SI20245A - Zmesi in metode za zmanjševanje dihalne depresije in spremljevalnih stranskih učinkov mi opioidnih spojin - Google Patents
Zmesi in metode za zmanjševanje dihalne depresije in spremljevalnih stranskih učinkov mi opioidnih spojin Download PDFInfo
- Publication number
- SI20245A SI20245A SI9720097A SI9720097A SI20245A SI 20245 A SI20245 A SI 20245A SI 9720097 A SI9720097 A SI 9720097A SI 9720097 A SI9720097 A SI 9720097A SI 20245 A SI20245 A SI 20245A
- Authority
- SI
- Slovenia
- Prior art keywords
- alkyl
- piperazinyl
- hydrogen
- dimethyl
- allyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 175
- 208000004756 Respiratory Insufficiency Diseases 0.000 title claims abstract description 117
- 206010038678 Respiratory depression Diseases 0.000 title claims abstract description 117
- 230000000694 effects Effects 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims description 66
- 238000000034 method Methods 0.000 title abstract description 31
- 239000000841 delta opiate receptor agonist Substances 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 15
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 claims abstract description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 79
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- -1 C 1 -C 3 alkoxy Chemical class 0.000 claims description 58
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- 150000003839 salts Chemical class 0.000 claims description 46
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 38
- 229910052757 nitrogen Inorganic materials 0.000 claims description 37
- 239000000556 agonist Substances 0.000 claims description 35
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 32
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 28
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- 150000002148 esters Chemical class 0.000 claims description 27
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- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims description 6
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- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims description 5
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 3
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- 125000006823 (C1-C6) acyl group Chemical group 0.000 claims description 2
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/887,312 US5985880A (en) | 1996-06-05 | 1997-07-03 | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| PCT/US1997/017852 WO1999001033A1 (en) | 1997-07-03 | 1997-10-01 | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI20245A true SI20245A (sl) | 2000-12-31 |
Family
ID=25390891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9720097A SI20245A (sl) | 1997-07-03 | 1997-10-01 | Zmesi in metode za zmanjševanje dihalne depresije in spremljevalnih stranskih učinkov mi opioidnih spojin |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US5985880A (zh) |
| EP (1) | EP1003373B1 (zh) |
| JP (1) | JP2002502432A (zh) |
| KR (1) | KR20010014279A (zh) |
| CN (1) | CN1165308C (zh) |
| AT (1) | ATE259226T1 (zh) |
| AU (1) | AU756120B2 (zh) |
| BR (1) | BR9714739A (zh) |
| CA (1) | CA2294924C (zh) |
| CZ (1) | CZ9904694A3 (zh) |
| DE (1) | DE69727593D1 (zh) |
| HU (1) | HUP0003842A3 (zh) |
| IL (1) | IL133600A0 (zh) |
| IS (1) | IS5309A (zh) |
| NO (1) | NO996310L (zh) |
| NZ (1) | NZ501817A (zh) |
| PL (1) | PL337578A1 (zh) |
| RU (1) | RU2201231C2 (zh) |
| SI (1) | SI20245A (zh) |
| SK (1) | SK185399A3 (zh) |
| TR (1) | TR199903324T2 (zh) |
| TW (1) | TW513426B (zh) |
| WO (1) | WO1999001033A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US6011035A (en) * | 1998-06-30 | 2000-01-04 | Neuromed Technologies Inc. | Calcium channel blockers |
