SI3224254T1 - Substituirani indazoli, postopek njihove priprave, farmacevtske formulacije, ki jih vsebujejo in njihova uporaba za pripravo zdravil - Google Patents
Substituirani indazoli, postopek njihove priprave, farmacevtske formulacije, ki jih vsebujejo in njihova uporaba za pripravo zdravilInfo
- Publication number
- SI3224254T1 SI3224254T1 SI201531182T SI201531182T SI3224254T1 SI 3224254 T1 SI3224254 T1 SI 3224254T1 SI 201531182 T SI201531182 T SI 201531182T SI 201531182 T SI201531182 T SI 201531182T SI 3224254 T1 SI3224254 T1 SI 3224254T1
- Authority
- SI
- Slovenia
- Prior art keywords
- preparation
- medicaments
- pharmaceutical formulations
- formulations containing
- substituted indazoles
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 150000002473 indoazoles Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14195032 | 2014-11-26 | ||
| EP15800828.4A EP3224254B1 (de) | 2014-11-26 | 2015-11-25 | Substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten sowie deren verwendung zur herstellung von arzneimitteln |
| PCT/EP2015/077596 WO2016083433A1 (de) | 2014-11-26 | 2015-11-25 | Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten sowie deren verwendung zur herstellung von arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3224254T1 true SI3224254T1 (sl) | 2020-07-31 |
Family
ID=51982455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201531182T SI3224254T1 (sl) | 2014-11-26 | 2015-11-25 | Substituirani indazoli, postopek njihove priprave, farmacevtske formulacije, ki jih vsebujejo in njihova uporaba za pripravo zdravil |
Country Status (42)
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10160753B2 (en) | 2014-01-10 | 2018-12-25 | Aurigene Discovery Technologies Limited | Indazole compounds as IRAK4 inhibitors |
| DK3805233T3 (da) | 2014-01-13 | 2024-04-15 | Aurigene Oncology Ltd | (r)- og (s)-enantiomerer af n-(5-(3-hydroxypyrrolidin-1-yl)-2-morpholinoxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazol-carboxamid som irak4-hæmmere til cancerbehandling |
| JO3705B1 (ar) * | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| UY36660A (es) * | 2015-04-30 | 2016-11-30 | Bayer Pharma AG | Combinaciones de inhibidores de irak4 |
| EP3195865A1 (de) * | 2016-01-25 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Kombinationen von irak4 inhibitoren und btk inhibitoren |
| EP3423446B1 (de) | 2016-03-03 | 2020-09-16 | Bayer Pharma Aktiengesellschaft | Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| EP3219329A1 (en) * | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib |
| DK3448846T3 (da) * | 2016-04-29 | 2021-08-16 | Bayer Pharma AG | Syntese af indazoler |
| EP3448847A1 (en) * | 2016-04-29 | 2019-03-06 | Bayer Pharma Aktiengesellschaft | Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide |
| EA035867B1 (ru) * | 2016-04-29 | 2020-08-24 | Байер Фарма Акциенгезельшафт | Синтез индазолов |
| MX2018014899A (es) | 2016-06-01 | 2019-04-24 | Bayer Animal Health Gmbh | Uso de indazoles sustituidos para el tratamiento y la prevencion de enfermedades en animales. |
| KR102460362B1 (ko) * | 2016-06-01 | 2022-10-28 | 바이엘 파마 악티엔게젤샤프트 | 자가면역 질환의 치료 및 예방을 위한 2-치환된 인다졸의 용도 |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| MX2019002750A (es) | 2016-09-09 | 2019-07-04 | Incyte Corp | Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer. |
| TW201811799A (zh) | 2016-09-09 | 2018-04-01 | 美商英塞特公司 | 吡唑并嘧啶化合物及其用途 |
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| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| AU2018242623A1 (en) | 2017-03-31 | 2019-10-17 | Aurigene Oncology Limited | Compounds and compositions for treating hematological disorders |
| US11957931B2 (en) | 2017-04-26 | 2024-04-16 | Yale University | Compositions and methods for treating vitiligo |
