DK0806966T3 - Katoniske copolymerer af vinylamin og vinylalkohol til administration af oligonukleotider - Google Patents

Katoniske copolymerer af vinylamin og vinylalkohol til administration af oligonukleotider

Info

Publication number
DK0806966T3
DK0806966T3 DK96902128T DK96902128T DK0806966T3 DK 0806966 T3 DK0806966 T3 DK 0806966T3 DK 96902128 T DK96902128 T DK 96902128T DK 96902128 T DK96902128 T DK 96902128T DK 0806966 T3 DK0806966 T3 DK 0806966T3
Authority
DK
Denmark
Prior art keywords
oligonucleotides
vinyl alcohol
vinylamine
administration
cationic copolymers
Prior art date
Application number
DK96902128T
Other languages
English (en)
Inventor
Alice C Beekman
Merrill S Goldenberg
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0806966T3 publication Critical patent/DK0806966T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3517Marker; Tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DK96902128T 1995-01-25 1996-01-11 Katoniske copolymerer af vinylamin og vinylalkohol til administration af oligonukleotider DK0806966T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/378,301 US5629184A (en) 1995-01-25 1995-01-25 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
EP96902128A EP0806966B1 (en) 1995-01-25 1996-01-11 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides

Publications (1)

Publication Number Publication Date
DK0806966T3 true DK0806966T3 (da) 2005-01-03

Family

ID=23492568

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96902128T DK0806966T3 (da) 1995-01-25 1996-01-11 Katoniske copolymerer af vinylamin og vinylalkohol til administration af oligonukleotider

Country Status (16)

Country Link
US (1) US5629184A (da)
EP (1) EP0806966B1 (da)
JP (1) JPH11503407A (da)
AT (1) ATE282433T1 (da)
AU (1) AU701543B2 (da)
BR (1) BR9606783A (da)
CA (1) CA2210875C (da)
DE (1) DE69633852T2 (da)
DK (1) DK0806966T3 (da)
ES (1) ES2233960T3 (da)
IL (1) IL116887A0 (da)
MX (1) MX9705536A (da)
PT (1) PT806966E (da)
SI (1) SI0806966T1 (da)
WO (1) WO1996022792A1 (da)
ZA (1) ZA96401B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US8217015B2 (en) * 2003-04-04 2012-07-10 Arrowhead Madison Inc. Endosomolytic polymers
US20010007771A1 (en) * 1996-05-29 2001-07-12 Sean M. Sullivan Cationic polymers and lipids for the delivery of nucleic acids
US6656508B2 (en) 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
FR2766195A1 (fr) * 1997-07-21 1999-01-22 Transgene Sa Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique
WO1999042091A2 (en) * 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
EP0987029B1 (en) * 1998-08-28 2003-01-22 Transgene S.A. Use of a catonic polymer for the preparation of a complex with nucleic acid and related compositions
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
KR100482774B1 (ko) * 2002-09-05 2005-04-14 주식회사 마이진 폴리비닐이미다졸계 화합물을 포함하는 유전자 전달체
US20050025741A1 (en) 2003-05-15 2005-02-03 Lau Aldrich N.K. Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis
CA2791853C (en) 2010-02-12 2018-03-06 Rhodia Operations Rheology modifier compositions and methods of use
FI20115664A0 (fi) * 2011-06-23 2011-06-23 Kemira Oyj Polymeerituote ja sen käyttö dispergointiaineena
ES2907486T3 (es) 2015-09-24 2022-04-25 Univ North Carolina Chapel Hill Métodos y composiciones para reducir metástasis
US11254964B1 (en) * 2016-03-15 2022-02-22 Fresenius Kabi Deutschland Gmbh Cell culture methods for increased cell viability
US11186858B1 (en) 2016-03-15 2021-11-30 Fresenius Kabi Deutschland Gmbh Methods for increasing biosimilarity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE751299A (en) * 1970-06-01 1970-11-16 Kakenyaku Kako Kk Dna polyamine compositions for treating - lesions caused by radiation
US4713236A (en) * 1981-12-07 1987-12-15 Morton Thiokol, Inc. Polymeric amine conditioning additives for hair care products
US5194492A (en) * 1988-04-15 1993-03-16 Air Products And Chemicals, Inc. Two-phase process for preparing poly(vinyl alcohol)-co-poly(vinylamine)
US5300566A (en) * 1988-04-15 1994-04-05 Air Products And Chemicals, Inc. Method for preparing poly(vinyl alcohol)-co-poly(vinylamine) via a two-phase process
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5281307A (en) * 1993-01-13 1994-01-25 Air Products And Chemicals, Inc. Crosslinked vinyl alcohol/vinylamine copolymers for dry end paper addition
WO1994018834A1 (en) * 1993-02-16 1994-09-01 Virginia Tech Intellectual Properties, Inc. Polyelectrolyte dna conjugation and genetic transformation of an animal
US5387641A (en) * 1993-05-25 1995-02-07 Yeung; Dominic W. K. Aqueous polymer emulsions useful as wallcovering prepaste adhesives

