SK113895A3 - Ultrasound contrast agent and preparation method thereof - Google Patents
Ultrasound contrast agent and preparation method thereof Download PDFInfo
- Publication number
- SK113895A3 SK113895A3 SK1138-95A SK113895A SK113895A3 SK 113895 A3 SK113895 A3 SK 113895A3 SK 113895 A SK113895 A SK 113895A SK 113895 A3 SK113895 A3 SK 113895A3
- Authority
- SK
- Slovakia
- Prior art keywords
- gas
- contrast agent
- oil
- liquid
- emulsion
- Prior art date
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- 239000002961 echo contrast media Substances 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title description 2
- 239000000839 emulsion Substances 0.000 claims abstract description 52
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- 239000002243 precursor Substances 0.000 claims abstract description 21
- 239000007789 gas Substances 0.000 claims description 66
- 239000002872 contrast media Substances 0.000 claims description 34
- 239000007788 liquid Substances 0.000 claims description 31
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- 239000003795 chemical substances by application Substances 0.000 claims description 8
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- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 description 1
- 229940018602 docusate Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- DANUORFCFTYTSZ-UHFFFAOYSA-N epinigericin Natural products O1C2(C(CC(C)(O2)C2OC(C)(CC2)C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)C)C(C)C(OC)CC1CC1CCC(C)C(C(C)C(O)=O)O1 DANUORFCFTYTSZ-UHFFFAOYSA-N 0.000 description 1
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 230000002169 extracardiac Effects 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000007925 intracardiac injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000002555 ionophore Substances 0.000 description 1
- 230000000236 ionophoric effect Effects 0.000 description 1
- ULYZAYCEDJDHCC-UHFFFAOYSA-N isopropyl chloride Chemical compound CC(C)Cl ULYZAYCEDJDHCC-UHFFFAOYSA-N 0.000 description 1
- 229910052743 krypton Inorganic materials 0.000 description 1
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- DANUORFCFTYTSZ-BIBFWWMMSA-N nigericin Chemical compound C([C@@H]1C[C@H]([C@H]([C@]2([C@@H](C[C@](C)(O2)C2O[C@@](C)(CC2)C2[C@H](CC(O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C)O1)C)OC)[C@H]1CC[C@H](C)C([C@@H](C)C(O)=O)O1 DANUORFCFTYTSZ-BIBFWWMMSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- PODAMDNJNMAKAZ-UHFFFAOYSA-N penta-2,3-diene Chemical compound CC=C=CC PODAMDNJNMAKAZ-UHFFFAOYSA-N 0.000 description 1
- 229960004692 perflenapent Drugs 0.000 description 1
- 229950003332 perflubutane Drugs 0.000 description 1
- LRMQIJUOLGKFKS-UHFFFAOYSA-N perfluoro-1,3-dimethyladamantane Chemical compound FC1(F)C(C2(F)F)(F)C(F)(F)C3(F)C(F)(F)C1(C(F)(F)F)C(F)(F)C2(C(F)(F)F)C3(F)F LRMQIJUOLGKFKS-UHFFFAOYSA-N 0.000 description 1
- WKHMXCIUCCIPOU-UHFFFAOYSA-N perfluoro-1-methyladamantane Chemical compound FC1(F)C(C2(F)F)(F)C(F)(F)C3(F)C(F)(F)C2(F)C(F)(F)C1(C(F)(F)F)C3(F)F WKHMXCIUCCIPOU-UHFFFAOYSA-N 0.000 description 1
- BPHQIXJDBIHMLT-UHFFFAOYSA-N perfluorodecane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F BPHQIXJDBIHMLT-UHFFFAOYSA-N 0.000 description 1
- YVBBRRALBYAZBM-UHFFFAOYSA-N perfluorooctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F YVBBRRALBYAZBM-UHFFFAOYSA-N 0.000 description 1
