SI2906546T1 - Benzamidi - Google Patents

Benzamidi Download PDF

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SI2906546T1
SI2906546T1 SI201330967T SI201330967T SI2906546T1 SI 2906546 T1 SI2906546 T1 SI 2906546T1 SI 201330967 T SI201330967 T SI 201330967T SI 201330967 T SI201330967 T SI 201330967T SI 2906546 T1 SI2906546 T1 SI 2906546T1
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Slovenia
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benzamide
trifluoromethyl
chloro
cyclopropyl
propyl
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SI201330967T
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John Paul Kilburn
Lars Kyhn Rasmussen
Mikkel Jessing
Eman Mohammed Eldemenky
Bin Chen
Yu Jiang
Allen T. Hopper
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H. Lundbeck A/S
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Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SI2906546T1 publication Critical patent/SI2906546T1/sl

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Claims (18)

  1. BENZAMIDI PATENTNI ZAHTEVKI
    1. Spojina s formulo I
    kjer je R1 pirimidil, ki je po izbiri substituiran z enim ali več Cm alkil, halogen, hidroksi, Cm hidroksialkil, Cm fluoroalkil, cikloalkil, Cm A alkoksi, Cm fluoroalkoksi, ciano ali -SO2R ; pri čemer je R2 C3-6 cikloalkil, C3-6 ciklohetalkil, Cm fluoroalkil, Cm fluoroalkoksi, Cm alkoksi, Cm alkenil, Cm alkinil, 6-členski heteroaril, fenil ali Cm alkil, po izbiri substituiran z enim ali več R9; kjer je R3 vodik, fluor, Cm alkil ali Cm fluoroalkil; ali pri čemer sta R2 in R3 združena z ogljikom, na katerega sta vezana, da tvorita cikloheksil, tetrahidropiranil, piperazinil, piperidinil, morfolinil, pirolidinil, azetidinil, homomorfolinil, homopiperidinil ali homopiperazinil od katerih je vsak po izbiri substituiran z enim ali več Cm alkil, Cm alkenil, C3.6 -cikloalkil, Cm alkoksi, okso, -NR6R7 ali fluor; kjer je R4 halogen, Cm -fluoroalkil, ciano, ciklopropil, Cm alkiloksi, Cm fluoroalkiloksi, SO2R8, -NR6R7 ali CMalkil; kjer je R5 halogen, Cm alkil, Cm fluoroalkil, ciano, -S02R8, -NR6R7, Cm alkoksi, Cm fluoroalkoksi ali C3.e -cikloalkil; pri čemer sta R6 in R7 neodvisno drug od drugega vodik ali Ci_6 alkil; kjer je R8 C1-6 alkil, C3-6 cikloalkil ali -fluoroalkil; kjer je R9 alkil, C3.6 cikloalkil, -NR10R11, C1-4 fluoroalkil ali 3- do 7-členski heterociklil, ki je po izbiri substituiran z enim ali več C1-6 alkil, halogen, hidroksi, C1-4 fluoroalkil, C3-6 cikloalkil, C-m alkoksi, C1-4 fluoroalkoksi ali ciano; pri čemer sta R10 in R11 neodvisno drug od drugega vodik ali C1.6 alkil; ali kjer R10 in R11 skupaj z dušikom, na katerega sta vezana, tvorita piperazinil, piperidinil, morfolinil, pirolidinil, azetidinil, homomorfolinil, homopiperidinil ali homopiperazinii, od katerih je vsak po izbiri substituiran z enim ali več C1-6 alkil, Ci^ alkoksi, okso ali fluorom; in kjer je n 0-3; ali njena farmacevtsko sprejemljiva sol.
  2. 2. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran piperazinil.
  3. 3. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran piperidinil.
  4. 4. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran morfolinil.
  5. 5. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran pirolidinil.
  6. 6. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran pirolo.
  7. 7. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran imidazo.
  8. 8. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran homomorfolinil.
  9. 9. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran homopiperidinil.
  10. 10. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran homopiperazinil.
  11. 11. Spojina po zahtevku 1, kjer R2 in R3 skupaj z ogljikom, na katerega sta vezana, tvorita po izbiri substituiran azetinil.
  12. 12. Spojina po katerem koli od zahtevkov 1-11, kjer je R4 klor, metil ali trifluorometil.
  13. 13. Spojina po katerem koli od zahtevkov 1-12, kjer je n 0.
