MX354409B - Derivados de estradiol sustituidos en 6 para uso en remielinización de axones nerviosos. - Google Patents
Derivados de estradiol sustituidos en 6 para uso en remielinización de axones nerviosos.Info
- Publication number
- MX354409B MX354409B MX2013010650A MX2013010650A MX354409B MX 354409 B MX354409 B MX 354409B MX 2013010650 A MX2013010650 A MX 2013010650A MX 2013010650 A MX2013010650 A MX 2013010650A MX 354409 B MX354409 B MX 354409B
- Authority
- MX
- Mexico
- Prior art keywords
- remyelination
- nerve axons
- estradiol derivatives
- substituted estradiol
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Abstract
Se revela un método para remielinizar axones con un compuesto estradiol sustituido en 6 de la fórmula (ver Fórmula) El método se puede usar para tratar una variedad de enfermedades de desmielinización.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161454873P | 2011-03-21 | 2011-03-21 | |
PCT/US2012/029973 WO2012129324A2 (en) | 2011-03-21 | 2012-03-21 | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013010650A MX2013010650A (es) | 2013-10-07 |
MX354409B true MX354409B (es) | 2018-03-05 |
Family
ID=46877849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013010650A MX354409B (es) | 2011-03-21 | 2012-03-21 | Derivados de estradiol sustituidos en 6 para uso en remielinización de axones nerviosos. |
Country Status (13)
Country | Link |
---|---|
US (2) | US9364486B2 (es) |
EP (1) | EP2688570B1 (es) |
JP (1) | JP6174563B2 (es) |
KR (1) | KR102080151B1 (es) |
CN (2) | CN106420767A (es) |
AU (1) | AU2012230974B2 (es) |
BR (1) | BR112013024168A2 (es) |
CA (1) | CA2830515C (es) |
DK (1) | DK2688570T3 (es) |
ES (1) | ES2561536T3 (es) |
MX (1) | MX354409B (es) |
SG (1) | SG193380A1 (es) |
WO (1) | WO2012129324A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG193380A1 (en) * | 2011-03-21 | 2013-10-30 | Endece Llc | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
US9315540B2 (en) | 2012-10-22 | 2016-04-19 | Intas Pharmaceuticals Ltd. | Process for the preparation of fulvestrant |
JP2017512769A (ja) * | 2014-03-19 | 2017-05-25 | エンディース エルエルシーEndece,Llc | アルツハイマー病の治療のための6−置換エストラジオール誘導体 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4136160A (en) * | 1977-08-17 | 1979-01-23 | Cohen Steven R | Specific assay for active demyelinization |
JPH0193529A (ja) * | 1987-10-05 | 1989-04-12 | Mect Corp | シアロシルコレステロールの脱髄性疾患治療剤 |
JPH01193529A (ja) | 1988-01-27 | 1989-08-03 | Yoshitsugu Takano | 液体循環装置 |
EP1931385B1 (en) * | 2005-09-30 | 2018-02-28 | Endece, LLC | (s)-6-methyloxaalkyl exemestane compounds and related methods of use |
US8168621B2 (en) * | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
ES2604079T3 (es) * | 2006-11-30 | 2017-03-02 | Endece, Llc | Derivados de 6-alcoxialquil estradiol y métodos de uso |
AU2011302065B2 (en) | 2010-09-14 | 2016-12-01 | Endece, Llc | 6-substituted demethyl-estradiol derivatives as ER-beta agonists |
SG193380A1 (en) * | 2011-03-21 | 2013-10-30 | Endece Llc | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
-
2012
- 2012-03-21 SG SG2013067962A patent/SG193380A1/en unknown
- 2012-03-21 DK DK12761491.5T patent/DK2688570T3/en active
- 2012-03-21 EP EP12761491.5A patent/EP2688570B1/en not_active Not-in-force
- 2012-03-21 KR KR1020137027657A patent/KR102080151B1/ko active IP Right Grant
- 2012-03-21 CN CN201610455383.0A patent/CN106420767A/zh active Pending
- 2012-03-21 MX MX2013010650A patent/MX354409B/es active IP Right Grant
- 2012-03-21 BR BR112013024168A patent/BR112013024168A2/pt not_active IP Right Cessation
- 2012-03-21 CN CN201280014512.2A patent/CN103501790B/zh not_active Expired - Fee Related
