SG87052A1 - Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides - Google Patents
Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamidesInfo
- Publication number
- SG87052A1 SG87052A1 SG9904595A SG1999004595A SG87052A1 SG 87052 A1 SG87052 A1 SG 87052A1 SG 9904595 A SG9904595 A SG 9904595A SG 1999004595 A SG1999004595 A SG 1999004595A SG 87052 A1 SG87052 A1 SG 87052A1
- Authority
- SG
- Singapore
- Prior art keywords
- preparation
- pinacol ester
- intermediates useful
- ester intermediates
- isoxazole sulfonamides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1197496P | 1996-02-20 | 1996-02-20 | |
US08/786,523 US5856507A (en) | 1997-01-21 | 1997-01-21 | Methods for the preparation of biphenyl isoxazole sulfonamides |
Publications (1)
Publication Number | Publication Date |
---|---|
SG87052A1 true SG87052A1 (en) | 2002-03-19 |
Family
ID=26682999
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG9904601A SG87053A1 (en) | 1996-02-20 | 1997-02-19 | High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide |
SG9904589A SG87051A1 (en) | 1996-02-20 | 1997-02-19 | Process for preparing biphenyl isoxazole sulfonamide intermediates |
SG9904595A SG87052A1 (en) | 1996-02-20 | 1997-02-19 | Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG9904601A SG87053A1 (en) | 1996-02-20 | 1997-02-19 | High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide |
SG9904589A SG87051A1 (en) | 1996-02-20 | 1997-02-19 | Process for preparing biphenyl isoxazole sulfonamide intermediates |
Country Status (15)
Country | Link |
---|---|
US (1) | US6515136B1 (xx) |
EP (1) | EP0904077A4 (xx) |
JP (1) | JP2001523218A (xx) |
KR (1) | KR19990087063A (xx) |
CN (1) | CN1211183A (xx) |
AU (1) | AU717230B2 (xx) |
BR (1) | BR9708151A (xx) |
CZ (1) | CZ263098A3 (xx) |
HU (1) | HUP0002351A3 (xx) |
IL (1) | IL124542A (xx) |
NO (1) | NO311430B1 (xx) |
NZ (1) | NZ330464A (xx) |
PL (1) | PL328571A1 (xx) |
SG (3) | SG87053A1 (xx) |
WO (1) | WO1997029747A1 (xx) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
CN1100047C (zh) * | 1998-04-28 | 2003-01-29 | 中国人民解放军空军总医院 | N3-(5-甲基异噁唑)基-3,4-二羟基肉桂酰胺及其制法 |
CA2336714A1 (en) | 1998-07-06 | 2000-01-13 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
DE19858593A1 (de) | 1998-12-18 | 2000-06-21 | Merck Patent Gmbh | Sulfonyloxazolamine als therapeutische Wirkstoffe |
WO2000056685A1 (en) | 1999-03-19 | 2000-09-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6639082B2 (en) * | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
JPWO2003061700A1 (ja) * | 2002-01-25 | 2005-05-19 | 大正製薬株式会社 | 慢性腎疾患治療薬 |
CN114262279B (zh) * | 2021-12-30 | 2022-12-16 | 上海汇禾医疗科技有限公司 | 一种x射线可显影分子、栓塞微球及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
US4661479A (en) * | 1982-02-19 | 1987-04-28 | Merck And Co., Inc. | Bicyclic lactams as antihypertensives |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB804036A (en) | 1956-03-02 | 1958-11-05 | Hoffmann La Roche | A process for the manufacture of a sulphanilamide of the isoxazole series |
CH364506A (de) | 1956-09-04 | 1962-09-30 | Shionogi & Co | Verfahren zur Herstellung des therapeutisch wirksamen 3-Sulfanilamido-5-methyl-isoxazols |
DE1059459B (de) | 1956-09-04 | 1959-06-18 | Shionogi & Co | Verfahren zur Herstellung des therapeutisch wertvollen 3-Sulfanilamido-5-methylisoxazols |
GB897440A (en) | 1960-02-08 | 1962-05-30 | Shionogi & Co | Improvements in or relating to sulfonamides |
GB1473433A (xx) | 1975-10-09 | 1977-05-11 | Banyu Pharmaceutical Co Ltd Hi | |
DE3276313D1 (en) | 1981-09-24 | 1987-06-19 | Beecham Wuelfing Gmbh & Co Kg | Sulphonamides |
EP0194548A3 (de) | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5464853A (en) | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5514691A (en) | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
CA2005741C (en) | 1988-12-26 | 1998-06-02 | Hiroyoshi Hidaka | Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity |
US5082838A (en) | 1989-06-21 | 1992-01-21 | Takeda Chemical Industries, Ltd. | Sulfur-containing fused pyrimidine derivatives, their production and use |
EP0443983B1 (de) | 1990-02-19 | 1996-02-28 | Ciba-Geigy Ag | Acylverbindungen |
