SG26593G - Low affinity mutant hemoglobins and wholly artificial hemoglobins as blood substitutes - Google Patents

Low affinity mutant hemoglobins and wholly artificial hemoglobins as blood substitutes

Info

Publication number
SG26593G
SG26593G SG265/93A SG26593A SG26593G SG 26593 G SG26593 G SG 26593G SG 265/93 A SG265/93 A SG 265/93A SG 26593 A SG26593 A SG 26593A SG 26593 G SG26593 G SG 26593G
Authority
SG
Singapore
Prior art keywords
hemoglobins
blood substitutes
low affinity
wholly artificial
mutant
Prior art date
Application number
SG265/93A
Other languages
English (en)
Original Assignee
Somatogenetics Int
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10617467&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG26593(G) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Somatogenetics Int, Medical Res Council filed Critical Somatogenetics Int
Publication of SG26593G publication Critical patent/SG26593G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG265/93A 1987-05-16 1993-03-11 Low affinity mutant hemoglobins and wholly artificial hemoglobins as blood substitutes SG26593G (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878711614A GB8711614D0 (en) 1987-05-16 1987-05-16 Proteins
PCT/US1988/001534 WO1988009179A1 (fr) 1987-05-16 1988-05-13 Succedanes de sang

Publications (1)

Publication Number Publication Date
SG26593G true SG26593G (en) 1993-05-21

Family

ID=10617467

Family Applications (1)

Application Number Title Priority Date Filing Date
SG265/93A SG26593G (en) 1987-05-16 1993-03-11 Low affinity mutant hemoglobins and wholly artificial hemoglobins as blood substitutes

Country Status (11)

Country Link
US (1) US5028588A (fr)
EP (1) EP0358708B1 (fr)
JP (1) JP3034529B2 (fr)
AT (1) ATE110276T1 (fr)
AU (1) AU614525B2 (fr)
CA (1) CA1341286C (fr)
DE (1) DE3851225T2 (fr)
GB (2) GB8711614D0 (fr)
HU (1) HU211989A9 (fr)
SG (1) SG26593G (fr)
WO (1) WO1988009179A1 (fr)

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US6828125B1 (en) * 1989-05-10 2004-12-07 Baxter Biotech Technology, S.A.R.L. DNA encoding fused di-alpha globins and use thereof
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EP0402300B1 (fr) * 1989-05-10 1996-09-11 Somatogen Inc. Production d'hémoglobine et de ses analogues par des bactéries ou des levures
US5173426A (en) * 1989-10-06 1992-12-22 Yale University DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
CA2025180A1 (fr) * 1989-10-12 1991-04-13 William G. Weisburg Sondes a l'acide nucleique et methodes pour la detection de levures pathogenes de candida
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ATE206760T1 (de) * 1990-12-20 2001-10-15 Univ Alabama Res Found Transgenes, vernetztes hämoglobin
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WO1993008831A1 (fr) * 1991-10-30 1993-05-13 Strohtech, Inc. Expression d'hemoglobine recombinee et de variants d'hemoglobine recombines dans des levures
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IS4198A (is) * 1993-08-13 1995-02-14 Somatogen, Inc Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
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US6812207B1 (en) 1995-10-23 2004-11-02 William Marsh Rice University Hemoglobin mutants that reduce heme loss
US6114505A (en) * 1995-10-23 2000-09-05 William Marsh Rice University Hemoglobin mutants that reduce heme loss
JP2000502058A (ja) * 1995-11-30 2000-02-22 ソマトジェン，インコーポレイテッド ヘモグロビン架橋の際の機能性制御のための方法
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US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
AU4652797A (en) 1996-09-27 1998-04-17 Board Of Trustees Of The University Of Illinois, The Oxygen-binding heme proteins incorporating circularly-permuted globins
DE69831248T2 (de) * 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
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EP1950298A3 (fr) 1997-05-02 2008-12-24 Baxter Biotech Technology S.A.R.L. Mutants d'hémoglobine dotés d'une expression soluble accrue et/ou d'une évacuation réduite de l'oxyde nitrique
US5900402A (en) * 1997-05-29 1999-05-04 Enzon, Inc. Method of reducing side effects associated with administration of oxygen-carrying proteins
US6485450B1 (en) 1998-03-16 2002-11-26 Life Science Holdings, Inc. Brain resuscitation apparatus and method
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
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US6894150B1 (en) * 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
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EP1469811A4 (fr) * 2002-01-11 2006-01-04 Sangart Inc Procedes et compositions pour transport d'oxygene comprenant une hemoglobine modifiee dans le plasma
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
AU2003202941A1 (en) * 2002-01-11 2003-07-30 Sangart, Inc. Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution
SI1465643T1 (sl) 2002-01-11 2008-06-30 Sangart Inc Postopki in sestavki za transport kisika z visokoafiniteto za kisik
US20050287125A1 (en) * 2002-05-22 2005-12-29 Medtronic, Inc. Cell delivery fluid for prevention of cell settling in delivery system
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
CN100431602C (zh) * 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
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EP3563859B1 (fr) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Exosomes dérivés de cardiosphères pour la régénération de tissus
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JP6878274B2 (ja) 2014-10-03 2021-05-26 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム
WO2017123662A1 (fr) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cellules dérivées de cardiosphères et exosomes sécrétés par ces cellules dans le traitement d'une insuffisance cardiaque à fraction d'éjection préservée
WO2017210652A1 (fr) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Exosomes dérivés de cdc pour le traitement des tachyarythmies ventriculaires
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
CN109528749B (zh) * 2017-09-22 2023-04-28 上海交通大学医学院附属瑞金医院 长链非编码rna-h19在制备治疗垂体瘤药物中的用途
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
WO2020236952A1 (fr) * 2019-05-20 2020-11-26 Ohio State Innovation Foundation Complexes d'apohémoglobine-haptoglobine et leurs procédés d'utilisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
ES2032802T5 (es) * 1986-11-10 2004-01-16 Biopure Corporation Sucedaneo de sangre semisintetico extrapuro.

Also Published As

Publication number Publication date
ATE110276T1 (de) 1994-09-15
GB8925769D0 (en) 1990-08-01
HU211989A9 (en) 1996-01-29
EP0358708B1 (fr) 1994-08-24
GB2234749A (en) 1991-02-13
JP3034529B2 (ja) 2000-04-17
AU1796788A (en) 1988-12-21
AU614525B2 (en) 1991-09-05
GB8711614D0 (en) 1987-06-24
CA1341286C (fr) 2001-08-28
JPH02503509A (ja) 1990-10-25
GB2234749B (en) 1992-01-08
EP0358708A1 (fr) 1990-03-21
DE3851225T2 (de) 1995-04-06
US5028588A (en) 1991-07-02
DE3851225D1 (de) 1994-09-29
EP0358708A4 (fr) 1990-04-10
WO1988009179A1 (fr) 1988-12-01

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