  14. 14. Spojina po katerem koli od zahtevkov 1-12, kjer je n 1.
  15. 15. Spojina po katerem koli od zahtevkov 1-12, kjer je n 2.
  16. 16. Spojina po katerem koli od zahtevkov 1-15, kjer je R5 fluor, klor, Ci_3-alkil, C^-fluoroalkil, ciano, C1.3 alkoksi ali Ci^fluoroalkoksi.
  17. 17. Spojina, izbrana iz skupine, ki jo sestavljajo
    2-Kloro-N-[4-(4-kloro-fenil)-tetrahidro-piran-4-ilmetil]-5-metil-benzamid,
    2-Kloro-N-[4-(4-kloro-fenil)-tetrahidro-piran-4-ilmetil]-5-metil-benzamid, N-[4-(4-Kloro-fenil)-tetrahidro-piran-4-ilmetil]-2,3-dimetil-benzamid, N-[4-(4-Kloro-fenil)-tetrahidro-piran-4-ilmetil]-2-metoksi-benzamid, 2,6-Dikloro-N-[4-(4-kloro-fenil)-tetrahidro-piran-4-ilmetil]-benzamid, N-[4-(4-Kloro-fenil)-tetrahidro-piran-4-ilmetil]-2-metil-benzamid, 2.3- Dikloro-N-(1-piridin-3-il-ciklopentilmetil)-benzamid,
    2-Kloro-5-metil-N-(1-piridin-3-il-ciklopentilmetil)-benzamid, N-[4-(4-Kloro-fenil)-tetrahidro-piran-4-ilmetil]-2-trifluorometil-benzamid,
    2- Metil-N-(1-piridin-3-il-ciklopentilmetil)-benzamid, N-[4-(4-Kloro-fenil)-tetrahidro-piran-4-ilmetil]-2-fluoro-3-trifluorometil-benzamid,
    3- Kloro-N-[4-(4-kloro-fenil)-tetrahidro-piran-4-ilmetil]-2-fluoro-benzamid, N-[4-(4-Kloro-fenil)-tetrahidro-piran-4-ilmetil]-2,5-difluoro-benzamid,
    2-Kloro-N-[ 1 -(4-metoksi-fenil)-ciklopentilmetil]-5-metil-benzamid, 2.3- Dikloro-N-[1-(4-metoksi-fenil)-ciklopentilmetil]-benzamid, N-[1-(4-Metoksi-fenil)-ciklopentilmetil]-2-metil-benzamid, N-[1-(4-Metoksi-fenil)-ciklopentilmetil]-2,3-dimetil-benzamid,
    2-Kloro-5-metil-N-(1-metil-4-fenil-piperidin-4-ilmetil)-benzannid,
    2-Metil-N-(1-metil-4-fenil-piperidin-4-ilmetil)-benzamid, N-[4-(4-Kloro-fenil)-tetrahidro-piran-4-ilmetil]-2,3,5-trifluoro-benzamid, N-[4-(4-Kloro-fenil)-1-metil-piperidin-4-ilmetil]-2-metil-benzamid, 2.3- Dikloro-N-[4-metil-2-(6-metil-piridin-3-il)-pentil]-benzamid, 2.3- Dimetil-N-[4-metil-2-(6-metil-piridin-3-il)-pentil]-benzamid,
    2-Metil-N-[4-metil-2-(6-metil-piridin-3-il)-pentil]-benzamid,
    2-Kloro-5-metil-N-[4-(6-metil-piridin-3-il)-tetrahidro-piran-4-ilmetil]- benzamid,
    5-Bromo-2-kloro-N-[4-(4-kloro-fenil)-tetrahidro-piran-4-ilmetil]-benzamid,
    2-Kloro-N-[4-(4-kloro-fenil)-tetrahidro-piran-4-ilmetil]-benzamid, 2.3- dikloro-N-[[4,4-difluoro-1-(6-fluoro-3- piridil)cikloheksil]metil]benzamid, 2.3- dikloro-N-[[4,4-difluoro-1-(6-fluoro-3-piridil)cikloheksil]metil]benzamid, 2-kloro-N-[4,4-difluoro-1-(6-fluoro-3-piridil)cikloheksil]metil]-6-fluoro-benzamid, 2-kloro-N-[4,4-difluoro-1-(6-fluoro-3-piridil)cikloheksil]metil]-5-metil- benzamid, 2-kloro-N-[4,4-difluoro-1-(6-fluoro-3-piridil)cikloheksil]metil]-5-(trifluorometil)benzamid, N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-2-fluorobenzamid, N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-2-fluoro-3- metoksibenzamid, 2-kloro-N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-5- (metilsulfonil)benzamid, 2-kloro-N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)benzamid, N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-2-fluoro-5- metoksibenzamid, N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-2-fluoro-3- metilbenzamid, N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-2,5- difluorobenzamid, 2,5-dikloro-N-((4,4-d if I uoro-1 -(6-f I uoropirid in-3-il)cikloheksil)metil)benzamid, 