SI2595958T1 - Novi postopki za proizvodnjo (3-(5-(4-kloro-fenil)-1h-pirolo(2,3-b)piridin-3-karbonil)-2,4-difluoro- fenil)-amida propan-1-sulfonske kisline - Google Patents
Novi postopki za proizvodnjo (3-(5-(4-kloro-fenil)-1h-pirolo(2,3-b)piridin-3-karbonil)-2,4-difluoro- fenil)-amida propan-1-sulfonske kislineInfo
- Publication number
- SI2595958T1 SI2595958T1 SI201130506T SI201130506T SI2595958T1 SI 2595958 T1 SI2595958 T1 SI 2595958T1 SI 201130506 T SI201130506 T SI 201130506T SI 201130506 T SI201130506 T SI 201130506T SI 2595958 T1 SI2595958 T1 SI 2595958T1
- Authority
- SI
- Slovenia
- Prior art keywords
- phenyl
- pyrrolo
- difluoro
- propane
- carbonyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 title 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10170266 | 2010-07-21 | ||
| PCT/EP2011/062207 WO2012010538A2 (en) | 2010-07-21 | 2011-07-18 | Novel processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
| EP20110735858 EP2595958B1 (en) | 2010-07-21 | 2011-07-18 | Novel processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2595958T1 true SI2595958T1 (sl) | 2015-07-31 |
Family
ID=44532792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201130506T SI2595958T1 (sl) | 2010-07-21 | 2011-07-18 | Novi postopki za proizvodnjo (3-(5-(4-kloro-fenil)-1h-pirolo(2,3-b)piridin-3-karbonil)-2,4-difluoro- fenil)-amida propan-1-sulfonske kisline |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8779150B2 (sl) |
| EP (1) | EP2595958B1 (sl) |
| JP (1) | JP5738992B2 (sl) |
| KR (1) | KR101501856B1 (sl) |
| CN (1) | CN103153956B (sl) |
| BR (1) | BR112013001111A2 (sl) |
| CA (1) | CA2804739A1 (sl) |
| DK (1) | DK2595958T3 (sl) |
| ES (1) | ES2538996T3 (sl) |
| HK (1) | HK1181387A1 (sl) |
| HU (1) | HUE025022T2 (sl) |
| MX (1) | MX2013000708A (sl) |
| PL (1) | PL2595958T3 (sl) |
| SI (1) | SI2595958T1 (sl) |
| WO (1) | WO2012010538A2 (sl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| WO2011143399A1 (en) * | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8779150B2 (en) | 2010-07-21 | 2014-07-15 | Hoffmann-La Roche Inc. | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
| EA028821B9 (ru) | 2011-02-07 | 2018-10-31 | Плексксикон, Инк. | Соединения и способы для модуляции киназ, а также показания к их применению |
| US9216170B2 (en) | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
| CN104387384A (zh) * | 2014-10-30 | 2015-03-04 | 上海蘅茂生物科技有限公司 | 5-溴-7-氮杂吲哚的合成工艺 |
| CN104761491B (zh) * | 2015-03-31 | 2018-08-21 | 山东友帮生化科技有限公司 | 2-氨基-3-碘-5-溴吡啶的合成方法 |
| CZ2015250A3 (cs) | 2015-04-14 | 2016-10-26 | Zentiva, K.S. | Amorfní formy vemurafenibu |
| WO2018002415A1 (en) | 2016-07-01 | 2018-01-04 | Fermion Oy | New processes for the preparation of vemurafenib |
| WO2018015307A1 (en) | 2016-07-18 | 2018-01-25 | Janssen Pharmaceutica Nv | Tau pet imaging ligands |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO748097A0 (en) | 1997-06-20 | 1997-07-17 | Commonwealth Scientific And Industrial Research Organisation | Alkene borates |
| GB0017256D0 (en) | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| WO2005062795A2 (en) | 2003-12-19 | 2005-07-14 | Plexxikon, Inc. | Compounds and methods for development of ret modulators |
