SG47977A1 - C-22 stabilized rapamycin derivatives - Google Patents

C-22 stabilized rapamycin derivatives

Info

Publication number
SG47977A1
SG47977A1 SG1996005836A SG1996005836A SG47977A1 SG 47977 A1 SG47977 A1 SG 47977A1 SG 1996005836 A SG1996005836 A SG 1996005836A SG 1996005836 A SG1996005836 A SG 1996005836A SG 47977 A1 SG47977 A1 SG 47977A1
Authority
SG
Singapore
Prior art keywords
rapamycin derivatives
image
diseases
stabilized
stabilized rapamycin
Prior art date
Application number
SG1996005836A
Other languages
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of SG47977A1 publication Critical patent/SG47977A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
SG1996005836A 1993-08-10 1994-08-10 C-22 stabilized rapamycin derivatives SG47977A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/105,090 US5387680A (en) 1993-08-10 1993-08-10 C-22 ring stabilized rapamycin derivatives

Publications (1)

Publication Number Publication Date
SG47977A1 true SG47977A1 (en) 1998-04-17

Family

ID=22303982

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996005836A SG47977A1 (en) 1993-08-10 1994-08-10 C-22 stabilized rapamycin derivatives

Country Status (20)

Country Link
US (1) US5387680A (de)
EP (1) EP0713490B1 (de)
JP (1) JPH09501436A (de)
KR (1) KR100330799B1 (de)
CN (1) CN1132512A (de)
AT (1) ATE163420T1 (de)
BR (1) BR9407236A (de)
CA (1) CA2169277A1 (de)
CZ (1) CZ291205B6 (de)
DE (1) DE69408678T2 (de)
DK (1) DK0713490T3 (de)
ES (1) ES2115255T3 (de)
GR (1) GR3026586T3 (de)
HU (1) HUT74675A (de)
NZ (1) NZ271822A (de)
PL (1) PL178625B1 (de)
RU (1) RU2152946C1 (de)
SG (1) SG47977A1 (de)
UA (1) UA45318C2 (de)
WO (1) WO1995004738A1 (de)

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US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
TWI256395B (en) * 1999-09-29 2006-06-11 Wyeth Corp Regioselective synthesis of rapamycin derivatives
US6277983B1 (en) 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
DE60124285T3 (de) * 2000-09-29 2011-03-17 Cordis Corp., Miami Lakes Beschichtete medizinische geräte
WO2002066019A2 (en) * 2001-02-19 2002-08-29 Novartis Ag Cancer treatment
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MXPA04007402A (es) * 2002-02-01 2005-06-17 Ariad Gene Therapeutics Inc Compuestos que contienen fosforo y usos de los mismos.
WO2004060283A2 (en) 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US7349971B2 (en) * 2004-02-05 2008-03-25 Scenera Technologies, Llc System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7812032B2 (en) * 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
CN101583347A (zh) * 2006-11-14 2009-11-18 阿里亚德医药股份有限公司 口服制剂
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8440185B2 (en) 2006-12-26 2013-05-14 The Johns Hopkins University Compositions and methods for the treatment of immunologic disorders
AU2007339773B2 (en) 2006-12-27 2011-03-10 The Johns Hopkins University Compositions and methods for stimulating an immune response
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
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WO2010024898A2 (en) 2008-08-29 2010-03-04 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US9011853B2 (en) 2009-08-31 2015-04-21 Amplimmune, Inc. B7-H4 fusion proteins and methods of use thereof
PL2836234T3 (pl) 2012-04-12 2020-02-28 Yale University Podłoża do kontrolowanego dostarczania różnych środków farmaceutycznych
EP2934576A1 (de) 2012-12-19 2015-10-28 The Johns Hopkins University Anti-human-b7-h4-antikörper und deren verwendungen
CA2912801A1 (en) 2013-05-17 2014-11-20 Medimmune, Llc Receptors for b7-h4
CA2905229C (en) 2013-06-11 2023-10-10 Clontech Laboratories, Inc. Protein enriched microvesicles and methods of making and using the same
US10864170B2 (en) 2015-09-04 2020-12-15 Yale University Polymeric bile acid nanocompositions targeting the pancreas and colon
WO2017173453A1 (en) 2016-04-01 2017-10-05 The Brigham And Women's Hospital, Inc. Stimuli-responsive nanoparticles for biomedical applications
RU2759334C2 (ru) 2016-09-21 2021-11-12 Нексткьюр, Инк. Антитела против siglec-15 и способы их применения
IL312291A (en) 2018-05-01 2024-06-01 Revolution Medicines Inc C-26-linked rapamycin analogs as MTOR inhibitors
CR20200578A (es) * 2018-05-01 2021-02-22 Revolution Medicines Inc Análogos de rapamicina a c40, c28 y c32 como inhibidores de mtor
US20210115378A1 (en) 2018-05-09 2021-04-22 Yale University Compositions and systems for ex vivo cell modulation and methods of use thereof
AU2019265632A1 (en) 2018-05-09 2021-01-07 Yale University Particles for spatiotemporal release of agents
WO2021258042A1 (en) 2020-06-19 2021-12-23 Yale University Polymeric bile acid ester nanoparticles comprising an immunomodulator agent to induce antigen-specific tolerance

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Also Published As

Publication number Publication date
ES2115255T3 (es) 1998-06-16
US5387680A (en) 1995-02-07
DE69408678T2 (de) 1998-06-18
GR3026586T3 (en) 1998-07-31
HUT74675A (en) 1997-01-28
ATE163420T1 (de) 1998-03-15
CZ291205B6 (cs) 2003-01-15
PL312991A1 (en) 1996-05-27
CN1132512A (zh) 1996-10-02
CZ35896A3 (en) 1996-09-11
KR100330799B1 (ko) 2002-10-18
WO1995004738A1 (en) 1995-02-16
EP0713490B1 (de) 1998-02-25
NZ271822A (en) 1998-05-27
CA2169277A1 (en) 1995-02-16
HU9600298D0 (en) 1996-04-29
UA45318C2 (uk) 2002-04-15
DE69408678D1 (de) 1998-04-02
RU2152946C1 (ru) 2000-07-20
DK0713490T3 (da) 1998-05-11
PL178625B1 (pl) 2000-05-31
AU676086B2 (en) 1997-02-27
JPH09501436A (ja) 1997-02-10
BR9407236A (pt) 1996-09-24
AU7560194A (en) 1995-02-28
EP0713490A1 (de) 1996-05-29

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