Also Published As

Publication number Publication date
ATE282433T1 (de) 2004-12-15
JPH11503407A (ja) 1999-03-26
WO1996022792A1 (en) 1996-08-01
IL116887A0 (en) 1996-05-14
PT806966E (pt) 2005-03-31
BR9606783A (pt) 1997-12-30
CA2210875A1 (en) 1996-08-01
ZA96401B (en) 1996-08-14
ES2233960T3 (es) 2005-06-16
SI0806966T1 (en) 2005-06-30
CA2210875C (en) 2001-05-01
AU4655496A (en) 1996-08-14
EP0806966B1 (en) 2004-11-17
AU701543B2 (en) 1999-01-28
US5629184A (en) 1997-05-13
MX9705536A (es) 1997-10-31
DE69633852D1 (de) 2004-12-23
EP0806966A1 (en) 1997-11-19
DE69633852T2 (de) 2005-11-03

Similar Documents

Publication Publication Date Title
DK0806966T3 (da) Katoniske copolymerer af vinylamin og vinylalkohol til administration af oligonukleotider
MX9705954A (es) Formulaciones y metodos para reducir irritacion de la piel.
DK0817847T3 (da) IL-17-receptor
BR9916857A (pt) 4 heteroaril diarilaminas
TR200100054T2 (tr) Paroksetin metansülfonat
MX9707431A (es) Inhibidores de la proteina cinasa c.
DE69840025D1 (de) Assoziierter antworten
TR199701574T2 (xx) �midazol bile�imleri
GR3034204T3 (en) Lipopolyamines as transfection agents and pharmaceutical uses thereof
SE9702385D0 (sv) Method and device in data network
ATE388237T1 (de) Dendritische zellhybride
FR2755608B1 (fr) Composition cosmetique comprenant un polymere anionique ou non ionique et une silicone carboxylique
MX9801987A (es) Nuevos derivados de aminoacido, su obtencion y su uso.
PT973486E (pt) Composicoes cosmeticas contendo um polimero cationico de fraca massa molecular e um silicone e suas utilizacoes
DK1238086T3 (da) Vaccine til forögelse af immunreaktioner på herpes simplex virus
MX9802730A (es) Agonistas receptores hematopoyeticos multifuncionales.
FR2776188B1 (fr) Oleamide de glycylglycine en dermo-cosmetologie
BR9811230A (pt) Aparelho para proporcionar uma apresentação para um terminal móvel de uma indicação de qual dentre uma primeira e pelo menos uma segunda assinaturas por serviço segundo a qual o terminal móvel é operável em um sistema de comunicação celular, processo para proporcionar uma apresentação para um terminal móvel de uma indicação de uma selecionada dentre uma primeira assinatura por serviço e pelo menos uma segunda assinatura por serviço, e, interface de usuário
TR200000291T2 (tr) Taşikinin reseptör antagonistleri olarak 2-asilaminopropanaminler.
TR200001724T2 (tr) 5-HT1F Agonistleri
BR9801143A (pt) Copolìmeros de bloco de siloxano inovativos com espaçamento rìgidos e uso dos mesmos.
BR9609114A (pt) Composição inseticida de terra diatomácea
AU1545401A (en) Targeted marketing system with third party confidential database
AP2000001746A0 (en) Anti- first-pass effect compounds.
DE69729618D1 (de) Abführmittel und verfahren zu deren herstellung