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 description 1
- XCRBXWCUXJNEFX-UHFFFAOYSA-N peroxybenzoic acid Chemical compound OOC(=O)C1=CC=CC=C1 XCRBXWCUXJNEFX-UHFFFAOYSA-N 0.000 description 1
- 150000008103 phosphatidic acids Chemical class 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
- 150000008106 phosphatidylserines Chemical class 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- 150000003219 pyrazolines Chemical class 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Coating Apparatus (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939305349A GB9305349D0 (en) | 1993-03-16 | 1993-03-16 | Improvements in or relating to contrast agents |
| PCT/GB1994/000521 WO1994021301A1 (en) | 1993-03-16 | 1994-03-16 | Improvements in or relating to contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK113895A3 true SK113895A3 (en) | 1997-02-05 |
Family
ID=10732116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1138-95A SK113895A3 (en) | 1993-03-16 | 1994-03-16 | Ultrasound contrast agent and preparation method thereof |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0689461B1 (fi) |
| JP (1) | JP3787639B2 (fi) |
| KR (1) | KR960700759A (fi) |
| CN (1) | CN1066963C (fi) |
| AT (1) | ATE194292T1 (fi) |
| AU (1) | AU696091B2 (fi) |
| BG (2) | BG62084B1 (fi) |
| BR (1) | BR9406228A (fi) |
| CA (1) | CA2158365A1 (fi) |
| CZ (1) | CZ237095A3 (fi) |
| DE (1) | DE69425136T2 (fi) |
| ES (1) | ES2147784T3 (fi) |
| FI (1) | FI954325A (fi) |
| GB (1) | GB9305349D0 (fi) |
| HK (1) | HK1004981A1 (fi) |
| HU (1) | HUT72982A (fi) |
| NO (1) | NO953637L (fi) |
| PL (1) | PL175128B1 (fi) |
| RU (1) | RU2128520C1 (fi) |
| SK (1) | SK113895A3 (fi) |
| WO (1) | WO1994021301A1 (fi) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874062A (en) * | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| CA2148372A1 (en) * | 1992-11-02 | 1994-05-11 | Margaret A. Wheatley | Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same |
| US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
| US5736121A (en) * | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
| US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US5897851A (en) * | 1995-06-07 | 1999-04-27 | Sonus Pharmaceuticals, Inc. | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging |
| US5834519A (en) * | 1996-10-11 | 1998-11-10 | Wayne State University | Stabilized gas-supersaturated emulsions and suspensions |
| US6548047B1 (en) * | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| GB9808581D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US6514209B1 (en) | 1999-06-07 | 2003-02-04 | Drexel University | Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals |
| AU2002223652A1 (en) * | 2000-10-24 | 2002-05-06 | C.C.H. S.A. | Endoscopic vascular visualisation, diagnostic and/or surgical procedure |
| US8323620B2 (en) * | 2004-10-22 | 2012-12-04 | Hitachi Medical Corporation | Ultrasound contrast agent |
| WO2007137236A2 (en) | 2006-05-19 | 2007-11-29 | Drexel University | Drug loaded contrast agents: combining diagnosis and therapy |
| JP4800862B2 (ja) * | 2006-06-21 | 2011-10-26 | 株式会社日立製作所 | ファントム |
| JP5124185B2 (ja) * | 2007-07-02 | 2013-01-23 | 株式会社日立製作所 | 診断又は治療用薬剤の調製方法及び装置 |
| CN104334197B (zh) | 2012-05-09 | 2017-03-15 | 辛维特有限公司 | 超声接触液 |
| CN107206111B (zh) | 2014-12-31 | 2021-04-27 | 蓝瑟斯医学影像公司 | 脂质封装的气体微球组合物及相关方法 |
