SI2229185T1 - Sočasno dajanje sredstva, vezanega na internalizacijski peptid tat, s protivnetnim sredstvom - Google Patents
Sočasno dajanje sredstva, vezanega na internalizacijski peptid tat, s protivnetnim sredstvomInfo
- Publication number
- SI2229185T1 SI2229185T1 SI200831555T SI200831555T SI2229185T1 SI 2229185 T1 SI2229185 T1 SI 2229185T1 SI 200831555 T SI200831555 T SI 200831555T SI 200831555 T SI200831555 T SI 200831555T SI 2229185 T1 SI2229185 T1 SI 2229185T1
- Authority
- SI
- Slovenia
- Prior art keywords
- agent
- administration
- internalization peptide
- linked
- tat internalization
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99267807P | 2007-12-05 | 2007-12-05 | |
| PCT/US2008/085280 WO2009076105A2 (en) | 2007-12-05 | 2008-12-02 | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
| EP08859906.3A EP2229185B8 (en) | 2007-12-05 | 2008-12-02 | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2229185T1 true SI2229185T1 (sl) | 2016-02-29 |
Family
ID=40756064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200831555T SI2229185T1 (sl) | 2007-12-05 | 2008-12-02 | Sočasno dajanje sredstva, vezanega na internalizacijski peptid tat, s protivnetnim sredstvom |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8080518B2 (https=) |
| EP (1) | EP2229185B8 (https=) |
| JP (1) | JP5520230B2 (https=) |
| CN (1) | CN101970011B (https=) |
| AU (1) | AU2008335490B2 (https=) |
| BR (1) | BRPI0820912B1 (https=) |
| DK (1) | DK2229185T3 (https=) |
| ES (1) | ES2555524T3 (https=) |
| HR (1) | HRP20151312T1 (https=) |
| HU (1) | HUE027216T2 (https=) |
| PL (1) | PL2229185T3 (https=) |
| PT (1) | PT2229185E (https=) |
| SI (1) | SI2229185T1 (https=) |
| WO (1) | WO2009076105A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| DK2043671T3 (da) * | 2006-07-11 | 2020-06-15 | Nono Inc | Peptid og sammensætning deraf til anvendelse ved behandling af slagtilfælde med feber |
| US8008253B2 (en) * | 2007-07-03 | 2011-08-30 | Andrew Tasker | Treatment for anxiety |
| DK2307035T3 (da) * | 2008-05-16 | 2014-01-20 | Nono Inc | Anvendelse af en PSD-95 inhibitor ved behandlingen af epilepsi |
| CA2739416C (en) | 2008-09-03 | 2017-10-31 | Arbor Vita Corporation | Agents and methods for treatment of pain |
| EP3682895A1 (en) | 2009-06-10 | 2020-07-22 | NoNO Inc. | Co-administration of an agent linked to a tat-internalization peptide with a mast cell degranulation inhibitor |
| WO2010144721A2 (en) | 2009-06-10 | 2010-12-16 | Arbor Vita Corporation | Model systems and treatment regimes for treatment of neurological disease |
| US9301999B2 (en) | 2009-09-28 | 2016-04-05 | Duke University | Peptide, adjuvants, vaccines, and methods of use |
| JP2013527834A (ja) * | 2010-03-29 | 2013-07-04 | マサチューセッツ インスティテュート オブ テクノロジー | 抗炎症因子 |
| AU2011279703B2 (en) * | 2010-06-10 | 2016-07-07 | Indiana University Research And Technology Corporation | Materials and method for suppressing inflamatory and neuropathic pain |
| EP2616094B1 (en) * | 2010-08-12 | 2017-11-08 | NoNO Inc. | Treatment of penetrative injury to the brain |
| JP6084207B2 (ja) * | 2011-05-13 | 2017-02-22 | ケベンハウンス ウニヴェルジテート（ユニバーシティ オブ コペンハーゲン）Ｋｏｅｂｅｎｈａｖｎｓ Ｕｎｉｖｅｒｓｉｔｅｔ（Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｏｐｅｎｈａｇｅｎ） | 虚血性脳損傷及び疼痛治療用の効率的な神経保護剤としてのｐｓｄ−９５の高親和性二量体阻害剤 |
| ES2912042T3 (es) | 2011-06-24 | 2022-05-24 | Nono Inc | Terapia de combinación para isquemia |
| US9730921B2 (en) | 2012-03-27 | 2017-08-15 | Duke University | Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage |
| US10251935B2 (en) | 2012-11-28 | 2019-04-09 | Nono Inc. | Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose |
| CA2892965C (en) * | 2012-11-28 | 2021-06-01 | Nono Inc. | Lyophilized formulation of tat-nr2b9c |
| US9783586B2 (en) * | 2013-03-15 | 2017-10-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of the linear ubiquitin chain assembly complex (LUBAC) and related methods |
| US20140349944A1 (en) * | 2013-05-23 | 2014-11-27 | Musc Foundation For Research Development | Chaperone-based integrin inhibitors for the treatment of cancer and inflammatory diseases |
| ES2572919T3 (es) | 2014-05-23 | 2016-06-03 | Ares Trading S.A. | Composición farmacéutica líquida |
