KR101888133B1 - Composition For Promoting Synthesis of Collagen and Cosmetic Composition Using Extracts of Roots of Chrysanthemum indicum - Google Patents
Composition For Promoting Synthesis of Collagen and Cosmetic Composition Using Extracts of Roots of Chrysanthemum indicum Download PDFInfo
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- KR101888133B1 KR101888133B1 KR1020160016203A KR20160016203A KR101888133B1 KR 101888133 B1 KR101888133 B1 KR 101888133B1 KR 1020160016203 A KR1020160016203 A KR 1020160016203A KR 20160016203 A KR20160016203 A KR 20160016203A KR 101888133 B1 KR101888133 B1 KR 101888133B1
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- root
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- extract
- collagen
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- Cosmetics (AREA)
Abstract
본 발명은 감국(Chrysanthemum indicum) 뿌리 추출물을 유효성분으로 포함하는, 콜라겐 생성 촉진용 조성물에 관한 것이다. 본 발명에 따른 조성물은 생체 이용율이 높고 콜라겐 생성 촉진 효능을 가짐으로써 주름 개선 등 항노화 기능성 화장품, 의약품, 비누, 식품 등에 유용하게 쓰일 수 있다. The present invention relates to a composition for promoting collagen production, which comprises Chrysanthemum indicum root extract as an active ingredient. The composition according to the present invention has high bioavailability and promotes collagen production, and thus can be useful for anti-aging functional cosmetics such as wrinkles, medicines, soaps, foods and the like.
Description
본 발명은 감국 뿌리 추출물을 포함하는 콜라겐 생성 촉진용 조성물 및 이를 이용한 화장료 조성물에 관한 것이다. The present invention relates to a composition for promoting collagen production comprising a root germ root root extract and a cosmetic composition using the same.
감국(Chrysanthemum indicum)은 다년생 식물로서 국내에서는 산지에서 많이 자생할 뿐만 아니라 대량으로도 재배되고 있으며, 본초강목에서는 간을 편안하게 다스리고 눈을 맑게 해주며, 열을 내리고 독기를 풀어준다고 기술하고 있다. 또한, 항균 작용과 항바이러스 작용 및 항염증 작용 등 다양한 생리학적 효과가 보고 되어 있다(Hu 등, Journal of Natural Products, 1994, 57, 42).Chrysanthemum indicum is a perennial plant. It is cultivated not only in Korea but also in large quantities in Korea. It is said that Chrysanthemum indicum regulates the liver comfortably, cleanses the eyes, releases fever, and relieves poisoning. In addition, various physiological effects such as antimicrobial action, antiviral action and anti-inflammatory action have been reported (Hu et al., Journal of Natural Products, 1994, 57, 42).
감국의 주성분은 플라보노이드 화합물, 테르페노이드 화합물 및 페놀성 화합물 등 다양한 성분에 대한 보고가 있다. The major components of ganoderma have been reported for various components such as flavonoid compounds, terpenoid compounds and phenolic compounds.
본 발명의 목적은 감국 뿌리 천연추출물을 이용함으로써 무독성이고 생체이용율 및 생리활성이 우수한 콜라겐 생성 촉진용 조성물을 제공하는 것이다. It is an object of the present invention to provide a composition for promoting collagen production which is non-toxic and excellent in bioavailability and physiological activity by using natural extract of Root Rot root.
본 발명의 또 다른 목적은 감국 뿌리 추출물을 포함하는 항산화/항노화 화장품 조성물 또는 식품조성물을 제공하는 것이다. Another object of the present invention is to provide an antioxidant / anti-aging cosmetic composition or a food composition comprising Root Root Extract.
본 발명의 일 예에서, 감국(Chrysanthemum indicum) 뿌리 추출물을 유효성분으로 포함하는, 콜라겐 생성 촉진용 조성물을 제공한다. In one example of the present invention, there is provided a composition for stimulating collagen production, comprising Chrysanthemum indicum root extract as an active ingredient.
