SI0806966T1 - Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides - Google Patents

Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides

Info

Publication number
SI0806966T1
SI0806966T1 SI9630699T SI9630699T SI0806966T1 SI 0806966 T1 SI0806966 T1 SI 0806966T1 SI 9630699 T SI9630699 T SI 9630699T SI 9630699 T SI9630699 T SI 9630699T SI 0806966 T1 SI0806966 T1 SI 0806966T1
Authority
SI
Slovenia
Prior art keywords
oligonucleotides
vinyl alcohol
delivery
vinylamine
cationic copolymers
Prior art date
Application number
SI9630699T
Other languages
English (en)
Slovenian (sl)
Inventor
Merrill S. Goldenberg
Alice C. Beekman
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of SI0806966T1 publication Critical patent/SI0806966T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3517Marker; Tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
SI9630699T 1995-01-25 1996-01-11 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides SI0806966T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/378,301 US5629184A (en) 1995-01-25 1995-01-25 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
PCT/US1996/000354 WO1996022792A1 (en) 1995-01-25 1996-01-11 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
EP96902128A EP0806966B1 (de) 1995-01-25 1996-01-11 Kationische kopolymere von vinylamine und vinylalkohol zur verabreichung von oligonukleotiden

Publications (1)

Publication Number Publication Date
SI0806966T1 true SI0806966T1 (en) 2005-06-30

Family

ID=23492568

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630699T SI0806966T1 (en) 1995-01-25 1996-01-11 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides

Country Status (16)

Country Link
US (1) US5629184A (de)
EP (1) EP0806966B1 (de)
JP (1) JPH11503407A (de)
AT (1) ATE282433T1 (de)
AU (1) AU701543B2 (de)
BR (1) BR9606783A (de)
CA (1) CA2210875C (de)
DE (1) DE69633852T2 (de)
DK (1) DK0806966T3 (de)
ES (1) ES2233960T3 (de)
IL (1) IL116887A0 (de)
MX (1) MX9705536A (de)
PT (1) PT806966E (de)
SI (1) SI0806966T1 (de)
WO (1) WO1996022792A1 (de)
ZA (1) ZA96401B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US8217015B2 (en) * 2003-04-04 2012-07-10 Arrowhead Madison Inc. Endosomolytic polymers
EP0904031A4 (de) * 1996-05-29 2002-05-02 Cell Genesys Inc Träger aus kationischem polymer und lipid zur verabreichung von nukleinsäuren
US6656508B2 (en) 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
FR2766195A1 (fr) * 1997-07-21 1999-01-22 Transgene Sa Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique
WO1999042091A2 (en) * 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
DK0987029T3 (da) * 1998-08-28 2003-03-31 Transgene Sa Anvendelse af en kationisk polymer til fremstilling af et kompleks med nukleinsyre samt relaterede præparater
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
KR100482774B1 (ko) * 2002-09-05 2005-04-14 주식회사 마이진 폴리비닐이미다졸계 화합물을 포함하는 유전자 전달체
US20050025741A1 (en) 2003-05-15 2005-02-03 Lau Aldrich N.K. Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis
CN102858883B (zh) 2010-02-12 2015-09-09 罗地亚管理公司 流变改进剂组合物及其使用方法
FI20115664A0 (fi) * 2011-06-23 2011-06-23 Kemira Oyj Polymeerituote ja sen käyttö dispergointiaineena
JP6933379B2 (ja) 2015-09-24 2021-09-08 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 転移を低減するための方法および組成物
US11254964B1 (en) * 2016-03-15 2022-02-22 Fresenius Kabi Deutschland Gmbh Cell culture methods for increased cell viability
US11186858B1 (en) 2016-03-15 2021-11-30 Fresenius Kabi Deutschland Gmbh Methods for increasing biosimilarity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE751299A (en) * 1970-06-01 1970-11-16 Kakenyaku Kako Kk Dna polyamine compositions for treating - lesions caused by radiation
US4713236A (en) * 1981-12-07 1987-12-15 Morton Thiokol, Inc. Polymeric amine conditioning additives for hair care products
US5300566A (en) * 1988-04-15 1994-04-05 Air Products And Chemicals, Inc. Method for preparing poly(vinyl alcohol)-co-poly(vinylamine) via a two-phase process
US5194492A (en) * 1988-04-15 1993-03-16 Air Products And Chemicals, Inc. Two-phase process for preparing poly(vinyl alcohol)-co-poly(vinylamine)
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5281307A (en) * 1993-01-13 1994-01-25 Air Products And Chemicals, Inc. Crosslinked vinyl alcohol/vinylamine copolymers for dry end paper addition
WO1994018834A1 (en) * 1993-02-16 1994-09-01 Virginia Tech Intellectual Properties, Inc. Polyelectrolyte dna conjugation and genetic transformation of an animal
US5387641A (en) * 1993-05-25 1995-02-07 Yeung; Dominic W. K. Aqueous polymer emulsions useful as wallcovering prepaste adhesives

Also Published As

Publication number Publication date
JPH11503407A (ja) 1999-03-26
DK0806966T3 (da) 2005-01-03
IL116887A0 (en) 1996-05-14
US5629184A (en) 1997-05-13
ATE282433T1 (de) 2004-12-15
MX9705536A (es) 1997-10-31
PT806966E (pt) 2005-03-31
AU4655496A (en) 1996-08-14
EP0806966A1 (de) 1997-11-19
WO1996022792A1 (en) 1996-08-01
CA2210875A1 (en) 1996-08-01
ES2233960T3 (es) 2005-06-16
DE69633852T2 (de) 2005-11-03
DE69633852D1 (de) 2004-12-23
EP0806966B1 (de) 2004-11-17
BR9606783A (pt) 1997-12-30
ZA96401B (en) 1996-08-14
CA2210875C (en) 2001-05-01
AU701543B2 (en) 1999-01-28

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