessation
- 1995-10-05 NZ NZ293642A patent/NZ293642A/xx not_active IP Right Cessation
- 1995-10-05 DE DE69528773T patent/DE69528773T2/de not_active Expired - Lifetime
- 1995-10-05 DK DK95933488T patent/DK0784476T3/da active
- 1995-10-05 ES ES95933488T patent/ES2184808T3/es not_active Expired - Lifetime
- 1995-10-05 WO PCT/GB1995/002361 patent/WO1996011009A1/en active IP Right Grant
- 1995-10-05 US US08/817,086 patent/US6096737A/en not_active Expired - Lifetime
- 1995-10-05 PL PL95319830A patent/PL181802B1/pl not_active IP Right Cessation
- 1995-10-05 AU AU36126/95A patent/AU710339B2/en not_active Ceased
- 1995-10-05 EP EP95933488A patent/EP0784476B1/en not_active Expired - Lifetime
- 1995-10-05 PT PT95933488T patent/PT784476E/pt unknown
- 1995-10-05 CZ CZ1997995A patent/CZ293873B6/cs not_active IP Right Cessation
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1997
- 1997-03-26 FI FI971290A patent/FI116659B/fi active IP Right Grant
- 1997-03-26 IS IS4454A patent/IS1956B/is unknown
- 1997-04-04 NO NO19971539A patent/NO314486B1/no not_active IP Right Cessation
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2000
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ES2184808T3 (es) | 2003-04-16 |
WO1996011009A1 (en) | 1996-04-18 |
NZ293642A (en) | 1998-10-28 |
EP0784476B1 (en) | 2002-11-06 |
US6569850B1 (en) | 2003-05-27 |
CA2200761C (en) | 2008-02-26 |
EP0784476A1 (en) | 1997-07-23 |
SK43897A3 (en) | 1998-08-05 |
CZ99597A3 (en) | 1997-11-12 |
PL181802B1 (en) | 2001-09-28 |
NO971539D0 (no) | 1997-04-04 |
FI971290A0 (fi) | 1997-03-26 |
FI116659B (fi) | 2006-01-31 |
AU3612695A (en) | 1996-05-02 |
CA2200761A1 (en) | 1996-04-18 |
ATE227124T1 (de) | 2002-11-15 |
IS1956B (is) | 2004-11-15 |
NO314486B1 (no) | 2003-03-31 |
JPH10508583A (ja) | 1998-08-25 |
PL319830A1 (en) | 1997-09-01 |
DE69528773T2 (de) | 2003-09-04 |
DK0784476T3 (da) | 2003-03-17 |
CZ293873B6 (cs) | 2004-08-18 |
PT784476E (pt) | 2003-03-31 |
NO971539L (no) | 1997-04-04 |
US6096737A (en) | 2000-08-01 |
IS4454A (is) | 1997-03-26 |
AU710339B2 (en) | 1999-09-16 |
DE69528773D1 (de) | 2002-12-12 |
FI971290L (fi) | 1997-06-02 |
HU225493B1 (en) | 2007-01-29 |
HUT77380A (hu) | 1998-04-28 |
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MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20091005 |