SI3480215T1 - Protitelo proti-HER2 in njegov konjugat - Google Patents

Protitelo proti-HER2 in njegov konjugat

Info

Publication number
SI3480215T1
SI3480215T1 SI201431847T SI201431847T SI3480215T1 SI 3480215 T1 SI3480215 T1 SI 3480215T1 SI 201431847 T SI201431847 T SI 201431847T SI 201431847 T SI201431847 T SI 201431847T SI 3480215 T1 SI3480215 T1 SI 3480215T1
Authority
SI
Slovenia
Prior art keywords
conjugate
her2 antibody
her2
antibody
Prior art date
Application number
SI201431847T
Other languages
English (en)
Inventor
Jianmin Fang
Changjiang Huang
Jing Jiang
Xuejing Yao
Hongwen Li
Qiaoyu Xu
Zhuanglin Li
Original Assignee
Remegen, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Remegen, Ltd. filed Critical Remegen, Ltd.
Publication of SI3480215T1 publication Critical patent/SI3480215T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
SI201431847T 2013-11-19 2014-11-18 Protitelo proti-HER2 in njegov konjugat SI3480215T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310586326 2013-11-19
EP18204950.2A EP3480215B8 (en) 2013-11-19 2014-11-18 Anti-her2 antibody and conjugate thereof

Publications (1)

Publication Number Publication Date
SI3480215T1 true SI3480215T1 (sl) 2021-12-31

Family

ID=53178934

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431847T SI3480215T1 (sl) 2013-11-19 2014-11-18 Protitelo proti-HER2 in njegov konjugat

Country Status (19)

Country Link
US (1) US10087260B2 (sl)
EP (2) EP3480215B8 (sl)
JP (2) JP6326137B2 (sl)
KR (3) KR101854443B1 (sl)
CN (3) CN110240655B (sl)
AU (1) AU2014352475B2 (sl)
CA (1) CA2919359C (sl)
CY (1) CY1124651T1 (sl)
DK (2) DK3072907T3 (sl)
ES (1) ES2879799T3 (sl)
HR (1) HRP20211023T1 (sl)
HU (1) HUE055269T2 (sl)
LT (1) LT3480215T (sl)
PL (1) PL3480215T3 (sl)
PT (1) PT3480215T (sl)
RS (1) RS62157B1 (sl)
RU (1) RU2656161C1 (sl)
SI (1) SI3480215T1 (sl)
WO (1) WO2015074528A1 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3480215B8 (en) * 2013-11-19 2021-07-28 RemeGen Co., Ltd. Anti-her2 antibody and conjugate thereof
KR101796277B1 (ko) * 2016-04-12 2017-11-13 앱클론(주) 안정성이 개선된 ｈｅｒ２에 특이적으로 결합하는 항체
AU2019330680A1 (en) * 2018-08-29 2020-04-23 Remegen Co., Ltd. Use of anti-HER2 antibody-drug conjugate in treating urothelial carcinoma
CN111433188B (zh) 2018-12-17 2023-08-01 荣昌生物制药(烟台)股份有限公司 一种用于抗体药物偶联物的连接子及其应用
CN109498816A (zh) * 2019-01-07 2019-03-22 合肥瀚科迈博生物技术有限公司 一种抗体偶联药物的制备方法
US20210238305A1 (en) * 2019-03-01 2021-08-05 Remegen Co., Ltd. Antibody for her2 concomitant diagnosis immunohistochemical detection and application thereof
PT3811979T (pt) 2019-03-26 2024-01-02 Remegen Co Ltd Preparação farmacêutica de conjugado fármaco anticorpo anti-her2
CN111939267A (zh) * 2019-05-17 2020-11-17 百奥泰生物制药股份有限公司 抗体-药物偶联物制剂、制备方法及应用
WO2021097220A1 (en) 2019-11-15 2021-05-20 Seagen Inc. Methods of treating her2 positive breast cancer with tucatinib in combination with an anti-her2 antibody-drug conjugate
EP4093774A4 (en) * 2020-01-23 2024-01-17 Bioatla Inc CONDITIONALLY ACTIVE ANTI-HER2 ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND RELATED USES
CN112353947A (zh) * 2020-11-23 2021-02-12 荣昌生物制药(烟台)股份有限公司 一种含二甲双胍和抗体药物偶联物的药物组合物及其应用
CN112402616A (zh) * 2020-11-23 2021-02-26 荣昌生物制药(烟台)股份有限公司 一种含环丙沙星和抗体药物偶联物的药物组合物及其应用
CN114796519A (zh) * 2021-01-27 2022-07-29 南开大学 一种蛋白质偶联小分子药物的制备和应用
WO2022174775A1 (en) * 2021-02-18 2022-08-25 Remegen Co., Ltd. Use of antibody-drug conjugate targeting her2 in treatment of specific breast cancer
US11814394B2 (en) * 2021-11-16 2023-11-14 Genequantum Healthcare (Suzhou) Co., Ltd. Exatecan derivatives, linker-payloads, and conjugates and thereof
CN114736300B (zh) * 2022-06-09 2022-08-19 苏州百道医疗科技有限公司 一种抗her2重组兔单克隆抗体及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1189641B1 (en) 1999-06-25 2009-07-29 Genentech, Inc. HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES
PT2283867E (pt) 1999-06-25 2014-08-29 Immunogen Inc Métodos de tratamento usando conjugados de anticorpo antierbb- maitansinóide
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
CN1993146A (zh) 2004-06-01 2007-07-04 健泰科生物技术公司 抗体－药物偶联物和方法
CN114053429A (zh) * 2004-06-01 2022-02-18 健泰科生物技术公司 抗体-药物偶联物和方法
KR20160096228A (ko) 2004-07-22 2016-08-12 제넨테크, 인크. Ｈｅｒ２ 항체 조성물
PE20090245A1 (es) 2007-05-08 2009-03-17 Genentech Inc Anticuerpos anti-muc16 disenados con cisteina y conjugados de anticuerpos y farmacos
CN101143902B (zh) * 2007-05-18 2010-06-02 中国医学科学院医药生物技术研究所 抗HER2单链抗体-力达霉素强化融合蛋白HER2(Fv-LDM)
US20090258005A1 (en) 2007-05-29 2009-10-15 Trubion Pharmaceuticals Inc. Therapeutic compositions and methods
JP2011517555A (ja) * 2008-03-14 2011-06-16 ジェネンテック， インコーポレイテッド 薬剤耐性に関連する遺伝的変異
TWI574698B (zh) * 2008-03-18 2017-03-21 建南德克公司 抗ｈｅｒ２抗體-藥物結合物及化療劑之組合及使用方法
EP2327177B1 (en) * 2008-09-19 2017-11-08 Telefonaktiebolaget LM Ericsson (publ) Protection mechanism for a communications network
CN102030827B (zh) * 2009-09-25 2014-09-24 上海抗体药物国家工程研究中心有限公司 一种高亲和力的抗her2单克隆抗体
WO2011084496A1 (en) * 2009-12-16 2011-07-14 Abbott Biotherapeutics Corp. Anti-her2 antibodies and their uses
CN102167742B (zh) * 2010-02-25 2014-05-14 上海百迈博制药有限公司 一种全人源抗her2单克隆抗体、其制备方法及用途
TW201141519A (en) * 2010-03-04 2011-12-01 Symphogen As Anti-HER2 antibodies and compositions
US8609095B2 (en) * 2010-03-04 2013-12-17 Symphogen A/S Anti-HER2 antibodies and compositions
JP6082344B2 (ja) 2010-05-27 2017-02-15 ゲンマブ エー／エス Ｈｅｒ２エピトープに対するモノクローナル抗体
CA3051311A1 (en) * 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
US9193791B2 (en) * 2010-08-03 2015-11-24 City Of Hope Development of masked therapeutic antibodies to limit off-target effects
KR101933990B1 (ko) 2012-05-02 2018-12-31 심포젠 에이/에스 인간화 ｐａｎ­ｈｅｒ 항체 조성물
EP3480215B8 (en) * 2013-11-19 2021-07-28 RemeGen Co., Ltd. Anti-her2 antibody and conjugate thereof

