CY1124651T1 - Αντισωμα εναντι toy her2 και συζευγμα αυτου - Google Patents
Αντισωμα εναντι toy her2 και συζευγμα αυτουInfo
- Publication number
- CY1124651T1 CY1124651T1 CY20211100704T CY211100704T CY1124651T1 CY 1124651 T1 CY1124651 T1 CY 1124651T1 CY 20211100704 T CY20211100704 T CY 20211100704T CY 211100704 T CY211100704 T CY 211100704T CY 1124651 T1 CY1124651 T1 CY 1124651T1
- Authority
- CY
- Cyprus
- Prior art keywords
- conjugate
- her2 antibody
- antibody
- disclosed
- pharmaceutical agent
- Prior art date
Links
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 title 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Γνωστοποιούνται ένα αντίσωμα έναντι του HER2 και σύζευγμα του αντισώματος έναντι του HER2 και φαρμακευτικό μέσο μικρών μορίων. Επίσης, γνωστοποιούνται χρήσεις του αντισώματος και του συζεύγματος αυτού στην παρασκευή φαρμακευτικού μέσου για τη θεραπευτική αντιμετώπιση όγκου.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310586326 | 2013-11-19 | ||
EP14864053.5A EP3072907B1 (en) | 2013-11-19 | 2014-11-18 | Anti-her2 antibody and conjugate thereof |
PCT/CN2014/091332 WO2015074528A1 (zh) | 2013-11-19 | 2014-11-18 | 抗her2抗体及其缀合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124651T1 true CY1124651T1 (el) | 2022-07-22 |
Family
ID=53178934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100704T CY1124651T1 (el) | 2013-11-19 | 2021-08-06 | Αντισωμα εναντι toy her2 και συζευγμα αυτου |
Country Status (19)
Country | Link |
---|---|
US (1) | US10087260B2 (el) |
EP (2) | EP3480215B8 (el) |
JP (2) | JP6326137B2 (el) |
KR (3) | KR101993136B1 (el) |
CN (3) | CN109320612B (el) |
AU (1) | AU2014352475B2 (el) |
CA (1) | CA2919359C (el) |
CY (1) | CY1124651T1 (el) |
DK (2) | DK3480215T5 (el) |
ES (1) | ES2879799T3 (el) |
HR (1) | HRP20211023T1 (el) |
HU (1) | HUE055269T2 (el) |
LT (1) | LT3480215T (el) |
PL (1) | PL3480215T3 (el) |
PT (1) | PT3480215T (el) |
RS (1) | RS62157B1 (el) |
RU (1) | RU2656161C1 (el) |
SI (1) | SI3480215T1 (el) |
WO (1) | WO2015074528A1 (el) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE055269T2 (hu) * | 2013-11-19 | 2021-11-29 | Remegen Co Ltd | Anti-HER2 ellenanyag és konjugátum |
KR101796277B1 (ko) * | 2016-04-12 | 2017-11-13 | 앱클론(주) | 안정성이 개선된 her2에 특이적으로 결합하는 항체 |
WO2020042941A1 (zh) * | 2018-08-29 | 2020-03-05 | 荣昌生物制药烟台有限公司 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
CA3106493C (en) | 2018-12-17 | 2024-01-09 | Remegen, Co., Ltd. | A linker for antibody-drug conjugates and its use |
CN109498816A (zh) * | 2019-01-07 | 2019-03-22 | 合肥瀚科迈博生物技术有限公司 | 一种抗体偶联药物的制备方法 |
WO2020177570A1 (zh) * | 2019-03-01 | 2020-09-10 | 荣昌生物制药(烟台)股份有限公司 | 一种Her2伴随诊断免疫组化检测抗体及其应用 |
EP4316521A3 (en) * | 2019-03-26 | 2024-04-10 | RemeGen Co., Ltd. | Anti-her2 antibody drug conjugate pharmaceutical preparation |
CN111939267A (zh) * | 2019-05-17 | 2020-11-17 | 百奥泰生物制药股份有限公司 | 抗体-药物偶联物制剂、制备方法及应用 |
AU2020381495A1 (en) | 2019-11-15 | 2022-05-19 | Seagen Inc. | Methods of treating HER2 positive breast cancer with tucatinib in combination with an anti-HER2 antibody-drug conjugate |
IL294829A (en) * | 2020-01-23 | 2022-09-01 | Bioatla Inc | Conditionally active anti-HER2 antibodies, antibody fragments, their immunoconjugates and their uses |
CN112402616A (zh) * | 2020-11-23 | 2021-02-26 | 荣昌生物制药(烟台)股份有限公司 | 一种含环丙沙星和抗体药物偶联物的药物组合物及其应用 |
CN112353947A (zh) * | 2020-11-23 | 2021-02-12 | 荣昌生物制药(烟台)股份有限公司 | 一种含二甲双胍和抗体药物偶联物的药物组合物及其应用 |
CN114796519A (zh) * | 2021-01-27 | 2022-07-29 | 南开大学 | 一种蛋白质偶联小分子药物的制备和应用 |
AU2022222937A1 (en) * | 2021-02-18 | 2023-08-17 | Remegen Co., Ltd. | Use of antibody-drug conjugate targeting her2 in treatment of specific breast cancer |
US11814394B2 (en) * | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
CN114736300B (zh) * | 2022-06-09 | 2022-08-19 | 苏州百道医疗科技有限公司 | 一种抗her2重组兔单克隆抗体及其应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01013240A (es) | 1999-06-25 | 2002-06-21 | Genentech Inc | Metodo de tratamiento utilizando conjugados de anticuerpo contra erbb-maytansionoide. |
