SI1951290T1 - Sredstvo za uporabo v primeru fruktozne intolerance - Google Patents

Sredstvo za uporabo v primeru fruktozne intolerance Download PDF

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Publication number
SI1951290T1
SI1951290T1 SI200632244T SI200632244T SI1951290T1 SI 1951290 T1 SI1951290 T1 SI 1951290T1 SI 200632244 T SI200632244 T SI 200632244T SI 200632244 T SI200632244 T SI 200632244T SI 1951290 T1 SI1951290 T1 SI 1951290T1
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Prior art keywords
fructose
dehydrogenase
use according
fructose dehydrogenase
intolerance
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SI200632244T
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English (en)
Inventor
Daniel Henry Wyrobnik
Isaac Harry Wyrobnik
Elliad Ronen Silcoff
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Pro Natura Gesellschaft Fuer Gesunde Ernaehrung Mbh
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Priority claimed from DE102006012244A external-priority patent/DE102006012244A1/de
Priority claimed from DE102006013624A external-priority patent/DE102006013624B4/de
Application filed by Pro Natura Gesellschaft Fuer Gesunde Ernaehrung Mbh filed Critical Pro Natura Gesellschaft Fuer Gesunde Ernaehrung Mbh
Publication of SI1951290T1 publication Critical patent/SI1951290T1/sl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/06—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/52—Isomerases (5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01124—Fructose 5-dehydrogenase (NADP+) (1.1.1.124)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0102—Alpha-glucosidase (3.2.1.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01026—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01005—Xylose isomerase (5.3.1.5)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Polymers & Plastics (AREA)
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  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (17)

  1. SREDSTVO ZA UPORABO V PRIMERU FRUKTOZNEINTOLERANCE EP1951290 Patentni zahtevki 1. 5-D-fruktoza dehidrogenaza za uporabo v medicini.
  2. 2. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 1, pri čemer je 5-D-fruktoza dehidrogenaza za uporabo pri terapevtskem zdravljenju človeškega ali živalskega telesa.
  3. 3. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 1 ali zahtevku 2, pri čemer je uporaba uporaba pri zdravljenju motenj presnove fruktoze.
  4. 4.
  5. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 3, pri čemer je motnja presnove fruktoze pomanjkanje fruktoze 1,6 difosfataze. 5. 5-D-fruktoza dehidrogenaza za uporabo pri zdravljenju fruktozne intolerance.
  6. 6. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 5, pri čemer je fruktozna intoleranca dedna fruktozna intoleranca.
  7. 7. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 5, pri čemer je fruktozna intoleranca črevesna fruktozna intoleranca.
  8. 8.5- D-fruktoza dehidrogenaza za uporabo po zahtevku 7, pri čemer fruktozno intoleranco povzroči motnja fruktozne resorpcije kot posledica motenj transportnih procesov v sluznici tankega črevesa.
  9. 9.5- D-fruktoza dehidrogenaza za uporabo po kateremkoli od zahtevkov 1 do 8, pri čemer je 5-D-fruktoza dehidrogenaza v kombinaciji z glukozno izomerazo.
  10. 10. 5-D-fruktoza dehidrogenaza za uporabo po kateremkoli od zahtevkov 1 do 8, pri čemer je 5-D-fruktoza dehidrogenaza v kombinaciji z invertazo in / ali maltazo.
  11. 11. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 1, pri čemer je omenjena 5-D-fruktoza dehidrogenaza prisotna v humano prebavljivem sestavku snovi, prilagojenem za peroralno zaužitje, ki obsega kapsulo, ki vsebuje 5-D-fruktoza dehidrogenazo.
  12. 12. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 11, označena s tem, da je sestavek snovi v obliki enotskega odmerka in omenjeni enotski odmerek vsebuje od 10 do 5 milijonov enot aktivnosti 5-D-fruktoza dehidrogenaze.
  13. 13. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 12, pri čemer enotski odmerek vsebuje od 25 do 2,5 milijona enot aktivnosti 5-D-fruktozea dehidrogenaze.
  14. 14. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 12, pri čemer enotski odmerek vsebuje od 50 do 1 milijon enot aktivnosti 5-D-fruktoza dehidrogenaze.
  15. 15. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 11, pri čemer omenjeni sestavek snovi nadalje obsega glukozno izomerazo.
  16. 16. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 1, pri čemer omenjena uporaba obsega terapevtsko metodo za zniževanje biološke razpoložljivosti fruktoze v človeškem ali živalskem telesu.
  17. 17. 5-D-fruktoza dehidrogenaza za uporabo po zahtevku 1, pri čemer je omenjena 5-D-fruktoza dehidrogenaza v kombinaciji z glukozno izomerazo in je omenjena kombinacija za uporabo pri terapevtski metodi zniževanja biološke razpoložljivosti fruktoze v človeškem ali živalskem telesu.
SI200632244T 2005-11-16 2006-11-15 Sredstvo za uporabo v primeru fruktozne intolerance SI1951290T1 (sl)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
DE102005055081 2005-11-16
DE102005056169 2005-11-23
DE102005060769 2005-12-16
DE102005060768 2005-12-16
DE102006000873 2006-01-04
DE102006000881 2006-01-04
DE102006001015 2006-01-05
US75742406P 2006-01-10 2006-01-10
US75741406P 2006-01-10 2006-01-10
DE102006012244A DE102006012244A1 (de) 2005-11-16 2006-03-15 Mittel zur Anwendung bei Fructoseintoleranz
DE102006013624A DE102006013624B4 (de) 2005-11-23 2006-03-22 Mittel zur Anwendung bei Fructoseintoleranz
DE102006014423 2006-03-27
US83117406P 2006-07-17 2006-07-17
US83105006P 2006-07-17 2006-07-17
EP06820896.6A EP1951290B1 (en) 2005-11-16 2006-11-15 Agent for use in the case of fructose intolerance
PCT/IB2006/003223 WO2007057749A2 (en) 2005-11-16 2006-11-15 Agent for use in the case of fructose intolerance

