SI0683168T1 - Postopek za pripravo 2-metilspiro(1,3-oksatiolan-5,3')kinuklidina - Google Patents

Postopek za pripravo 2-metilspiro(1,3-oksatiolan-5,3')kinuklidina

Info

Publication number
SI0683168T1
SI0683168T1 SI9530467T SI9530467T SI0683168T1 SI 0683168 T1 SI0683168 T1 SI 0683168T1 SI 9530467 T SI9530467 T SI 9530467T SI 9530467 T SI9530467 T SI 9530467T SI 0683168 T1 SI0683168 T1 SI 0683168T1
Authority
SI
Slovenia
Prior art keywords
methylspiro
oxathiolane
quinuclidine
producing
msoq
Prior art date
Application number
SI9530467T
Other languages
English (en)
Inventor
Koji Hayashi
Sho Tokumoto
Hiroshi Yoshizawa
Tatsuo Isogai
Masaru Ishihara Sangyo Kaisha Ltd. Kimura
Masahiko Ishihara Sangyo Kaisha Ltd. Sawaki
Takayoshi Ishihara Sangyo Kaisha Ltd. Ando
Isamu 346-2 Minamishimohara-cho Katsuyama
Hayato Ishihara Sangyo Kaisha Ltd. Ariyoshi
Tadashi Ishihara Sangyo Kaisha Ltd. Nakamura
Original Assignee
Ishihara Sangyo Kaisha, Ltd.
Snow Brand Milk Products Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha, Ltd., Snow Brand Milk Products Co., Ltd. filed Critical Ishihara Sangyo Kaisha, Ltd.
Publication of SI0683168T1 publication Critical patent/SI0683168T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
SI9530467T 1994-05-19 1995-05-19 Postopek za pripravo 2-metilspiro(1,3-oksatiolan-5,3')kinuklidina SI0683168T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13090794 1994-05-19
JP15287394 1994-06-10
JP25880294 1994-09-27
JP8746195 1995-03-20
EP95107738A EP0683168B1 (en) 1994-05-19 1995-05-19 Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine

Publications (1)

Publication Number Publication Date
SI0683168T1 true SI0683168T1 (sl) 2002-02-28

Family

ID=27467385

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530467T SI0683168T1 (sl) 1994-05-19 1995-05-19 Postopek za pripravo 2-metilspiro(1,3-oksatiolan-5,3')kinuklidina

Country Status (11)

Country Link
US (1) US5571918A (sl)
EP (2) EP1004586B1 (sl)
JP (1) JP2782330B2 (sl)
KR (3) KR100371892B1 (sl)
AT (2) ATE435228T1 (sl)
DE (2) DE69535977D1 (sl)
DK (2) DK1004586T3 (sl)
ES (2) ES2164119T3 (sl)
PT (2) PT683168E (sl)
SI (1) SI0683168T1 (sl)
TW (1) TW394772B (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
US8080663B2 (en) * 2007-04-04 2011-12-20 Apotex Pharmachem Inc Process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine
US8143400B2 (en) 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
JP5452165B2 (ja) * 2009-10-23 2014-03-26 第一ファインケミカル株式会社 キヌクリジン類の製造法
US8450487B2 (en) 2010-06-08 2013-05-28 Apicore, Llc Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine
EP3347011A4 (en) 2015-09-11 2019-06-19 Chase Pharmaceuticals Corporation MUSCARIN COMBINATION AND ITS USE FOR COMBATING HYPOCHOLINERGEN DISORDERS OF THE CENTRAL NERVOUS SYSTEM
JP2019052093A (ja) * 2016-02-01 2019-04-04 宇部興産株式会社 ２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン硫酸塩の製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705134A (en) 1985-04-30 1987-11-10 Fuji Jukogyo Kabushiki Kaisha System for controlling a transfer clutch of a four-wheel drive vehicle
US4855290A (en) 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
JPH0816111B2 (ja) 1987-07-21 1996-02-21 石原産業株式会社 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン又はこれらの酸付加塩の異性化方法
US4861886A (en) * 1987-07-10 1989-08-29 Ishahara Sangyo Kaisha Ltd Method for isomerization of trans-form 2-methylspiro (1,3-oxathiolane-5,3')q
JP2529576B2 (ja) 1987-07-10 1996-08-28 石原産業株式会社 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジンの異性化方法
JP2529577B2 (ja) 1987-08-13 1996-08-28 石原産業株式会社 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジン又はこれらの酸付加塩の異性化方法
IL87234A (en) * 1987-08-13 1992-02-16 Israel Inst Biolog Res Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them
JPH01290680A (ja) * 1988-05-18 1989-11-22 Ishihara Sangyo Kaisha Ltd シス型キヌクリジン誘導体の分離方法

Also Published As

Publication number Publication date
ES2328754T3 (es) 2009-11-17
EP0683168B1 (en) 2001-09-12
JPH08319287A (ja) 1996-12-03
EP1004586A3 (en) 2001-09-12
KR950032189A (ko) 1995-12-20
ES2164119T3 (es) 2002-02-16
DK1004586T3 (da) 2009-09-07
KR100371892B1 (ko) 2003-03-19
JP2782330B2 (ja) 1998-07-30
EP1004586B1 (en) 2009-07-01
DK0683168T3 (da) 2001-12-03
EP1004586A2 (en) 2000-05-31
KR100371893B1 (ko) 2003-02-12
TW394772B (en) 2000-06-21
DE69522603T2 (de) 2002-04-18
ATE205495T1 (de) 2001-09-15
PT683168E (pt) 2001-12-28
PT1004586E (pt) 2009-07-13
KR100371894B1 (ko) 2003-02-12
DE69522603D1 (de) 2001-10-18
EP0683168A1 (en) 1995-11-22
ATE435228T1 (de) 2009-07-15
US5571918A (en) 1996-11-05
DE69535977D1 (de) 2009-08-13

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