2-kloro-N-((4,4-difluoro-1-(6-fluoropiridin-3-it)cikloheksil)metil)-5- metoksibenzamid, N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-2,3- difluorobenzamid, 2.3- dikloro-N-((4-(4-klorofenil)tetrahidro-2H-piran-4-il)metil)benzamid, 2.3- dikloro-N-((4-(4-(trifluorometil)fenil)tetrahidro-2H-piran-4-il)metil)benzamid, 2.3- dikloro-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)benzamid, 2.3- dikloro-N-((4-(6-(trifluorometil)piridin-3-il)tetrahidro-2H-piran-4-il)metil)benzamid, 2.3- dikloro-N-((1-(6-ciklopropilpiridin-3-il)-4,4-difluorocikloheksil)metil)benzamid, 2.3- dikloro-N-((4,4-difluoro-1-(6-metoksipiridin-3-il)cikloheksil)metil)benzamid, 2-ciano-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)benzamid, 2-kloro-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-4- (metilsulfonil)benzamid, N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-2- metilbenzamid, 2.3- dikloro-N-(2-ciklopropil-2-(6-(trifluorometil)piridin-3-il)etil)benzamid, N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-2-(metilsulfonil)benzamid, 2.3- dikloro-N-((4,4-difluoro-1-(5-fluoropiridin-3-il)cikloheksil)metil)benzamid, 2.3- dikloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]benzamid, 2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]benzamid, N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-3-fIuoro-2-metilbenzamid, N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-3-metoksi- 2- metilbenzamid, N-((4)4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-5-fluoro-2- metilbenzamid, N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-2-metil-5- (trifluorometil)benzamid, 3- bromo-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-2-metilbenzamid, 2- klorO'N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-3-metilbenzamid, 3- ciano-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-2-metilbenzamid, 2.3- dikloro-N-(2-(5-kloropiridin-3-il)-3-ciklopropilpropil)benzamid, 2.3- dikloro-N-(2-(4-klorofenil)-2-feniletil)benzamid, 2.3- dikloro-N-[3-ciklopropil-2-(2,6-dimetil-3-piridil)propil]benzamid, 2.3- dikloro-N-[2-(2-metilpirimidin-5-il)-3-[1-(trifluorometil)ciklopropil]propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]benzamid, (-)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]benzamid, (+)2,3-dikloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propillbenzamid, (-)2,3-dikloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]benzamid, 2.3- dikloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometil)-3-piridil]propil]benzamid, 2.3- dikloro-N-[2-(6-ciklopropil-3-piridil)-3-[1-(trifluorometil)ciklopropil]propil]benzamid, 2.3- dikloro-N-[2-(6-ciklopropil-3-piridil)-3-[1-(difluorometil)ciklopropil]propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-3-(trifluorometil)benzamid, (-)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-3-(trifluorometil)benzam id, 2.3- d ikloro-N-[3-[ 1 -(d ifluorometil)ciklopropil]-2-[6-(trif luorometil)-3-piridil]propil]benzamid, (-)2,3-dikloro-N-[2-(2-metilpirimidin-5-il)-3-[1- (trifluorometil)ciklopropil]propil]benzamid, (+)2,3-dikloro-N-[2-(2-metilpirimidin-5-il)-3-[1- (trifluorometil)ciklopropil]propil]benzamid, (-)2-kloro-N-[2-(2-metilpirimidin-5-il)-3-[1- (trifluorometil)ciklopropil]propil]benzamid, (+)2-kloro-N-[2-(2-metilpirimidin-5-il)-3-[1- (trifluorometil)ciklopropil]propil]benzamid, 2-kloro-N-[2-(6-ciklopropil-3-piridil)-3-[1- (trifluorometil)ciklopropil]propil]benzamid, N-[2-(6-ciklopropil-3-piridil)-3-[1-(trifluorometil)ciklopropil]propil]-2-fluoro- benzamid, 