SG189942A1 - In vivo polynucleotide delivery conjugates having enzyme sensitive linkages - Google Patents
In vivo polynucleotide delivery conjugates having enzyme sensitive linkages Download PDFInfo
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- SG189942A1 SG189942A1 SG2013029830A SG2013029830A SG189942A1 SG 189942 A1 SG189942 A1 SG 189942A1 SG 2013029830 A SG2013029830 A SG 2013029830A SG 2013029830 A SG2013029830 A SG 2013029830A SG 189942 A1 SG189942 A1 SG 189942A1
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- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07—ORGANIC CHEMISTRY
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07K5/06—Dipeptides
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- C07K5/06113—Asp- or Asn-amino acid
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/10—Vectors comprising a non-peptidic targeting moiety
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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US201061427936P | 2010-12-29 | 2010-12-29 | |
US13/336,028 US8426554B2 (en) | 2010-12-29 | 2011-12-23 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
PCT/US2011/067588 WO2012092373A2 (en) | 2010-12-29 | 2011-12-28 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
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SG189942A1 true SG189942A1 (en) | 2013-06-28 |
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SG2013029830A SG189942A1 (en) | 2010-12-29 | 2011-12-28 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
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JP (1) | JP5941926B2 (ja) |
KR (1) | KR20130136494A (ja) |
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AU (1) | AU2011352204B2 (ja) |
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SG (1) | SG189942A1 (ja) |
WO (1) | WO2012092373A2 (ja) |
ZA (1) | ZA201302896B (ja) |
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AU2013346767B2 (en) | 2012-11-15 | 2019-04-11 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
EP3030244B1 (en) * | 2013-08-07 | 2021-04-21 | Arrowhead Pharmaceuticals, Inc. | Polyconjugates for delivery of rnai triggers to tumor cells in vivo |
JOP20210043A1 (ar) | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
PL3630742T3 (pl) | 2017-05-24 | 2024-04-08 | Ramot At Tel-Aviv University Ltd. | Sondy chemiluminescencyjne do obrazowania/wykrywania proteaz |
CA3083526A1 (en) | 2017-12-06 | 2019-06-13 | Andrew John Geall | Compositions and methods of treating muscle atrophy and myotonic dystrophy |
AU2019416109A1 (en) * | 2018-12-28 | 2021-07-22 | Sirnaomics, Inc. | Targeted delivery of therapeutic molecules |
JP2023537798A (ja) | 2020-03-19 | 2023-09-06 | アビディティー バイオサイエンシーズ,インク. | 顔面肩甲上腕型筋ジストロフィーを処置するための組成物および方法 |
JP2024504475A (ja) * | 2021-01-28 | 2024-01-31 | 南京▲樺▼冠生物技▲術▼有限公司 | 複合体およびその使用 |
WO2022270607A1 (ja) * | 2021-06-24 | 2022-12-29 | 株式会社 東北テクノアーチ | 蛍光プローブ |
KR20230016999A (ko) * | 2021-07-27 | 2023-02-03 | 안동대학교 산학협력단 | 등검은말벌 추출물을 유효성분으로 함유하는 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품 |
CN113621003B (zh) * | 2021-09-10 | 2023-02-03 | 国科温州研究院(温州生物材料与工程研究所) | 一种制备有机分子共价修饰的功能化核酸材料的方法及其应用 |
AU2022345098A1 (en) | 2021-09-16 | 2024-04-04 | Avidity Biosciences, Inc. | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
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US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
AU3366901A (en) * | 1999-12-30 | 2001-07-16 | Novartis Ag | Novel colloid synthetic vectors for gene therapy |
HUP0300024A2 (en) * | 2000-02-24 | 2003-05-28 | Genentech Inc | Caspase activated prodrugs therapy |
EP1243276A1 (en) * | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
US7091186B2 (en) * | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
US7541330B2 (en) * | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
WO2007059404A2 (en) * | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
RU2430740C2 (ru) * | 2006-08-18 | 2011-10-10 | Ф.Хоффманн-Ля Рош Аг | Поликонъюгаты для введения in vivo полинуклеотидов |
WO2008022309A2 (en) * | 2006-08-18 | 2008-02-21 | F. Hoffmann-La Roche Ag | Polyconjugates for in vivo delivery of polynucleotides |
CA2916671C (en) * | 2007-01-17 | 2018-01-09 | Immunomedics, Inc. | Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites |
TW201004647A (en) * | 2008-05-20 | 2010-02-01 | Sigma Tau Ind Farmaceuti | Novel dual targeting antitumoural conjugates |
US8501930B2 (en) * | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
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2011
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2015
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ZA201302896B (en) | 2014-07-25 |
NZ611656A (en) | 2014-10-31 |
JP2014505685A (ja) | 2014-03-06 |
WO2012092373A3 (en) | 2013-10-24 |
PE20140198A1 (es) | 2014-02-21 |
CN103491982A (zh) | 2014-01-01 |
KR20130136494A (ko) | 2013-12-12 |
MX347298B (es) | 2017-04-21 |
AU2011352204A1 (en) | 2013-05-02 |
CL2015003580A1 (es) | 2016-07-15 |
CA2816041A1 (en) | 2012-07-05 |
CL2013001876A1 (es) | 2014-04-11 |
RU2619453C2 (ru) | 2017-05-16 |
WO2012092373A2 (en) | 2012-07-05 |
BR112013014115A2 (pt) | 2019-09-24 |
MX341118B (es) | 2016-08-09 |
JP5941926B2 (ja) | 2016-06-29 |
EP2658579A2 (en) | 2013-11-06 |
MX2013007316A (es) | 2013-07-29 |
CN103491982B (zh) | 2017-09-12 |
RU2013117286A (ru) | 2015-03-10 |
EP2658579A4 (en) | 2015-07-22 |
AU2011352204B2 (en) | 2015-05-21 |
CA2816041C (en) | 2019-01-08 |
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