| US10508105B2 (en) | 2017-08-16 | 2019-12-17 | Vanderbilt University | Indazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
| CA3091517A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer |
| WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| TW202136268A (zh) | 2018-07-13 | 2021-10-01 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| WO2020035019A1 (zh) * | 2018-08-17 | 2020-02-20 | 浙江海正药业股份有限公司 | 吲唑胺类衍生物及其制备方法和其在医药上的用途 |
| CN110835338A (zh) * | 2018-08-17 | 2020-02-25 | 浙江海正药业股份有限公司 | 咪唑并吡啶类衍生物及其制备方法和其在医药上的用途 |
| MA53726A (fr) | 2018-09-25 | 2022-05-11 | Incyte Corp | Composés pyrazolo[4,3-d]pyrimidine en tant que modulateurs des alk2 et/ou fgfr |
| US20220204473A1 (en) * | 2018-12-25 | 2022-06-30 | Shanghai Meiyue Biotech Development Co., Ltd. | Compound as irak inhibitor |
| CN111362920A (zh) * | 2018-12-25 | 2020-07-03 | 上海美悦生物科技发展有限公司 | 一种作为irak抑制剂的化合物 |
| CN111499612B (zh) * | 2019-01-30 | 2022-12-30 | 上海美悦生物科技发展有限公司 | 一种作为irak抑制剂的化合物及其制备方法和用途 |
| CN111560012B (zh) * | 2019-02-14 | 2023-06-23 | 上海美悦生物科技发展有限公司 | 一种作为irak抑制剂的化合物 |
| CN111793064B (zh) * | 2019-04-02 | 2023-06-23 | 上海美悦生物科技发展有限公司 | 一种作为irak抑制剂的化合物及其制备方法和用途 |
| US20220227758A1 (en) * | 2019-06-26 | 2022-07-21 | Medshine Discovery Inc. | Imidazopyridine compound as irak4 inhibitor |
| MX2021015499A (es) * | 2019-06-27 | 2022-04-20 | Biogen Ma Inc | Derivados de 2h-indazol y su uso en el tratamiento de enfermedades. |
| BR112022000325A2 (pt) | 2019-07-11 | 2022-03-15 | Escape Bio Inc | Indazois e azaindazois como inibidores de lrrk2 |
| JP2022543155A (ja) | 2019-08-06 | 2022-10-07 | インサイト・コーポレイション | Ｈｐｋ１阻害剤の固体形態 |
| JP7353474B2 (ja) * | 2019-09-24 | 2023-09-29 | 上海美悦生物科技発展有限公司 | Ｉｒａｋ阻害剤、その製造方法及び用途 |
| CN111072634B (zh) * | 2020-01-03 | 2022-07-22 | 中国医科大学 | 1-取代-3-取代-5-取代酰胺-1h-吲哚类化合物及其制备方法和应用 |
| CN113521079A (zh) * | 2020-04-20 | 2021-10-22 | 上海领泰生物医药科技有限公司 | Irak4抑制剂在治疗ali/ards中的应用 |
| US11866405B2 (en) | 2020-12-10 | 2024-01-09 | Astrazeneca Ab | Substituted indazoles as IRAK4 inhibitors |
| CN113278017B (zh) * | 2021-05-27 | 2023-03-28 | 上海应用技术大学 | 取代吲唑类化合物、制备方法、应用和包含其的组合物 |
| CN113402499B (zh) | 2021-06-21 | 2022-05-13 | 上海勋和医药科技有限公司 | 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途 |
| WO2023283372A1 (en) * | 2021-07-07 | 2023-01-12 | Biogen Ma Inc. | Compounds for targeting degradation of irak4 proteins |
| WO2023098857A1 (zh) * | 2021-12-03 | 2023-06-08 | 武汉人福创新药物研发中心有限公司 | Irak4抑制剂及其用途 |
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| US10160753B2 (en) * | 2014-01-10 | 2018-12-25 | Aurigene Discovery Technologies Limited | Indazole compounds as IRAK4 inhibitors |
| JO3705B1 (ar) * | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| UY36660A (es) | 2015-04-30 | 2016-11-30 | Bayer Pharma AG | Combinaciones de inhibidores de irak4 |
| EP3423446B1 (de) | 2016-03-03 | 2020-09-16 | Bayer Pharma Aktiengesellschaft | Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| EP3219329A1 (en) | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib |
| EP3448847A1 (en) | 2016-04-29 | 2019-03-06 | Bayer Pharma Aktiengesellschaft | Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide |
| DK3448846T3 (da) | 2016-04-29 | 2021-08-16 | Bayer Pharma AG | Syntese af indazoler |
| KR102460362B1 (ko) | 2016-06-01 | 2022-10-28 | 바이엘 파마 악티엔게젤샤프트 | 자가면역 질환의 치료 및 예방을 위한 2-치환된 인다졸의 용도 |
| MX2018014899A (es) | 2016-06-01 | 2019-04-24 | Bayer Animal Health Gmbh | Uso de indazoles sustituidos para el tratamiento y la prevencion de enfermedades en animales. |
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2015
- 2015-11-23 JO JOP/2015/0287A patent/JO3705B1/ar active
- 2015-11-25 US US15/529,996 patent/US10308634B2/en active Active
- 2015-11-25 RS RS20200564A patent/RS60284B1/sr unknown
- 2015-11-25 UA UAA201909772A patent/UA123813C2/uk unknown
- 2015-11-25 EP EP15800828.4A patent/EP3224254B1/de active Active