Also Published As

Publication number Publication date
CN109320612B (zh) 2020-10-27
RU2656161C1 (ru) 2018-05-31
EP3480215B1 (en) 2021-06-23
JP2018138034A (ja) 2018-09-06
PT3480215T (pt) 2021-07-05
AU2014352475A1 (en) 2016-02-18
DK3072907T3 (en) 2019-04-01
BR112016002752A2 (pt) 2017-11-21
RU2016106339A (ru) 2017-12-25
JP6728264B2 (ja) 2020-07-22
KR20180050423A (ko) 2018-05-14
KR101936697B1 (ko) 2019-01-10
CY1124651T1 (el) 2022-07-22
HRP20211023T1 (hr) 2021-09-17
CN105008398A (zh) 2015-10-28
EP3480215A1 (en) 2019-05-08
KR101993136B1 (ko) 2019-06-26
EP3072907A1 (en) 2016-09-28
CA2919359C (en) 2019-01-15
WO2015074528A1 (zh) 2015-05-28
BR112016002752A8 (pt) 2023-02-28
JP6326137B2 (ja) 2018-05-16
LT3480215T (lt) 2021-08-25
PL3480215T3 (pl) 2021-12-13
US20160304621A1 (en) 2016-10-20
US10087260B2 (en) 2018-10-02
CN105008398B (zh) 2018-10-16
DK3480215T5 (da) 2021-08-16
CN110240655B (zh) 2023-05-16
EP3072907B1 (en) 2019-02-20
KR101854443B1 (ko) 2018-06-15
AU2014352475B2 (en) 2017-08-17
JP2016528902A (ja) 2016-09-23
KR20190002716A (ko) 2019-01-08
ES2879799T3 (es) 2021-11-23
DK3480215T3 (da) 2021-07-05
RS62157B1 (sr) 2021-08-31
CN109320612A (zh) 2019-02-12
EP3480215B8 (en) 2021-07-28
CN110240655A (zh) 2019-09-17
HUE055269T2 (hu) 2021-11-29
EP3072907A4 (en) 2017-06-14
KR20160065972A (ko) 2016-06-09
CA2919359A1 (en) 2015-05-28

Similar Documents

Publication Publication Date Title
IL261743B (en) and their uses 33–il antibodies against
HK1232243A1 (zh) 抗- 抗體及其用途
HK1217956A1 (zh) 新的抗體綴合物及其用途
IL261547B (en) Antibodies against pesidine and their uses
IL245040B (en) Antibodies against pdgfr-beta and their uses
SI3480215T1 (sl) Protitelo proti-HER2 in njegov konjugat
IL243974B (en) Antibodies against –prlr and uses
ZA201508896B (en) Anti-c10orf54 antibodies and uses thereof
IL240517A0 (en) Antibodies against b7–h4 and immunoconjugates
SG11201509116VA (en) Anti-tweakr antibodies and uses thereof
IL240440A0 (en) Antibodies against her2 with a high level of galactosylation and their uses
HK1223950A1 (zh) 單克隆 抗體及其用途