| EP1237544A1 (en) * | 1999-12-16 | 2002-09-11 | Trident Technologies, LLC | System and method for extended delivery of a therapeutic agent with its receptor loading dose |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| AU2001264935A1 (en) | 2000-05-24 | 2001-12-03 | University Of Maryland Biotechnology Institute | Method for introducing and expressing genes in animal cells, and bacterial blebsfor use in same |
| IL158631A0 (en) | 2001-05-18 | 2004-05-12 | Astrazeneca Ab | 4-(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
| RU2309153C2 (ru) * | 2001-09-25 | 2007-10-27 | Маунт Кук Байосайенсиз, Инк. | Энантиомерно чистый опиоидный диарилметилпиперазин и способы его применения |
| US7355042B2 (en) * | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| EP1450807B1 (en) * | 2001-10-29 | 2013-12-25 | Versi Group, LLC | Method of treating depression with delta receptor agonist compounds |
| PL372096A1 (en) | 2002-01-02 | 2005-07-11 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| US7160910B2 (en) * | 2002-12-04 | 2007-01-09 | Xechem International, Inc. | Anti-sickling agents |
| US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
| NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| US7119208B2 (en) * | 2003-12-03 | 2006-10-10 | Virginia Commonwealth University | Anti-sickling agents |
| DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
| MX2007010833A (es) | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| TW200724144A (en) * | 2005-04-14 | 2007-07-01 | Ardent Pharmaceuticals Inc | Compositions of novel opioid compounds and method of use thereof |
| GB0606124D0 (en) * | 2006-03-28 | 2006-05-03 | Reckitt Benckiser Healthcare | Buprenorphine derivatives and uses thereof |
| EP2214672B1 (en) * | 2007-10-18 | 2012-10-17 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| CN104302280A (zh) * | 2012-04-17 | 2015-01-21 | 普渡制药公司 | 用于治疗阿片样物质所致不良药效学响应的系统和方法 |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| CA3007673A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| EP4293009A3 (en) | 2015-12-22 | 2024-02-21 | Zogenix International Limited | Fenfluramine compositions and methods of preparing the same |
| US20180055789A1 (en) | 2016-08-24 | 2018-03-01 | Zogenix International Limited | Formulation for inhibiting formation of 5-ht2b agonists and methods of using same |
| CA3061323C (en) | 2017-04-30 | 2023-09-26 | Versi Group, Llc | An opioid for use to reduce and/or treat drug addiction |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| CA3097335A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| EP3806835A1 (en) * | 2018-06-14 | 2021-04-21 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
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| US2630435A (en) * | 1948-09-09 | 1953-03-03 | Burroughs Wellcome Co | N-benzohydryl-n-methyl piperazines and process of preparing same |
| US4167574A (en) * | 1978-03-13 | 1979-09-11 | Janssen Pharmaceutica, N.V. | N-phenyl-N-(4-piperidinyl)amides |
| US4518711A (en) * | 1983-05-16 | 1985-05-21 | Gibson-Stephens Institute | Conformationally constrained cyclic enkephalin analogs with delta receptor specificity |
| GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
| NZ224236A (en) * | 1987-04-16 | 1990-08-28 | Lilly Co Eli | Trans 3,4 pyridine derivatives and pharmaceutical compositions |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| WO1990015599A1 (en) * | 1989-06-19 | 1990-12-27 | The Wellcome Foundation Limited | Medicaments useful in cancer therapy and having antihistaminic properties |
| DE415693T1 (de) * | 1989-08-28 | 1991-10-17 | Arizona Technology Development Corp., Tucson, Ariz. | Zusammensetzung und verfahren zur selektiven verstaerkung der opiat-wirkung und verminderung von opiat-toleranz und abhaengigkeit. |
| EP0458160A3 (en) | 1990-05-25 | 1992-03-18 | Sociedad Espanola De Especialidades Farmaco-Terapeuticas, S.A. | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5681830A (en) | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| HU221726B1 (hu) | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
