ES2151638T3 - Peptidos ciclicos como agentes antifungicos. - Google Patents

Peptidos ciclicos como agentes antifungicos.

Info

Publication number
ES2151638T3
ES2151638T3 ES96305345T ES96305345T ES2151638T3 ES 2151638 T3 ES2151638 T3 ES 2151638T3 ES 96305345 T ES96305345 T ES 96305345T ES 96305345 T ES96305345 T ES 96305345T ES 2151638 T3 ES2151638 T3 ES 2151638T3
Authority
ES
Spain
Prior art keywords
hydrogen
chem
alkyl
benzyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96305345T
Other languages
English (en)
Inventor
Michael John Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2151638T3 publication Critical patent/ES2151638T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROPORCIONAN FORMULACIONES FARMACEUTICAS, Y METODOS DE INHIBICION DE LA ACTIVIDAD FUNGICA Y PARASITICA USANDO UN COMPUESTO DE FORMULA I: EN DONDE: R{SUP,Z1} ES HIDROGENO, -CH{SUB,2}OH, -CHOHCH{SUB,3} O CHOHCH{SUB,2}C(O)NH{SUB,2}; R{SUP,Z2} ES HIDROGENO, -CH{SUB,2}OH O -CHOHCH{SUB,3}; R{SUP,Z3} ES HIDROGENO O METILO; R{SUP,X1} ES HIDROGENO, HIDROXI O O-R{SUP,X1}; R{SUP,X1`} ES C{SUB,1}-C{SUB,6} ALQUILO, BENCILO, (CH{SUB,2}){SUB,2}SI(CH{SUB,3}){SUB,3}, -CH{SUB,2}CH=CH{SUB,2}, CH{SUB,2}CHOHCH{SUB,2}OH, -(CH{SUB,2}){SUB,A}COOH, (CH{SUB,2}){SUB,B}NR{SUP,W1}R{SUP,W2}, (CH{SUB,2}){SUB,C}POR{SUP,W3R{SUP,W4} O [(CH{SUB,2}){SUB,2}O]{SUB,D}]-(C{SUB,1}-C{SUB,6} ALQUILO; A,B Y C SON INDEPENDIENTEMENTE 1,2,3,4,5 O 6; R{SUP,W1} Y R{SUP,W2} SON INDEPENDIENTEMENTE HIDROGENO, C{SUB,1}C{SUB,6} ALQUILO, O R{SUP,W1} Y R{SUP,W2} SE COMBINAN PARA FORMAR -CH{SUB,2}(CH{SUB,2}){SUB,E}CH{SUB,2}-; R{SUP,W3} Y R{SUP,W4} SON INDEPENDIENTEMENTE HIDROXI, O C{SUB,1}C{SUB,6} ALCOXI; D ES 1 O 2; E ES 1,2 O 3; R{SUP,X2},R{SUP,Y1},R{SUP,Y2},R{SUP,Y3} Y R{SUP,Y4} SON INDEPENDIENTEMENTE HIDROXI O HIDROGENO; R{SUP,0} ES HIDROXI, -OP(O)(OH){SUB,2} O UN GRUPO DE LA FORMULA: R{SUP,1} ES C{SUB,1}-C{SUB,6} ALQUILO, FENILO, P-HALO-FENILO, PNITROFENILO, BENCILO, P-HALO-BENCILO O P-NITRO-BENCILO; R{SUP,2} ES R{SUP,3} ES O R{SUP,3A},R{SUP,3B},R{SUP,3C} Y R{SUP,3D} SON INDEPENDIENTEMENTE HIDROGENO, C{SUB,1}-C{SUB,12} ALQUILO, C{SUB,2}-C{SUB,12} ALQUINILO, C{SUB,1}-C{SUB,12} ALCOXI, C{SUB,1}-C{SUB,12} ALQUILTIO, HALO, -O-(CH{SUB,2}){SUB,M}-[O(CH{SUB,2}){SUB,N}]{SUB,P} -O-(C{SUB,1}-C{SUB,12}) ALQUILO O -O(CH{SUB,2}){SUB,Q}-X-R{SUP,4}; M ES 2,3 O 4; N ES 2,3 O 4; P ES 0 O 1; Q ES 2,3 O 4; X ES PIRROLIDINO, PIPERIDINO O PIPERAZINO; Y R{SUP,4} ES HIDROGENO, C{SUB,1}-C{SUB,12} ALQUILO, C{SUB,3}C{SUB,12} CICLOALQUILO, BENCILO O C{SUB,3}-C{SUB,12} CICLOALQUILMETILO; CON LA CONDICION DE QUE AL MENOS UNO DE R{SUP,Z1} Y R{SUP,Z2} DEBE SER HIDROGENO; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO.
ES96305345T 1995-07-25 1996-07-22 Peptidos ciclicos como agentes antifungicos. Expired - Lifetime ES2151638T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/506,790 US5629289A (en) 1995-07-25 1995-07-25 Cyclic peptide antifungal agents