| AU2017260532B2 (en) | 2016-05-04 | 2024-08-22 | Lantheus Medical Imaging, Inc. | Methods and devices for preparation of ultrasound contrast agents |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
| US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| EP0245019A3 (en) * | 1986-04-30 | 1989-05-10 | Michael A. Davis | Low density contrast medium for diagnosis of pathologic conditions |
| WO1989006978A1 (en) * | 1988-02-05 | 1989-08-10 | Schering Aktiengesellschaft Berlin Und Bergkamen | Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents |
| US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| DK0605477T4 (da) * | 1991-09-17 | 2007-10-01 | Ge Healthcare As | Gasformige ultralydskontrastmidler |
| IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
-
1993
- 1993-03-16 GB GB939305349A patent/GB9305349D0/en active Pending
-
1994
- 1994-03-16 BR BR9406228A patent/BR9406228A/pt not_active Application Discontinuation
- 1994-03-16 ES ES94909226T patent/ES2147784T3/es not_active Expired - Lifetime
- 1994-03-16 CN CN94191801A patent/CN1066963C/zh not_active Expired - Fee Related
- 1994-03-16 AU AU62152/94A patent/AU696091B2/en not_active Ceased
- 1994-03-16 AT AT94909226T patent/ATE194292T1/de active
- 1994-03-16 JP JP52077594A patent/JP3787639B2/ja not_active Expired - Fee Related
- 1994-03-16 CA CA002158365A patent/CA2158365A1/en not_active Abandoned
- 1994-03-16 PL PL94310656A patent/PL175128B1/pl unknown
- 1994-03-16 WO PCT/GB1994/000521 patent/WO1994021301A1/en not_active Application Discontinuation
- 1994-03-16 KR KR1019950703923A patent/KR960700759A/ko not_active Application Discontinuation
- 1994-03-16 SK SK1138-95A patent/SK113895A3/sk unknown
- 1994-03-16 EP EP94909226A patent/EP0689461B1/en not_active Expired - Lifetime
- 1994-03-16 CZ CZ952370A patent/CZ237095A3/cs unknown
- 1994-03-16 RU RU95121645A patent/RU2128520C1/ru active
- 1994-03-16 DE DE69425136T patent/DE69425136T2/de not_active Expired - Fee Related
- 1994-03-16 HU HU9502694A patent/HUT72982A/hu unknown
-
1995
- 1995-09-12 BG BG99998A patent/BG62084B1/bg unknown
- 1995-09-12 BG BG100272A patent/BG100272A/xx unknown
- 1995-09-14 FI FI954325A patent/FI954325A/fi unknown
- 1995-09-15 NO NO953637A patent/NO953637L/no not_active Application Discontinuation
-
1998
- 1998-05-13 HK HK98104117A patent/HK1004981A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BG100272A (en) | 1996-05-31 |
| ES2147784T3 (es) | 2000-10-01 |
| DE69425136D1 (de) | 2000-08-10 |
| CZ237095A3 (en) | 1996-03-13 |
| BR9406228A (pt) | 1995-12-12 |
| CN1066963C (zh) | 2001-06-13 |
| NO953637D0 (no) | 1995-09-15 |
| AU696091B2 (en) | 1998-09-03 |
| JP3787639B2 (ja) | 2006-06-21 |
| PL175128B1 (pl) | 1998-11-30 |
| HK1004981A1 (en) | 1998-12-18 |
| CN1121315A (zh) | 1996-04-24 |
| GB9305349D0 (en) | 1993-05-05 |
| KR960700759A (ko) | 1996-02-24 |
| BG62084B1 (bg) | 1999-02-26 |
| RU2128520C1 (ru) | 1999-04-10 |
| ATE194292T1 (de) | 2000-07-15 |
| AU6215294A (en) | 1994-10-11 |
| FI954325A (fi) | 1995-10-11 |
| HU9502694D0 (en) | 1995-11-28 |
| PL310656A1 (en) | 1995-12-27 |
| HUT72982A (en) | 1996-06-28 |
| NO953637L (no) | 1995-09-15 |
| FI954325A0 (fi) | 1995-09-14 |
| CA2158365A1 (en) | 1994-09-29 |
| EP0689461A1 (en) | 1996-01-03 |
| WO1994021301A1 (en) | 1994-09-29 |
| EP0689461B1 (en) | 2000-07-05 |
| DE69425136T2 (de) | 2001-03-22 |
| JPH08509706A (ja) | 1996-10-15 |
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