PL2595958T3 - Nowy sposób wytwarzania {3-[5-(4-chlorofenylo)-1 h-pirolo[2,3-b]pirydyno-3-karbonylo]-2,4-difluorofenylo}amidu kwasu propano-1-sulfonowego - Google Patents
Nowy sposób wytwarzania {3-[5-(4-chlorofenylo)-1 h-pirolo[2,3-b]pirydyno-3-karbonylo]-2,4-difluorofenylo}amidu kwasu propano-1-sulfonowegoInfo
- Publication number
- PL2595958T3 PL2595958T3 PL11735858T PL11735858T PL2595958T3 PL 2595958 T3 PL2595958 T3 PL 2595958T3 PL 11735858 T PL11735858 T PL 11735858T PL 11735858 T PL11735858 T PL 11735858T PL 2595958 T3 PL2595958 T3 PL 2595958T3
- Authority
- PL
- Poland
- Prior art keywords
- phenyl
- pyrrolo
- difluoro
- propane
- carbonyl
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10170266 | 2010-07-21 | ||
| EP20110735858 EP2595958B1 (en) | 2010-07-21 | 2011-07-18 | Novel processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
| PCT/EP2011/062207 WO2012010538A2 (en) | 2010-07-21 | 2011-07-18 | Novel processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2595958T3 true PL2595958T3 (pl) | 2015-10-30 |
Family
ID=44532792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11735858T PL2595958T3 (pl) | 2010-07-21 | 2011-07-18 | Nowy sposób wytwarzania {3-[5-(4-chlorofenylo)-1 h-pirolo[2,3-b]pirydyno-3-karbonylo]-2,4-difluorofenylo}amidu kwasu propano-1-sulfonowego |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8779150B2 (pl) |
| EP (1) | EP2595958B1 (pl) |
| JP (1) | JP5738992B2 (pl) |
| KR (1) | KR101501856B1 (pl) |
| CN (1) | CN103153956B (pl) |
| BR (1) | BR112013001111A2 (pl) |
| CA (1) | CA2804739A1 (pl) |
| DK (1) | DK2595958T3 (pl) |
| ES (1) | ES2538996T3 (pl) |
| HU (1) | HUE025022T2 (pl) |
| MX (1) | MX2013000708A (pl) |
| PL (1) | PL2595958T3 (pl) |
| SI (1) | SI2595958T1 (pl) |
| WO (1) | WO2012010538A2 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| US8969356B2 (en) * | 2010-05-12 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US8779150B2 (en) | 2010-07-21 | 2014-07-15 | Hoffmann-La Roche Inc. | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
| PL2672967T3 (pl) * | 2011-02-07 | 2019-04-30 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania ku temu |
| US9216170B2 (en) | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
| CN104387384A (zh) * | 2014-10-30 | 2015-03-04 | 上海蘅茂生物科技有限公司 | 5-溴-7-氮杂吲哚的合成工艺 |
| CN104761491B (zh) * | 2015-03-31 | 2018-08-21 | 山东友帮生化科技有限公司 | 2-氨基-3-碘-5-溴吡啶的合成方法 |
| CZ2015250A3 (cs) | 2015-04-14 | 2016-10-26 | Zentiva, K.S. | Amorfní formy vemurafenibu |
| JP6911062B2 (ja) * | 2016-07-01 | 2021-07-28 | フェルミオン オサケ ユキチュア | ベムラフェニブの新規な製造方法 |
| WO2018015307A1 (en) | 2016-07-18 | 2018-01-25 | Janssen Pharmaceutica Nv | Tau pet imaging ligands |
| MX393780B (es) | 2017-01-17 | 2025-03-24 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos |
| CN116693449A (zh) | 2022-03-04 | 2023-09-05 | 上海致根医药科技有限公司 | 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO748097A0 (en) * | 1997-06-20 | 1997-07-17 | Commonwealth Scientific And Industrial Research Organisation | Alkene borates |