Publications (1)

Publication Number Publication Date
ES2151638T3 true ES2151638T3 (es) 2001-01-01

Family

ID=24016022

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96305345T Expired - Lifetime ES2151638T3 (es) 1995-07-25 1996-07-22 Peptidos ciclicos como agentes antifungicos.

Country Status (13)

Country Link
US (1) US5629289A (es)
EP (1) EP0757058B1 (es)
JP (1) JPH11510165A (es)
AT (1) ATE197460T1 (es)
AU (1) AU6593896A (es)
CA (1) CA2227364A1 (es)
DE (1) DE69610880T2 (es)
DK (1) DK0757058T3 (es)
ES (1) ES2151638T3 (es)
GR (1) GR3035351T3 (es)
PT (1) PT757058E (es)
SI (1) SI0757058T1 (es)
WO (1) WO1997005163A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384013B1 (en) * 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
WO1996015142A1 (en) * 1994-11-15 1996-05-23 Eli Lilly And Company Process for performing retro-aldol reaction
WO1997047738A1 (fr) 1996-06-13 1997-12-18 Fujisawa Pharmaceutical Co., Ltd. Acylase des lipopeptides cycliques
CA2320416A1 (en) * 1998-02-09 1999-08-12 Fujisawa Pharmaceutical Co., Ltd. New compound
US6323176B1 (en) * 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
ES2233070T3 (es) 1998-08-20 2005-06-01 ELI LILLY & COMPANY Sintesis de analogos peptidicos ciclicos modificados en el anillo.
CA2353930A1 (en) 1998-12-09 2000-06-15 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
WO2000035945A1 (en) * 1998-12-16 2000-06-22 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
KR20020003864A (ko) 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
ATE338060T1 (de) 1999-03-03 2006-09-15 Lilly Co Eli Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
AU771727B2 (en) * 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
WO2000051564A1 (en) * 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260214A (en) * 1988-07-19 1993-11-09 Takara Shuzo Co. Aureobasidium pullulans which produces antibiotic R106
US5057493A (en) * 1988-07-19 1991-10-15 Takara Shuzo Co., Ltd. Novel antibiotics r106
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
JPH0826071B2 (ja) * 1989-07-11 1996-03-13 寶酒造株式会社 抗真菌抗生物質ｒ１０６誘導体
JP2639737B2 (ja) * 1990-01-23 1997-08-13 寳酒造株式会社 新規ｒ１０６類化合物
US5059540A (en) * 1990-08-13 1991-10-22 City Of Hope Sequential C-terminal degradation of peptides and proteins using cleaving reagents such as sodium trimethylsilanolate or trimethylamine N-oxide
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Peptides, of antibiotics, processes for their preparation and pharmaceutical preparations containing them
MY136593A (en) * 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
JP3480848B2 (ja) * 1992-06-19 2003-12-22 タカラバイオ株式会社 環状ペプチドの合成方法
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
JPH09500103A (ja) * 1993-05-04 1997-01-07 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルアミノアルキルエーテル
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
AU7874494A (en) * 1993-09-22 1995-04-10 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
WO1996015142A1 (en) * 1994-11-15 1996-05-23 Eli Lilly And Company Process for performing retro-aldol reaction

Also Published As

Publication number Publication date
PT757058E (pt) 2001-04-30
ATE197460T1 (de) 2000-11-11
WO1997005163A1 (en) 1997-02-13
CA2227364A1 (en) 1997-02-13
JPH11510165A (ja) 1999-09-07
DK0757058T3 (da) 2000-12-27
US5629289A (en) 1997-05-13
EP0757058B1 (en) 2000-11-08
DE69610880D1 (de) 2000-12-14
EP0757058A1 (en) 1997-02-05
DE69610880T2 (de) 2001-05-10
AU6593896A (en) 1997-02-26
SI0757058T1 (en) 2001-04-30
GR3035351T3 (en) 2001-05-31

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