SI1507798T1 - Izvoz in modifikacija (poli)peptidov na lantibiotični način - Google Patents
Izvoz in modifikacija (poli)peptidov na lantibiotični načinInfo
- Publication number
- SI1507798T1 SI1507798T1 SI200332339T SI200332339T SI1507798T1 SI 1507798 T1 SI1507798 T1 SI 1507798T1 SI 200332339 T SI200332339 T SI 200332339T SI 200332339 T SI200332339 T SI 200332339T SI 1507798 T1 SI1507798 T1 SI 1507798T1
- Authority
- SI
- Slovenia
- Prior art keywords
- lantibiotic
- peptides
- export
- poly
- modification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02077060 | 2002-05-24 | ||
US10/360,101 US6861236B2 (en) | 2002-05-24 | 2003-02-07 | Export and modification of (poly)peptides in the lantibiotic way |
PCT/NL2003/000389 WO2003099862A1 (en) | 2002-05-24 | 2003-05-26 | Export and modification of (poly)peptides in the lantibiotic way |
EP03733622.9A EP1507798B2 (en) | 2002-05-24 | 2003-05-26 | Export and modification of (poly)peptides in the lantibiotic way |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1507798T1 true SI1507798T1 (sl) | 2014-05-30 |
Family
ID=30011145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332339T SI1507798T1 (sl) | 2002-05-24 | 2003-05-26 | Izvoz in modifikacija (poli)peptidov na lantibiotični način |
Country Status (11)
Country | Link |
---|---|
US (1) | US6861236B2 (sl) |
EP (1) | EP1507798B2 (sl) |
CN (1) | CN1671737B (sl) |
AU (1) | AU2003238714A1 (sl) |
CA (1) | CA2487351C (sl) |
CY (1) | CY1114998T1 (sl) |
DK (1) | DK1507798T4 (sl) |
ES (1) | ES2444840T5 (sl) |
PT (1) | PT1507798E (sl) |
SI (1) | SI1507798T1 (sl) |
WO (1) | WO2003099862A1 (sl) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
EP1789440A4 (en) * | 2004-02-11 | 2008-03-12 | Amylin Pharmaceuticals Inc | REASONS FOR THE FAMILY OF PANCREATIC POLYPEPTIDES AND POLYPEPTIDES CONTAINING THEM |
GB0406870D0 (en) * | 2004-03-26 | 2004-04-28 | Novacta Biosystems Ltd | Improvements relating to the production of lantibiotics |
US7592308B2 (en) | 2004-03-26 | 2009-09-22 | Novacta Biosystems Limited | F3W variants of the lantibiotic mersacidin and its use |
EP2100904B1 (en) * | 2004-04-23 | 2010-07-07 | ConjuChem Biotechnologies Inc. | Solid phase for use in a method for the purification of albumin conjugates |
JO2937B1 (en) * | 2004-08-11 | 2016-03-15 | فيرينغ.بي.في | Tight muscles of the peptide vascular tensioner receptor |
DK1819816T3 (da) * | 2004-12-07 | 2009-01-26 | Applied Nanosystems Bv | Fremgangsmåder til fremstilling og udskillelse af modificerede peptider |
WO2007000332A2 (en) * | 2005-06-29 | 2007-01-04 | Biotech Concepts Gmbh | Biosynthetic process for the preparation of gallidermin |
US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
EP1976876A4 (en) * | 2005-12-22 | 2010-01-13 | Conjuchem Biotechnologies Inc | PROCESS FOR PRODUCING PREFORMED ALBUMIN CONJUGATES AND THERAPEUTIC AGENT |
GB0600928D0 (en) | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
RU2415149C2 (ru) * | 2006-02-10 | 2011-03-27 | Ферринг Б.В. | Пептидные соединения |
MX2009000800A (es) * | 2006-07-21 | 2009-04-16 | Cristalia Prod Quimicos Farm | Peptidos ciclicos anti-inflamatorios y anti-alergicos. |
WO2008130217A1 (en) * | 2006-08-08 | 2008-10-30 | Applied Nanosystems B.V. | Cyclic angiotensin analogs |
GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
EP2175874A2 (en) * | 2007-08-14 | 2010-04-21 | Ferring B.V. | Use of peptidic vasopressin receptor agonists |
SG185263A1 (en) | 2007-09-28 | 2012-11-29 | Portola Pharm Inc | Antidotes for factor xa inhibitors and methods of using the same |
CA2708762A1 (en) * | 2007-12-11 | 2009-06-18 | Conjuchem Biotechnologies Inc. | Formulation of insulinotropic peptide conjugates |
TWI532498B (zh) | 2008-03-17 | 2016-05-11 | 巴克斯特保健公司 | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
KR20110086582A (ko) * | 2008-11-24 | 2011-07-28 | 센티넬라 파마세티컬즈, 인크. | 항균활성이 강화된 란티바이오틱 카르복시아미드 유도체 |
CN102348718B (zh) | 2009-01-14 | 2015-06-03 | 诺瓦克塔生物系统有限公司 | 去氧阿肽加定衍生物 |
EP2393829A1 (en) | 2009-02-04 | 2011-12-14 | Novacta Biosystems Limited | Actagardine derivatives |
