SI9400005A - Novel opioid peptide analogs - Google Patents

Novel opioid peptide analogs Download PDF

Info

Publication number
SI9400005A
SI9400005A SI9400005A SI9400005A SI9400005A SI 9400005 A SI9400005 A SI 9400005A SI 9400005 A SI9400005 A SI 9400005A SI 9400005 A SI9400005 A SI 9400005A SI 9400005 A SI9400005 A SI 9400005A
Authority
SI
Slovenia
Prior art keywords
phe
tic
tyr
boc
peptide
Prior art date
Application number
SI9400005A
Other languages
English (en)
Slovenian (sl)
Inventor
Peter Schiller
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of SI9400005A publication Critical patent/SI9400005A/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
SI9400005A 1993-01-05 1994-01-05 Novel opioid peptide analogs SI9400005A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9300012A SE9300012D0 (sv) 1993-01-05 1993-01-05 New peptides

Publications (1)

Publication Number Publication Date
SI9400005A true SI9400005A (en) 1994-12-31

Family

ID=20388466

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9400005A SI9400005A (en) 1993-01-05 1994-01-05 Novel opioid peptide analogs

Country Status (25)

Country Link
US (1) US5602099A (sv)
EP (1) EP0678099A1 (sv)
JP (1) JPH08505386A (sv)
KR (1) KR960700269A (sv)
CN (1) CN1096515A (sv)
AP (1) AP508A (sv)
AU (1) AU681372B2 (sv)
CA (1) CA2152380A1 (sv)
CZ (1) CZ171195A3 (sv)
EE (1) EE9400326A (sv)
FI (1) FI953302A0 (sv)
HU (1) HUT72597A (sv)
IL (1) IL108169A0 (sv)
IS (1) IS4115A (sv)
LV (1) LV10962B (sv)
MX (1) MX9400255A (sv)
NO (1) NO952650L (sv)
NZ (1) NZ259597A (sv)
PL (1) PL309778A1 (sv)
SE (1) SE9300012D0 (sv)
SI (1) SI9400005A (sv)
SK (1) SK83995A3 (sv)
WO (1) WO1994015959A1 (sv)
YU (1) YU394A (sv)
ZA (1) ZA9455B (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854211A (en) * 1993-12-23 1998-12-29 Novo Nordisk A/S Compounds with growth hormone releasing properties
IS4261A (is) * 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
IL114046A0 (en) * 1994-06-20 1995-10-31 Astra Ab New opioid peptide antagonists
RU2067000C1 (ru) * 1994-06-29 1996-09-27 Владислав Исакович Дейгин Пептид и способ его получения
US6184208B1 (en) 1994-06-29 2001-02-06 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
SE9402880D0 (sv) * 1994-08-30 1994-08-30 Astra Ab New peptide derivatives
US5780589A (en) * 1994-11-30 1998-07-14 The United States Of America As Represented By The Department Of Health And Human Services Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
AU708620B2 (en) * 1995-03-29 1999-08-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0837857A4 (en) * 1995-03-29 1998-08-05 Merck & Co Inc FARNESYL-PROTEIN TRANSFERASE INHIBITORS
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
SE9600769D0 (sv) * 1996-02-28 1996-02-28 Astra Ab Compounds useful as analgesic
JP2002512625A (ja) * 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
US6903075B1 (en) 1997-05-29 2005-06-07 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6306576B1 (en) * 1999-02-19 2001-10-23 Cleveland Clinic Foundation Diagnostic methods for asthma
US7601739B2 (en) 2003-08-08 2009-10-13 Virgina Commonwealth University Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3160497A4 (en) * 2014-06-27 2018-01-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Conjugates for immunotherapy

Also Published As

Publication number Publication date
LV10962A (lv) 1995-12-20
CN1096515A (zh) 1994-12-21
LV10962B (en) 1997-04-20
FI953302A (sv) 1995-07-04
IL108169A0 (en) 1994-04-12
CA2152380A1 (en) 1994-07-21
FI953302A0 (sv) 1995-07-04
YU394A (sh) 1997-07-31
SK83995A3 (en) 1996-09-04
NZ259597A (en) 1996-07-26
CZ171195A3 (en) 1996-09-11
EE9400326A (et) 1996-04-15
AU681372B2 (en) 1997-08-28
HU9502041D0 (en) 1995-09-28
ZA9455B (en) 1994-07-05
PL309778A1 (en) 1995-11-13
IS4115A (is) 1994-07-06
WO1994015959A1 (en) 1994-07-21
JPH08505386A (ja) 1996-06-11
AP508A (en) 1996-07-22
AP9400605A0 (en) 1994-01-31
HUT72597A (en) 1996-05-28
NO952650L (no) 1995-08-30
NO952650D0 (no) 1995-07-04
AU5844894A (en) 1994-08-15
KR960700269A (ko) 1996-01-19
MX9400255A (es) 1994-07-29
EP0678099A1 (en) 1995-10-25
SE9300012D0 (sv) 1993-01-05
US5602099A (en) 1997-02-11

Similar Documents

Publication Publication Date Title
SI9400005A (en) Novel opioid peptide analogs
US5455230A (en) Delta opioid receptor antagonists and their use as analgesic agents
US5811400A (en) Peptide derivatives with δ opioid receptor antagonist or mixed μ agδ antagonist effects
US4103005A (en) Novel-enkephalin analogs
HU185229B (en) Process for preparing pharmaceutically active peptides and acetates thereof
EP0853484B1 (en) Novel mu opioid receptor ligands: agonists and antagonists
US5733881A (en) Opioid peptide antagonists
US5786447A (en) Opioid peptide analogs
AU691630C (en) New opioid peptide antagonists
EP0777682A1 (en) New opioid peptide antagonists
MAEDA et al. Amino acids and peptides. XXIII. Leu-enkephalin analogs containing a fluorinated amino acid at position 2, 4 or 5
AU5580898A (en) New use of dipeptide derivatives
Di Marzoc et al. Luigi Longobardo,* Dominique Melck, c Rosa Siciliano, b Antonello Santini