EP0713490A1 - C-22 ringstabilisierte rapamycin derivate - Google Patents
C-22 ringstabilisierte rapamycin derivateInfo
- Publication number
- EP0713490A1 EP0713490A1 EP94925809A EP94925809A EP0713490A1 EP 0713490 A1 EP0713490 A1 EP 0713490A1 EP 94925809 A EP94925809 A EP 94925809A EP 94925809 A EP94925809 A EP 94925809A EP 0713490 A1 EP0713490 A1 EP 0713490A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- rapamycin derivatives
- image
- diseases
- ring stabilized
- stabilized rapamycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/105,090 US5387680A (en) | 1993-08-10 | 1993-08-10 | C-22 ring stabilized rapamycin derivatives |
US105090 | 1993-08-10 | ||
PCT/US1994/009041 WO1995004738A1 (en) | 1993-08-10 | 1994-08-10 | C-22 ring stabilized rapamycin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0713490A1 true EP0713490A1 (de) | 1996-05-29 |
EP0713490B1 EP0713490B1 (de) | 1998-02-25 |
Family
ID=22303982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94925809A Expired - Lifetime EP0713490B1 (de) | 1993-08-10 | 1994-08-10 | C-22 ringstabilisierte rapamycin derivate |
Country Status (20)
Country | Link |
---|---|
US (1) | US5387680A (de) |
EP (1) | EP0713490B1 (de) |
JP (1) | JPH09501436A (de) |
KR (1) | KR100330799B1 (de) |
CN (1) | CN1132512A (de) |
AT (1) | ATE163420T1 (de) |
BR (1) | BR9407236A (de) |
CA (1) | CA2169277A1 (de) |
CZ (1) | CZ291205B6 (de) |
DE (1) | DE69408678T2 (de) |
DK (1) | DK0713490T3 (de) |
ES (1) | ES2115255T3 (de) |
GR (1) | GR3026586T3 (de) |
HU (1) | HUT74675A (de) |
NZ (1) | NZ271822A (de) |
PL (1) | PL178625B1 (de) |
RU (1) | RU2152946C1 (de) |
SG (1) | SG47977A1 (de) |
UA (1) | UA45318C2 (de) |
WO (1) | WO1995004738A1 (de) |
Families Citing this family (56)
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US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
WO1996006847A1 (en) * | 1994-08-31 | 1996-03-07 | Pfizer Inc. | Process for preparing demethylrapamycins |
US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US6187757B1 (en) * | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
ES2187660T3 (es) * | 1995-06-09 | 2003-06-16 | Novartis Ag | Derivados de rapamicina. |
US6984635B1 (en) | 1998-02-13 | 2006-01-10 | Board Of Trustees Of The Leland Stanford Jr. University | Dimerizing agents, their production and use |
US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
EP1212331B1 (de) * | 1999-08-24 | 2004-04-21 | Ariad Gene Therapeutics, Inc. | 28-epirapaloge |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
TWI256395B (en) * | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
ES2275737T3 (es) * | 2000-09-29 | 2007-06-16 | Cordis Corporation | Dispositivos medicos revestidos. |
CN104116738A (zh) * | 2001-02-19 | 2014-10-29 | 诺华股份有限公司 | 癌症的治疗 |
US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
EA008379B1 (ru) * | 2002-02-01 | 2007-04-27 | Ариад Джин Терапьютикс, Инк. | Фосфорсодержащие соединения и их применения |
AU2003293529A1 (en) | 2002-12-16 | 2004-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
DE60331367D1 (de) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
US7349971B2 (en) * | 2004-02-05 | 2008-03-25 | Scenera Technologies, Llc | System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
US7812032B2 (en) * | 2006-07-25 | 2010-10-12 | Abbott Laboratories | Crystalline forms of rapamycin analogs |
US20080161335A1 (en) * | 2006-11-14 | 2008-07-03 | Vladyka Ronald S | Oral formulations |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
WO2008083169A2 (en) | 2006-12-26 | 2008-07-10 | The Johns Hopkins University | Compositions and methods for the treatment of immunologic disorders |
US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
CA2673752A1 (en) | 2006-12-27 | 2008-07-10 | The Johns Hopkins University | Compositions and methods for stimulating an immune response |
US8921642B2 (en) | 2008-01-11 | 2014-12-30 | Massachusetts Eye And Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
AU2010286361A1 (en) | 2009-08-31 | 2012-03-15 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
PL2836234T3 (pl) | 2012-04-12 | 2020-02-28 | Yale University | Podłoża do kontrolowanego dostarczania różnych środków farmaceutycznych |
JP2016505843A (ja) | 2012-12-19 | 2016-02-25 | アンプリミューン, インコーポレイテッド | B7−h4特異的抗体、並びにその組成物及び使用方法 |
US20160146806A1 (en) | 2013-05-17 | 2016-05-26 | Amplimmune, Inc. | Receptors for b7-h4 |
EP3008192B1 (de) | 2013-06-11 | 2019-07-17 | Takara Bio USA, Inc. | Proteinangereicherte mikrovesikel und verfahren zur herstellung und verwendung davon |
PL3347794T3 (pl) | 2015-09-04 | 2024-01-03 | Yale University | Polimerowe nanokompozycje kwasów żółciowych ukierunkowane do trzustki i okrężnicy |
