SI0757058T1 - Cyclic peptide anti-fungal agents - Google Patents

Cyclic peptide anti-fungal agents

Info

Publication number
SI0757058T1
SI0757058T1 SI9630272T SI9630272T SI0757058T1 SI 0757058 T1 SI0757058 T1 SI 0757058T1 SI 9630272 T SI9630272 T SI 9630272T SI 9630272 T SI9630272 T SI 9630272T SI 0757058 T1 SI0757058 T1 SI 0757058T1
Authority
SI
Slovenia
Prior art keywords
hydrogen
chem
alkyl
benzyl
independently
Prior art date
Application number
SI9630272T
Other languages
English (en)
Inventor
Michael John Rodriguez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SI0757058T1 publication Critical patent/SI0757058T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9630272T 1995-07-25 1996-07-22 Cyclic peptide anti-fungal agents SI0757058T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/506,790 US5629289A (en) 1995-07-25 1995-07-25 Cyclic peptide antifungal agents
EP96305345A EP0757058B1 (en) 1995-07-25 1996-07-22 Cyclic peptide anti-fungal agents

Publications (1)

Publication Number Publication Date
SI0757058T1 true SI0757058T1 (en) 2001-04-30

Family

ID=24016022

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630272T SI0757058T1 (en) 1995-07-25 1996-07-22 Cyclic peptide anti-fungal agents

Country Status (13)

Country Link
US (1) US5629289A (xx)
EP (1) EP0757058B1 (xx)
JP (1) JPH11510165A (xx)
AT (1) ATE197460T1 (xx)
AU (1) AU6593896A (xx)
CA (1) CA2227364A1 (xx)
DE (1) DE69610880T2 (xx)
DK (1) DK0757058T3 (xx)
ES (1) ES2151638T3 (xx)
GR (1) GR3035351T3 (xx)
PT (1) PT757058E (xx)
SI (1) SI0757058T1 (xx)
WO (1) WO1997005163A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) * 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
CA2205369A1 (en) * 1994-11-15 1996-05-23 Eli Lilly And Company Process for performing retro-aldol reaction
US6146872A (en) * 1996-06-13 2000-11-14 Fukisawa Pharmaceutical Co., Ltd. Cyclic lipopeptide acylase
WO1999040108A1 (en) * 1998-02-09 1999-08-12 Fujisawa Pharmaceutical Co., Ltd. New compound
US6323176B1 (en) * 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
WO2000011023A2 (en) 1998-08-20 2000-03-02 Eli Lilly And Company Ring modified cyclic peptide analogs
WO2000034315A2 (en) 1998-12-09 2000-06-15 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
CA2354055A1 (en) * 1998-12-16 2000-06-22 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
RU2001126723A (ru) * 1999-03-03 2003-09-27 Эли Лилли энд Компани (US) Эхинокандин/углеводные комплексы
AU776782C (en) * 1999-03-03 2005-04-07 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
CA2362482A1 (en) * 1999-03-03 2000-09-08 Eli Lilly And Company Processes for making pharmaceutical oral ecb formulations and compositions
ES2270819T3 (es) 1999-03-03 2007-04-16 Eli Lilly And Company Formacion e intercambio anionico de sales de amonio internas cristalinas de equinocandina.
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057493A (en) * 1988-07-19 1991-10-15 Takara Shuzo Co., Ltd. Novel antibiotics r106
US5260214A (en) * 1988-07-19 1993-11-09 Takara Shuzo Co. Aureobasidium pullulans which produces antibiotic R106
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
JPH0826071B2 (ja) * 1989-07-11 1996-03-13 寶酒造株式会社 抗真菌抗生物質ｒ１０６誘導体
JP2639737B2 (ja) * 1990-01-23 1997-08-13 寳酒造株式会社 新規ｒ１０６類化合物
US5059540A (en) * 1990-08-13 1991-10-22 City Of Hope Sequential C-terminal degradation of peptides and proteins using cleaving reagents such as sodium trimethylsilanolate or trimethylamine N-oxide
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
FI912873A (fi) * 1990-06-18 1991-12-19 Fujisawa Pharmaceutical Co Ny polypeptidfoerening och foerfarande foer dess framstaellning.
IL105048A (en) * 1992-03-19 2001-06-14 Eli Lilly And Company U S Antifungal substances of the cyclic peptide type and a process for their preparation
JP3480848B2 (ja) * 1992-06-19 2003-12-22 タカラバイオ株式会社 環状ペプチドの合成方法
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
WO1994025045A1 (en) * 1993-05-04 1994-11-10 Merck & Co., Inc. Cyclohexapeptidyl aminoalkyl ethers
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
AU7874494A (en) * 1993-09-22 1995-04-10 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
CA2205369A1 (en) * 1994-11-15 1996-05-23 Eli Lilly And Company Process for performing retro-aldol reaction

Also Published As

Publication number Publication date
US5629289A (en) 1997-05-13
DE69610880D1 (de) 2000-12-14
DE69610880T2 (de) 2001-05-10
EP0757058B1 (en) 2000-11-08
PT757058E (pt) 2001-04-30
ES2151638T3 (es) 2001-01-01
ATE197460T1 (de) 2000-11-11
AU6593896A (en) 1997-02-26
DK0757058T3 (da) 2000-12-27
GR3035351T3 (en) 2001-05-31
WO1997005163A1 (en) 1997-02-13
JPH11510165A (ja) 1999-09-07
CA2227364A1 (en) 1997-02-13
EP0757058A1 (en) 1997-02-05

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