본 발명자들은 감국(Chrysanthemum indicum) 뿌리 추출물이 콜라겐 생성 및 합성에 대한 활성이 있고, 특히 감국꽃 추출물에 비해 더 높은 콜라겐 합성능을 가짐을 확인하고, 이를 이용하여 항노화 및 항산화 효과가 있는 화장료 또는 식품 조성물을 개발하기에 이르렀다. The inventors of the present invention confirmed that Chrysanthemum indicum root extract has activity against collagen production and synthesis, and has a higher collagen synthesis performance than that of T. vaginalis flower extract. To develop food compositions.
일 예에서, 상기 감국 뿌리 추출물은 정제수와 유기용매, 예를 들어 에탄올을 50: 50 ~ 10:90, 바람직하게는 30: 70의 부피비로 혼합 첨가할 수 있으며, 상기 유기용매는 70% 내지 90%의 에탄올로서 열수 추출방법으로 얻을 수 있다. In one example, the root germ root extract may be mixed with purified water and an organic solvent such as ethanol at a volume ratio of 50:50 to 10:90, preferably 30:70, and the organic solvent may be 70% to 90% % Ethanol by hot water extraction method.
일 예에서, 상기 감국 뿌리 추출물은 초음파 추출방법으로 얻을 수 있다. In one example, the gut root extract can be obtained by an ultrasonic extraction method.
본 발명의 또 다른 측면에서, 상기 콜라겐 생성 촉진용 조성물은 콜라겐 생성으로 항노화 기능성 화장료 조성물, 약제학적 조성물 또는 기능성 식품 조성물에 포함될 수 있다. In another aspect of the present invention, the composition for promoting collagen production may be contained in an anti-aging functional cosmetic composition, a pharmaceutical composition or a functional food composition by collagen production.
본 발명에 따른 감국(Chrysanthemum indicum) 뿌리 추출물은 천연물 기반으로서 생체 이용율이 높고, 콜라겐 합성을 증가시킴으로써 주름방지 또는 개선 등 항노화 기능성 화장품, 의약품 또는 식품에 유용하게 쓰일 수 있다. The root extract of Chrysanthemum indicum according to the present invention is useful as an anti-aging functional cosmetics, medicines or foods, such as preventing or improving wrinkles by increasing bioavailability and enhancing collagen synthesis based on natural products.
도 1은 실시예 1에 따른 감국 뿌리 추출물에 대한 섬유아세포를 이용한 감국뿌리 추출물의 콜라겐 생성효능 시험 결과이다. 1 is a graph showing the results of a collagen production test of the root rot root extract using fibroblasts for the root rot root extract according to Example 1. Fig.
본 발명에서 사용되는 모든 기술용어는, 달리 정의되지 않는 이상, 하기의 정의를 가지며 본 발명의 관련 분야에서 통상의 당업자가 일반적으로 이해하는 바와 같은 의미에 부합된다. 또한 본 명세서에는 바람직한 방법이나 시료가 기재되나, 이와 유사하거나 동등한 것들도 본 발명의 범주에 포함된다. 본 명세서에 참고문헌으로 기재되는 모든 간행물의 내용은 본 발명에 도입된다. Unless defined otherwise, all technical terms used in the present invention have the following definitions and are consistent with the meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Also, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention. The contents of all publications referred to herein are incorporated herein by reference.
용어 "약"이라는 것은 참조 양, 수준, 값, 수, 빈도, 퍼센트, 치수, 크기, 양, 중량 또는 길이에 대해 30, 25, 20, 25, 10, 9, 8, 7, 6, 5, 4, 3, 2 또는 1% 정도로 변하는 양, 수준, 값, 수, 빈도, 퍼센트, 치수, 크기, 양, 중량 또는 길이를 의미한다.The term "about" is used herein to refer to a reference quantity, a level, a value, a number, a frequency, a percent, a dimension, a size, a quantity, a weight, or a length of 30, 25, 20, 25, 10, 9, 8, 7, Level, value, number, frequency, percent, dimension, size, quantity, weight or length of a variable, such as 4, 3, 2 or 1%.
본 명세서를 통해, 문맥에서 달리 필요하지 않으면, "포함하다" 및 "포함하는"이란 말은 제시된 단계 또는 구성요소, 또는 단계 또는 구성요소들의 군을 포함하나, 임의의 다른 단계 또는 구성요소, 또는 단계 또는 구성요소들의 군이 배제되지는 않음을 내포하는 것으로 이해하여야 한다.Throughout this specification, the words "comprises" and "comprising ", unless the context requires otherwise, include the steps or components, or groups of steps or elements, Steps, or groups of elements are not excluded.
본 발명에서 "감국(Chrysanthemum indicum) 뿌리 추출물"은 생화 도는 건화 상태의 감국의 뿌리로부터 수득한 물질을 의미하며, 추출물은 당업계에서 통상적으로 사용되는 추출 방법을 제한 없이 사용하여 수득할 수 있다. 예를 들어, 열수추출, 실온추출, 가온추출, 초음파추출, 초임계 추출 방법, 용매 추출법, 여과법 및 환류추출법 등 당업계의 통상적인 추출방법으로 제조된 것일 수 있다. 바람직하게는 감국 뿌리를 물, C1~C4의 저급 알코올 또는 이들의 혼합용매로 추출한 추출물일 수 있으며, 더욱 바람직하게는 물과 에탄올 또는 메탄올의 혼합용매로 추출한 추출물일 수 있다. 상기 감국 뿌리 추출물은 바람직하게는 열수추출물일 수 있는바, 예를 들어 정제수와 유기용매를 50: 50 ~ 30:70의 부피비로 혼합 첨가하여 열수 추출하여 얻을 수 있고, 이에 제한되는 것은 아니나, 여과한 후 농축될 수 있으며, 농축된 추출액은 살균될 수 있다. 또 상기 "추출물"의 의미에는 여과 등을 통하여 정제된 형태의 추출물, 추출 용매가 제거된 액상의 농축된 추출물 또는 고형상의 추출물이 포함된다. In the present invention, " Chrysanthemum indicum root extract" means a substance obtained from the roots of the germinating organs in the biotissue state, and the extract can be obtained by using an extraction method commonly used in the art without limitation. For example, they may be prepared by conventional extraction methods such as hot water extraction, room temperature extraction, warming extraction, ultrasonic extraction, supercritical extraction, solvent extraction, filtration and reflux extraction. Preferably, the extract may be an extract obtained by extracting rootstock from rootstock with water, C1-C4 lower alcohol or a mixed solvent thereof, more preferably extracting with water and a mixed solvent of ethanol and methanol. For example, purified water and an organic solvent may be mixed and added in a volume ratio of 50:50 to 30:70, followed by hot water extraction. However, , And the concentrated extract can be sterilized. The term "extract" includes an extract in purified form through filtration, a concentrated liquid extract in which the extraction solvent is removed, or a solid extract.
본 발명에서 "유효성분"이란 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.In the present invention, the term "active ingredient" means an ingredient that exhibits the desired activity alone or can exhibit activity together with a carrier that is itself inactive.
피부주름의 발생원인 중 하나로 피부교원질(콜라겐)의 결핍을 들고 있다. 콜라겐은 피부진피를 구성하는 주요 단백질로서 피부구조와 탄력을 유지하는 역할을 하고 있다. 콜라겐은 나이가 들면서 생성의 감소를 보이며 분해도 증가되어 피부 진피층의 함몰을 유도하여 피부의 주름을 생성하는 것으로 알려져 있다. 진피층에 존재하는 섬유아세포는 피부 구성 주요 단백질인 콜라겐의 합성을 담당하고 있다. 따라서 섬유아세포를 이용하여 콜라겐의 생성 증가 정도를 측정함으로써 추출물의 콜라겐 생성능 향상 및 주름개선 효력을 평가할 수 있다. 본 발명자들은 감국 뿌리 추출물이 사람의 섬유아세포에 처리될 경우 콜라겐의 생합성이 촉진시킴을 확인할 수 있었다. 여기서 콜라겐은 피부 탄력 및 피부 보습과 밀접한 관련성을 가지는 것으로 보고되어 있다. 본 발명자들은 나아가 감국 뿌리 추출용매 당 고형분의 농도가 높을수록 콜락겐 합성 촉진 능이 높아짐을 확인하였고, 특히 70% 에탄올 수용액 추출물이 우수한 활성을 나타내는 것을 확인할 수 있었다.One of the causes of skin wrinkles is the lack of collagen in the skin. Collagen is the main protein that constitutes the skin dermis and plays a role in keeping skin structure and elasticity. It is known that collagen shows a decrease in production with age and is increased in degradation to induce depression of the dermal layer of the skin to produce wrinkles of the skin. Fibroblasts present in the dermis are responsible for the synthesis of collagen, a major protein in the skin. Therefore, by measuring the degree of increase of collagen production using fibroblast, the collagen production ability and the wrinkle improvement effect of the extract can be evaluated. The present inventors have confirmed that the collagen biosynthesis is accelerated when human root fibroblasts are treated with root rot root extract. Here, collagen has been reported to be closely related to skin elasticity and skin moisturization. The present inventors further confirmed that the higher the concentration of the solid content per solvent in the root extract of the rootstock root, the higher the ability to promote collagen synthesis, and in particular, the 70% ethanol aqueous solution extract showed excellent activity.
