SK145398A3 - Pyrazinone thrombin inhibitors - Google Patents
Pyrazinone thrombin inhibitors Download PDFInfo
- Publication number
- SK145398A3 SK145398A3 SK1453-98A SK145398A SK145398A3 SK 145398 A3 SK145398 A3 SK 145398A3 SK 145398 A SK145398 A SK 145398A SK 145398 A3 SK145398 A3 SK 145398A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- pyrazinone
- alkyl
- amino
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1604196P | 1996-04-23 | 1996-04-23 | |
| GBGB9609714.2A GB9609714D0 (en) | 1996-05-09 | 1996-05-09 | Pyridinone thrombin inhibitors |
| US4300997P | 1997-04-14 | 1997-04-14 | |
| PCT/US1997/006744 WO1997040024A1 (en) | 1996-04-23 | 1997-04-18 | Pyrazinone thrombin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK145398A3 true SK145398A3 (en) | 1999-05-07 |
Family
ID=27268274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1453-98A SK145398A3 (en) | 1996-04-23 | 1997-04-18 | Pyrazinone thrombin inhibitors |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0900207B1 (is) |
| JP (1) | JP3140790B2 (is) |
| KR (1) | KR20000010650A (is) |
| AT (1) | ATE209191T1 (is) |
| AU (1) | AU714985B2 (is) |
| BG (1) | BG102948A (is) |
| BR (1) | BR9708859A (is) |
| CA (1) | CA2252964A1 (is) |
| CZ (1) | CZ340898A3 (is) |
| DE (1) | DE69709727T2 (is) |
| EE (1) | EE9800353A (is) |
| HR (1) | HRP970211A2 (is) |
| IL (1) | IL126404A0 (is) |
| IS (1) | IS4853A (is) |
| NO (1) | NO984928L (is) |
| NZ (1) | NZ331993A (is) |
| PE (1) | PE13399A1 (is) |
| PL (1) | PL329441A1 (is) |
| SK (1) | SK145398A3 (is) |
| TR (1) | TR199802133T2 (is) |
| WO (1) | WO1997040024A1 (is) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU746024B2 (en) * | 1996-04-23 | 2002-04-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| US6159980A (en) * | 1996-09-16 | 2000-12-12 | Dupont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
| WO1998042342A1 (en) * | 1997-03-24 | 1998-10-01 | Merck & Co., Inc. | Thrombin inhibitors |
| US6011038A (en) * | 1997-09-05 | 2000-01-04 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| EP1079835A4 (en) * | 1998-05-19 | 2002-10-29 | Merck & Co Inc | PYRAZINONE AS THROMBINE INHIBITORS |
| US6147078A (en) * | 1998-05-19 | 2000-11-14 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| CA2333040A1 (en) * | 1998-05-26 | 1999-12-02 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
| AU759427B2 (en) | 1998-06-11 | 2003-04-17 | 3-Dimensional Pharmaceuticals, Inc. | Pyrazinone protease inhibitors |
| EP0997474B1 (en) * | 1998-08-14 | 2003-10-29 | Pfizer Inc. | Antithrombotic agents |
| WO2000018762A1 (en) * | 1998-09-28 | 2000-04-06 | Merck & Co., Inc. | Thrombin inhibitors |
| AU747776B2 (en) | 1998-10-30 | 2002-05-23 | Merck & Co., Inc. | Thrombin inhibitors |
| EP1124823A1 (en) | 1998-10-30 | 2001-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
| WO2000039102A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| CA2372617A1 (en) * | 1999-05-19 | 2000-11-23 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) * | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| EP1586565A1 (en) * | 1999-05-19 | 2005-10-19 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| UA58636C2 (uk) * | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
| DE60031686T2 (de) * | 1999-07-19 | 2007-08-30 | Merck Frosst Canada Ltd., Kirkland | Pyrazinone, diese verbindungen enthaltende zusammenstellungen |
| WO2001038323A1 (en) * | 1999-11-23 | 2001-05-31 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| WO2001068605A1 (en) | 2000-03-13 | 2001-09-20 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| EP1267876A1 (en) | 2000-03-23 | 2003-01-02 | Merck & Co., Inc. | Thrombin inhibitors |
| EP1268463B1 (en) | 2000-04-05 | 2005-02-16 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| WO2001077079A2 (en) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| US6506761B1 (en) | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| WO2001079193A2 (en) * | 2000-04-14 | 2001-10-25 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| US6506760B1 (en) | 2000-04-14 | 2003-01-14 | Corvas International, Inc. | Substituted hydrazinyl heteroaromatic inhibitors of thrombin |