2-kloro-N-[3-ciklopropil-2-(2-metilpirimidin-5-il)propil]benzamid, 2I3-dikloro-N-[3-ciklopropil-2-(2-metilpirimidin-5-il)propil]benzamid, 2-kloro-N-[3-[1-(trifluorometil)cikloprop»l]-2-[6-(trifluorometil)-3-piridil]propil]benzamid, 2-fluoro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometiI)-3- piridil]propil]benzamid, 2-kloro-N-[[4,4-difluoro-1-(2-metilpirimidin-5-il)cikloheksil]metil]benzamid, 2,3*dikloro-N-[[4,4-difluoro-1-(2-metilpirimidin-5- il)cikloheksil]metil]benzamid, 2.3- dikloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]benzamid, 2.3- dikloro-N-[[4,4-difluoro-1 -[6-(1 -hidroksi-1 -metil-etil)-3-piridil]cikloheksil]metil]benzamid, 2-kloro-N-[[4,4-difluoro-1 -[6-(1-hidroksi-1-metil-etil)-3-pirid il]cikloheksil]metil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-3-metoksi- benzamid, (-)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-3-metoksi- benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-6-fluoro- benzamid, (-)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-6-fluoro- benzamid, (+)N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-2-metoksi-benzamid, (-)N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-2-metoksi-benzamid, (+)N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-2,6-difluoro- benzamid, (“)N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]~2,6-difluoro-benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-5- metilsulfonilbenzamid, (-)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-5- metilsulfonilbenzamid, 2.3- dikloro-N-((4,4-difluoro-1-(4-metil-1H-imidazol-1-il)cikloheksil)metil)benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-3-fluoro- benzamid, 2(-)-kloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]-3-fluoro- benzamid, (-)2-kloro-N-[3-ciklopropil-2-(6-fluoro-3-piridil)propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-(6-fluoro-3-piridil)propil]benzamid, N -(1 -(1 -(6-bromop irid in-3-il)-4,4-d ifl uorocikloheksil)eti l)-2,3-diklorobenzamid, (-)2,3-dikloro-N-[3-ciklopropil-2-(2-metilpirimidin-5-il)propil]benzamid, (+)2,3-dikloro-N-[3-ciklopropil-2-(2-metilpirimidin-5-il)propil]benzannidl 2-kloro-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3- il)cikloheksil)metil)benzamid, 2.3- dikloro-N-((4,4-difluoro-1-(6-metilpiridin-3-il)cikloheksil)metil)benzamid, 2-kloro-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-3-metoksibenzamid, 2-kloro-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-3- fluorobenzamid, 2-kloro-N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-3- fluorobenzamid, 3-kloro-N-((4,4-difluoro-1-(6-(trifluorometil)piridin-3-il)cikloheksil)metil)-2- fluorobenzamid, 3-kloro-N-((4,4-difluoro-1-(6-fluoropiridin-3-il)cikloheksil)metil)-2- fluorobenzamid, 3-kloro-N-(3-ciklopropil-2-(6-(trifluorometil)piridin-3-il)propil)-2- fluorobenzamid, 2-kloro-N-(3-ciklopropil-2-(6-(trifluorometil)piridin-3-il)propil)-4- fluorobenzamid, 2,6-dikloro-N-(3-ciklopropil-2-(6-(trifluorometil)piridin-3-il)propil)benzamid, 2-kloro-N-[3-ciklopropil-2-metil-2-[2-(trifluorometil)pirimidin-5- il]propil]benzamid, 