본 발명은 이러한 실험 결과에 기초하여 제공되는 것으로서, 본 발명은 일 측면에 있어서, 감국 뿌리 추출물을 유효성분으로 포함하는 콜라겐 생성 촉진용 조성물로 파악할 수 있고, 다른 측면에 있어서는 감국 뿌리 추출물을 유효성분으로 하는 피부 주름 억제 등 항노화 화장료 조성물로 파악할 수 있다. 나아가 또 다른 측면에 있어서는 감국 뿌리 추출물을 유효성분으로 하는 항노화 기능성 식품 조성물로 파악할 수 있다. The present invention is based on the results of these experiments. In one aspect, the present invention can be grasped as a composition for promoting collagen production comprising an extract from Root Root Extract as an active ingredient, and in another aspect, And anti-aging cosmetic compositions such as skin wrinkle suppression. Furthermore, in another aspect, the composition can be regarded as an anti-aging functional food composition containing root extract of root rot root as an active ingredient.
상기 감국 뿌리 추출물은 추출 방법을 불문하고 추출 대상인 감국 뿌리를 메탄올, 에탄올, 아세톤, 에틸아세테이트, 포화노말부탄올, 클로로포름, 메틸렌클로라이드, 물, 또는 이들의 혼합 용매로 추출하여 얻어진 조추출물과 그 조추출물을 상기 열거된 용매로 분획하여 얻어진 추출물을 포함하는 의미로서 이해된다. 추출 방법을 불문하므로, 추출 대상을 추출 용매에 침지시키는 단계를 통하여 추출되는 한, 추출 방법은 냉침, 환류, 가온, 초음파 방사 등 임의의 방식이 모두 적용될 수 있다. 바람직한 예에 따르면 상기 감국 뿌리 추출물은 물, 에탄올 또는 이들의 혼합 용매로 추출하여 얻어진 것을 의미하며, 더 바람직하게는 에탄올 함량이 70% 내지 90%의 에탄올 수용액에 침지시켜 얻어진 추출물, 또는 70% 내지 90%의 에탄올 수용액 추출물을 물에 현탁하고 헥산, 디클로메탄, 에틸아세테이트 및 부탄올로 순차적으로 분획하였을 때 얻어지는 각 분획물을 의미한다. The extract of Root Root Extract is a crude extract obtained by extracting Root Root, which is a target to be extracted, with methanol, ethanol, acetone, ethyl acetate, saturated normal butanol, chloroform, methylene chloride, water or a mixed solvent thereof, Is extracted with the solvent listed above. As long as it is extracted through the step of immersing the object to be extracted in the extraction solvent, any method such as cold-rolling, refluxing, heating, and ultrasonic irradiation can be applied to the extraction method. According to a preferred example, the root rot root extract is obtained by extracting with water, ethanol or a mixed solvent thereof, more preferably an extract obtained by immersing in an ethanol aqueous solution having an ethanol content of 70% to 90% Means a fraction obtained by suspending an aqueous 90% aqueous solution of ethanol in water and sequentially fractionating it with hexane, dichloromethane, ethyl acetate and butanol.
