SI1761515T1 - 2-(hetero-)aril substituirani derivati tetrahidrokinolina - Google Patents

2-(hetero-)aril substituirani derivati tetrahidrokinolina

Info

Publication number
SI1761515T1
SI1761515T1 SI200430985T SI200430985T SI1761515T1 SI 1761515 T1 SI1761515 T1 SI 1761515T1 SI 200430985 T SI200430985 T SI 200430985T SI 200430985 T SI200430985 T SI 200430985T SI 1761515 T1 SI1761515 T1 SI 1761515T1
Authority
SI
Slovenia
Prior art keywords
nnr
nar
halo
aryl
coor
Prior art date
Application number
SI200430985T
Other languages
English (en)
Slovenian (sl)
Inventor
Kai Schiemann
Ulrich Emde
Dirk Finsinger
Johannes Gleitz
Helmut Reubold
Frank Zenke
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10360154A external-priority patent/DE10360154A1/de
Priority claimed from DE102004026026A external-priority patent/DE102004026026A1/de
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SI1761515T1 publication Critical patent/SI1761515T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
SI200430985T 2003-12-20 2004-12-14 2-(hetero-)aril substituirani derivati tetrahidrokinolina SI1761515T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10360154A DE10360154A1 (de) 2003-12-20 2003-12-20 Tetrahydrochinoline
US53996104P 2004-01-30 2004-01-30
DE102004026026A DE102004026026A1 (de) 2004-05-27 2004-05-27 Tetrahydrochinoline
EP04803833A EP1761515B1 (de) 2003-12-20 2004-12-14 2-(hetero-)aryl substituierte tetrahydrochinolinderivate

Publications (1)

Publication Number Publication Date
SI1761515T1 true SI1761515T1 (sl) 2009-02-28

Family

ID=43969203

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200430985T SI1761515T1 (sl) 2003-12-20 2004-12-14 2-(hetero-)aril substituirani derivati tetrahidrokinolina
SI200431714T SI2033959T1 (sl) 2003-12-20 2004-12-14 Derivati tetrahidropiranokinolina

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200431714T SI2033959T1 (sl) 2003-12-20 2004-12-14 Derivati tetrahidropiranokinolina

Country Status (14)

Country Link
US (1) US7868172B2 (https=)
EP (2) EP2033959B1 (https=)
JP (1) JP5237555B2 (https=)
AT (2) ATE507220T1 (https=)
AU (1) AU2004309028B9 (https=)
BR (1) BRPI0417838A (https=)
CA (1) CA2550350C (https=)
DE (1) DE502004012458D1 (https=)
DK (2) DK2033959T3 (https=)
ES (1) ES2315727T3 (https=)
PL (2) PL1761515T3 (https=)
PT (2) PT1761515E (https=)
SI (2) SI1761515T1 (https=)
WO (1) WO2005063735A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0219660D0 (en) 2002-08-23 2002-10-02 Astrazeneca Ab Therapeutic use
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
GB0425854D0 (en) * 2004-11-25 2004-12-29 Astrazeneca Ab Therapeutic treatment
DE102005027170A1 (de) * 2005-06-13 2006-12-14 Merck Patent Gmbh Substituierte Tetrahydrochinoline
US7875721B2 (en) 2005-08-04 2011-01-25 Stc.Unm Compounds for binding to ERα/β and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof
CA2656064C (en) 2006-06-19 2013-11-05 Merck Patent Gesellschaft Mit Beschraenkter Haftung Polymorphic forms and process
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
DE102007013854A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
DE102007013855A1 (de) * 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
DE102007021862A1 (de) * 2007-05-10 2008-11-13 Merck Patent Gmbh Wässrige pharmazeutische Zubereitung
CN101873848B (zh) * 2007-07-19 2014-12-10 帝斯曼知识产权资产管理有限公司 亲脂性健康成分的可片剂化制剂
EP2220067A2 (en) 2007-12-18 2010-08-25 Merck Patent GmbH Process for preparing tetrahydroquinoline derivatives
US20100280070A1 (en) * 2008-01-04 2010-11-04 Akkinepally Raghuram Rao Novel tetrahydroquinolines as aromatase inhibitors
WO2011009523A1 (en) 2009-07-24 2011-01-27 Merck Patent Gmbh Eg5 as biomarker in rare thoracic cancer
EP2620438A1 (en) * 2012-01-24 2013-07-31 Laboratorios Del. Dr. Esteve, S.A. Substituted pyrano and furanoquinolines, their preparation and use as medicaments
EP2647638A1 (en) * 2012-04-02 2013-10-09 Almirall, S.A. Substituted tricyclic compounds with activity towards ep1 receptors
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
CN110627770A (zh) 2013-11-18 2019-12-31 福马疗法公司 作为bet溴域抑制剂的四氢喹啉组成物
WO2017214468A1 (en) 2016-06-09 2017-12-14 Tien Yang Der Nanodroplet compositions for the efficient delivery of anti-cancer agents
CN110684031B (zh) * 2019-08-14 2021-07-02 西北大学 一种反式-四氢呋喃/吡喃并四氢喹啉衍生手性化合物的不对称合成方法
WO2022006365A2 (en) * 2020-07-02 2022-01-06 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline-containing compounds and uses thereof
EP4269392A4 (en) 2020-12-25 2025-01-29 Toray Industries, Inc. TETRAHYDROQUINOLINE DERIVATIVE AND MEDICAL USE THEREOF
AU2023286251A1 (en) 2022-06-24 2024-12-05 Toray Industries, Inc. Therapeutic agent or prophylactic agent for amyotrophic lateral sclerosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100310939B1 (ko) * 1992-10-01 2002-06-20 추후제출 태그로암호화한복합조합화학라이브러리
CN1154640C (zh) * 1993-10-01 2004-06-23 纽约市哥伦比亚大学理事 用标示物编码的多元组合化学库
EP1187633A4 (en) 1999-04-08 2005-05-11 Arch Dev Corp USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY
AU7558900A (en) * 1999-10-14 2001-04-23 Kaken Pharmaceutical Co., Ltd. Tetrahydroquinoline derivatives
MXPA03008691A (es) * 2001-03-29 2003-12-12 Bristol Myers Squibb Co Metodo para tratamiento de enfermedades proliperativas usando inhibidores eg5.
US7250423B2 (en) * 2001-09-24 2007-07-31 Chao-Jun Li Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate

Also Published As

Publication number Publication date
EP2033959B1 (de) 2011-04-27
ES2315727T3 (es) 2009-04-01
US7868172B2 (en) 2011-01-11
EP1761515B1 (de) 2008-11-05
CA2550350C (en) 2013-03-12
ATE507220T1 (de) 2011-05-15
PT1761515E (pt) 2009-02-11
DK1761515T3 (da) 2009-02-16
EP2033959A1 (de) 2009-03-11
BRPI0417838A (pt) 2007-04-17
PL1761515T3 (pl) 2009-04-30
EP1761515A1 (de) 2007-03-14
DE502004012458D1 (de) 2011-06-09
SI2033959T1 (sl) 2011-08-31
JP5237555B2 (ja) 2013-07-17
AU2004309028B9 (en) 2011-06-16
AU2004309028A1 (en) 2005-07-14
CA2550350A1 (en) 2005-07-14
PT2033959E (pt) 2011-07-29
PL2033959T3 (pl) 2011-09-30
DK2033959T3 (da) 2011-07-25
JP2007515419A (ja) 2007-06-14
WO2005063735A1 (de) 2005-07-14
US20070203167A1 (en) 2007-08-30
ATE413393T1 (de) 2008-11-15
AU2004309028B2 (en) 2011-04-21

Similar Documents

Publication Publication Date Title
PL1761515T3 (pl) 2-(hetero-)arylo podstawione pochodne tetrahydrochinoliny
AU2017382436B2 (en) Compounds and methods for the targeted degradation of Rapidly Accelerated Fibrosarcoma polypeptides
NO20051870L (no) 1H-1,2,4-triazol-3-karboksamidderivater som cannabinoid-CB1-reseptorligander
IL127296A (en) Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
HK33189A (en) 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4-one derivatives
WO1999008501A3 (en) New heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
CA2258949A1 (en) Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
HUT55228A (en) Process for producing pharmaceutical composition comprising imidazole derivatives with antinociceptive effect
CA2534798A1 (en) Thiazole derivatives as cannabinoid receptor modulators
TR200102054T2 (tr) Pirazolkarboksilik asit türevleri, hazırlanmaları ve bunları içeren farmasötik kompozisyonlar.
NO991384L (no) Substituerte heterocykler som anti-tumormidler
HRP20020643B1 (hr) Novi spojevi koji imaju hipolipedemiäśne, hipokolesteremiäśne aktivnosti, postupak njihove priprave i farmaceutski pripravci koji ih sadržavaju
MX2025005222A (es) Derivados de pirazol microbiocidas
ATE421524T1 (de) 5-ring-heterocyclen, ihre herstellung, ihre verwendung als inhibitoren der leukozytenadhäsion und sie enthaltende pharmazeutische präparate
PH12022553516A1 (en) Novel pyrazole derivatives
HUT77363A (hu) 5-Lipoxigenáz inhibitor hatású azolszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
Takeuchi et al. 1, 2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors
ATE444965T1 (de) Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
NO20060191L (no) 1-(alkylaminoalkyl-pyrolidin-/piperidinyl)2,2-difenylacetamidderivater som muskarinreceptoragonister
IL103021A0 (en) Imidazoindolizine derivatives,their preparation and pharmaceutical compositions containing them
ATE343580T1 (de) Tetracyclische arylcarbonyl indole mit serotoninrezeptoraffinität als arzneimittel, verfahren zu ihrer herstellung und pharmazeutische zubereitungen
GB2066067A (en) Antifungal compositions
ZA200605022B (en) Benzofurans and benzothiophenes
MX2023012246A (es) Nuevos derivados de pirazolo[1,5-a]pirimidina como ligandos sigma.
MX2023013305A (es) Compuesto polimorfo de imidazolidinona, método de preparación del mismo y uso del mismo.