SI3408407T1 - Postopki za odkrivanje CPG metilacije iz tumorja pridobljene DNA v vzorcih krvi - Google Patents

Postopki za odkrivanje CPG metilacije iz tumorja pridobljene DNA v vzorcih krvi

Info

Publication number
SI3408407T1
SI3408407T1 SI201730624T SI201730624T SI3408407T1 SI 3408407 T1 SI3408407 T1 SI 3408407T1 SI 201730624 T SI201730624 T SI 201730624T SI 201730624 T SI201730624 T SI 201730624T SI 3408407 T1 SI3408407 T1 SI 3408407T1
Authority
SI
Slovenia
Prior art keywords
tumor
methods
blood samples
derived dna
cpg methylation
Prior art date
Application number
SI201730624T
Other languages
English (en)
Inventor
Jorn Lewin
Denise Kottwitz
Selina Esche
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Publication of SI3408407T1 publication Critical patent/SI3408407T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SI201730624T 2016-01-29 2017-01-27 Postopki za odkrivanje CPG metilacije iz tumorja pridobljene DNA v vzorcih krvi SI3408407T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16153452 2016-01-29
EP17702586.3A EP3408407B1 (en) 2016-01-29 2017-01-27 Methods for detecting cpg methylation of tumor-derived dna in blood samples
PCT/EP2017/051710 WO2017129716A1 (en) 2016-01-29 2017-01-27 Methods for detecting cpg methylation of tumor-derived dna in blood samples

Publications (1)

Publication Number Publication Date
SI3408407T1 true SI3408407T1 (sl) 2021-04-30

Family

ID=55272352

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201730624T SI3408407T1 (sl) 2016-01-29 2017-01-27 Postopki za odkrivanje CPG metilacije iz tumorja pridobljene DNA v vzorcih krvi

Country Status (11)

Country Link
US (1) US20190032148A1 (sl)
EP (2) EP3408407B1 (sl)
JP (2) JP7261587B2 (sl)
CN (1) CN109312404A (sl)
DK (1) DK3408407T3 (sl)
ES (1) ES2849559T3 (sl)
HR (1) HRP20210198T1 (sl)
HU (1) HUE054225T2 (sl)
LT (1) LT3408407T (sl)
SI (1) SI3408407T1 (sl)
WO (1) WO2017129716A1 (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3368686A1 (en) 2015-10-30 2018-09-05 Exact Sciences Development Company, LLC Multiplex amplification detection assay and isolation and detection of dna from plasma
EP3452616A4 (en) 2016-05-05 2020-01-22 Exact Sciences Development Company, LLC DETECTION OF LUNG NEOPLASIA BY ANALYSIS OF METHYLATED DNA
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CN110475875A (zh) * 2017-01-27 2019-11-19 精密科学发展有限责任公司 通过分析甲基化dna检测结肠瘤形成
US11884966B2 (en) 2018-03-15 2024-01-30 Grail, Llc Tissue-specific methylation marker
WO2021192397A1 (ja) * 2020-03-25 2021-09-30 富士フイルム株式会社 がん検査方法
CN111540469A (zh) * 2020-05-29 2020-08-14 杭州广科安德生物科技有限公司 构建体外检测胃癌的数学模型的方法及其应用
CN112375822B (zh) * 2020-06-01 2021-11-02 广州市基准医疗有限责任公司 用于检测乳腺癌的甲基化生物标记物及其应用
CN114507731A (zh) * 2020-11-16 2022-05-17 南京腾辰生物科技有限公司 一种用于辅助癌症诊断的甲基化标志物及试剂盒
EP4278006A1 (en) * 2021-01-12 2023-11-22 The Board of Trustees of the Leland Stanford Junior University Layered analysis of methylated biomarkers for use in cancer diagnosis and prognosis
WO2023017001A1 (en) 2021-08-09 2023-02-16 Epigenomics Ag Improved methods for detecting colorectal cancer
WO2024074558A1 (en) 2022-10-04 2024-04-11 Epigenomics Ag Improved methods for detecting cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2877000A (en) * 1999-02-10 2000-08-29 University Of Maryland Photo-induced nucleic acid hybridization
WO2002018632A2 (de) * 2000-09-01 2002-03-07 Epigenomics Ag Verfahren zur bestimmung des methylierungsgrades von bestimmten cytosinen in genomischer dna im sequenzkontext 5'-cpg-3'
EP1394172A1 (en) 2002-08-29 2004-03-03 Boehringer Mannheim Gmbh Improved method for bisulfite treatment
GB201000688D0 (en) * 2010-01-15 2010-03-03 Diagenic Asa Product and method
AU2013266341B2 (en) * 2012-05-22 2019-01-03 The Johns Hopkins University A quantitative multiplex methylation specific PCR method- cMethDNA, reagents, and its use
WO2014036314A2 (en) * 2012-08-31 2014-03-06 Ignyta, Inc. Diagnosis of rheumatoid arthritis (ra) using differentially methylated loci identified in peripheral blood mononuclear cells, t-cells, b-cells and monocytes
EP3152333B1 (en) * 2014-06-04 2019-09-11 Quest Diagnostics Investments Incorporated Methylated markers for colorectal cancer

Also Published As

Publication number Publication date
DK3408407T3 (da) 2021-02-08
EP3828281A1 (en) 2021-06-02
US20190032148A1 (en) 2019-01-31
ES2849559T3 (es) 2021-08-19
JP2023052157A (ja) 2023-04-11
CN109312404A (zh) 2019-02-05
HUE054225T2 (hu) 2021-08-30
JP2019504642A (ja) 2019-02-21
WO2017129716A1 (en) 2017-08-03
EP3408407A1 (en) 2018-12-05
JP7261587B2 (ja) 2023-04-20
EP3408407B1 (en) 2021-01-06
HRP20210198T1 (hr) 2021-04-16
LT3408407T (lt) 2021-03-10

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