SG49863A1 - In vitro processing of fusion proteins - Google Patents

In vitro processing of fusion proteins

Info

Publication number
SG49863A1
SG49863A1 SG9607721A SG1996007721A SG49863A1 SG 49863 A1 SG49863 A1 SG 49863A1 SG 9607721 A SG9607721 A SG 9607721A SG 1996007721 A SG1996007721 A SG 1996007721A SG 49863 A1 SG49863 A1 SG 49863A1
Authority
SG
Singapore
Prior art keywords
protein
biologically active
amino acid
terminal amino
active protein
Prior art date
Application number
SG9607721A
Other languages
English (en)
Inventor
Jutta Dr Heim
Peter Dr Seeboth
Kenji Dr Takabayashi
Jutta Heim
Peter Seeboth
Kenji Takabayashi
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG49863A1 publication Critical patent/SG49863A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
SG9607721A 1990-07-18 1991-07-09 In vitro processing of fusion proteins SG49863A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015825A GB9015825D0 (en) 1990-07-18 1990-07-18 In vitro processing of fusion proteins

Publications (1)

Publication Number Publication Date
SG49863A1 true SG49863A1 (en) 2002-03-19

Family

ID=10679295

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9607721A SG49863A1 (en) 1990-07-18 1991-07-09 In vitro processing of fusion proteins

Country Status (19)

Country Link
EP (1) EP0467839B1 (ja)
JP (1) JP3140488B2 (ja)
AT (1) ATE141645T1 (ja)
AU (1) AU651830B2 (ja)
CA (1) CA2047119C (ja)
DE (1) DE69121489T2 (ja)
DK (1) DK0467839T3 (ja)
ES (1) ES2091897T3 (ja)
FI (1) FI106720B (ja)
GB (1) GB9015825D0 (ja)
GR (1) GR3020840T3 (ja)
HU (1) HU216104B (ja)
IE (1) IE73209B1 (ja)
NO (1) NO303132B1 (ja)
NZ (1) NZ238989A (ja)
PT (1) PT98332B (ja)
SG (1) SG49863A1 (ja)
TW (1) TW209247B (ja)
ZA (1) ZA915579B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525491A (en) * 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
WO1997023639A1 (fr) * 1995-12-22 1997-07-03 Toray Industries, Inc. Procede de production de proteines fusionnees biologiquement actives
US6800726B1 (en) 1996-11-01 2004-10-05 Pioneer Hi-Bred International, Inc. Proteins with increased levels of essential amino acids
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
GB9716790D0 (en) 1997-08-07 1997-10-15 Creative Peptides Sweden Ab Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof
AU2014225678B2 (en) 2013-03-06 2016-11-17 Glaxosmithkline Llc Host cells and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252854A1 (fr) * 1986-07-10 1988-01-13 Transgene S.A. Bloc fonctionnel d'ADN et plasmide codant pour l'hirudine, levure transformée et procédé de préparation de l'hirudine.
EP0301669A1 (en) * 1987-07-28 1989-02-01 Gist-Brocades N.V. DNA constructs containing a Kluyveromyces alpha-factor leader sequence for directing secretion of heterologous derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252854A1 (fr) * 1986-07-10 1988-01-13 Transgene S.A. Bloc fonctionnel d'ADN et plasmide codant pour l'hirudine, levure transformée et procédé de préparation de l'hirudine.
EP0301669A1 (en) * 1987-07-28 1989-02-01 Gist-Brocades N.V. DNA constructs containing a Kluyveromyces alpha-factor leader sequence for directing secretion of heterologous derivatives

Also Published As

Publication number Publication date
JPH04229188A (ja) 1992-08-18
EP0467839B1 (en) 1996-08-21
ZA915579B (en) 1992-03-25
FI106720B (fi) 2001-03-30
NZ238989A (en) 1992-09-25
NO303132B1 (no) 1998-06-02
AU651830B2 (en) 1994-08-04
HUT58369A (en) 1992-02-28
ATE141645T1 (de) 1996-09-15
HU216104B (hu) 1999-04-28
DE69121489D1 (de) 1996-09-26
CA2047119C (en) 2002-10-08
PT98332A (pt) 1992-05-29
JP3140488B2 (ja) 2001-03-05
ES2091897T3 (es) 1996-11-16
IE73209B1 (en) 1997-05-07
AU8046391A (en) 1992-01-23
DE69121489T2 (de) 1997-02-27
HU912398D0 (en) 1991-12-30
TW209247B (ja) 1993-07-11
PT98332B (pt) 1999-01-29
GR3020840T3 (en) 1996-11-30
NO912803D0 (no) 1991-07-17
EP0467839A1 (en) 1992-01-22
DK0467839T3 (da) 1996-09-16
IE912501A1 (en) 1992-01-29
GB9015825D0 (en) 1990-09-05
FI913405A (fi) 1992-01-19
NO912803L (no) 1992-01-20
FI913405A0 (fi) 1991-07-15
CA2047119A1 (en) 1992-01-19

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