SI1791860T1 - ÄŚistilni postopek za bakterijski citolizin - Google Patents
ÄŚistilni postopek za bakterijski citolizinInfo
- Publication number
- SI1791860T1 SI1791860T1 SI200530269T SI200530269T SI1791860T1 SI 1791860 T1 SI1791860 T1 SI 1791860T1 SI 200530269 T SI200530269 T SI 200530269T SI 200530269 T SI200530269 T SI 200530269T SI 1791860 T1 SI1791860 T1 SI 1791860T1
- Authority
- SI
- Slovenia
- Prior art keywords
- bacterial cytolysin
- salt
- extract
- cytolysin
- culture
- Prior art date
Links
- 102000004503 Perforin Human genes 0.000 title abstract 5
- 108010056995 Perforin Proteins 0.000 title abstract 5
- 230000001580 bacterial effect Effects 0.000 title abstract 5
- 238000000746 purification Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000003599 detergent Substances 0.000 abstract 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0421083.7A GB0421083D0 (en) | 2004-09-22 | 2004-09-22 | Purification process |
| EP05797390A EP1791860B1 (en) | 2004-09-22 | 2005-09-20 | Purification process for bacterial cytolysin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1791860T1 true SI1791860T1 (sl) | 2008-08-31 |
Family
ID=33397075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200530269T SI1791860T1 (sl) | 2004-09-22 | 2005-09-20 | ÄŚistilni postopek za bakterijski citolizin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070231876A1 (sl) |
| EP (1) | EP1791860B1 (sl) |
| JP (1) | JP4934591B2 (sl) |
| AT (1) | ATE393165T1 (sl) |
| CA (1) | CA2580113C (sl) |
| CY (1) | CY1107960T1 (sl) |
| DE (1) | DE602005006294T2 (sl) |
| DK (1) | DK1791860T3 (sl) |
| ES (1) | ES2304724T3 (sl) |
| GB (1) | GB0421083D0 (sl) |
| HR (1) | HRP20080242T3 (sl) |
| PL (1) | PL1791860T3 (sl) |
| PT (1) | PT1791860E (sl) |
| SI (1) | SI1791860T1 (sl) |
| WO (1) | WO2006032499A1 (sl) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101818185B (zh) | 2003-03-13 | 2016-05-25 | 葛兰素史密丝克莱恩生物有限公司 | 纯化细菌溶细胞素的方法 |
| EP3020411A1 (en) | 2005-12-22 | 2016-05-18 | GlaxoSmithKline Biologicals s.a. | Vaccine |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| US20100021504A1 (en) * | 2006-08-03 | 2010-01-28 | Newcastle Innovation Limited | Treatment and prevention of allergic airways diseases |
| PT2167121E (pt) | 2007-06-26 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vacina compreendendo conjugados de polissacáridos capsulares de streptococcus pneumoniae |
| US8226959B2 (en) | 2008-02-01 | 2012-07-24 | Newcastle Innovation Pty Ltd | Vaccine compositions |
| EP2473605B1 (en) | 2009-09-03 | 2018-04-11 | Pfizer Vaccines LLC | Pcsk9 vaccine |
| CN103687600B (zh) * | 2011-03-22 | 2016-05-04 | 印度血清研究所私人有限公司 | 一种制备多糖的方法 |
| EP4365196A3 (en) * | 2011-04-22 | 2024-08-07 | Wyeth LLC | Compositions relating to a mutant clostridium difficile toxin and methods thereof |
| SG194733A1 (en) | 2011-05-17 | 2013-12-30 | Glaxosmithkline Biolog Sa | Vaccine against streptococcus pneumoniae |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| KR102157200B1 (ko) | 2014-01-21 | 2020-09-21 | 화이자 인코포레이티드 | 접합된 캡슐 사카라이드 항원을 포함하는 면역원성 조성물 및 그의 용도 |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| PL3244917T3 (pl) | 2015-01-15 | 2023-07-17 | Pfizer Inc. | Kompozycje immunogenne do zastosowania w szczepionkach przeciwko pneumokokom |
| KR102225282B1 (ko) | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
| CA3005524C (en) | 2015-11-20 | 2023-10-10 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| GB201603029D0 (en) * | 2016-02-22 | 2016-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| TWI789357B (zh) | 2016-08-05 | 2023-01-11 | 南韓商Ｓｋ生物科技股份有限公司 | 多價肺炎球菌多醣-蛋白質共軛物組成物(二) |
| CA3031797A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN118662649A (zh) | 2016-12-30 | 2024-09-20 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
| KR102459629B1 (ko) | 2017-01-20 | 2022-10-28 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| JP6950099B2 (ja) | 2018-02-05 | 2021-10-13 | サノフィ パスツール インコーポレイティッド | 多価肺炎球菌多糖体−タンパク質複合体組成物 |
| BR112020014978A2 (pt) | 2018-02-05 | 2020-12-22 | Sanofi Pasteur, Inc. | Composição de conjugado polissacarídeo-proteína pneumocócico multivalente |
| BR112020021296A2 (pt) | 2018-04-18 | 2021-01-26 | Sk Bioscience Co., Ltd. | polissacarídeo capsular de streptococcus pneumoniae e conjugado imunogênico do mesmo |
| GB201807303D0 (en) * | 2018-05-03 | 2018-06-20 | London School Of Hygeine & Tropical Medicine | Glyconjugate vaccines |
| CA3120922A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| US20220054632A1 (en) | 2018-12-12 | 2022-02-24 | Glaxosmithkline Biologicals Sa | Modified carrier proteins for o-linked glycosylation |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| EP4003410A1 (en) | 2019-07-31 | 2022-06-01 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same |
| JP2021132644A (ja) | 2020-02-21 | 2021-09-13 | ファイザー・インク | 糖の精製 |
| CA3199094A1 (en) | 2020-10-22 | 2022-04-28 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| CN116744965A (zh) | 2020-11-04 | 2023-09-12 | 辉瑞大药厂 | 用于肺炎球菌疫苗的免疫原性组合物 |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| EP4333879A1 (en) | 2021-05-03 | 2024-03-13 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| EP4346893A2 (en) | 2021-05-28 | 2024-04-10 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| MX2023013434A (es) | 2021-05-28 | 2023-12-12 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos. |
| CN118510548A (zh) | 2022-01-13 | 2024-08-16 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其用途 |
| WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
| WO2023218322A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
| WO2024110839A2 (en) | 2022-11-22 | 2024-05-30 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
| WO2024166008A1 (en) | 2023-02-10 | 2024-08-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024201324A2 (en) | 2023-03-30 | 2024-10-03 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE205534T1 (de) * | 1988-12-16 | 2001-09-15 | Nederlanden Staat | Pneumolysin-mutanten und pneumokokken-impfstoffe daraus |
| DE4133707A1 (de) * | 1991-10-11 | 1993-04-15 | Behringwerke Ag | Verfahren zur reinigung von streptolysin o, intaktes streptolysin o erhaeltlich nach diesem verfahren und seine verwendung |
| US5652125A (en) * | 1996-06-10 | 1997-07-29 | Pharmacia S.P.A. | Process for preparing daunorubicin |
| WO1999003884A2 (en) * | 1997-07-21 | 1999-01-28 | North American Vaccine, Inc. | Modified immunogenic pneumolysin, compositions and their use as vaccines |
| CN101818185B (zh) * | 2003-03-13 | 2016-05-25 | 葛兰素史密丝克莱恩生物有限公司 | 纯化细菌溶细胞素的方法 |
| JP4578067B2 (ja) * | 2003-06-06 | 2010-11-10 | 宏 清水 | 局所医薬組成物 |
-
2004
- 2004-09-22 GB GBGB0421083.7A patent/GB0421083D0/en not_active Ceased
-
2005
- 2005-09-20 ES ES05797390T patent/ES2304724T3/es active Active
- 2005-09-20 AT AT05797390T patent/ATE393165T1/de active
- 2005-09-20 PT PT05797390T patent/PT1791860E/pt unknown
- 2005-09-20 SI SI200530269T patent/SI1791860T1/sl unknown
- 2005-09-20 WO PCT/EP2005/010258 patent/WO2006032499A1/en active IP Right Grant
- 2005-09-20 PL PL05797390T patent/PL1791860T3/pl unknown
- 2005-09-20 CA CA2580113A patent/CA2580113C/en not_active Expired - Fee Related
- 2005-09-20 DE DE602005006294T patent/DE602005006294T2/de active Active
- 2005-09-20 DK DK05797390T patent/DK1791860T3/da active
- 2005-09-20 JP JP2007531717A patent/JP4934591B2/ja not_active Expired - Fee Related
- 2005-09-20 EP EP05797390A patent/EP1791860B1/en active Active
- 2005-09-20 US US11/575,676 patent/US20070231876A1/en not_active Abandoned
-
2008
- 2008-05-26 CY CY20081100535T patent/CY1107960T1/el unknown
- 2008-06-02 HR HR20080242T patent/HRP20080242T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1791860E (pt) | 2008-05-20 |
| US20070231876A1 (en) | 2007-10-04 |
| HRP20080242T3 (en) | 2008-09-30 |
| CA2580113A1 (en) | 2006-03-30 |
| EP1791860A1 (en) | 2007-06-06 |
| DE602005006294T2 (de) | 2008-08-14 |
| CY1107960T1 (el) | 2013-09-04 |
| WO2006032499A1 (en) | 2006-03-30 |
| JP2008513408A (ja) | 2008-05-01 |
| DK1791860T3 (da) | 2008-07-14 |
| EP1791860B1 (en) | 2008-04-23 |
| GB0421083D0 (en) | 2004-10-27 |
| PL1791860T3 (pl) | 2008-09-30 |
| ES2304724T3 (es) | 2008-10-16 |
| ATE393165T1 (de) | 2008-05-15 |
| DE602005006294D1 (de) | 2008-06-05 |
| JP4934591B2 (ja) | 2012-05-16 |
| CA2580113C (en) | 2018-01-16 |
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