본 발명의 구체적인 양태에 있어서, 상기 본 발명에 따른 감국 뿌리 추출물을 포함하는 피부주름 개선 등 항노화 기능성 화장료 조성물을 제공한다. In a specific embodiment of the present invention, there is provided an anti-aging functional cosmetic composition such as a skin wrinkle-improving agent containing the root root extract according to the present invention.
본 발명의 화장료 조성물은 다양한 형태로 제조될 수 있는데, 예컨대, 에멀젼, 로션, 크림(수중유적형, 유중수적형, 다중상), 용액, 현탁액(무수 및 수계), 무수 생성물(오일 및 글리콜계), 젤, 마스크, 팩, 분말 등의 제형으로 제조될 수 있다.The cosmetic composition of the present invention can be prepared in various forms such as emulsion, lotion, cream (aquatic type, water type, multiphase), solution, suspension (anhydrous and aquatic), anhydrous product ), A gel, a mask, a pack, a powder, and the like.
본 발명의 화장료 조성물은 그 유효성분 이외에 화장료 제제에 있어서 수용가능한 담체를 포함할 수 있다. 여기서 "화장료 제제에 있어서 수용가능한 담체"란 화장료 제제에 포함될 수 있는 이미 공지되어 사용되고 있는 화합물 또는 조성물이거나 앞으로 개발될 화합물 또는 조성물로서 피부와의 접촉시 인체가 적응 가능한 이상의 독성을 지니지 않는 것을 말한다.The cosmetic composition of the present invention may contain an acceptable carrier in cosmetic formulations in addition to its effective ingredient. As used herein, the term " acceptable carrier for a cosmetic preparation "refers to a compound or composition that is already known and used in the cosmetic preparation, or a compound or composition to be developed in the future, and has no toxicity that the human body can adapt to when contacted with skin.
상기 담체는 본 발명의 조성물에 그것의 전체 중량에 대하여 약 1 중량 % 내지 약 99.99 중량 %, 바람직하게는 조성물의 중량의 약 50 중량% 내지 약 99 중량 %로 포함될 수 있다. 그러나 상기 비율은 화장료의 전술한 바의 제형에 따라 또 그것의 구체적인 적용 부위(얼굴이나 손)나 그것의 바람직한 적용량 등에 따라 달라지는 것이기 때문에, 상기 비율은 어떠한 측면으로든 본 발명의 범위를 제한하는 것으로 이해되어서는 안 된다. The carrier may be included in the composition of the present invention in an amount of from about 1% by weight to about 99.99% by weight, preferably from about 50% by weight to about 99% by weight of the composition, based on the total weight thereof. However, since the ratio depends on the above-mentioned formulation of the cosmetic composition and its specific application site (face or hands) or its preferable application amount, the ratio is limited in any aspect to the scope of the present invention It should not be.
한편 상기 담체로서는 알코올, 오일, 계면활성제, 지방산, 실리콘 오일, 습윤제, 보습제, 점성 변형제, 유제, 안정제, 자외선 차단제, 발색제, 향료 등이 예시될 수 있다. Examples of the carrier include alcohols, oils, surfactants, fatty acids, silicone oils, humectants, moisturizers, viscosifiers, emulsifiers, stabilizers, sunscreens, coloring agents and perfumes.
상기 담체로서 사용될 수 있는 알코올, 오일, 계면활성제, 지방산, 실리콘 오일, 습윤제, 보습제, 점성 변형제, 유제, 안정제, 자외선 차단제, 발색제, 향료 로 사용될 수 있는 화합물/조성물 등은 이미 당업계에 공지되어 있기 때문에 당업자라면 적절한 해당 물질/조성물을 선택하여 사용할 수 있다.The compounds / compositions which can be used as the carrier and which can be used as alcohols, oils, surfactants, fatty acids, silicone oils, wetting agents, moisturizers, viscosifiers, emulsions, stabilizers, sunscreens, A person skilled in the art can select and use appropriate substances / compositions.