| RU2403252C2 (ru) | 2004-03-30 | 2010-11-10 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов jak и других протеинкиназ |
| CN101027302B (zh) * | 2004-07-27 | 2011-05-11 | Sgx药物公司 | 吡咯并吡啶激酶调节剂 |
| MX2007001127A (es) | 2004-07-27 | 2007-07-11 | Sgx Pharmaceuticals Inc | Moduladores de pirrolo-piridina cinasa. |
| US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
| PL1863818T3 (pl) * | 2005-03-23 | 2010-08-31 | Hoffmann La Roche | Pochodne acetylenylo-pirazolo-pirymidyny jako antagoniści MGLUR2 |
| EP1893612B1 (en) | 2005-06-22 | 2011-08-03 | Plexxikon, Inc. | Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors |
| AU2008281543A1 (en) | 2007-08-01 | 2009-02-05 | Pfizer Inc. | Pyrazole compounds and their use as Raf inhibitors |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| US8779150B2 (en) | 2010-07-21 | 2014-07-15 | Hoffmann-La Roche Inc. | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
-
2011
- 2011-07-15 US US13/183,694 patent/US8779150B2/en active Active
- 2011-07-18 CA CA2804739A patent/CA2804739A1/en not_active Abandoned
- 2011-07-18 MX MX2013000708A patent/MX2013000708A/es active IP Right Grant
- 2011-07-18 SI SI201130506T patent/SI2595958T1/sl unknown
- 2011-07-18 CN CN201180035703.2A patent/CN103153956B/zh active Active
- 2011-07-18 EP EP20110735858 patent/EP2595958B1/en active Active
- 2011-07-18 KR KR1020137004227A patent/KR101501856B1/ko active IP Right Grant
- 2011-07-18 BR BR112013001111A patent/BR112013001111A2/pt not_active IP Right Cessation
- 2011-07-18 HU HUE11735858A patent/HUE025022T2/hu unknown
- 2011-07-18 JP JP2013520097A patent/JP5738992B2/ja active Active
- 2011-07-18 ES ES11735858.0T patent/ES2538996T3/es active Active
- 2011-07-18 PL PL11735858T patent/PL2595958T3/pl unknown
- 2011-07-18 DK DK11735858.0T patent/DK2595958T3/en active
- 2011-07-18 WO PCT/EP2011/062207 patent/WO2012010538A2/en active Application Filing
-
2013
- 2013-07-29 HK HK13108813.3A patent/HK1181387A1/xx unknown
-
2014
- 2014-06-04 US US14/296,316 patent/US9150594B2/en active Active
-
2015
- 2015-08-27 US US14/838,197 patent/US9556172B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2013105102A (ru) | 2014-08-27 |
| CN103153956A (zh) | 2013-06-12 |
| WO2012010538A3 (en) | 2013-02-21 |
| HUE025022T2 (hu) | 2016-05-30 |
| CA2804739A1 (en) | 2012-01-26 |
| KR20130041230A (ko) | 2013-04-24 |
| ES2538996T3 (es) | 2015-06-25 |
| EP2595958B1 (en) | 2015-04-29 |
| US9556172B2 (en) | 2017-01-31 |
| US20160083378A1 (en) | 2016-03-24 |
| JP2013537521A (ja) | 2013-10-03 |
| KR101501856B1 (ko) | 2015-03-11 |
| MX2013000708A (es) | 2013-02-27 |
| HK1181387A1 (en) | 2013-11-08 |
| PL2595958T3 (pl) | 2015-10-30 |
| US20140288308A1 (en) | 2014-09-25 |
| US9150594B2 (en) | 2015-10-06 |
| US8779150B2 (en) | 2014-07-15 |
| WO2012010538A2 (en) | 2012-01-26 |
| EP2595958A2 (en) | 2013-05-29 |
| BR112013001111A2 (pt) | 2016-05-24 |
| JP5738992B2 (ja) | 2015-06-24 |
| DK2595958T3 (en) | 2015-05-18 |
| CN103153956B (zh) | 2015-05-27 |
| US20120022258A1 (en) | 2012-01-26 |
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