EP0523141A4 (en) | 1990-03-30 | 1993-04-21 | Merck & Co. Inc. | Substituted pyrazoles, isoxazoles and isothiazoles |
US5236928A (en) | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
TW270116B (xx) | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
JP2667294B2 (ja) | 1991-11-05 | 1997-10-27 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗剤 |
SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Kabi Pharmacia Ab | Nya substituerade salicylsyror |
US5378715A (en) | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
TW224462B (xx) | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
TW215434B (xx) | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
WO1993023404A1 (en) | 1992-05-19 | 1993-11-25 | Immunopharmaceutics, Inc. | Compounds that modulate endothelin activity |
TW287160B (xx) | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
ATE189217T1 (de) | 1993-03-19 | 2000-02-15 | Merck & Co Inc | Phenoxyphenylessigsäurederivate |
EP0626174A3 (en) | 1993-04-21 | 1996-01-03 | Takeda Chemical Industries Ltd | Method and composition for the prophylaxis and / or treatment of underactive organs. |
TW394761B (en) | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
EP0634175B1 (de) | 1993-07-15 | 2001-01-10 | F. Hoffmann-La Roche Ag | Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält |
US5965732A (en) | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
GB9504854D0 (en) | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
GB9409618D0 (en) | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
IL116916A (en) * | 1995-02-06 | 2000-09-28 | Bristol Myers Squibb Co | Substituted biphenyl sulfonamide derivatives and pharmaceutical compositions containing the same |
DE19509950A1 (de) | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
KR100359396B1 (ko) | 1995-04-04 | 2003-03-15 | 텍사스 바이오테크놀로지 코포레이션 | 엔도텔린의활성을조절하는티에닐-,푸릴-및피롤릴설폰아미드및이의유도체 |
UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
GB9512697D0 (en) | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US5580894A (en) * | 1996-01-11 | 1996-12-03 | Howard University | Isoxazolyl enaminones |
-
1997
- 1997-02-19 HU HU0002351A patent/HUP0002351A3/hu unknown
- 1997-02-19 SG SG9904601A patent/SG87053A1/en unknown
- 1997-02-19 SG SG9904589A patent/SG87051A1/en unknown
- 1997-02-19 EP EP97907841A patent/EP0904077A4/en not_active Withdrawn
- 1997-02-19 BR BR9708151A patent/BR9708151A/pt not_active IP Right Cessation
- 1997-02-19 WO PCT/US1997/002917 patent/WO1997029747A1/en not_active Application Discontinuation
- 1997-02-19 AU AU19737/97A patent/AU717230B2/en not_active Ceased
- 1997-02-19 PL PL97328571A patent/PL328571A1/xx unknown
- 1997-02-19 SG SG9904595A patent/SG87052A1/en unknown
- 1997-02-19 IL IL12454297A patent/IL124542A/xx not_active IP Right Cessation
- 1997-02-19 CZ CZ982630A patent/CZ263098A3/cs unknown
- 1997-02-19 KR KR1019980706449A patent/KR19990087063A/ko not_active Application Discontinuation
- 1997-02-19 NZ NZ330464A patent/NZ330464A/xx unknown
- 1997-02-19 JP JP52960897A patent/JP2001523218A/ja active Pending
- 1997-02-19 CN CN97192338A patent/CN1211183A/zh active Pending
-
1998
- 1998-08-19 NO NO19983784A patent/NO311430B1/no not_active IP Right Cessation
- 1998-08-27 US US09/141,402 patent/US6515136B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
US4661479A (en) * | 1982-02-19 | 1987-04-28 | Merck And Co., Inc. | Bicyclic lactams as antihypertensives |
Also Published As
Publication number | Publication date |
---|---|
NZ330464A (en) | 2000-04-28 |
KR19990087063A (ko) | 1999-12-15 |
CN1211183A (zh) | 1999-03-17 |
CZ263098A3 (cs) | 1999-05-12 |
BR9708151A (pt) | 1999-07-27 |
US6515136B1 (en) | 2003-02-04 |
EP0904077A2 (en) | 1999-03-31 |
JP2001523218A (ja) | 2001-11-20 |
NO983784D0 (no) | 1998-08-19 |
AU1973797A (en) | 1997-09-02 |
PL328571A1 (en) | 1999-02-01 |
WO1997029747A1 (en) | 1997-08-21 |
AU717230B2 (en) | 2000-03-23 |
IL124542A (en) | 2003-07-06 |
NO311430B1 (no) | 2001-11-26 |
IL124542A0 (en) | 1998-12-06 |
NO983784L (no) | 1998-08-19 |
SG87051A1 (en) | 2002-03-19 |
HUP0002351A2 (hu) | 2001-09-28 |
EP0904077A4 (en) | 1999-12-22 |
HUP0002351A3 (en) | 2001-10-29 |
SG87053A1 (en) | 2002-03-19 |
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