본 발명의 화장료 조성물은 당업계에 알려진 피부 보습 활성 물질, 항아토피 활성 물질, 항여드름 활성 물질, 미백 활성 물질 등 기능성 물질을 추가로 포함할 수도 있다.The cosmetic composition of the present invention may further comprise a functional substance such as a skin moisturizing active substance, an anti-atopic active substance, an anti-acne active substance, a whitening active substance, etc., which are known in the art.
본 발명의 조성물은 다른 구체적인 양태에 있어서 항노화 기능성 약제학적 조성물로 파악될 수 있다.The composition of the present invention may be identified as an anti-aging functional pharmaceutical composition in another specific embodiment.
본 발명의 약제학적 조성물은 그 유효성분 이외에 약제학적으로 허용되는 담체, 부형제 등을 포함하여, 국소형 제형 예컨대 크림, 로션, 연고(반고형의 외용약), 마이크로로에멀젼, 젤, 페이스트, 경피제제(TTS)(예컨대 패치제, 붕대 등) 등으로 제조될 수 있다. 상기에서 "약제학적으로 허용되는" 의미는 유효성분의 활성을 억제하지 않으면서 적용(처방) 대상이 적응가능한 이상의 독성을 지니지 않는다는 의미이다.The pharmaceutical composition of the present invention may be formulated into a wide variety of dosage forms, including pharmaceutically acceptable carriers, excipients and the like, in addition to the active ingredient, and may be formulated into a wide variety of dosage forms such as a localized preparation such as cream, lotion, ointment (semi-solid external drug), micro loo emulsion, (TTS) (e.g., patches, bandages, etc.), and the like. The term "pharmaceutically acceptable" as used herein means that the application (prescribing) subject does not have the above-mentioned toxicity that is adaptable without inhibiting the activity of the active ingredient.
약제학적으로 허용되는 담체의 예로서는 락토스, 글루코스, 슈크로스, 전분(예컨대 옥수수 전분, 감자 전분 등), 셀룰로오스, 그것의 유도체(예컨대 나트륨 카르복시메틸 셀룰로오스, 에틸셀룰로오스, 등), 맥아, 젤라틴, 탈크, 고체 윤활제(예컨대 스테아르산, 스테아르산 마그네슘 등), 황산 칼슘, 식물성 기름(예컨대 땅콩 기름, 면실유, 참기름, 올리브유 등), 폴리올(예컨대 프로필렌 글리콜, 글리세린 등), 알긴산, 유화제(예컨대 TWEENS), 습윤제(예컨대 라우릴 황산 나트륨), 착색제, 풍미제, 안정화제, 항산화제, 보존제, 물, 식염수, 인산염 완충 용액 등을 들 수 있다. 이러한 담체는 본 발명의 약제학적 조성물의 제형에 따라 적당한 것을 하나 이상 선택하여 사용할 수 있다.Examples of pharmaceutically acceptable carriers include lactose, glucose, sucrose, starch (e.g. corn starch, potato starch, etc.), cellulose, derivatives thereof (e.g. sodium carboxymethylcellulose, ethylcellulose, etc.), malt, gelatin, talc, (E.g., peanut oil, cottonseed oil, sesame oil, olive oil, etc.), polyols (e.g., propylene glycol, glycerin, etc.), alginic acid, emulsifiers (e.g., TWEENS), wetting agents (For example, sodium lauryl sulfate), a coloring agent, a flavoring agent, a stabilizer, an antioxidant, a preservative, water, a saline solution, and a phosphate buffer solution. The carrier may be selected from one or more of suitable pharmaceutical formulations according to the formulation of the pharmaceutical composition of the present invention.
부형제도 본 발명의 약제학적 조성물의 제형에 따라 적합한 것을 선택하여 사용할 수 있는데, 예컨대 나트륨 카르복시메틸 셀룰로오스, 메틸 셀룰로오스, 히드로프로필메틸셀룰로오스, 알긴산 나트륨, 폴리비닐피롤리돈 등의 현탁제나 분산제 등을 들 수 있다. The excipient may be selected according to the formulation of the pharmaceutical composition of the present invention. For example, suspending agents such as sodium carboxymethyl cellulose, methyl cellulose, hydropropyl methyl cellulose, sodium alginate, polyvinyl pyrrolidone, .
본 발명의 약제학적 조성물은 그 1일 투여량이 통상 0.001 ~ 150 mg/kg 체중 범위이고, 1회 또는 수회로 나누어 투여할 수 있다. 그러나, 본 발명의 약제학적 조성물의 투여량은 투여 경로, 환자의 연령, 성별, 체중, 환자의 중증도 등의 여러 관련 인자에 비추어 결정되는 것이므로 상기 투여량은 어떠한 측면으로든 본 발명의 범위를 제한하는 것으로 이해되어서는 아니 된다.The daily dose of the pharmaceutical composition of the present invention is usually 0.001 to 150 mg / kg body weight, and may be administered once or several times. However, since the dosage of the pharmaceutical composition of the present invention is determined in view of various related factors such as route of administration, age, sex, weight, and patient's severity of the patient, the dose is limited in any aspect to the scope of the present invention Should not be understood to be.
본 발명의 조성물은 또 다른 구체적인 양태에 있어 비누 조성물로서 파악될 수 있다.The composition of the present invention can be identified as a soap composition in another specific embodiment.
본 발명의 조성물이 비누 조성물로서 파악될 경우에, 본 발명의 비누 조성물은 비누 기재에 유효성분을 포함하여 제조될 수 있다.When the composition of the present invention is identified as a soap composition, the soap composition of the present invention can be prepared by incorporating the active ingredient into a soap base.
상기 비누 기재로서는 야자유, 팜유, 대두유, 파마자유, 올리브유, 팜핵류 등의 식물유지 또는 우지, 돈지, 양지, 어유 등의 동물유지 등이 사용될 수 있고, 상기 피부 보습제로서는 글리세린, 에리트리톨, 폴리에틸렌글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실글리콜, 이소프로필미리스테이트, 실리콘 유도체, 알로에베라, 솔비톨 등이 사용될 수 있으며, 상기 유화제로서는 천연오일, 왁스 지방알콜, 탄화수소류, 천연식물 추출물 등이 사용될 수 있고, 상기 경수연화제로서는 테트라소듐 이디티에이 등이 사용될 수 있다.Examples of the soap base material include vegetable oils such as palm oil, palm oil, soybean oil, perm free oil, olive oil and palm kernel oil or animal fats such as tallow, lard, sunshine and fish oil. Examples of the skin moisturizers include glycerin, erythritol, polyethylene glycol , Propylene glycol, butylene glycol, pentylene glycol, hexyl glycol, isopropyl myristate, silicone derivatives, aloe vera, sorbitol and the like. Examples of the emulsifier include natural oils, wax fatty alcohols, hydrocarbons, May be used. As the water softening agent, tetrasodium ethylenediate and the like may be used.
본 발명의 비누 조성물은 또한 첨가제로서 항균제, 분산제, 거품억제제, 용매, 물때 방지제, 부식 방지제, 향료, 색소, 금속이온 봉쇄제, 산화방지제, 방부제 등을 추가적으로 포함할 수 있다.The soap composition of the present invention may further contain, as an additive, an antibacterial agent, a dispersant, a foam inhibitor, a solvent, a scouring inhibitor, a corrosion inhibitor, a fragrance, a dye, a sequestering agent, an antioxidant and an antiseptic.
본 발명의 비누 조성물에 있어서, 비누 기재나 첨가제는 당업계에 일반적으로 사용되고 있는 함량으로 포함될 수 있는데, 비누 기재는 일반적으로 비누 조성물의 전체 중량을 기준으로 하였을 때 99.999 중량 % 내지 50 중량 %로 첨가될 수 있으며, 첨가제는 1 중량 % 내지 20 중량 %로 첨가될 수 있다. In the soap composition of the present invention, the soap base or additive may be included in a content commonly used in the art, wherein the soap base generally comprises from 99.999% to 50% by weight, based on the total weight of the soap composition And the additive may be added in an amount of 1 wt% to 20 wt%.