WO2017173453A1 (en) | 2016-04-01 | 2017-10-05 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
CA3033571A1 (en) | 2016-09-21 | 2018-03-29 | Nextcure, Inc. | Antibodies for siglec-15 and methods of use thereof |
BR112020022201A2 (pt) * | 2018-05-01 | 2021-02-02 | Revolution Medicines, Inc. | análogos de rapamicina ligada a c40, c28, e c-32 como inibidores de mtor |
WO2019212991A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
WO2019217661A1 (en) | 2018-05-09 | 2019-11-14 | Yale University | Compositions and systems for ex vivo cell modulation and methods of use thereof |
AU2019265632A1 (en) | 2018-05-09 | 2021-01-07 | Yale University | Particles for spatiotemporal release of agents |
WO2021258042A1 (en) | 2020-06-19 | 2021-12-23 | Yale University | Polymeric bile acid ester nanoparticles comprising an immunomodulator agent to induce antigen-specific tolerance |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
US4316885A (en) * | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5130307A (en) * | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
US5080899A (en) * | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
IL101353A0 (en) * | 1991-04-03 | 1992-11-15 | American Home Prod | Pharmaceutical compositions for treating diabetes |
US5100883A (en) * | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5118678A (en) * | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5194447A (en) * | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
US5138051A (en) * | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
WO1992021341A1 (en) * | 1991-05-31 | 1992-12-10 | Pfizer Inc. | Use of rapamycin prodrugs as immunosuppressant agents |
ATE135583T1 (de) * | 1991-06-18 | 1996-04-15 | American Home Prod | Verwendung von rapamycin zur behandlung von t- zellen lymphom/leukämie bei erwachsenen |
US5169851A (en) * | 1991-08-07 | 1992-12-08 | American Home Products Corporation | Rapamycin analog as immunosuppressants and antifungals |
US5162333A (en) * | 1991-09-11 | 1992-11-10 | American Home Products Corporation | Aminodiesters of rapamycin |
US5151413A (en) * | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
-
1993
- 1993-08-10 US US08/105,090 patent/US5387680A/en not_active Expired - Lifetime
-
1994
- 1994-08-10 DK DK94925809.9T patent/DK0713490T3/da active
- 1994-08-10 AT AT94925809T patent/ATE163420T1/de not_active IP Right Cessation
- 1994-08-10 RU RU96107113/04A patent/RU2152946C1/ru not_active IP Right Cessation
- 1994-08-10 BR BR9407236A patent/BR9407236A/pt not_active Application Discontinuation
- 1994-08-10 KR KR1019960700698A patent/KR100330799B1/ko not_active IP Right Cessation
- 1994-08-10 EP EP94925809A patent/EP0713490B1/de not_active Expired - Lifetime
- 1994-08-10 PL PL94312991A patent/PL178625B1/pl unknown
- 1994-08-10 ES ES94925809T patent/ES2115255T3/es not_active Expired - Lifetime
- 1994-08-10 UA UA96020492A patent/UA45318C2/uk unknown
- 1994-08-10 CN CN94193603A patent/CN1132512A/zh active Pending
- 1994-08-10 DE DE69408678T patent/DE69408678T2/de not_active Expired - Fee Related
- 1994-08-10 JP JP7506598A patent/JPH09501436A/ja not_active Ceased
- 1994-08-10 CZ CZ1996358A patent/CZ291205B6/cs not_active IP Right Cessation
- 1994-08-10 NZ NZ271822A patent/NZ271822A/en unknown
- 1994-08-10 WO PCT/US1994/009041 patent/WO1995004738A1/en active IP Right Grant
- 1994-08-10 CA CA002169277A patent/CA2169277A1/en not_active Abandoned
- 1994-08-10 HU HU9600298A patent/HUT74675A/hu unknown
- 1994-08-10 SG SG1996005836A patent/SG47977A1/en unknown
-
1998
- 1998-04-10 GR GR980400775T patent/GR3026586T3/el unknown
Non-Patent Citations (1)
Title |
---|
See references of WO9504738A1 * |
Also Published As
Publication number | Publication date |
---|---|
US5387680A (en) | 1995-02-07 |
KR100330799B1 (ko) | 2002-10-18 |
EP0713490B1 (de) | 1998-02-25 |
CZ35896A3 (en) | 1996-09-11 |
HUT74675A (en) | 1997-01-28 |
WO1995004738A1 (en) | 1995-02-16 |
NZ271822A (en) | 1998-05-27 |
DE69408678D1 (de) | 1998-04-02 |
CZ291205B6 (cs) | 2003-01-15 |
DE69408678T2 (de) | 1998-06-18 |
PL312991A1 (en) | 1996-05-27 |
ES2115255T3 (es) | 1998-06-16 |
GR3026586T3 (en) | 1998-07-31 |
CA2169277A1 (en) | 1995-02-16 |
AU676086B2 (en) | 1997-02-27 |
HU9600298D0 (en) | 1996-04-29 |
UA45318C2 (uk) | 2002-04-15 |
BR9407236A (pt) | 1996-09-24 |
ATE163420T1 (de) | 1998-03-15 |
DK0713490T3 (da) | 1998-05-11 |
AU7560194A (en) | 1995-02-28 |
JPH09501436A (ja) | 1997-02-10 |
PL178625B1 (pl) | 2000-05-31 |
RU2152946C1 (ru) | 2000-07-20 |
SG47977A1 (en) | 1998-04-17 |
CN1132512A (zh) | 1996-10-02 |
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