SG193380A1 - 6-substituted estradiol derivatives for use in remyelination of nerve axons - Google Patents
6-substituted estradiol derivatives for use in remyelination of nerve axons Download PDFInfo
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- SG193380A1 SG193380A1 SG2013067962A SG2013067962A SG193380A1 SG 193380 A1 SG193380 A1 SG 193380A1 SG 2013067962 A SG2013067962 A SG 2013067962A SG 2013067962 A SG2013067962 A SG 2013067962A SG 193380 A1 SG193380 A1 SG 193380A1
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- Prior art keywords
- methyl
- cyclopenta
- decahydro
- phenanthrene
- diol
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- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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Landscapes
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| US201161454873P | 2011-03-21 | 2011-03-21 | |
| PCT/US2012/029973 WO2012129324A2 (en) | 2011-03-21 | 2012-03-21 | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
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| EP2909224B1 (en) * | 2012-10-22 | 2020-03-18 | Intas Pharmaceuticals Limited | An improved process for the preparation of fulvestrant |
| WO2015143201A2 (en) * | 2014-03-19 | 2015-09-24 | Endece Llc | 6-substituted estradiol derivatives for the treatment of alzheimer's disease |
| US20210024568A1 (en) * | 2019-07-23 | 2021-01-28 | Endece Llc | Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states |
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| US4136160A (en) * | 1977-08-17 | 1979-01-23 | Cohen Steven R | Specific assay for active demyelinization |
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| JPH01193529A (ja) | 1988-01-27 | 1989-08-03 | Yoshitsugu Takano | 液体循環装置 |
| US8168621B2 (en) * | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
| US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| CN101312743A (zh) * | 2005-09-30 | 2008-11-26 | 安德西有限公司 | (s)-6-甲基氧杂烷基依西美坦化合物及相关使用方法 |
| JP5290189B2 (ja) * | 2006-11-30 | 2013-09-18 | エンディース エルエルシー | ６−アルコキシアルキルエストラジオール誘導体およびその使用 |
| MX343059B (es) | 2010-09-14 | 2016-10-24 | Endece Llc | Derivados de desmetil-estradiol sustituido en 6 como agonistas de er-beta selectivos. |
| CN106420767A (zh) * | 2011-03-21 | 2017-02-22 | 安德斯有限责任公司 | 用于神经轴突的髓鞘再生的6‑取代的雌二醇衍生物 |
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| US9364486B2 (en) | 2016-06-14 |
| KR102080151B1 (ko) | 2020-02-21 |
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| JP6174563B2 (ja) | 2017-08-02 |
| CN103501790A (zh) | 2014-01-08 |
| AU2012230974A1 (en) | 2013-09-26 |
| US20120245131A1 (en) | 2012-09-27 |
| EP2688570B1 (en) | 2015-11-18 |
| MX2013010650A (es) | 2013-10-07 |
| EP2688570A4 (en) | 2014-09-10 |
| EP2688570A2 (en) | 2014-01-29 |
| CA2830515A1 (en) | 2012-09-27 |
| CA2830515C (en) | 2015-09-15 |
| CN106420767A (zh) | 2017-02-22 |
| ES2561536T3 (es) | 2016-02-26 |
| CN103501790B (zh) | 2016-08-17 |
| WO2012129324A9 (en) | 2012-11-15 |
| US9636348B2 (en) | 2017-05-02 |
| BR112013024168A2 (pt) | 2017-07-11 |
| WO2012129324A2 (en) | 2012-09-27 |
| US20160279144A1 (en) | 2016-09-29 |
| DK2688570T3 (en) | 2015-12-21 |
| KR20140074253A (ko) | 2014-06-17 |
| MX354409B (es) | 2018-03-05 |
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