| EP2946767B1 (en) | 2014-05-23 | 2016-10-05 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP3050557A1 (en) | 2014-05-23 | 2016-08-03 | Ares Trading S.A. | Liquid pharmaceutical composition |
| WO2016049280A1 (en) * | 2014-09-24 | 2016-03-31 | Memorial Sloan Kettering Cancer Center | mTORC1 MODULATION |
| KR102545825B1 (ko) * | 2017-09-30 | 2023-06-22 | 바이오셀즈(베이징) 바이오테크 코., 엘티디. | 흥분성 신경 독성 관련 손상 치료를 위한 펩타이드 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1159418A2 (en) * | 1998-12-11 | 2001-12-05 | Biomira Inc. | Muc-1 antagonists and methods of treating immune disorders |
| US20040226056A1 (en) | 1998-12-22 | 2004-11-11 | Myriad Genetics, Incorporated | Compositions and methods for treating neurological disorders and diseases |
| US20060148711A1 (en) * | 1999-05-14 | 2006-07-06 | Arbor Vita Corporation | Molecular interactions in neurons |
| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| DE60026313D1 (de) | 1999-07-23 | 2006-04-27 | Uutech Ltd | Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes |
| CA2381425A1 (en) | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| US6864355B1 (en) * | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
| US20020032154A1 (en) * | 2000-06-07 | 2002-03-14 | Peyman John A. | Interferon-suppressing placental lactogen peptides |
| US6887687B2 (en) | 2001-07-30 | 2005-05-03 | Immunex Corporation | Nucleic acids encoding human ataxin-1-like polypeptide IMX97018 |
| EP1601380A1 (en) * | 2003-02-13 | 2005-12-07 | Licentia OY | Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia |
| US7947645B2 (en) * | 2004-09-02 | 2011-05-24 | Cognosci, Inc. | APO E analogs and methods for their use |
| US7151084B2 (en) * | 2004-12-27 | 2006-12-19 | Miller Landon C G | Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes |
| WO2009006611A1 (en) * | 2007-07-03 | 2009-01-08 | Arbor Vita Corporation | Small molecule inhibitors of pdz interactions |
| CN101842107B (zh) * | 2007-07-26 | 2014-04-23 | 雷文斯治疗公司 | 抗微生物肽，组合物和使用方法 |
| ES2328776B1 (es) * | 2007-11-19 | 2010-07-06 | Proyecto De Biomedicina Cima S.L. | Peptidos con capacidad para unirse a escurfina y aplicaciones. |
| EP3682895A1 (en) | 2009-06-10 | 2020-07-22 | NoNO Inc. | Co-administration of an agent linked to a tat-internalization peptide with a mast cell degranulation inhibitor |
-
2008
- 2008-11-26 US US12/323,915 patent/US8080518B2/en active Active
- 2008-12-02 SI SI200831555T patent/SI2229185T1/sl unknown
- 2008-12-02 JP JP2010537016A patent/JP5520230B2/ja not_active Expired - Fee Related
- 2008-12-02 HR HRP20151312TT patent/HRP20151312T1/hr unknown
- 2008-12-02 ES ES08859906.3T patent/ES2555524T3/es active Active
- 2008-12-02 DK DK08859906.3T patent/DK2229185T3/en active
- 2008-12-02 AU AU2008335490A patent/AU2008335490B2/en not_active Ceased
- 2008-12-02 EP EP08859906.3A patent/EP2229185B8/en active Active
- 2008-12-02 WO PCT/US2008/085280 patent/WO2009076105A2/en not_active Ceased
- 2008-12-02 CN CN2008801261196A patent/CN101970011B/zh not_active Expired - Fee Related
- 2008-12-02 PL PL08859906T patent/PL2229185T3/pl unknown
- 2008-12-02 BR BRPI0820912-0A patent/BRPI0820912B1/pt not_active IP Right Cessation
- 2008-12-02 PT PT88599063T patent/PT2229185E/pt unknown
- 2008-12-02 HU HUE08859906A patent/HUE027216T2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101970011B (zh) | 2013-04-24 |
| BRPI0820912A2 (pt) | 2018-07-17 |
| JP5520230B2 (ja) | 2014-06-11 |
| EP2229185B1 (en) | 2015-10-07 |
| US8080518B2 (en) | 2011-12-20 |
| EP2229185A2 (en) | 2010-09-22 |
| US20090176713A1 (en) | 2009-07-09 |
| EP2229185B8 (en) | 2016-12-21 |
| CN101970011A (zh) | 2011-02-09 |
| HRP20151312T1 (hr) | 2016-03-11 |
| AU2008335490B2 (en) | 2013-08-22 |
| AU2008335490A1 (en) | 2009-06-18 |
| DK2229185T3 (en) | 2016-01-11 |
| WO2009076105A2 (en) | 2009-06-18 |
| JP2011506328A (ja) | 2011-03-03 |
| PL2229185T3 (pl) | 2016-03-31 |
| HUE027216T2 (en) | 2016-08-29 |
| BRPI0820912B1 (pt) | 2022-05-24 |
| EP2229185A4 (en) | 2011-11-23 |
| PT2229185E (pt) | 2016-01-26 |
| ES2555524T3 (es) | 2016-01-04 |
| WO2009076105A3 (en) | 2010-01-07 |
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