2-kloro-N-[3-ciklopropil-2-metil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3- fluoro-benzamid, (-)2,3-dikloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5- il]propil]benzamid, (+)2,3-dikloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5- il]propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]benzamid, (-)2-kloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3-fIuoro- benzamid, (-)2-kloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3-fluoro- benzamid, (+)2-kloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]-6-fluoro- benzamid, 2,3-dikloro-N-[2-(4-klorofenil)-2-tetrahidropiran-4-il-etil]benzamid, 2-kloro-N-[2-(4-klorofenil)-2-tetrahidropiran-4-il-etil]benzamid, 2-kloro-N-[2-(4-klorofenil)-2-tetrahidropiran-4-il-etil]-6-fluoro-benzamid, 2-kloro-N-[2-(4-klorofenil)-2-tetrahidropiran-4-il-etil]-3-fluoro-benzamid, 2,6-dikloro-N-(3-ciklopropil-2-(2-(trifluorometil)pirimidin-5- il)propil)benzamid, 2-kloro-N-(3-ciklopropil-2-(2-(trifluorometil)pirimidin-5-il)propil)benzamid, 2-kloro-N-(3-ciklopropil-2-(2-(trifluorometil)pirimidin-5-il)propil)-3- fiuorobenzamid, 2-kloro-N-(3-ciklopropil-2-(2-(trifluorometil)pirimidin-5-il)propil)-6- fluorobenzamid, 2.3- dikloro-N-[[4-[2-(trifluorometil)pirimidin-5-il]tetrahidropiran-4-il]metil]benzamid, 2-kloro-N-[[4-[2-(trifluorometil)pirimidin-5-il]tetrahidropiran-4- il]metil]benzamid, 2-kloro-6-fluoro-N-[[4-[2-(trifluorometil)pirimidin-5-il]tetrahidropiran-4- il]metil]benzamid, (-)2-kloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3-metoksi- benzamid, (+)2-kloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3- metoksi-benzamid, (-)N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3-metoksi-2-metil- benzamid, (+)N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3-metoksi-2- metil-benzamid, 2.3- dikloro-N-[3-(1-fluorociklopropil)-2-[6-(trifluorometil)-3-ptridil]propil]benzamid, (-)2,6-dikloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]benzamid, (+)2,6-dikloro-N-[3-ciklopropil-2-[6-(trifluorometil)-3-piridil]propil]benzamid, (-)2,6-dikloro-N-[3-ciklopropil-2-[2-(trifluorometil)pirimidin-5-il]propil]benzamid, (+)2,6-dikloro-N-[3-dklopropil-2-[2-(trifluorometil)pirimidin-5- il]propil]benzamid, 2.3- dikloro-N-[3-(1-fluorociklopropil)-2-[2-(trifluorometil)pirimidin-5-il]propil]benzamid, 2.3- dikloro-N-[2-(2-metilpirimidin-5-il)-2-(4-piridil)etil]benzamid, 2-kloro-N-[2-(2-metilpirimidin-5-il)-2-(4-piridil)etil]benzamid, 2-kloro-6-fluoro-N-[2-(2-metilpirimidin-5-il)-2-(4-piridil)ethil]benzamid, 2-kloro-3-fluoro-N-[2-(2-metilpirimidin-5-il)-2-(4-piridil)etil]benzamid, (-)2,6-dikloro-N-[3-ciklopropil-2-(2-metilpirimidin-5-il)propil]benzamid, (+)2,6-dikloro-N-[3-ciklopropil-2-(2-metilpirimidin-5-il)propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-metil-2-[2-(trifluorometil)pirimidin-5-il]propil]benzamid, (-)2-kloro-N-[3-ciklopropil-2-metil-2-[2-(trifluorometil)pirimidin-5- il]propil]benzamid, 2.3- dikloro-N-[[4,4-difluoro-1-[2-(trifluorometil)pirimidin-5-il]cikloheksil]metil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-metil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3- fluoro-benzamid, (-)2-kloro-N-[3-ciklopropil-2-metil-2-[2-(trifluorometil)pirimidin-5-il]propil]-3- fluoro-benzamid, (+)2,3-dikloro-N-[3-ciklopropil-2-metil-2-[2-(trifluorometil)pirimidin-5- il]propil]benzamid, (-)2,3-dikloro-N-[2-(2-metilpirimidin-5-il)-2-tetrahidropiran-4-il-etiljbenzamid, (+)2,3-dikloro-N-[2-(2-metilpirimidin-5-il)-2-tetrahidropiran-4-il-etiljbenzamid, (-)2-kloro-N-[2-(2-metilpirimidin-5-il)-2-tetrahidropiran-4-il-etil] benzamid, (+)2-kloro-N-[2-(2-metilpirimidin-5-il)-2-tetrahidropiran-4-il-etil]benzamid, 2,3-d ikloro-N-[2-(4,4-d ifluorocikloheksil)-2-(2-metilpirimid in-5-il)etil]benzamid, 2-kloro-N-[2-(4,4-difluorocikloheksil)-2-(2-metilpirimidin-5-il)etil]benzamid, (+)2-kloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[2-(trifluorometil)pirimidin-5- il]propil]benzamid, 2-kloro-6-fluoro-N-[2-(2-metilpirimidin-5-il)-2-tetrahidropiran-4-il- etil]benzamid, 2-kloro-3-fluoro-N-[2-(2-metilpirimidin-5-il)-2-tetrahidropiran-4-il- etil]benzamid, 2-kloro-N-[2-(4,4-difluorocikloheksil)-2-(2-metilpirimidin-5-il)etil]-6-fluoro- benzamid, 2-kloro-N-[2-(4,4-difluorocikloheksil)-2-(2-metilpirimidin-5-il)etil]-3-fluoro- benzamid, (+)2-kloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometil)-3- piridil]propil]benzamid, (-)2-kloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometil)-3- piridil]propil]benzamid, (+)2,3-dikloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometil)-3- piridil]propil]benzamid, (-)2,3-dikloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometil)-3-piridil]propil]benzamid, (+)2-kloro-3-fluoro-N-[3-[1-(trifluorometil)ciklopropil]-2-[2- (trifluorometil)pirimidin-5-il]propil]benzamid, (-)2-kloro-3-fluoro-N-[3-[1-(trifluorometil)ciklopropil]-2-[2- (trifluorometil)pirimidin-5-il]propil]benzamid, (+)2,3-dikloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[2-(trifluorometil)pirimidin- 5-il]propil]benzamid, (-)2,3-dikloro-N-[3-[1-(trifluorometil)ciklopropil]-2-[2-(trifluorometil)pirimidin- 5-il]propil]benzamid, (+)2-kloro-3-fluoro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometil)-3- piridil]propil]benzamid, (-)2-kloro-3-fluoro-N-[3-[1-(trifluorometil)ciklopropil]-2-[6-(trifluorometil)-3- piridil]propil]benzamid, (+)2,3-dikloro-N-[3-ciklopropil-2-[6-(1-hidroksi-1-metil-etil)-3- piridil]propil]benzamid, (-)2,3-dikloro-N-[3-ciklopropil-2-[6-(1-hidroksi-1-metil-etil)-3-piridil]propil]benzamid, (+)2l3-dikloro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2,3-dikloro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (+)2-kloro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2-kloro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (+)2-kloro-6-fluoro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2-kloro-6-fluoro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (+)2-kloro-3-fluoro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2-kloro-3-fluoro-N-[2-tetrahidropiran-4-il-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (+)2,6-dikloro-N-[2-fenil-2-[6-(trifluorometil)-3-piridil]etil]benzamidI (-)2,6-dikloro-N-[2-fenil-2-[6-(trifluorometil)-3-piridil]etil]benzamid, 2,4-dikloro-N-(2-fenil-2-(6-(trifluorometil)piridin-3-il)etil)benzamid, 2-kloro-6-fluoro-N-[1-[4-(2-metilpirimidin-5-il)tetrahidropiran-4- il]etil]benzamid, 2-kloro-3-fluoro-N-[1-[4-(2*metilpirimidin-5-il)tetrahidropiran-4- il]etil]benzamid, 2,3-dikloro-N-((3-(2-metilpirimidin-5-il)tetrahidrofuran-3-il)metil)benzamid, (+)2,3-dikloro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3-piridil]etil]benzamid, (-)2,3-dikloro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3-piridil]etil]benzamid, (+)2-kloro-6-fluoro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3- piridil]etil]benzamid, (-)2-kloro-6-fluoro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3- piridil]etil]benzamid, (+)2-kloro-3-fluoro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3- piridil]etil]benzamid, (-)2-kloro-3-fluoro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3- piridil]etil]benzamid, (+)2-kloro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3-piridil]etil]benzamid, (-)2-kloro-N-[2-(4-fluorofenil)-2-[6-(trifluorometil)-3-piridil]etil]benzamid, 