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SI1951290T1 true SI1951290T1 (sl) 2018-04-30

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SI200632244T SI1951290T1 (sl) 2005-11-16 2006-11-15 Sredstvo za uporabo v primeru fruktozne intolerance

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US (3) US20090081300A1 (sl)
EP (2) EP3318271A1 (sl)
JP (1) JP2009519897A (sl)
KR (1) KR20080080122A (sl)
AU (1) AU2006314188B2 (sl)
CA (1) CA2669431C (sl)
CY (1) CY1119940T1 (sl)
HR (1) HRP20180327T1 (sl)
IL (1) IL191363B (sl)
PL (1) PL1951290T3 (sl)
SI (1) SI1951290T1 (sl)
WO (1) WO2007057749A2 (sl)
ZA (1) ZA200805143B (sl)

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Publication number Publication date
US20180344818A1 (en) 2018-12-06
PL1951290T3 (pl) 2018-05-30
CA2669431A1 (en) 2007-05-24
HRP20180327T1 (hr) 2018-04-06
US20130224171A1 (en) 2013-08-29
US9446101B2 (en) 2016-09-20
EP1951290A4 (en) 2009-03-11
WO2007057749A3 (en) 2008-10-16
CA2669431C (en) 2019-04-23
EP1951290B1 (en) 2017-12-27
AU2006314188A1 (en) 2007-05-24
JP2009519897A (ja) 2009-05-21
WO2007057749A2 (en) 2007-05-24
US20090081300A1 (en) 2009-03-26
EP3318271A1 (en) 2018-05-09
IL191363B (en) 2018-05-31
CY1119940T1 (el) 2018-12-12
EP1951290A2 (en) 2008-08-06
US10568942B2 (en) 2020-02-25
KR20080080122A (ko) 2008-09-02
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