- 2015-11-25 LT LTEP15800828.4T patent/LT3224254T/lt unknown
- 2015-11-25 WO PCT/EP2015/077596 patent/WO2016083433A1/de active Application Filing
- 2015-11-25 ME MEP-2020-115A patent/ME03745B/me unknown
- 2015-11-25 SG SG10201903474PA patent/SG10201903474PA/en unknown
- 2015-11-25 BR BR122021002613-0A patent/BR122021002613B1/pt active IP Right Grant
- 2015-11-25 EA EA201791137A patent/EA032509B1/ru not_active IP Right Cessation
- 2015-11-25 FI FIEP19191936.4T patent/FI3674298T3/fi active
- 2015-11-25 CR CR20170220A patent/CR20170220A/es unknown
- 2015-11-25 MX MX2020010623A patent/MX2020010623A/es unknown
- 2015-11-25 TN TN2017000226A patent/TN2017000226A1/en unknown
- 2015-11-25 SG SG11201704092YA patent/SG11201704092YA/en unknown
- 2015-11-25 AU AU2015352603A patent/AU2015352603B2/en active Active
- 2015-11-25 DK DK19191936.4T patent/DK3674298T3/da active
- 2015-11-25 UA UAA201706382A patent/UA120948C2/uk unknown
- 2015-11-25 ES ES15800828T patent/ES2796285T3/es active Active
- 2015-11-25 NZ NZ732126A patent/NZ732126A/en unknown
- 2015-11-25 MA MA41011A patent/MA41011B1/fr unknown
- 2015-11-25 CN CN201910670725.4A patent/CN110305109B/zh active Active
- 2015-11-25 PE PE2017000922A patent/PE20171376A1/es unknown
- 2015-11-25 DK DK15800828.4T patent/DK3224254T3/da active
- 2015-11-25 BR BR112017011005-9A patent/BR112017011005B1/pt active IP Right Grant
- 2015-11-25 EP EP19191936.4A patent/EP3674298B1/de active Active
- 2015-11-25 PL PL15800828T patent/PL3224254T3/pl unknown
- 2015-11-25 KR KR1020177017079A patent/KR102083857B1/ko active IP Right Grant
- 2015-11-25 CN CN201580073989.1A patent/CN107406416B/zh active Active
- 2015-11-25 CU CU2017000073A patent/CU24448B1/es unknown
- 2015-11-25 MX MX2017006910A patent/MX2017006910A/es unknown
- 2015-11-25 LT LTEP19191936.4T patent/LT3674298T/lt unknown
- 2015-11-25 CA CA2968614A patent/CA2968614C/en active Active
- 2015-11-25 PT PT158008284T patent/PT3224254T/pt unknown
- 2015-11-25 SG SG10201903475TA patent/SG10201903475TA/en unknown
- 2015-11-25 JP JP2017528139A patent/JP6496823B2/ja active Active
- 2015-11-25 SI SI201531182T patent/SI3224254T1/sl unknown
- 2015-11-25 EP EP23189515.2A patent/EP4260909A3/de active Pending
- 2015-11-25 HU HUE15800828A patent/HUE049341T2/hu unknown
- 2015-11-26 AR ARP150103876A patent/AR102827A1/es active IP Right Grant
- 2015-11-26 TW TW104139563A patent/TWI689502B/zh active
- 2015-11-26 UY UY0001036411A patent/UY36411A/es active IP Right Grant
- 2015-11-26 TW TW108137338A patent/TWI717061B/zh active
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2017
- 2017-05-09 IL IL25218517A patent/IL252185B/en active IP Right Grant
- 2017-05-25 EC ECIEPI201732530A patent/ECSP17032530A/es unknown
- 2017-05-25 PH PH12017500972A patent/PH12017500972A1/en unknown
- 2017-05-26 DO DO2017000127A patent/DOP2017000127A/es unknown
- 2017-05-26 CL CL2017001364A patent/CL2017001364A1/es unknown
- 2017-05-26 NI NI201700063A patent/NI201700063A/es unknown
- 2017-06-26 CO CONC2017/0005374A patent/CO2017005374A2/es unknown
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2019
- 2019-04-05 US US16/377,025 patent/US10793545B2/en active Active
- 2019-06-20 IL IL267537A patent/IL267537B/en active IP Right Grant
- 2019-09-19 IL IL269444A patent/IL269444B/en active IP Right Grant
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2020
- 2020-02-11 AU AU2020200979A patent/AU2020200979B2/en active Active
- 2020-06-05 CY CY20201100506T patent/CY1123815T1/el unknown
- 2020-06-19 HR HRP20200974TT patent/HRP20200974T1/hr unknown
- 2020-09-01 US US17/009,553 patent/US20210053941A1/en not_active Abandoned
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2022
- 2022-07-20 US US17/869,673 patent/US20230174508A1/en active Pending
- 2022-07-20 US US17/869,674 patent/US20220388982A1/en active Pending
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