2-kloro-N-[2-(4-piridil)-2-[2-(trifluorometil)pirimidin-5-il]etil]benzamid, 2.3- dikloro-N-[2-(4-piridil)-2-[2-(trifluorometil)pirimidin-5-ilJetil]benzamid, 2-kloro-N-[2-(4-piridil)-2-[6-(trifluorometil)-3-piridil]etil]benzamid, 2.3- dikloro-N-[2-(4-piridil)-2-[6-(trifluorometil)-3-piridil]etil]benzamid, (+)2,3-dikloro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5-il]etil]benzamid, (-)2,3-dikloro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (+)2-kloro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2-kloro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5-il]etil]benzamid, 2.3- dikloro-N-[1 -[4,4-difluoro-1 -(2-metilpirimidin-5-il)cikloheksil]etil]benzamid, 2-kloro-N-[1-[4)4-difluoro-1-(2-metilpirimidin-5-il)cikloheksil]etil]benzamid, (+)2-kloro-6-fluoro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2-kloro-6-fluoro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (+)2-kloro-3-fluoro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2-kloro-3-fluoro-N-[2-(4-fluorofenil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, 2-kloro-N-1-[4,4-difluoro-1-(2-metilpirimidin-5-il)cikloheksil]etil]-6-fluoro- benzamid, 2- kloro-N-1-[4,4-difluoro-1-(2-metilpirimidin-5-il)cikloheksil]etil]-3-fluoro-benzamid, (-)2,3-dikloro-N-[2-(4,4-difluorocikloheksil)-2-(2-metilpirimidin-5-il)etil]benzamid, (+)2,3-dikloro-N-[2-(4,4-difluorocikloheksil)-2-(2-metilpirimidin-5- il)etil]benzamid, (+)2-kloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5- il]etil]-3-fluoro-benzamid, (-)2-kloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5-il]etil]- 3- fluoro-benzamid, (+)2-kloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2-kloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (+)2,3-dikloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5- il]etil]benzamid, (-)2,3-dikloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5- it]etil]benzamid, (+)2-kloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5-il]etil]-6-fluoro-benzamid, (-)2-kloro-N-[2-(4,4-difluorocikloheksil)-2-[2-(trifluorometil)pirimidin-5-il]etil]- 6-fluoro-benzamid, 2.3- dikloro-N-[4-metoksi-2-[2-(trifluorometil)pirimidin-5-il]butil]benzamid, 2.3- dikloro-N-(2-fenil-2-piridazin-4-il-etil)benzamid, 2.4- dikloro-N-(2-fenil-2-piridazin-4-il-etil)benzamid, (+)2,3-dikloro-N-[3-ciklopropil-2-[2-(difluorometil)pirimidin-5-il]propil]benzamid, (-)2,3-dikloro-N-[3-ciklopropil-2-[2-(difluorometil)pirimidin-5-il]propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(difluorometil)-3-piridil]propil]benzamid, (-)2-kloro-N-[3-ciklopropil-2-[6-(difluorometil)-3-piridil]propil]benzamid, (+)2,3-dikloro-N-[3-ciklopropil-2-[6-(difluorometil)-3-piridil]propil]benzamidI (-)2,3-dikloro-N-[3-ciklopropil-2-[6-(difluorometil)-3-piridil]propil]benzamid, (+)2-kloro-N-[3-ciklopropil-2-[6-(difluorometil)-3-piridil]propil]-3-fluoro- benzamid, {-)2-kloro-N-[3-ciklopropil-2-[6-(difluorometil)-3-piridi!]propil]-3-fluoro-benzamid, in N-[4,4-Difluoro1 -(6-fluoro-piridin-3-il)-cikloheksilmetil]-2-fluoro-benzamid.
  18. 18. Farmacevtski sestavek, ki obsega spojino po katerem koli od zahtevkov 1-17.