- 2012-03-21 JP JP2014501213A patent/JP6174563B2/ja not_active Expired - Fee Related
- 2012-03-21 US US13/426,364 patent/US9364486B2/en active Active
- 2012-03-21 ES ES12761491.5T patent/ES2561536T3/es active Active
- 2012-03-21 AU AU2012230974A patent/AU2012230974B2/en not_active Ceased
- 2012-03-21 WO PCT/US2012/029973 patent/WO2012129324A2/en active Application Filing
- 2012-03-21 CA CA2830515A patent/CA2830515C/en not_active Expired - Fee Related
-
2016
- 2016-06-10 US US15/179,349 patent/US9636348B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2830515A1 (en) | 2012-09-27 |
CA2830515C (en) | 2015-09-15 |
EP2688570B1 (en) | 2015-11-18 |
CN103501790A (zh) | 2014-01-08 |
WO2012129324A9 (en) | 2012-11-15 |
AU2012230974A1 (en) | 2013-09-26 |
JP6174563B2 (ja) | 2017-08-02 |
JP2014508807A (ja) | 2014-04-10 |
WO2012129324A2 (en) | 2012-09-27 |
ES2561536T3 (es) | 2016-02-26 |
US20160279144A1 (en) | 2016-09-29 |
EP2688570A2 (en) | 2014-01-29 |
SG193380A1 (en) | 2013-10-30 |
CN106420767A (zh) | 2017-02-22 |
AU2012230974B2 (en) | 2016-05-12 |
CN103501790B (zh) | 2016-08-17 |
MX2013010650A (es) | 2013-10-07 |
US9636348B2 (en) | 2017-05-02 |
KR102080151B1 (ko) | 2020-02-21 |
US20120245131A1 (en) | 2012-09-27 |
KR20140074253A (ko) | 2014-06-17 |
DK2688570T3 (en) | 2015-12-21 |
EP2688570A4 (en) | 2014-09-10 |
BR112013024168A2 (pt) | 2017-07-11 |
US9364486B2 (en) | 2016-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA030383B9 (ru) | Бициклически замещённые урацилы, способы их получения, их применение, лекарственное средство и способ лечения с их применением | |
MX348470B (es) | Pirimidinas anilladas sustituidas y uso de las mismas. | |
MX361653B (es) | Procedimiento para la preparación de derivados del ácido biliar. | |
JO3091B1 (ar) | مشتقات حمض 3- فنيل بروبيونيك متفرعة واستخداماتها | |
MX2015007916A (es) | Peri-carbinoles. | |
TN2014000122A1 (en) | 1 - arylcarbonyl - 4 - oxy - piperidine compounds useful for the treatment of neurodegenerative diseases | |
MX2020005533A (es) | Nuevo proceso para la preparacion de derivados de piperidinilo-azetidina e intermediarios de los mismos, en donde dichos compuestos son inhibidores de mek. | |
PH12014501258A1 (en) | Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof | |
WO2011123946A8 (en) | Kinase inhibitors and method of treating cancer with same | |
IN2015DN01151A (es) | ||
MX2017000330A (es) | Derivado de piridona que tiene un grupo tetrahidropiranilmetilo. | |
MX2014011354A (es) | Compuestos de piridopirimidina sustituida y su uso como inhibidores de tirosina cinasa 3 similar a fms. | |
NZ711343A (en) | Sodium salt of (2s, 5r)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1 ] octane-2-carboxylic acid and its preparation | |
MX340816B (es) | Compuestos que inhiben el glioblastoma y su uso. | |
IN2014MN01469A (es) | ||
BR112014014762A8 (pt) | método para preparação de cisteína ou de um derivado desta usando uma nova o-fosferina sulfidrilase | |
MX354409B (es) | Derivados de estradiol sustituidos en 6 para uso en remielinización de axones nerviosos. | |
GB201107985D0 (en) | Process | |
NZ707773A (en) | Methods of treating liver diseases | |
MX2013006658A (es) | Métodos para producir y usar brasinoesteroides para promover el crecimiento, la reparación y mantenimiento del músculo esquelético y la piel. | |
TN2015000095A1 (en) | Macrolide derivatives, preparation thereof and therapeutic use thereof | |
MX348841B (es) | Derivados de pirimidooxazocina como inhibidores de mtor. | |
IN2014DN07498A (es) | ||
UA80063U (ru) | Способ борьбы c колорадским жуком на посадках картофеля | |
IN2012DE00262A (es) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |