SG186061A1 - Composition for skin external application and functional food containing rose placenta tissue culture or extract thereof - Google Patents
Composition for skin external application and functional food containing rose placenta tissue culture or extract thereof Download PDFInfo
- Publication number
- SG186061A1 SG186061A1 SG2012084125A SG2012084125A SG186061A1 SG 186061 A1 SG186061 A1 SG 186061A1 SG 2012084125 A SG2012084125 A SG 2012084125A SG 2012084125 A SG2012084125 A SG 2012084125A SG 186061 A1 SG186061 A1 SG 186061A1
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- Singapore
- Prior art keywords
- skin
- extract
- tissue culture
- placenta tissue
- functional food
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
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- Natural Medicines & Medicinal Plants (AREA)
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
AbstractThe present invention relates to a skin improvement composition for skin external application containing a rose placenta tissue culture or extract thereof. and a functional food, and more particularl, to a skin improvement composition for skin external application5 containing, a rose placenta tissue culture extract as an active ingredient, and a functional food. The skin improvement composition for skin external application containing a rose placenta tissue culture or extract thereof, and a functional food according to the present invention have skin regeneration and wrinkle betterment effect by activating skin cells via skin cell growth or proliferation, and contain physiological active substances to exhibit10 excellent antioxidant effect.
Description
eee (AURORA
CL *150150%
COMPOSITION FOR SKIN EXTERNAL APPLICATION AND FUNCTIONAL
FOOD CONTAINING ROSE PLACENTA TISSUE CULTURE OR EXTRACT
: THEREOF 5 Technical Field :
The present invention relates to a composition for skin external application containing a rose placenta tissue culture or extract thereof, and a functional food containing the same.
Approximately 300,000 species of plants are known worldwide, and it is being discovered that active ingredients of various physiological activities are included in plants.
Such active ingredients are secondary metabolites additionally produced from regular - metabolic process of cells and are accumulated within special intracellular locations, and level of interest is being increased by the fact that the components are substances advantageous for physiological activity or self-defense from animals or microorganisms, when seen from biochemical or ecological perspective. The secondary metabolites manufactured by plants include alkaloids, flavonoids, carotenoids, glycosides, terpenoids, etc Among these secondary metabolic products, there are many compounds that show moisturizing, skin soothing and astringent effect, UV proof, whitening, abrade, skin aging prevention, antioxidation, skin wrinkle betterment, antibiotics, anti-inflammation, antitumor, etc. :
After separating placenta, a place where ovules are attached within ovaries, from plants, physiological active substances, which are secondary metabolites, are being produced via in vitro culture, a plant tissue cultivating technology that cultures in sterile 1 TT eee
URI oo S*GOOOMWF
Loo culture medium with nutrients included. If done by plant tissue culture, commercial production of secondary metabolites that show exceptional physiological activity effects is possible by overcoming various restrictive conditions, such as limitations in growth of plants under influence of climate, season and location, different productivities for each part of plant body, and overly low concentration within plants for direct extraction, by developing plant cell cultivating system, since technology of mass-producing useful substances via tissue culture -from organs, tissues and cells of plants as factories is well developed.
Meanwhile, as environmental pollution is becoming worse as industries develop and level of interest in skin aging prevention and whitening, noticeable amount of effort is being invested in developing products for UV proof, skin soothing and astringent effect, antioxidation and skin wrinkle betterment, and especially, production of cosmetics using placenta extract is being attempted, but animal placenta extracts may bring Bovine
Spongiform Encephalopathy from cows, and pathogenicity and allergy such as cholera are concerned for pigs, and if extracted directly from mammals‘ placenta, including humans, and used for cosmetics material, large quantity of foreign substances that are not involved in skin care may be included depending on the extract method, and immunological rejection response may be caused if there is any damage in skin, and especially, in case of human placenta, selling cosmetics with human placenta extract is systemically inhibited due to ethical problems. On the contrary, development of composition for skin external application or functional foods using plant placenta extract is currently inadequate.
While attempting on manufacturing a composition for skin external application or foods that have skin improvement effect, the inventors have completed the present invention by identifying the fact that rose placenta tissue culture or extract thereof activates growth and proliferation of skin cells and have antioxidant function and wrinkle betterment effect from separating placenta tissues of rose and cultivating it through plant tissue : © culture.
Therefore, an object of the present invention is to provide a rose placenta tissue culture or an extract thereof that activates growth and proliferation of skin cells, has antioxidant function and wrinkle betterment effect, and promotes immune disease betterment function and metabolism activity under expression of various cytokines.
Another object of the present invention is to provide a skin improvement composition for skin external application containing a rose placenta tissue culture or an extract thereof as an active ingredient.
A further object of the present invention is to provide a functional food containing the rose placenta tissue culture or extract thereof as an active ingredient.
Still another object of the present invention is to provide a method of manufacturing a composition for skin external application containing the rose placenta tissue culture or extract thereof as an active ingredient.
Yet another object of the present invention is to provide a method of manufacturing functional foods that include the rose placenta tissue culture or extract thereof as an active ingredient.
To ‘achieve these objects. the present invention provides a rose placenta tissue culture or extract thereof that activates growth and proliferation of skin cells, has antioxidant function and wrinkle betterment effect, and promotes immune disease betterment function and metabolism activity under expression of various cytokines.
Also, the present invention provides a skin improvement composition for skin external application containing a rose placenta tissue culture or extract thereof as an active ingredient. ~~ Further, the present invention provides a method of manufacturing a skin improvement composition for skin external application containing a rose placenta tissue culture or extract thereof as an active ingredient. the method comprises the steps of: (a) separating a placenta tissue within rose ovary and cultivating the separated placenta tissue; and (b) manufacturing a composition containing the culture or extract thereof obtained in the step (a).
Furthermore, the present invention provides a functional food containing a rose placenta tissue culture or extract thereof as an active ingredient.
Moreover, the present invention provides an antioxidant composition containing a : rose placenta tissue culture or extract thereof.
Hereinafter, the present invention will be explained in detail.
The present invention relates to a rose placenta tissue culture or extract thereof, and more particularly, to a rose placenta tissue culture or extract thereof that can be applicable for skin improvement, immune disease improvement, metabolism activation promotion and antioxidation objects, activate growth and proliferation of skin cells, have antioxidant function and wrinkle betterment effect, and promote immune disease betterment function and metabolism activity under expression of various cytokines.
.
Also, the present invention relates to a composition for skin external application containing a rose placenta tissue culture or extract thereof and a method of manufacturing the same, and a functional food containing the same.
Further, the present invention relates to a skin improvement method including wrinkle betterment using a rose placenta tissue culture or extract thereof, a method for aging prevention of skin, or a method for improvement or prevention of immune disease, and more specifically, to a method which includes a step of injecting the rose placenta tissue culture or extract thereof into targets. The target here, is relevant to animals including human, plants and microorganisms, injection may be performed in vivo, or in vitro, and may be performed appropriately using the various injection methods and forms that are previously known.
Also, the present invention relates to use of a rose placenta tissue culture or extract thereof under object of skin aging prevention, skin improvement, immune disease improvement, metabolism activity promotion, or antioxidation.
In an aspect of the present invention, there is provided a composition for skin external application and skin improvement, containing a rose placenta tissue culture or extract thereof as an active ingredients. Specifically, the rose placenta tissue culture or extract thereof may be included 0.1 to 10 weight % for the total weight of the composition.
This ratio is only a preferred range, for example, the example hereafter tested cases of 0.1 to 5 weight %, but it is obvious for the person skilled in art that exceptional skin improvement effect, skin proliferation, regeneration, wrinkle betterment and antioxidant functions exist for up to 10 weight %, or even more, 20% and over 30% cases.
In the present invention, the rose placenta tissue culture material (culture body) itself may be used, the culture material may be extracted and used, the culture material may be fragmented and used, or the culture material may be pulverized after drying and used by dissolving in purified water.
In the present invention, “Extract” means extract obtained from various extracting methods previously known, including pulverization of rose placenta tissue culture extract, hot water extraction and ethanol extraction.
In the present invention, the extraction method is not particularly limited, and may include, for example, cold water extraction, ultrasound extraction, reflux extraction, hot water extraction, etc. Here, for ultrasound extraction, ultrasound generator (Elma,
Transsonic 1040/H) is used and ultrasound extraction is held for 60 minutes in 40kHz, reaction is done by stirring for 2 hours in 65 C then hot water extract is collected by heating in 80~ 100 Cfor 8~ 48 hours in hot bath distiller.
Or, the extract may be manufactured by using method of extracting using water. organic solvent, or their mixture solvent. The extracted solution may be used immediately or condensed and / or dried to be used. When extracting using organic solvent, extraction can be done in room temperature or heating, under condition of zero or minimum breakdown of active ingredients of crude drugs, by using organic solvents such as methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N,N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), 1.3-butylene elycol, propylene glycol or their mixture solvents. The level of extraction and loss of drugs’ active ingredient may vary depending on the organic solvent used for extraction, so appropriate organic solvent must be chosen to be used.
In the present invention, the extract may be used after condensation, or dilution, and distillate of the extract may be used. v
In the present invention, “skin improvement purpose” is, a concept that includes skin protection and skin condition improvement, skin whitening, prevention or betterment of skin aging and wrinkle, skin protection and relieve of skin inflammatory response, immune disease improvement, or skin barrier function improvement, skin irritation relieve, skin cell proliferation and regeneration, antioxidation, collagen synthesis enhancement, etc.
In the present invention, meaning of “containing as an active ingredient” is, including enough level to show skin improvement effect as composition for skin external application, for example, improving proliferation activity of skin cells and activating it.
Also, it means including effective dose high enough to show collagen synthesis or MMP- 1.9 inhibition activity related with wrinkle betterment effect as composition for skin external application, or antioxidant function, or cytokine expression function.In the present invention, rose is a general term of plants associated in dicotyledon order Rosales, family Rosaceae, genus Rosa, and is shrub-type flower tree. Plants of genus
Rosa are deciduous shrubs that may be sometimes vine plants, having large number of thorns in their stems, leaves grow in alternation, flowers are solitude or peduncles’ length becomes shorter as the location is higher, making each flower almost coplanar to one another. The number of calyx and petals is normally 5, but rarely there are cases with 4.
There are numbers of stamen, and numerous pistils exist in receptacles. Receptacles become fruits, sometimes become lengthy fruit types by swelling, and consist of numerous hard achenes. The roses named today are natural hybrids of these wild types and improved breeds. Each species has numerous individual mutations, enabling interspecific hybrid easily. Roses have been cultivated under object of ornament and perfume with the flower’s beautiful form and fragrance, and it is Rosa hybrid Hort., which is a garden specie grown under improvements. It has been the most beloved ornamental shrub since the ancient times in western history, and is still one of the most popular ornamental shrubs in the world even today. The ancient western species include Rosa gallica, R. centifolia, R. damascena, etc. The modern species were created of Hybrid Tea from complex crossbreeding between China Rose or R. odorata with Mediterranean Sea’s R. gallica, R. damascena, R. moschata. The pure yellow specie was created from crossbreed of R. foetida, an Iranian specie, with Hybread Tea. By crossbreeding Hybrid Tea with a crossbreed of baby brier and China Rose, floribunda, a specie with large sized and abundant flowers, was created.
In the present invention, “Rose”, is genus Rosa that includes, but is not limited to,
Rosa gallica, Rosa centifola, Rosa damascene, Rosa chinensis, Rosa odorata, Rosa moschata, Rosa foetida, Rosa canina, Rosa rugosa, Rosa davurica Pall, Rosa multiflora,
Rosa luciae, Rosa wichuraiana, Rosa gigantea, Rosa alba, Rosa primula, Rosa banksiae,
Rosa Mundi, Rosa brunonii, Rosa cinnamomea, Rosa glauca, Rosa spinosissma, Rosa foetida bicolor, Rosa foetida persiana, Rosa fedtschenkoana, Rosa mulliganii, Rosa sericana pteracantha, Rosa hugonis, Rosa banksiae lutea, Rosa banksiae, Rosa roxburghii,
Rosa hirtula, Rosa aciculaisis nipponensis, Rosa uchiyamana, Rosa jasminoides, Rosa fujisanensis, Rosa laevigata, Rosa cinnamomea, Rosa nitida, Rosa. california, Rosa virginiana, and Rosa palustris.
Plant tissue cultivation is a technology that proliferate plant cells, organs and plant body under object of cultivation by aseptically cultivating living small plant tissue in vitro.
It can be considered that plant tissue cultivation uses basic characteristics of plants. Plant tissue cultivation technology is a technology based on usage of totipotency, which is a unique feature of plants that can regenerate plant body from body cell of plants. Hence, if single cell (including protoplast). leaf and root fragment of plant is cultivated in culture medium that includes specific nutrients and growth controllers, plant body can be regenerated from these cells and tissues. Such ability of plants having totipotency is a strategy of surviving from inadequate environments and damages from herbivores, for sustaining plants’ original characteristic of immobilized life and long-term survival.
Therefore it can be considered that plants have come to acquire ability of regenerating their lost organs. Plant tissue cells separated from mother plant body have potential of fully generated into a complete plant body in adequate culture environment, therefore plants having totipotency have not only academic importance for fields such as embryology, but : also have high applicability for commercialization of cosmetics materials, etc.
As animal-originated placenta, plant placenta is an important part in charge of seed foster, where ovule is attached within ovary of pistil. It is regularly located at the edge of carpel that forms ovary, and sometimes is located in media of carpel. Also, it is sometimes formed in pillar shape that stands upright in base of ovary or from base to ovary.
Also, in another aspect, the present invention relates to a method of manufacturing a composition for skin external application and skin improvement, containing a rose placenta tissue culture or extract thereof as an active ingredient, the method including the steps of: (a) separating a placenta tissue within rose ovary and cultivating the separated placenta tissue; and (b) manufacturing a composition containing the placenta tissue culture or extract thereof, and a method of manufacturing a functional food containing a rose placenta tissue culture or extract thereof.
In the step (a), specifically, appropriate culture medium can be chosen to cultivate rose placenta tissue. If there is a culture medium generally used in the technical field for plant tissue cultivation, it may be used without restrictions. For plants, generally, MS medium and B5 medium are mostly used, and for example, composition of MS medium (for 1L) is NH4;NO; 1650 mg, KNO; 1900 mg, CaCl, . 2H,0 440 mg, MgSO, . 7H,O 370 mg, KH,POy . 170 mg. KI 0.83 mg. H;BO; 6.2 mg, MnSOy . 4H,0 22.3 mg, ZnSOy4 - 7H>0 8.6 mg, Na,MoO; -2H,O 0.25 mg, CuSO; .5H,0 0.025 mg, CoCls . 6H,0 0.025 mg,
FeSO, . 7H,0 27.8 mg, Na,EDTA . 2H,0 37.3 mg. Myoinositol 100 mg, Nicotinic acid 0.5 mg, Pyridoxine-HCI 0.5 mg, Thiamine-HCI 0.5 mg, Glycine 2 mg, Sucrose 30000 mg.
In the present invention, in the step (b), the composition containing a rose placenta tissue culture acquired from cultivation of the step (a) may be produced into appropriate form of composition for skin external application or functional food, or the culture may be collected into form of extract through notified extraction methods and produced into appropriate form of composition for skin external application or functional food. For example. the culture acquired from the step (a) may be hot air dried and pulverized, and if needed, combined with appropriate binder to be manufactured.
In the present invention, the binder is an additive added for enhancement of convenience for handling and shaping, when rose placenta culture or extract thereof according to the present invention is provided for food ingredients, for example, liquid, powder. granule and tablet. As example of such binder, for liquid, water, alcohol, glycerin and thickening polysaccharides exist, for powder, lactose, starch, dextrin, sucrose, oligosaccharide, cyclodextrin, cellulose derivatives exist, and for granules, tablets and capsules, lactose, starch, dextrin, sucrose, oligosaccharide, cyclodextrin, cellulose derivatives, sucrose ester and fatty acid esters exist.
In the present invention, the composition for skin external application may be cosmetic composition or pharmaceutical composition.
For the cosmetic composition, applicable carrier for cosmetics formulation may be included. Herein, “applicable carrier for cosmetics formulation” is compound or composition already notified and in use that may be included in cosmetics formulation, or compound or composition to be developed in the future, that have no irritation, instability or toxicity beyond the adaptability of human body when touched with skin.
The carrier may be included 1 to 99.99 weight % for the total weight of the present invention’s composition for skin external application, preferably 90 weight % to approximately 99.99 weight % of the weight of the composition. However, the ratio varies on formulation type of the present invention’s composition for skin external application manufacture described hereafter and its specific application area (face, neck, etc.) or its : preferable application dose, so the ratio must not be interpreted in a way that restricts the present invention’s range whatsoever.
For the carrier, alcohol, oil, surfactant, fatty acid, silicon oil, humectants, moistener, viscosity modifier, emulsion, stabilizer, UV dispersion, UV absorbent, coloring agent, flavoring agent may be indicated. The compounds/compositions that can be used as the alcohol, oil, surfactant, fatty acid, silicon oil, humectants, moistener, viscosity modifier, emulsion, stabilizer, UV dispersion, UV absorbent, coloring agent and flavoring agent are previously notified in the field of art, so the person skilled in art may choose appropriate substance/compositions to use.
As an exemplary example of the present invention, the composition for skin external application according to the present invention may include, in addition to rose placenta tissue culture extract, glycerin, butylenes glycol, propylene glycol, polyoxyethylene hydrogenated catser oil, ethanol, triethanolamine, etc., and may include small amount of preservative, flavoring agent, coloring agent and purified water.
The composition for skin external application according to the present invention may be manufactured in various forms, for example, face lotion, essence, gel, emulsion, lotion, cream (oil-in-water type, water-in-oil type, multi-phase), solution, suspension (anhydrous and hydrous), anhydrous product (oil and glycol type), gel, mask, pack, powder, or capsules with films such as gelatin (soft capsule, hard capsule) formulation type.
The skin in the present invention is a concept that includes not only face but also head skin and entire body, and for composition for skin external application that can be applied for head skin, shampoo, rinse, treatment and hair growth solution are available, and may be produced into various forms under object such as body cleanser that can be applied for entire body.
The method of manufacturing a composition for skin external application containing a rose placenta tissue culture extract according to the present invention is not limited to the manufacture method mentioned above, and those skilled in the art to which the present invention belongs may manufacture a composition for skin external application containing a rose placenta tissue culture extract according to the present invention by a method which partially changes the manufacture methods mentioned above.
In particular, the composition for skin external application may be manufactured in general emulsifying formulation type and soluble formulation type by using generally known manufacture methods, in addition to the manufacture methods particularly disclosed in the present invention.
In case of being manufactured into cosmetic composition, for emulsifying formulation type cosmetics, nutrient toilet water, cream and essence exist, and for soluble formulation type cosmetics, emollient toilet water exists. Also, it may be manufactured into adjuvant form used widely in dermatology field that can be applied locally or generally by including dermatologically acceptable medium or mechanism.