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598325B (zh) * 2012-10-12 2017-09-11 Ｈ 朗德貝克公司 苯甲醯胺類
TW201427947A (zh) 2012-10-12 2014-07-16 Lundbeck & Co As H 環狀胺
US9718774B2 (en) 2012-12-12 2017-08-01 Idorsia Pharmaceuticals Ltd Indole carboxamide derivatives as P2X7 receptor antagonist
EP2935211B1 (en) 2012-12-18 2016-11-09 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as p2x7 receptor antagonists
CA2896790C (en) 2013-01-22 2022-05-10 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
US9388198B2 (en) 2013-01-22 2016-07-12 Actelion Pharmaceuticals Ltd. Heterocyclic amide derivatives as P2X7 receptor antagonists
CN105503787A (zh) * 2015-12-31 2016-04-20 阜阳欣奕华材料科技有限公司 一种索非布韦中间体的纯化方法
CN106366056B (zh) * 2016-08-26 2018-12-11 常州市阳光药业有限公司 3-氨甲基四氢呋喃的制备方法
PL3609868T3 (pl) * 2017-03-13 2024-04-02 Raqualia Pharma Inc. Pochodne tetrahydrochinoliny jako antagoniści receptora P2X7
UA128288C2 (uk) 2018-03-08 2024-05-29 Інсайт Корпорейшн СПОЛУКИ АМІНОПІРАЗИНДІОЛУ ЯК ІНГІБІТОРИ PI3K-<font face="Symbol">g</font>
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445707A1 (de) 1962-05-05 1969-03-13 Hoechst Ag Piperidinverbindungen und Verfahren zu ihrer Herstellung
US3435038A (en) * 1965-06-01 1969-03-25 Sandoz Ag 5,6,7,9,10,14b-hexahydroisoquinolo (2,1-d) benzo (1,4) diazepines
US6632836B1 (en) * 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors
US6303637B1 (en) * 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
US6194458B1 (en) * 1998-10-30 2001-02-27 Merck & Co., Inc. Benzamide potassium channel inhibitors
SE0003476D0 (sv) * 2000-09-28 2000-09-28 Astrazeneca Ab Compounds
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
TW200300083A (en) 2001-11-12 2003-05-16 Pfizer Prod Inc Benzamide, heteroarylamide and reverse amides
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
DE602004005033T2 (de) * 2003-05-12 2007-08-09 Pfizer Products Inc., Groton Benzamidinhibitoren des p2x7-rezeptors
CA2539227A1 (en) 2003-08-08 2005-02-17 Vertex Pharmaceuticals Incorporated Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain
TWI368482B (en) * 2003-12-19 2012-07-21 Bayer Sas New 2-pyridinylethylbenzamide derivatives
CA2560256C (en) * 2004-03-24 2013-02-19 Merck & Co., Inc. Heteroaryl piperidine glycine transporter inhibitors
JP2008504363A (ja) * 2004-06-29 2008-02-14 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Ｐ２ｘ７受容体のベンズアミド阻害剤を利用する併用療法
AU2005317846B2 (en) * 2004-12-21 2011-12-08 Merck Sharp & Dohme Limited Piperidine and azetidine derivatives as GlyT1 inhibitors
JP2008528580A (ja) * 2005-01-27 2008-07-31 アストラゼネカ・アクチエボラーグ Ｐ２ｘ７受容体の阻害剤である新規二環式芳香族化合物
WO2006134341A1 (en) * 2005-06-13 2006-12-21 Merck Sharp & Dohme Limited Therapeutic agents
EP1940782B1 (en) 2005-10-19 2009-03-11 F.Hoffmann-La Roche Ag N-phenyl phenylacetamide non-nucleoside reverse transcriptase inhibitors
JP2009057282A (ja) 2005-12-19 2009-03-19 Astellas Pharma Inc カルボン酸誘導体又はその塩
TWI435863B (zh) 2006-03-20 2014-05-01 Nihon Nohyaku Co Ltd Ｎ-２-（雜）芳基乙基甲醯胺衍生物及含該衍生物之蟲害防治劑
BRPI0813781A2 (pt) * 2007-07-02 2019-09-24 Syngenta Participations Ag microbiocidas
EP2219646A4 (en) * 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
KR101598397B1 (ko) * 2008-04-22 2016-02-29 얀센 파마슈티카 엔.브이. 퀴놀린 또는 이소퀴놀린 치환된 피2엑스7 안타고니스트
ES2345527B1 (es) * 2008-10-08 2011-09-08 Hospital Clinic I Provincial De Barcelona Sustancias bloqueadoras de los canales kv 1.3 para el tratamiento de enfermedades asociadas a hiperplasia de la intima.
US9096500B2 (en) 2010-07-12 2015-08-04 Pfizer Limited Acyl sulfonamide compounds
US9447042B2 (en) * 2011-03-02 2016-09-20 The University Of Tokyo Endoparasite control agent
KR20140097243A (ko) * 2011-11-02 2014-08-06 바이엘 인텔렉쳐 프로퍼티 게엠베하 살선충 활성을 갖는 화합물
ES2762249T3 (es) * 2011-11-25 2020-05-22 Bayer Ip Gmbh Uso de aril- y hetarilcarboxamidas como endoparasiticidas
TW201427947A (zh) * 2012-10-12 2014-07-16 Lundbeck & Co As H 環狀胺
TWI598325B (zh) 2012-10-12 2017-09-11 Ｈ 朗德貝克公司 苯甲醯胺類

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