SG87053A1 - High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide - Google Patents
High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamideInfo
- Publication number
- SG87053A1 SG87053A1 SG9904601A SG1999004601A SG87053A1 SG 87053 A1 SG87053 A1 SG 87053A1 SG 9904601 A SG9904601 A SG 9904601A SG 1999004601 A SG1999004601 A SG 1999004601A SG 87053 A1 SG87053 A1 SG 87053A1
- Authority
- SG
- Singapore
- Prior art keywords
- polymorth
- isoxazolyl
- sulfonamide
- oxazolyl
- biphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1197496P | 1996-02-20 | 1996-02-20 | |
US08/786,523 US5856507A (en) | 1997-01-21 | 1997-01-21 | Methods for the preparation of biphenyl isoxazole sulfonamides |
Publications (1)
Publication Number | Publication Date |
---|---|
SG87053A1 true SG87053A1 (en) | 2002-03-19 |
Family
ID=26682999
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG9904601A SG87053A1 (en) | 1996-02-20 | 1997-02-19 | High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide |
SG9904595A SG87052A1 (en) | 1996-02-20 | 1997-02-19 | Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides |
SG9904589A SG87051A1 (en) | 1996-02-20 | 1997-02-19 | Process for preparing biphenyl isoxazole sulfonamide intermediates |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG9904595A SG87052A1 (en) | 1996-02-20 | 1997-02-19 | Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides |
SG9904589A SG87051A1 (en) | 1996-02-20 | 1997-02-19 | Process for preparing biphenyl isoxazole sulfonamide intermediates |
Country Status (15)
Country | Link |
---|---|
US (1) | US6515136B1 (fr) |
EP (1) | EP0904077A4 (fr) |
JP (1) | JP2001523218A (fr) |
KR (1) | KR19990087063A (fr) |
CN (1) | CN1211183A (fr) |
AU (1) | AU717230B2 (fr) |
BR (1) | BR9708151A (fr) |
CZ (1) | CZ263098A3 (fr) |
HU (1) | HUP0002351A3 (fr) |
IL (1) | IL124542A (fr) |
NO (1) | NO311430B1 (fr) |
NZ (1) | NZ330464A (fr) |
PL (1) | PL328571A1 (fr) |
SG (3) | SG87053A1 (fr) |
WO (1) | WO1997029747A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
CN1100047C (zh) * | 1998-04-28 | 2003-01-29 | 中国人民解放军空军总医院 | N3-(5-甲基异噁唑)基-3,4-二羟基肉桂酰胺及其制法 |
ES2318899T3 (es) | 1998-07-06 | 2009-05-01 | Bristol-Myers Squibb Company | Bifenil sulfonamidas como antagonistas duales de los receptores de angiotensina y endotelina. |
DE19858593A1 (de) * | 1998-12-18 | 2000-06-21 | Merck Patent Gmbh | Sulfonyloxazolamine als therapeutische Wirkstoffe |
JP2002540088A (ja) | 1999-03-19 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | ビフェニルイソキサゾール・スルホンアミド化合物の製造法 |
US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US20050203189A1 (en) * | 2002-01-25 | 2005-09-15 | Noriyuki Miyata | Remedies for chronic kidney diseases |
CN114262279B (zh) * | 2021-12-30 | 2022-12-16 | 上海汇禾医疗科技有限公司 | 一种x射线可显影分子、栓塞微球及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
US4661479A (en) * | 1982-02-19 | 1987-04-28 | Merck And Co., Inc. | Bicyclic lactams as antihypertensives |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB804036A (en) | 1956-03-02 | 1958-11-05 | Hoffmann La Roche | A process for the manufacture of a sulphanilamide of the isoxazole series |
DE1059459B (de) | 1956-09-04 | 1959-06-18 | Shionogi & Co | Verfahren zur Herstellung des therapeutisch wertvollen 3-Sulfanilamido-5-methylisoxazols |
CH364506A (de) | 1956-09-04 | 1962-09-30 | Shionogi & Co | Verfahren zur Herstellung des therapeutisch wirksamen 3-Sulfanilamido-5-methyl-isoxazols |
GB897440A (en) | 1960-02-08 | 1962-05-30 | Shionogi & Co | Improvements in or relating to sulfonamides |
GB1473433A (fr) | 1975-10-09 | 1977-05-11 | Banyu Pharmaceutical Co Ltd Hi | |
EP0076072B1 (fr) | 1981-09-24 | 1987-05-13 | BEECHAM - WUELFING GmbH & Co. KG | Sulfonamides |
EP0194548A3 (fr) | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Composés sulfonylaminoéthyl, médicament contenant ces composés et leur procédé de préparation |
US5514691A (en) | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5464853A (en) | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
CA2005741C (fr) | 1988-12-26 | 1998-06-02 | Hiroyoshi Hidaka | Sulfonoaminoquinolines ayant une activite de relaxation des muscles lisses des vaisseaux |
US5082838A (en) | 1989-06-21 | 1992-01-21 | Takeda Chemical Industries, Ltd. | Sulfur-containing fused pyrimidine derivatives, their production and use |
DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
EP0523141A4 (en) | 1990-03-30 | 1993-04-21 | Merck & Co. Inc. | Substituted pyrazoles, isoxazoles and isothiazoles |
US5236928A (en) | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
TW270116B (fr) | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
RU2125980C1 (ru) | 1991-11-05 | 1999-02-10 | Смитклайн Бичам Корпорейшн | Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов |
SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Kabi Pharmacia Ab | Nya substituerade salicylsyror |
TW224462B (fr) | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
US5378715A (en) | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
TW215434B (fr) | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
WO1993023404A1 (fr) | 1992-05-19 | 1993-11-25 | Immunopharmaceutics, Inc. | Composes modulant l'activite de l'endotheline |
TW287160B (fr) | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
ATE189217T1 (de) | 1993-03-19 | 2000-02-15 | Merck & Co Inc | Phenoxyphenylessigsäurederivate |
EP0626174A3 (fr) | 1993-04-21 | 1996-01-03 | Takeda Chemical Industries Ltd | Procédé et composition de prophylaxie et/ou traitement de la hypofonction d'organes. |
TW394761B (en) | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
DE59409631D1 (de) | 1993-07-15 | 2001-02-15 | Hoffmann La Roche | Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält |
US5965732A (en) | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
GB9504854D0 (en) | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
GB9409618D0 (en) | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
CA2168154A1 (fr) * | 1995-02-06 | 1996-08-07 | Natesan Murugesan | Derives de substitution biphenyliques de sulfonamide, antagonistes de l'endotheline |
DE19509950A1 (de) | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
EA199900808A1 (ru) | 1995-04-04 | 2000-06-26 | Тексаз Байотекнолоджи Корпорейшн | Бифенилсульфонамиды и их производные, модулирующие активность эндотелина |
UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
GB9512697D0 (en) | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US5580894A (en) * | 1996-01-11 | 1996-12-03 | Howard University | Isoxazolyl enaminones |
-
1997
- 1997-02-19 CZ CZ982630A patent/CZ263098A3/cs unknown
- 1997-02-19 JP JP52960897A patent/JP2001523218A/ja active Pending
- 1997-02-19 CN CN97192338A patent/CN1211183A/zh active Pending
- 1997-02-19 SG SG9904601A patent/SG87053A1/en unknown
- 1997-02-19 WO PCT/US1997/002917 patent/WO1997029747A1/fr not_active Application Discontinuation
- 1997-02-19 IL IL12454297A patent/IL124542A/xx not_active IP Right Cessation
- 1997-02-19 KR KR1019980706449A patent/KR19990087063A/ko not_active Application Discontinuation
- 1997-02-19 EP EP97907841A patent/EP0904077A4/fr not_active Withdrawn
- 1997-02-19 NZ NZ330464A patent/NZ330464A/xx unknown
- 1997-02-19 BR BR9708151A patent/BR9708151A/pt not_active IP Right Cessation
- 1997-02-19 HU HU0002351A patent/HUP0002351A3/hu unknown
- 1997-02-19 PL PL97328571A patent/PL328571A1/xx unknown
- 1997-02-19 SG SG9904595A patent/SG87052A1/en unknown
- 1997-02-19 SG SG9904589A patent/SG87051A1/en unknown
- 1997-02-19 AU AU19737/97A patent/AU717230B2/en not_active Ceased
-
1998
- 1998-08-19 NO NO19983784A patent/NO311430B1/no not_active IP Right Cessation
- 1998-08-27 US US09/141,402 patent/US6515136B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
US4661479A (en) * | 1982-02-19 | 1987-04-28 | Merck And Co., Inc. | Bicyclic lactams as antihypertensives |
Also Published As
Publication number | Publication date |
---|---|
HUP0002351A2 (hu) | 2001-09-28 |
PL328571A1 (en) | 1999-02-01 |
IL124542A (en) | 2003-07-06 |
US6515136B1 (en) | 2003-02-04 |
AU717230B2 (en) | 2000-03-23 |
WO1997029747A1 (fr) | 1997-08-21 |
KR19990087063A (ko) | 1999-12-15 |
IL124542A0 (en) | 1998-12-06 |
SG87052A1 (en) | 2002-03-19 |
NO311430B1 (no) | 2001-11-26 |
SG87051A1 (en) | 2002-03-19 |
NO983784L (no) | 1998-08-19 |
EP0904077A4 (fr) | 1999-12-22 |
AU1973797A (en) | 1997-09-02 |
NZ330464A (en) | 2000-04-28 |
NO983784D0 (no) | 1998-08-19 |
HUP0002351A3 (en) | 2001-10-29 |
EP0904077A2 (fr) | 1999-03-31 |
CN1211183A (zh) | 1999-03-17 |
CZ263098A3 (cs) | 1999-05-12 |
JP2001523218A (ja) | 2001-11-20 |
BR9708151A (pt) | 1999-07-27 |
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