| AU2001253363A1 (en) | 2000-04-17 | 2001-10-30 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| WO2002006248A2 (en) * | 2000-07-17 | 2002-01-24 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine pyrazinones as protease inhibitors |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| MXPA03004458A (es) | 2000-11-20 | 2005-01-25 | Pharmacia Corp | Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion. |
| WO2003029216A1 (en) | 2001-10-03 | 2003-04-10 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| WO2003093242A2 (en) | 2001-10-03 | 2003-11-13 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
| RS52392B (en) | 2002-02-14 | 2013-02-28 | Pharmacia Corporation | SUBSTITUTED PYRIDINONES AS P38 MAP KINASE MODULATORS |
| GB0306615D0 (en) * | 2003-03-22 | 2003-04-30 | Astrazeneca Ab | New use |
| EP1526131A1 (en) * | 2003-10-22 | 2005-04-27 | Graffinity Pharmaceuticals Aktiengesellschaft | Aminoalkyl-pyrazinones and -pyridones as thrombin inhibitors |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| JP2008546684A (ja) * | 2005-06-17 | 2008-12-25 | アストラゼネカ アクチボラグ | トロンビン阻害性２−オキソ−１，２，５，６−テトラヒドロピリジン誘導体 |
| CN108271369A (zh) | 2015-10-23 | 2018-07-10 | 法尔玛赞公司 | 用于制备色胺及其衍生物的新工艺 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0262096B1 (de) * | 1986-09-26 | 1992-01-02 | Ciba-Geigy Ag | Aminopyrazinone und Aminotriazinone |
-
1997
- 1997-04-18 DE DE69709727T patent/DE69709727T2/de not_active Expired - Fee Related
- 1997-04-18 BR BR9708859A patent/BR9708859A/pt not_active Application Discontinuation
- 1997-04-18 TR TR1998/02133T patent/TR199802133T2/xx unknown
- 1997-04-18 EE EE9800353A patent/EE9800353A/xx unknown
- 1997-04-18 WO PCT/US1997/006744 patent/WO1997040024A1/en not_active Application Discontinuation
- 1997-04-18 CZ CZ983408A patent/CZ340898A3/cs unknown
- 1997-04-18 KR KR1019980708609A patent/KR20000010650A/ko not_active Application Discontinuation
- 1997-04-18 IL IL12640497A patent/IL126404A0/xx unknown
- 1997-04-18 AU AU26799/97A patent/AU714985B2/en not_active Ceased
- 1997-04-18 NZ NZ331993A patent/NZ331993A/xx unknown
- 1997-04-18 EP EP97918780A patent/EP0900207B1/en not_active Expired - Lifetime
- 1997-04-18 AT AT97918780T patent/ATE209191T1/de active
- 1997-04-18 PL PL97329441A patent/PL329441A1/xx unknown
- 1997-04-18 SK SK1453-98A patent/SK145398A3/sk unknown
- 1997-04-18 CA CA002252964A patent/CA2252964A1/en not_active Abandoned
- 1997-04-18 JP JP09538296A patent/JP3140790B2/ja not_active Expired - Fee Related
- 1997-04-21 HR HR60/043,009A patent/HRP970211A2/xx not_active Application Discontinuation
- 1997-04-23 PE PE1997000308A patent/PE13399A1/es not_active Application Discontinuation
-
1998
- 1998-09-25 IS IS4853A patent/IS4853A/is unknown
- 1998-10-22 NO NO984928A patent/NO984928L/no unknown
- 1998-11-23 BG BG102948A patent/BG102948A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9708859A (pt) | 1999-08-03 |
| HRP970211A2 (en) | 1998-06-30 |
| KR20000010650A (ko) | 2000-02-25 |
| WO1997040024A1 (en) | 1997-10-30 |
| DE69709727D1 (de) | 2002-02-21 |
| JP2000508334A (ja) | 2000-07-04 |
| NZ331993A (en) | 2000-04-28 |
| PE13399A1 (es) | 1999-02-11 |
| AU2679997A (en) | 1997-11-12 |
| AU714985B2 (en) | 2000-01-13 |
| IS4853A (is) | 1998-09-25 |
| NO984928D0 (no) | 1998-10-22 |
| PL329441A1 (en) | 1999-03-29 |
| DE69709727T2 (de) | 2002-08-08 |
| NO984928L (no) | 1998-12-22 |
| EP0900207A1 (en) | 1999-03-10 |
| EP0900207B1 (en) | 2001-11-21 |
| BG102948A (bg) | 1999-11-30 |
| CA2252964A1 (en) | 1997-10-30 |
| CZ340898A3 (cs) | 1999-02-17 |
| EE9800353A (et) | 1999-04-15 |
| TR199802133T2 (xx) | 2000-09-21 |
| JP3140790B2 (ja) | 2001-03-05 |
| IL126404A0 (en) | 1999-05-09 |
| ATE209191T1 (de) | 2001-12-15 |
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