HUE057174T2 (hu) * | 2009-05-20 | 2022-04-28 | Biomarin Pharm Inc | A C-típusú nátriuretikus peptid variánsai |
EP2267003A1 (en) * | 2009-06-24 | 2010-12-29 | Applied NanoSystems B.V. | Biologically produced cyclic affinity tags |
GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
US9714943B2 (en) * | 2010-12-30 | 2017-07-25 | University Of South Florida | Methods and materials for capture antibody targeted fluorescent in-situ hybridization (CAT-FISH) |
US9976133B2 (en) | 2012-06-20 | 2018-05-22 | The Regents Of The University Of California | Synzymes |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
CN104902920A (zh) | 2012-12-21 | 2015-09-09 | 赛诺菲 | 作为glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂的毒蜥外泌肽-4衍生物 |
CN104211802B (zh) * | 2013-05-29 | 2018-07-27 | 成都渊源生物科技有限公司 | 人凝血因子轻链蛋白及其应用 |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
US9995758B1 (en) | 2014-10-31 | 2018-06-12 | Western Autotroph Company LLC | Methods and systems for controlling oxidative stress in humans and animals |
US20170267981A1 (en) * | 2014-12-05 | 2017-09-21 | Danisco Us Inc. | Compositions and methods comprising the use of a bacillus agaradhaerens inulosucrase (inuo) |
MX2017011654A (es) * | 2015-03-13 | 2018-02-09 | Lanthiopep Bv | Analogos ciclicos de galanina y usos de los mismos. |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
CN106366168B (zh) * | 2016-08-26 | 2020-09-15 | 上海交通大学 | 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法 |
CN106589135B (zh) * | 2016-11-25 | 2018-08-28 | 东北农业大学 | 一种靶向抗菌肽及其制备方法和应用 |
CN110627880B (zh) * | 2018-06-25 | 2024-03-19 | 武汉合生科技有限公司 | 分离的多肽及其应用 |
AU2020395323A1 (en) * | 2019-12-06 | 2022-06-30 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor VIII function |
WO2022202785A1 (ja) * | 2021-03-22 | 2022-09-29 | 美智子 甲賀 | ポリペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
CN113354718B (zh) * | 2021-06-21 | 2023-06-02 | 重庆市畜牧科学院 | 一种哌尼生素前体、表达盒及其制备方法 |
Family Cites Families (35)
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---|---|---|---|---|
US5837485A (en) | 1988-05-18 | 1998-11-17 | Dr. Karl Tomae Gmbh | DNA encoding and biosynthetic process for the preparation of chemical compounds, lantibiotics |
GB8811760D0 (en) | 1988-05-18 | 1988-06-22 | Thomae Gmbh Dr K | Antibiotic |
GB8811761D0 (en) | 1988-05-18 | 1988-06-22 | Thomae Gmbh Dr K | Biosynthetic process for preparation of chemical compounds |
US5218101A (en) | 1988-07-05 | 1993-06-08 | The University Of Maryland | Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor |
US5516682A (en) | 1988-07-05 | 1996-05-14 | University Of Maryland | Subtilin variant of enhanced stability and activity |
IN167138B (sl) | 1988-08-17 | 1990-09-01 | Hoechst India | |
IE910663A1 (en) | 1990-02-28 | 1991-08-28 | Gist Brocades Nv | Improved processing of proteins |
EP0579730B1 (en) | 1991-04-11 | 2003-02-26 | Stichting Nederlands Instituut Voor Zuivelonderzoek (Nizo) | Lantibiotics similar to nisin a, lactic acid bacteria which produce such lantibiotics, method for constructing such lactic acid bacteria and method for preserving foodstuffs with the aid of these lantibiotics and these lactic acid bacteria producing lantibiotics |
WO1993003058A2 (en) | 1991-07-01 | 1993-02-18 | University Technologies International Inc. | NON-DESENSITIZING ANALOGS OF GnRH AND OTHER BIOLOGICALLY ACTIVE LIGANDS |
US6028168A (en) | 1991-08-09 | 2000-02-22 | Winfried Kolbeck | Lanthionine bridged peptides |
WO1993003056A1 (en) | 1991-08-09 | 1993-02-18 | Winfried Kolbeck | Lanthionine bridged peptides |
CA2081704C (en) | 1991-10-31 | 2007-05-01 | Karl-Dieter Entian | Biosynthetic process for the preparation of lantibiotics |
GB9207267D0 (en) | 1992-04-02 | 1992-05-13 | Agricultural & Food Res | Nisins |
GB2282813A (en) | 1993-10-15 | 1995-04-19 | Merck & Co Inc | Annular antigen scaffolds comprising thioether linkages |
US5872001A (en) | 1994-04-20 | 1999-02-16 | Uab Research Foundation | Lanthionine antibiotic compositions and methods |