SI1189641T1 (sl) | 1999-06-25 | 2009-12-31 | Genentech Inc | Humanizirana protitelesa proti ErbB2 in zdravljenje s protitelesi proti ErbB2 |
US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
EP2286844A3 (en) * | 2004-06-01 | 2012-08-22 | Genentech, Inc. | Antibody-drug conjugates and methods |
CN109045307A (zh) | 2004-06-01 | 2018-12-21 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
JP2008507520A (ja) | 2004-07-22 | 2008-03-13 | ジェネンテック・インコーポレーテッド | Her2抗体組成物 |
PE20090245A1 (es) | 2007-05-08 | 2009-03-17 | Genentech Inc | Anticuerpos anti-muc16 disenados con cisteina y conjugados de anticuerpos y farmacos |
CN101143902B (zh) * | 2007-05-18 | 2010-06-02 | 中国医学科学院医药生物技术研究所 | 抗HER2单链抗体-力达霉素强化融合蛋白HER2(Fv-LDM) |
US20090258005A1 (en) | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
DK2260111T3 (en) | 2008-03-14 | 2015-09-14 | Genentech Inc | Genetic variations that are associated with drug resistance |
EP2644204B1 (en) * | 2008-03-18 | 2017-04-19 | Genentech, Inc. | Combinations of an Anti-HER2 antibody-drug conjugate and pertuzumab |
EP2327177B1 (en) * | 2008-09-19 | 2017-11-08 | Telefonaktiebolaget LM Ericsson (publ) | Protection mechanism for a communications network |
CN102030827B (zh) | 2009-09-25 | 2014-09-24 | 上海抗体药物国家工程研究中心有限公司 | 一种高亲和力的抗her2单克隆抗体 |
WO2011084496A1 (en) | 2009-12-16 | 2011-07-14 | Abbott Biotherapeutics Corp. | Anti-her2 antibodies and their uses |
CN102167742B (zh) * | 2010-02-25 | 2014-05-14 | 上海百迈博制药有限公司 | 一种全人源抗her2单克隆抗体、其制备方法及用途 |
US8609095B2 (en) * | 2010-03-04 | 2013-12-17 | Symphogen A/S | Anti-HER2 antibodies and compositions |
CN102884084B (zh) * | 2010-03-04 | 2016-12-07 | 西福根有限公司 | 抗her2抗体及组合物 |
EP2575880B1 (en) * | 2010-05-27 | 2019-01-16 | Genmab A/S | Monoclonal antibodies against her2 epitope |
EP3539988A3 (en) * | 2010-05-27 | 2019-12-04 | Genmab A/S | Monoclonal antibodies against her2 |
US9193791B2 (en) * | 2010-08-03 | 2015-11-24 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects |
JP6325527B2 (ja) | 2012-05-02 | 2018-05-16 | シムフォゲン・アクティーゼルスカブSymphogen A/S | ヒト化pan−her抗体組成物 |
HUE055269T2 (hu) * | 2013-11-19 | 2021-11-29 | Remegen Co Ltd | Anti-HER2 ellenanyag és konjugátum |
-
2014
- 2014-11-18 HU HUE18204950A patent/HUE055269T2/hu unknown
- 2014-11-18 ES ES18204950T patent/ES2879799T3/es active Active
- 2014-11-18 KR KR1020187036881A patent/KR101993136B1/ko active IP Right Grant
- 2014-11-18 CA CA2919359A patent/CA2919359C/en active Active
- 2014-11-18 LT LTEP18204950.2T patent/LT3480215T/lt unknown
- 2014-11-18 US US15/037,104 patent/US10087260B2/en active Active
- 2014-11-18 JP JP2016537121A patent/JP6326137B2/ja active Active
- 2014-11-18 WO PCT/CN2014/091332 patent/WO2015074528A1/zh active Application Filing
- 2014-11-18 PL PL18204950T patent/PL3480215T3/pl unknown
- 2014-11-18 RU RU2016106339A patent/RU2656161C1/ru active
- 2014-11-18 KR KR1020187012035A patent/KR101936697B1/ko active IP Right Grant
- 2014-11-18 PT PT182049502T patent/PT3480215T/pt unknown
- 2014-11-18 CN CN201810804801.1A patent/CN109320612B/zh active Active
- 2014-11-18 CN CN201811053363.6A patent/CN110240655B/zh active Active
- 2014-11-18 CN CN201480006648.8A patent/CN105008398B/zh active Active
- 2014-11-18 AU AU2014352475A patent/AU2014352475B2/en active Active
- 2014-11-18 DK DK18204950.2T patent/DK3480215T5/da active
- 2014-11-18 SI SI201431847T patent/SI3480215T1/sl unknown
- 2014-11-18 EP EP18204950.2A patent/EP3480215B8/en active Active
- 2014-11-18 EP EP14864053.5A patent/EP3072907B1/en active Active
- 2014-11-18 RS RS20210939A patent/RS62157B1/sr unknown
- 2014-11-18 KR KR1020167012018A patent/KR101854443B1/ko active IP Right Grant
- 2014-11-18 DK DK14864053.5T patent/DK3072907T3/en active
-
2018
- 2018-04-13 JP JP2018077954A patent/JP6728264B2/ja active Active
-
2021
- 2021-06-28 HR HRP20211023TT patent/HRP20211023T1/hr unknown
- 2021-08-06 CY CY20211100704T patent/CY1124651T1/el unknown
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