Also, for appropriate formulation form of cosmetics, for example, solution, gel. solid or paste anhydrous product, emulsion acquired by dispersion oil phase in water phase. suspension, microemulsion, microcapsule, microgranule or ionic (liposome), nonionic vesicle dispersing agent, cream, skin, lotion, powder, ointment, spray or conceal stick. Also, it may be manufactured in form of foam or aerosol composition that includes more amount of compressed propellant. :
Also, the present invention’s composition for skin external application may additionally include adjuvant generally used in cosmetology or dermatology, such as lipid substance, organic solvent, solubilizer, thickening agent, gelling agent, softening agent, antioxidant agent, suspending agent, stabilizing agent, foaming agent, flavoring agent, surfactant, water, ionic or nonionic emulsifier, filler, metal ion sequestering agent, chelating agent, preserving agent, vitamin. blocker. wetting agent. essential oil, dye, pigment, hydrophilic or hydrophobic activator, lipid vesicle or other random compositions generally used in cosmetics. Also, the components may be introduced in dose generally used in dermatology field.
Such composition for skin external application according to the present invention includes form of functional cosmetics that can serve the role of skin cell regeneration, betterment of skin condition via excellent proliferating ability, antioxidant capacity, prevention of skin aging following enhancement of collagen synthesis enhancement, skin whitening, relieve/prevention of inflammation via excellent cytokine expression ability and treatment/prevention of immune disease.
In the present invention, pharmaceutical compositions express various cytokine of
VEGF, EGF, FGF, TGF-f1, 1L-la, IL-6, IL-8 and TNF-a provided in the following examples, and especially, among them, since the pharmaceutical compositions have excellent level of cytokine expressing ability for EGF, TGF-f1 and TNF-a, they may function as pharmaceutical composition for treatment and prevention of immune diseases.
Such pharmaceutical composition may inciude, in addition to active ingredient rose placenta tissue culture or extract thereof, “pharmaceutically acceptable carrier”. and such carrier may be chosen from a group that consists of diluents, slip modifier, bonding agent, disintegrating agent, flavoring agent, stabilizer and preservative. The pharmaceutical composition may include more additives. For the additives, flavoring agents, vitamin and antioxidant agents may be included. For the carrier, every pharmaceutically acceptable carriers are possible, for example, for diluents, lactose, dextrin, tapioca starch, corn starch, soybean oil, microcrystalline cellulose, or mannitol, for slip modifier, magnesium stearate or talc, for bonding agent, calcium carboxymethyl cellulose, sodium starch glycolate, polacrillin potassium, or crospovidone, for flavoring agent, sucrose, fructose, sorbitol, or aspartame, for stabilizer, sodium carboxymethyl cellulose, beta-cyclodextrin, or xanthan gum, for preservatives, methyl p-hydroxybenzoate. propyl p-hydroxybenzoate, or potassium solvate.
The pharmaceutical compositions may be formulated into general pharmaceutical formulation type notified in the technical field. The pharmaceutical compositions may be administrated after having been formulated into formulation forms such as oral administrative formulation, injections, suppository, transdermal administration formulation, and transnasal administration formulation. For example, the formulation type may be orally administrated formulation type, such as liquid, suspension, powder. granule. tablet, capsule, pill, or extract.
In other aspects, the present invention relates to functional foods or food additives . that include the rose placenta tissue culture or extract thereof.
The rose placenta tissue culture or extract thereof according to the present invention has almost no toxicity or side effect for itself, so it can be safely used for foods.
In the present invention, the term “functional food” is a same word as food for special health use (FoSHU), meaning foods of high medicinal and medical effect that were processed to express efficient body adjustment functions in addition to nutrient supply. In the present invention, the terminology “functional food” is freely substituted with terminologies health food and health supplement food. “Health food” means foods having more active effect in health maintenance or enhancement than regular foods, and health supplement foods mean foods under object of health supplement. Such functional foods may be manufactured into various forms such as tablets, soft capsules, hard capsules, powders, granules, liquids, pills, beverages, jellies, gummies, candies, cookies, biscuits, energy bars, etc.. to gain effects such as skin whitening, wrinkle betterment and antioxidant capacity.
The rose placenta tissue culture or extract thereof of the present invention may be added to foods or beverages under the object of skin protection and skin condition improvement, skin whitening, prevention or betterment of skin aging and wrinkle, skin protection and relieve of skin inflammatory response, or recovery of skin barrier function.
Also, since it includes physiological active substances such as polyphenol and flavonoid, it may recover body functions including metabolism activation that antioxidant effects have, and prevent aging, by providing antioxidant ability. Also, it is expressing various cytokine of VEGF, EGF, FGF, TGF-B1, IL-1a, IL-6. IL-8 and TNF-a and especially, among them, exceptional level of cytokine expressing ability exists for EGF, TGF-pI and TNF-a, capable of serving immune disease improvement function. At this, the amount of rose placenta tissue culture extract within foods or beverages may be added 0.01 to 5 weight % of the entire food weight in general, and 0.01 to 2g, preferably 0.3 to 1g per 100md for beverage.
In the present invention, rose placenta tissue culture or extract thereof may be included under nondiluted status, or diluted status using inorganic solvent such as purified water, and organic solvent.
There are no special restrictions for liquid component for beverages including the present invention’s rose placenta tissue culture or extract thereof, other than including the rose placenta tissue culture or extract thereof as essential ingredient with directed ratio. and may include various flavoring agents or natural carbohydrates as additional component, as general beverages. Examples of the natural carbohydrates are monosaccharides such as glucose, fructose, galactose and mannose; disaccharides such as maltose and sucrose; general sugars such as dextrin and cyclodextrin; and sugar alcohols such as xylitol, sorbitol and erythritol. For the flavoring agents, natural flavoring agents such as thaumatin and stevia extracts (for example, rebaudioside A, glycyrrhizin), and artificial flavoring agents such as saccharine and aspartame, can be used favorably. The natural carbohydrates ratio is generally approximately 1 to 20g, preferably 5 to 12g, per 100ml of composition that includes rose placenta tissue culture extract of the invention.
The foods and beverages other than previously mentioned may include various nutritional supplements, vitamins, minerals (electrolytes). synthetic and natural flavoring agents, coloring agents and flavor enhancer (cheese, chocolate, etc.), pectic acid and its salt, alginic acid and its salt, organic acid, protective colloid thickener. pH controller. stabilizer, preservative, glycerin, alcohol, carbonation agent used for carbonated beverages, etc. In addition, fruit pulp for manufacturing natural fruit juice, fruit juice beverage and vegetable beverage may be included. Such ingredients can be independently used. The ratio of such additives is in general chosen from 0 to approximately 20 weight % range per 100 weight % of the present invention’s functional food.
The rose placenta tissue culture or extract thereof of the present invention may be added directly to foods or beverages and used, but the target foods may be dipped directly in rose placenta tissue culture or extract thereof or rose placenta tissue culture extract can be sprayed onto foods to gain effects of skin protection and skin condition improvement, : skin whitening, prevention or betterment of skin aging and wrinkle, skin protection and relieve of skin inflammatory response, or recovery of skin barrier function. Also, since it includes physiological active substances such as polyphenol and flavonoid, it may recover body functions including metabolism activation that antioxidant effects have. and prevent aging, by providing antioxidant ability. Also, it is expressing various cytokine of VEGF,
EGF, FGF, TGF-pl, IL-1a, IL-6, IL-8 and TNF-u and especially, among them, exceptional level of cytokine expressing ability exists for EGF, TGF-B1 and TNF-a. capable of serving immune disease improvement function.
In the present invention, such functional foods may be in various forms such as tablets, soft capsules, hard capsules, powders, granules, liquids, pills, beverages, jellies, gummies, candies, cookies, biscuits, balance nutrient foods or beverages, and manufacture technologies into such forms may be used from the previously known methods including the manufacture examples hereafter and have no significant restrictions.
: The functional foods as above can be done by providing rose placenta tissue culture or extract thereof according to the present invention as food additives.
For the food additives, one or more than one of the following substances may be included: organic acids such as citric acid, fumaric acid, adipic acid, lactic acid and malic acid, phosphate salts such as sodium phosphate, potassium phosphate, dihydrogen pyrophosphates, polyphosphates, natural antioxidants such as polyphenol, catechin, a- tocopherol, rosemary extract, licorice root extract, chitosan, tannic acid, phytic acid, etc.
Also, the present invention provides a method of using food additives, the method characterized by using the food additives as essential ingredient of foods, or germicides, spices, various nutritional supplements, vitamins, minerals (electrolytes), synthetic and natural flavoring agents, coloring agents and flavor enhancer (cheese, chocolate, etc.), pectic acid and its salt, alginic acid and its salt, organic acid, protective colloid thickener, pH controller, stabilizer, preservative, glycerin, alcohol, carbonation agent used for carbonated beverages, etc. At this, the food additive may be included in the foods by dipping the food into the additives, spraying or mixing the additives with the foods, and the ratio of such additives is not very important, but generally is chosen within range of 0 to 20 weight % for the present inventions rose placenta tissue culture or extract thereof, for 100 weight % of the entire composition.
The foods include natural foods such as grains, potatoes, beans, vegetables, fruits, fishes, meats, dairy products, seaweeds; or processed foods such as breads, cookies, ramen, ice cream; or beverages.
In other aspects, the present invention relates to an antioxidant composition containing a rose placenta tissue culture or extract thereof, which has excellent antioxidant capacity. Such antioxidant compositions can activate metabolic functions, recover body functions and prevent aging. Also, it is expressing various cytokine of VEGF, EGF, FGF,
TGF-f1, IL-1a, IL-6, IL-8 and TNF-a and exceptional level of cytokine expressing ability exists for EGF, TGF-B1 and TNF-o, capable of serving immune disease improvement function, therefore, such antioxidant compositions can include forms of anti-aging compositions and immune disease improvement compositions.
The composition for skin external application that includes rose placenta tissue culture or extract thereof according to the present invention has exceptional effect in improving skin regeneration, antioxidation and wrinkle betterment effect by activating skin cells via growth or proliferation, from having rose placenta tissue culture or extract thereof that has excellent antioxidant capacity. :
FIG. 1 is a graph that identifies cell proliferation effect of rose placenta tissue culture extract according to the present invention in human skin keratinocytes.
FIG. 2 is a graph that identifies antioxidant capacity of rose placenta tissue culture extract.
FIG. 3 is a graph that identifies collagen enhancement effect of rose placenta tissue culture extract in human fibroblasts.
FIG. 4 is a graph that identifies cytokine expression rate of rose placenta tissue culture extract.
Examples oo
The present invention will be now described in detail through examples. The examples are only used for illustrating the present invention, and it will be obvious to a person skilled in the art that the scope of the present invention should not be construed as limited by the examples set forth herein.
Especially, it will be apparent to a person skilled in the art, that although effects of rose placenta tissue culture extracts were identified in the examples hereafier, but such effects also exist for culture materials that are not extracts.
Example 1: Manufacture of rose placenta tissue culture extract according to the present invention 1.1 Separation of Rose (Rosa Damascena) placenta tissue
For cultivation, ovule and ovary within rose bud was sterilized for 5 minutes with 70% ethanol and 0.5% sodium hypochlorite, and was washed for few times with sterilized water. Forceps was used to remove the wall of ovary, placenta was separated and was cultivated for 2-3 weeks in MS culture medium with 5% sucrose (Duchefa, Cat# M0256) 1.2. Mass-production and cultivation of the separated rose placenta tissue
The aseptically separated rose placenta tissue was subcultured with 2-3 weeks of interval in MS culture medium with 5% sucrose. Afterwards, mass production was done by culturing and proliferating with 14 days interval while controlling the air supply in 0.1 vvm under 25 C temperature, in the liquid with same constituent except agar using balloon shaped bioreactor (Samsung Science Co.). 1.3. Manufacture of rose placenta tissue culture extract
The proliferated rose placenta tissue culture was collected and was dried in a drier for two days in 60 C after removing water thoroughly with clean tissue. 100g of the dried rose placenta tissue culture powder was put in a container, 10L of purified water was added, ultrasound extract was done for 60 minutes at 40kHz using ultrasound generator (Elma, Transsonic 1040/H), reaction was done by stirring for 2 hours in 65 C, then hot water extract was collected after heating in 80-100 C for 8-48 hours in hot bath distiller.
After extraction, it was filtered with mesh to remove any solid content, and rose placenta tissue culture extract was manufactured.
Comparative Example 1: Manufacture of rose petal extract
Rose petals were collected and were dried in a drier for two days in 60 C. 100g of the dried rose petals was put in a container, 10L of purified water was added, ultrasound extract was done for 60 minutes at 40kHz using ultrasound generator (Elma, Transsonic 1040/H), reaction was done by stirring for 2 hours in 65 C, then hot water extract was collected after heating in 80-100 C for 8-48 hours in hot bath distiller. After extraction, it was filtered with mesh to remove any solid content, and rose extract was manufactured.