| GB0017256D0 (en) | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| CN1925855B (zh) | 2003-12-19 | 2010-06-16 | 普莱希科公司 | 开发Ret调节剂的化合物和方法 |
| NZ584499A (en) | 2004-03-30 | 2011-08-26 | Vertex Pharma | Azaindoles Useful as Inhibitors of Jak and Other Protein Kinases |
| CN101027302B (zh) * | 2004-07-27 | 2011-05-11 | Sgx药物公司 | 吡咯并吡啶激酶调节剂 |
| US7361763B2 (en) * | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
| ATE460417T1 (de) | 2005-03-23 | 2010-03-15 | Hoffmann La Roche | Acetylenylpyrazolopyrimidinderivate als mglur2- antagonsten |
| PL2395004T3 (pl) | 2005-06-22 | 2016-08-31 | Plexxikon Inc | Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej |
| CN101815712A (zh) | 2007-08-01 | 2010-08-25 | 辉瑞有限公司 | 吡唑化合物及其作为raf抑制剂的用途 |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| US8779150B2 (en) | 2010-07-21 | 2014-07-15 | Hoffmann-La Roche Inc. | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
-
2011
- 2011-07-15 US US13/183,694 patent/US8779150B2/en active Active
- 2011-07-18 CA CA2804739A patent/CA2804739A1/en not_active Abandoned
- 2011-07-18 DK DK11735858.0T patent/DK2595958T3/en active
- 2011-07-18 WO PCT/EP2011/062207 patent/WO2012010538A2/en not_active Ceased
- 2011-07-18 ES ES11735858.0T patent/ES2538996T3/es active Active
- 2011-07-18 JP JP2013520097A patent/JP5738992B2/ja active Active
- 2011-07-18 MX MX2013000708A patent/MX2013000708A/es active IP Right Grant
- 2011-07-18 CN CN201180035703.2A patent/CN103153956B/zh active Active
- 2011-07-18 BR BR112013001111A patent/BR112013001111A2/pt not_active IP Right Cessation
- 2011-07-18 PL PL11735858T patent/PL2595958T3/pl unknown
- 2011-07-18 HU HUE11735858A patent/HUE025022T2/hu unknown
- 2011-07-18 EP EP20110735858 patent/EP2595958B1/en active Active
- 2011-07-18 KR KR1020137004227A patent/KR101501856B1/ko not_active Expired - Fee Related
- 2011-07-18 SI SI201130506T patent/SI2595958T1/sl unknown
-
2014
- 2014-06-04 US US14/296,316 patent/US9150594B2/en active Active
-
2015
- 2015-08-27 US US14/838,197 patent/US9556172B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9150594B2 (en) | 2015-10-06 |
| WO2012010538A3 (en) | 2013-02-21 |
| EP2595958B1 (en) | 2015-04-29 |
| WO2012010538A2 (en) | 2012-01-26 |
| US20140288308A1 (en) | 2014-09-25 |
| HK1181387A1 (en) | 2013-11-08 |
| US8779150B2 (en) | 2014-07-15 |
| CN103153956A (zh) | 2013-06-12 |
| KR20130041230A (ko) | 2013-04-24 |
| EP2595958A2 (en) | 2013-05-29 |
| BR112013001111A2 (pt) | 2016-05-24 |
| RU2013105102A (ru) | 2014-08-27 |
| US20120022258A1 (en) | 2012-01-26 |
| US20160083378A1 (en) | 2016-03-24 |
| US9556172B2 (en) | 2017-01-31 |
| MX2013000708A (es) | 2013-02-27 |
| CA2804739A1 (en) | 2012-01-26 |
| HUE025022T2 (hu) | 2016-05-30 |
| CN103153956B (zh) | 2015-05-27 |
| SI2595958T1 (sl) | 2015-07-31 |
| JP2013537521A (ja) | 2013-10-03 |
| DK2595958T3 (en) | 2015-05-18 |
| KR101501856B1 (ko) | 2015-03-11 |
| ES2538996T3 (es) | 2015-06-25 |
| JP5738992B2 (ja) | 2015-06-24 |
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