| IT1270612B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Derivati eterociclo-condensatori di morfinoidi |
| US5753516A (en) * | 1995-02-03 | 1998-05-19 | Heagy; Wyrta E. | Screening method for ligands of the EBI-1 receptor |
| IT1275433B (it) * | 1995-05-19 | 1997-08-07 | Smithkline Beecham Farma | Derivati di diarildiammine |
| IT1277597B1 (it) * | 1995-09-15 | 1997-11-11 | Smithkline Beecham Spa | Derivati di diarilalchenilammina |
| GB9709972D0 (en) | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9804734D0 (en) | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
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1997
- 1997-07-03 US US08/887,312 patent/US5985880A/en not_active Expired - Fee Related
- 1997-10-01 SI SI9720097A patent/SI20245A/sl not_active IP Right Cessation
- 1997-10-01 CN CNB971822719A patent/CN1165308C/zh not_active Expired - Fee Related
- 1997-10-01 HU HU0003842A patent/HUP0003842A3/hu unknown
- 1997-10-01 CZ CZ19994694A patent/CZ9904694A3/cs unknown
- 1997-10-01 AT AT97910777T patent/ATE259226T1/de not_active IP Right Cessation
- 1997-10-01 NZ NZ501817A patent/NZ501817A/en unknown
- 1997-10-01 TR TR1999/03324T patent/TR199903324T2/xx unknown
- 1997-10-01 WO PCT/US1997/017852 patent/WO1999001033A1/en not_active Application Discontinuation
- 1997-10-01 CA CA2294924A patent/CA2294924C/en not_active Expired - Fee Related
- 1997-10-01 IL IL13360097A patent/IL133600A0/xx unknown
- 1997-10-01 PL PL97337578A patent/PL337578A1/xx unknown
- 1997-10-01 BR BR9714739-7A patent/BR9714739A/pt not_active Application Discontinuation
- 1997-10-01 SK SK1853-99A patent/SK185399A3/sk unknown
- 1997-10-01 DE DE69727593T patent/DE69727593D1/de not_active Expired - Lifetime
- 1997-10-01 RU RU2000100816/14A patent/RU2201231C2/ru not_active IP Right Cessation
- 1997-10-01 KR KR1019997012402A patent/KR20010014279A/ko not_active Application Discontinuation
- 1997-10-01 JP JP50859899A patent/JP2002502432A/ja active Pending
- 1997-10-01 EP EP97910777A patent/EP1003373B1/en not_active Expired - Lifetime
- 1997-10-01 AU AU48066/97A patent/AU756120B2/en not_active Ceased
- 1997-10-24 TW TW086115899A patent/TW513426B/zh not_active IP Right Cessation
-
1999
- 1999-07-12 US US09/352,308 patent/US6300332B1/en not_active Expired - Fee Related
- 1999-12-17 NO NO996310A patent/NO996310L/no not_active Application Discontinuation
- 1999-12-17 IS IS5309A patent/IS5309A/is unknown
-
2001
- 2001-10-09 US US09/974,004 patent/US6919350B2/en not_active Expired - Fee Related
-
2005
- 2005-07-19 US US11/184,762 patent/US20050255151A1/en not_active Abandoned
-
2008
- 2008-04-07 US US12/098,899 patent/US20080193383A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2294924C (en) | 2010-12-21 |
| KR20010014279A (ko) | 2001-02-26 |
| US5985880A (en) | 1999-11-16 |
| JP2002502432A (ja) | 2002-01-22 |
| NO996310L (no) | 2000-02-22 |
| WO1999001033A1 (en) | 1999-01-14 |
| NZ501817A (en) | 2002-02-01 |
| HUP0003842A1 (hu) | 2001-04-28 |
| CZ9904694A3 (cs) | 2002-03-13 |
| RU2201231C2 (ru) | 2003-03-27 |
| AU4806697A (en) | 1999-01-25 |
| NO996310D0 (no) | 1999-12-17 |
| EP1003373A4 (en) | 2000-09-20 |
| EP1003373A1 (en) | 2000-05-31 |
| CN1262600A (zh) | 2000-08-09 |
| ATE259226T1 (de) | 2004-02-15 |
| SK185399A3 (en) | 2001-08-06 |
| US20020111359A1 (en) | 2002-08-15 |
| TR199903324T2 (xx) | 2000-09-21 |
| US20050255151A1 (en) | 2005-11-17 |
| HUP0003842A3 (en) | 2001-12-28 |
| PL337578A1 (en) | 2000-08-28 |
| AU756120B2 (en) | 2003-01-02 |
| IL133600A0 (en) | 2001-04-30 |
| EP1003373B1 (en) | 2004-02-11 |
| CN1165308C (zh) | 2004-09-08 |
| US6919350B2 (en) | 2005-07-19 |
| DE69727593D1 (de) | 2004-03-18 |
| BR9714739A (pt) | 2000-07-25 |
| US20080193383A1 (en) | 2008-08-14 |
| IS5309A (is) | 1999-12-17 |
| TW513426B (en) | 2002-12-11 |
| US6300332B1 (en) | 2001-10-09 |
| CA2294924A1 (en) | 1999-01-14 |
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