Experimental Example 1: Experiment of influence of rose placenta tissue culture extract according to the present invention on cell growth and proliferation
To investigate on skin cell proliferation activity of rose placenta tissue culture extract according to the present invention, human skin keratinocyte (HaCaT) was received from ATCC (American Type Culture Collection) to be cultured. The cells were cultured on 24 well culture plate with concentration of 1x10* cells/ml. The culture medium was
DMEM (Dulbecco's Modified Eagle Medium, BRL, USA) with 10% FBS. After having cultured for 48 hours in DMEM with 10% FBS to have 25-30% of the surface area of culture container cultured, the medium was exchanged with FBS-free DMEM with 0.1-5 weight % rose placenta tissue culture extract manufactured from the example 1 and cultivation was done for 24 more hours. After cultivation, 50ul of 3-(4.5- dimethylthiazole-2-yl)-2.5-diphenyl tetrazolium bromide (MTT, Sigma M5655, USA) solution (2.5 mg/ml) was included cultivation was done for additional 3 hours, supernatant was removed, 200 uf of dimethylsulfoxide (DMSO, Sigma D2650, USA) solution was added for each well and was stirred for 20 minutes to dissolve the created formazan crystals, and 100 wf was collected for 96 wells and absorbance was measured in 570 nm with Enzyme-Linked Immunosorbent Assay (ELISA). The skin cell proliferation activity level was calculated with the mathematical equation hereafter based on the control group’s absorbance intensity using pure water and was shown with percentage. [Mathematical Equation 1} + Cell proliferation effect (%) = (absorbance when treated with extract/absorbance of control group) >< 100 :
Table 1
Processed concentration | Cell proliferation effect (weight %)
CC Jeowgw fw
As a result of experiment on influence for cell growth and proliferation using the human skin keratinocytes, as shown in Table 1 and Figure 1, cell proliferation effect was identified in case of 5 weight % rose placenta tissue culture extract was included with 124% in comparison with the control group. In case of 1 weight % rose placenta tissue culture extract was included, 116% proliferation level was shown in comparison with the control group, and 0.5%, 0.1% of rose placenta tissue culture extract cases showed 109%, 102% proliferation respectively in comparison with the control group. Therefore, rose placenta tissue culture extract according to the present invention showed influence in skin cell growth and proliferation activation, and in case of rose petal extract instead of placenta tissue culture, cell proliferation effect was inadequate.
Experimental Example 2: Experiment of antioxidant capacity of rose placenta tissue culture extract according to the present invention
Antioxidant Assay Kit (Cayman, Ann Arbor, Mich.) was used for the antioxidant capacity of rose placenta tissue culture extract according to the present invention, and experiment was conducted according to the manufacturer's instructions.
The antioxidant capacity of rose placenta tissue culture extract was measured by converting into Trolox concentration based on antioxidant capacity of Trolox as standards of different concentrations, using Antioxidant Assay Kit (Caymen, Cat No. 709001,
Antioxidant Kit).
Table 2
Processed concentration | mM Trolox equiv. (weight %) : :
Neiveconogo aes lo os des ~ | Rose placenta tissue culture
As a result, as shown in Table 2 and Figure 2, the antioxidant capacity increased dose-dependently for rose placenta tissue culture extract. 5 weight % of rose placenta tissue culture extract showed higher antioxidant capacity than the positive control group, 100 uM Vitamin C, which demonstrated high antioxidant capacity of rose placenta tissue culture extract. On the contrary, rose petal extract showed very low antioxidant capacity in comparison with rose placenta tissue culture extract.
Experimental Example 3: Experiment of wrinkle betterment (collagen synthesis) of rose placenta tissue culture extract according to the present invention
Human skin fibroblast was cultured with DMEM (Dulbecco’s Modified Eagle’s
Medium, Gibco, USA) including 10% FBS, Penicillin (50U/ml), Streptomycin (50U/ml) in cell incubator that maintains constant humidity, under 37°C, 5% CO,, was cultivated 5004 in 24 well plate with 1X 10° cells / ml for 24 hours. The control group (DMEM medium) and medium that includes various concentration, ranging from 0.1-5 weight %, of
Example 1°s rose placenta tissue culture extract were added and cultivation was done for 48 hours in 37°C, 5% CO; incubator. After 48 hours, 20.4 of supernatant was collected from each medium and the amount of newly synthesized collagen was measured by measuring with Procollagen Type 1 C-Peptide EIA Kit (PICP, Takara, Cat No. MK101).
The result was found by experimenting with rose petal extract of the example using the same method as the above. The PICP quantity was converted intong/ 1X 10° cells.
Table 3
Processed concentration | Collagen biosynthesis (weight %) increase rate osu we
Rose placenta tissue culture
With the control group’s value as 100, the collagen biosynthesis increase rate of rose petal extract processed group, rose placenta tissue culture extract process group and positive control group are as shown in Table 3 and Figure 3.
As shown in Table 3 and Figure 3, the composition of the present invention demonstrates that biosynthesis quantity of collagen increases as the proportion of rose placenta tissue culture extract increases, and it is also identified that the present invention’s composition shows exceptional collagen synthesis enhancement effect when compared with rose extract.
Experimental Example 4: Experiment of cytokine expression analysis of rose placenta tissue culture extract according to the present invention
To investigate on expression rate of cytokine for rose placenta tissue culture extract according to the present invention, human fibroblast (Cell Lines Service, Germany) was cultured on 24 well culture plate with 1X 10° cells / ml concentration. After having cultured for 48 hours in DMEM (Dulbecco's Modified Eagle Medium, BRL, USA) with 10% FBS to have 25-30% of the surface area of culture container cultured, the medium was exchanged with FBS-free DMEM with 1 weight % rose placenta tissue culture extract manufactured from the example 1 and FBS-free DMEM used for control group and cultivation was done for 48 more hours. The cytokine expression rate for VEGF, EGF,
FGF, TGF-B1, IL-la, IL-6, IL-8 and TNF-a was investigated using Human Cytokine
Assay Kit (Millipore). The experimental methods were followed under instructions of
Human Cytokine Assay Kit.
Table 4
Co lero oom tissue culture extract fore
As shown in Table 4 and Figure 4, it was identified that for expression rate of cytokine, EGF, TGF-B1 and TNF-a were expressed with significant level when 1 weight % rose placenta tissue culture extract was processed, in comparison with the non-treated control group.
Such result demonstrates that rose placenta tissue culture extract of the invention can function as immune controller by having cytokine expression effect.