US5650320A (en) | 1994-04-20 | 1997-07-22 | University Of Alabama At Birmingham Research Foundation | Lanthionine antibiotic compositions and methods |
IL109943A (en) | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
EP0700998B1 (en) | 1994-09-12 | 2003-11-26 | Aventis Pharma Deutschland GmbH | Recombinant mersacidin and a method for production |
DE69527126T2 (de) | 1994-11-18 | 2002-12-12 | Stichting Nederlands Instituut Voor Zuivelonderzoek, Ede | Verfahren zur Kontrolle der Genexpression in Milchsäurebakterien |
GB9423404D0 (en) | 1994-11-19 | 1995-01-11 | Biotech & Biolog Scien Res | Production of nisin |
IES70514B2 (en) | 1995-04-12 | 1996-12-11 | Teagasc Agric Food Dev Authori | Bacteriocins |
US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
US5861275A (en) * | 1995-09-28 | 1999-01-19 | The University Of Maryland | Lantibiotic mutants and chimeras of enhanced stability and activity, leader sequences therefor, genes encoding the same, and methods of producing and using the same |
US5817752A (en) * | 1996-06-06 | 1998-10-06 | La Jolla Pharmaceutical Company | Cyclic polypeptides comprising a thioether linkage and methods for their preparation |
US5786197A (en) | 1996-11-25 | 1998-07-28 | Smithkline Beecham Corporation | lep |
US5932469A (en) | 1997-06-10 | 1999-08-03 | University Of Florida | Antimicrobial polypeptide, nucleic acid, and methods of use |
US6541607B1 (en) | 1997-07-18 | 2003-04-01 | University Of Maryland | Sublancin lantibiotic produced by Bacillus subtilis 168 |
US6218362B1 (en) | 1997-09-08 | 2001-04-17 | Universite Laval | Lantibiotic from Streptococcus mutans and uses thereof |
CA2209893A1 (en) | 1997-09-08 | 1999-03-08 | Christophe Lacroix | Lantibiotic from streptococcus mutans, method of production and use thereof |
DE19745583A1 (de) | 1997-10-15 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben |
GB9902399D0 (en) | 1999-02-03 | 1999-03-24 | Smithkline Beecham Plc | Compounds |
CA2363713C (en) | 1999-10-12 | 2007-11-06 | Blis Technologies Limited | Lantibiotic |
US6759205B2 (en) | 2000-06-29 | 2004-07-06 | University Of Maryland | Construction of a strain of Bacillus subtilis 168 that displays the sublancin lantibiotic on the surface of the cell |
US6342385B1 (en) | 2000-07-28 | 2002-01-29 | The Uab Research Foundation | Mutacin I biosynthesis genes and proteins |
WO2002020610A2 (en) | 2000-09-07 | 2002-03-14 | Biosynthema Inc. | Conformationally constrained labeled peptides for imaging and therapy |
-
2003
- 2003-02-07 US US10/360,101 patent/US6861236B2/en not_active Expired - Lifetime
- 2003-05-26 CA CA2487351A patent/CA2487351C/en not_active Expired - Fee Related
- 2003-05-26 SI SI200332339T patent/SI1507798T1/sl unknown
- 2003-05-26 EP EP03733622.9A patent/EP1507798B2/en not_active Expired - Lifetime
- 2003-05-26 PT PT37336229T patent/PT1507798E/pt unknown
- 2003-05-26 DK DK03733622.9T patent/DK1507798T4/en active
- 2003-05-26 AU AU2003238714A patent/AU2003238714A1/en not_active Abandoned
- 2003-05-26 CN CN03817698.XA patent/CN1671737B/zh not_active Expired - Fee Related
- 2003-05-26 WO PCT/NL2003/000389 patent/WO2003099862A1/en not_active Application Discontinuation
- 2003-05-26 ES ES03733622.9T patent/ES2444840T5/es not_active Expired - Lifetime
-
2014
- 2014-02-20 CY CY20141100130T patent/CY1114998T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1507798B2 (en) | 2016-11-16 |
WO2003099862A1 (en) | 2003-12-04 |
AU2003238714A1 (en) | 2003-12-12 |
DK1507798T3 (en) | 2014-02-24 |
CA2487351C (en) | 2013-07-23 |
CN1671737B (zh) | 2011-12-28 |
ES2444840T5 (es) | 2017-06-01 |
PT1507798E (pt) | 2014-02-24 |
AU2003238714A8 (en) | 2003-12-12 |
CN1671737A (zh) | 2005-09-21 |
WO2003099862A8 (en) | 2004-03-11 |
CA2487351A1 (en) | 2003-12-04 |
CY1114998T1 (el) | 2016-12-14 |
DK1507798T4 (en) | 2017-02-13 |
EP1507798B1 (en) | 2013-11-20 |
US20040009550A1 (en) | 2004-01-15 |
US6861236B2 (en) | 2005-03-01 |
EP1507798A1 (en) | 2005-02-23 |
ES2444840T3 (es) | 2014-02-27 |
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