Experimental Example 5: Experiment of Physiological active substance content analvsis of rose placenta tissue culture extract according to the present invention (1) The total polyphenol content was measured with Folins-Denis method, a commonly used analysis method. After adding 0.5 ml of Folin reagent in 0.5 ml of rose placenta tissue culture extract and leaving it for 3 minutes, 0.5 ml of 10% Na2CO3 solution was added. After leaving the solution for an hour, absorbance was measured at 760 nm using spectrophotometer (UV/VIS spectrometer, Jasco, Japan). The total polyphenol content of the sample was shown in mM gallic acid equivalent by constructing standard curve with gallic acid.
Table 5
Processed concentration | mM gallic acid equiv. (weight %) cows Joos os le
Rose placenta tissue culture
As shown in table 5, rose placenta tissue culture extract shows the total polyphenol content increases dose dependently on its concentration, in comparison with rose petal extract. : (2) The total flavonoid content was measured via Moreno et al. method. 0.1 mL of 10% aluminum nitrate was added to 0.5 mL of rose placenta tissue culture extract, then 0.1 mL of 1 M potassium acetate and 4.3 mL of ethanol was mixed respectively, was reacted for 40 minutes at room temperature and absorbance was measured at 415 nm, and total flavonoid content was measured using standard curve with catechin as standard substance, calculating content per g of rose placenta tissue culture extract.
Table 6 : Processed concentration | mg/g catechin equiv. (weight %)
CC lcomoiwowoves 12
I
Rose placenta tissue culture
As shown in table 6, rose placenta tissue culture extract shows the total flavonoid content increases dose dependently on its concentration, in comparison with rose petal extract.
Such polyphenol, flavonoid have antioxidant effect, which are substances preventing aging, and the rose placenta tissue culture extract of the present invention includes such polyphenol and flavonoid, therefore identified with function of enhancing function of body and activating body.
Example 2: Manufacture of Cosmetic composition
For cosmetics that include rose placenta tissue culture extract of the invention as an active ingredient, cosmetics of emulsifying formulation type such as face lotion. cream, essence and soluble formulation type such as emollient toilet water were manufactured. :
Manufacture example 2-1: Face lotion
Manufacture was done according to the prescription hereafter, based on the general method of manufacturing face lotion
Table 7
I
Manufacture example 2-2: Essence
Manufacture was done according to the prescription hereafter, based on the general method of manufacturing essence
Table 8 ovens geo monosearne so
Manufacture example 2-3: Lotion
Manufacture was done according to the prescription hereafter, based on the general method of manufacturing lotion
Table 9 coseapaors os [ovemyencgycotmonesearse 12
Manufacture example 2-4: Cream
Manufacture was done according to the prescription hereafter, based on the general method of manufacturing Cream
Table 10 ep se
Ghee veg fees
Manufacture example 2-5: Gel
Manufacture was done according to the prescription hereafter, based on the general method of manufacturing Gel
Table 11
Example 3: Manufacture of Functional Food
Foods that include rose placenta tissue culture extract of the present invention were manufactured as the following.
Manufacture Example 3-1: Flour food 0.5-5.0 parts by weight of rose placenta tissue culture extract of the present invention was added to flour and this mixture was used to manufacture bread, cake, cookie, cracker and noodles.
Manufacture Exampie 3-2: Soup and gravies 0.5-5.0 parts by weight of rose placenta tissue culture extract of the present invention was added to soup and gravies to manufacture health improvement meat processed products, noodles’ soup and gravies. .
Manufacture Example 3-3: Ground beef ; 10 parts by weight of rose placenta tissue culture extract of the present invention was added to ground beef to manufacture health improvement ground beef. : Manufacture Example 3-4: Dairy products 5-10 parts by weight of rose placenta tissue culture extract of the present invention was added to milk and the milk was used to manufacture various dairy products, such as butter and ice cream. i
Manufacture Example 3-5: Grain powder food
Unpolished rice, barley, glutinous rice and Chinese pearl barley were gelatinized and dried with previously notified methods, then were produced into powder of 60 mesh particle size with pulverizer after roasting it. Black bean, black sesame and perilla seeds were also steamed and dried with previously notified methods, then were produced into powder of 60 mesh particle size with pulverizer after roasting it. Rose placenta tissue culture extract of the invention was vacuum evaporated in vacuum condenser, and the dried substance collected after drying with hot air drier was pulverized with pulverizer into 60 mesh particle size to obtain the dried powder.
The grains, seeds and rose placenta tissue culture extract manufactured above were mixed into the following ratio to manufacture.
Grains (unpolished rice 30 parts by weight, Chinese pearl barley 15 parts by weight, barley 20 parts by weight),
Seeds (perilla seeds 7 parts by weight, black bean 8 parts by weight, black sesame 7 parts by weight),
Rose placenta tissue culture extract (3 parts by weight)
Appropriate amount of water and etc. can be added and mixed to the grain powder food acquired from the manufacture method and can be eaten.
Manufacture Example 3-6: Beverage 6-1) Manufacture of health beverage
Submaterials such as liquid fructose (0.5%), oligosaccharide (2%), sugar (2%), table salt (0.5%). water (75%) and 5 g of rose placenta tissue culture extract of the present invention were homogeneously mixed and instantaneously sterilized, then were packed in small package containers such as glass bottles and PET bottles to manufacture.
6-2) Manufacture of vegetable juice g of rose placenta tissue culture extract of the present invention was added to 1,000 m{ of tomato or carrot juice to manufacture vegetable juice. 6-3) Manufacture of fruit juice 5 1 g of rose placenta tissue culture extract of the present invention was added to 1,000 mf of apple or grape juice to manufacture vegetable juice.
Manufacture Example 3-7: Soft capsule 25% of rose placenta tissue culture extract of the invention was mixed to plant oils, such as safflower oil, corn oil, cotton seed oil, peanut oil, rapeseed oil, sesame oil, rice germ oil, soybean oil, sunflower oil, evening primrose oil, avocado oil, linseed oil and perilla seed oil, then vitamin, mineral and various health functional materials were appropriately mixed under their objects, and was adjusted into slurry status that includes emulsifier such as wax, glycerin, fatty acid and ester. With 280mg of the slurry as content, vegetable film formed with gelatin, glycerin, processed or film starch, glycerin and thickened polysaccharides was used to wrap the content, thermally forming soft capsule of 450mg total weight.
Manufacture Example 3-8: Hard capsule
To 180mg of rose placenta tissue culture extract of the invention, 40mg of dextrin was mixed, and 220mg of the powder was used as content and was placed in hard capsule formed with gelatin or cellulose.
While specific examples of the present invention have been described in detail, such detailed description is only desirable embodiment to a person skilled in the art. and it will be apparent that the scope of the present invention is not construed as limited by the examples set forth herein.
Therefore, the practical scope of the present invention will be defined by the attached claims and their equivalents.
Claims (20)
1. A skin improvement composition for skin external application, containing a rose placenta tissue culture or extract thereof as an active ingredient.
2. The skin improvement composition of claim 1, wherein the rose placenta tissue culture or extract thereof is in a range from 0.1 to 10 weight % based on the entire weight of the composition.
3. The skin improvement composition of claim 1, wherein the rose placenta tissue culture or extract thereof is pulverized and then contained in the composition.
4. The skin improvement composition of claim 1, wherein the skin improvement composition is used for skin cell proliferation and regeneration.
5. The skin improvement composition of claim 1, wherein the skin improvement composition has antioxidant capacity.
6. The skin improvement composition of claim 1, wherein the skin improvement composition has collagen synthesis enhancement ability.
7. The skin improvement composition of claim I, wherein the skin improvement composition is used for skin aging prevention.
8. A method of manufacturing a skin improvement composition for skin external application containing a rose placenta tissue culture or extract thereof, the method comprising the steps of (a) separating placenta tissue within rose ovary and cultivating the separated placenta tissue; and (b) manufacturing a composition containing the culture or extract thereof obtained in the step (a).
9. The method of claim 8. wherein the step (b) comprises a step of drying and pulverizing the rose placenta tissue culture obtained in the step (a) and mixing with purified water to manufacture the composition.
10. The method of claim 8, wherein the step (b) comprises a step of drying and pulverizing the rose placenta tissue culture obtained in the step (a), mixing with purified : water, and then performing ultrasound extraction or hot water extraction to manufacture the composition.
11. A functional food containing a rose placenta tissue culture or extract thereof.
12. The functional food of claim 11, wherein the functional food is used for skin improvement.
13. The functional food of claim 12, wherein the functional food has skin cell proliferation and regeneration ability.
14. The functional food of claim 11, wherein the functional food has antioxidant capacity.
15. The functional food of claim 11, wherein the functional food has collagen synthesis enhancement function.
16. The functional food of claim 11, wherein the functional food is used for skin aging prevention.
17. The functional food of claim 11, wherein the functional food has ability of improving immune diseases by having expression ability of EGF, TGF-1 and TNF-a.
18. The functional food of claim 11, wherein the functional food is in forms of powder, granules, tablets, soft capsules, hard capsules, liquids, pills, jellies, gummies, candies, cookies, biscuits, balance nutrient foods or beverages.
19. The functional food of claim 18, wherein the functional food skin is manufactured in a capsule form by no diluting of or diluting of the rose placenta tissue culture or extract thereof.
20. An antioxidant composition containing a rose placenta tissue culture or extract : thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110054325A KR101372789B1 (en) | 2011-06-07 | 2011-06-07 | Composition for Skin External Application Comprising Culture Extract of Rosa Placenta and Functional Food Comprising the Same |
| PCT/KR2011/004120 WO2012169664A1 (en) | 2011-06-07 | 2011-06-07 | External dermal agent and functional food containing rose placenta tissue-cultured product or extract thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG186061A1 true SG186061A1 (en) | 2013-01-30 |
Family
ID=47296209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012084125A SG186061A1 (en) | 2011-06-07 | 2011-06-07 | Composition for skin external application and functional food containing rose placenta tissue culture or extract thereof |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR101372789B1 (en) |
| MY (1) | MY157534A (en) |
| SG (1) | SG186061A1 (en) |
| WO (1) | WO2012169664A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102157395B1 (en) * | 2013-10-28 | 2020-09-18 | 에스엠생명과학 주식회사 | Cosmetic Composition including Rosa davurica Pall Callus Cultured in medicum containing mineral water |
| KR102178963B1 (en) * | 2013-11-12 | 2020-11-13 | 주식회사 엘지생활건강 | Method for manufacturing cultured bean placenta extract having high content of isoflavone |
| KR101651321B1 (en) * | 2014-03-06 | 2016-08-25 | 주식회사 바이오에프디엔씨 | Anti-aging and Enhancing Skin Barrier Function composition for skin external application comprising Aloe vera Placenta Cell Culture Extract |
| KR101726854B1 (en) * | 2014-11-14 | 2017-04-13 | 재단법인 홍천메디칼허브연구소 | Mist composition with the extract of wood-cultivated ginseng for skin moisturizing |
| KR101766538B1 (en) * | 2015-11-09 | 2017-08-09 | 한국식품연구원 | A method for acquiring extract comprising polyphenols components from Rosae Multiflorae Fructus with high yield |
| CN105232687A (en) * | 2015-11-30 | 2016-01-13 | 湖南省广林农业科技开发有限公司 | Extraction method for effective ingredients in roses and rose hips |
| KR101966374B1 (en) | 2017-11-28 | 2019-04-05 | 이노팜 주식회사 | Composition for accelerating wound healing comprising and Aquilaria crassna extract and β-Glucan |
| JP7109110B2 (en) | 2018-07-26 | 2022-07-29 | エクソコバイオ インコーポレイテッド | Cosmetic composition containing exosomes derived from rose stem cells as an active ingredient |
| KR102364823B1 (en) * | 2020-05-06 | 2022-02-21 | 연세대학교 산학협력단 | Cosmetics for Skin Cell Regeneration |
| EP4129317A4 (en) * | 2020-06-04 | 2024-04-10 | Exocobio Inc | Composition for anti-inflammation, wound healing or wound healing promotion, comprising rose stem cell-derived exosomes as active ingredient |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4025600B2 (en) * | 2002-08-12 | 2007-12-19 | 山川貿易株式会社 | Topical skin preparation |
| JP2006273811A (en) * | 2005-03-30 | 2006-10-12 | Naris Cosmetics Co Ltd | Maillard reaction inhibitor |
| KR20110017566A (en) * | 2009-08-14 | 2011-02-22 | (주)아모레퍼시픽 | Composition containing extracts of rose |
-
2011
- 2011-06-07 WO PCT/KR2011/004120 patent/WO2012169664A1/en active Application Filing
- 2011-06-07 MY MYPI2012004878A patent/MY157534A/en unknown
- 2011-06-07 SG SG2012084125A patent/SG186061A1/en unknown
- 2011-06-07 KR KR1020110054325A patent/KR101372789B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR101372789B1 (en) | 2014-03-12 |
| KR20120135550A (en) | 2012-12-17 |
| WO2012169664A1 (en) | 2012-12-13 |
| MY157534A (en) | 2016-06-15 |
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