본 발명의 조성물은 또 다른 구체적인 양태에 있어 감국 뿌리 추출물을 유효성분으로 하는 항산화 기능성 식품 조성물로 파악할 수 있다.The composition of the present invention can be regarded as an antioxidant-functional food composition containing Root Rot root extract as an active ingredient in another specific embodiment.
본 발명의 식품 조성물에는 그 유효성분 이외에 감미제, 풍미제, 생리활성 성분, 미네랄 등이 포함될 수 있다.The food composition of the present invention may contain sweetening agents, flavoring agents, physiologically active ingredients, minerals and the like in addition to the active ingredients thereof.
감미제는 식품이 적당한 단맛을 나게 하는 양으로 사용될 수 있으며, 천연의 것이거나 합성된 것일 수 있다. 바람직하게는 천연 감미제를 사용하는 경우인데, 천연 감미제로서는 옥수수 시럽 고형물, 꿀, 수크로오스, 프룩토오스, 락토오스, 말토오스 등의 당 감미제를 들 수 있다. Sweetening agents may be used in an amount that sweetens the food in a suitable manner, and may be natural or synthetic. Preferably, natural sweeteners are used. Examples of natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.
풍미제는 맛이나 향을 좋게 하기 위하여 사용될 수 있는데, 천연의 것과 합성된 것 모두 사용될 수 있다. 바람직하게는 천연의 것을 사용하는 경우이다. 천연의 것을 사용할 경우에 풍미 이외에 영양 강화의 목적도 병행할 수 있다. 천연 풍미제로서는 사과, 레몬, 감귤, 포도, 딸기, 복숭아 등에서 얻어진 것이거나 녹차잎, 둥굴레, 대잎, 계피, 국화 잎, 자스민 등에서 얻어진 것일 수 있다. 또 인삼(홍삼), 죽순, 알로에 베라, 은행 등에서 얻어진 것을 사용할 수 있다. 천연 풍미제는 액상의 농축액이나 고형상의 추출물일 수 있다. 경우에 따라서 합성 풍미제가 사용될 수 있는데, 합성 풍미제는 에스테르, 알콜, 알데하이드, 테르펜 등의 형태의 것들이 이용될 수 있다. Flavors may be used to enhance taste or flavor, both natural and synthetic. Preferably, a natural one is used. When using natural ones, the purpose of nutritional fortification can be performed in addition to the flavor. Examples of natural flavoring agents include those obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or those obtained from green tea leaves, Asiatica, Daegu, Cinnamon, Chrysanthemum leaves and Jasmine. Also, those obtained from ginseng (red ginseng), bamboo shoots, aloe vera, banks and the like can be used. The natural flavoring agent may be a liquid concentrate or a solid form of extract. Synthetic flavoring agents may be used depending on the case. Synthetic flavoring agents such as esters, alcohols, aldehydes and terpenes may be used.
생리 활성 물질로서는 카테킨, 에피카테킨, 갈로가테킨, 에피갈로카테킨 등의 카테킨류나, 레티놀, 아스코르브산, 토코페롤, 칼시페롤, 티아민, 리보플라빈 등의 비타민류 등이 사용될 수 있다.Examples of the physiologically active substance include catechins such as catechin, epicatechin, gallocatechin and epigallocatechin, and vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamine and riboflavin.
미네랄로서는 칼슘, 마그네슘, 크롬, 코발트, 구리, 불소화물, 게르마늄, 요오드, 철, 리튬, 마그네슘, 망간, 몰리브덴, 인, 칼륨, 셀레늄, 규소, 나트륨, 황, 바나듐, 아연 등이 사용될 수 있다.As the mineral, calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, silicon, sodium, sulfur, vanadium and zinc can be used.
또한 본 발명의 식품 조성물은 상기 감미제 등 이외에도 필요에 따라 보존제, 유화제, 산미료, 점증제 등을 포함할 수 있다. In addition, the food composition of the present invention may contain preservatives, emulsifiers, acidifiers, thickeners and the like as needed in addition to the above sweeteners.
이러한 보존제, 유화제 등은 그것이 첨가되는 용도를 달성할 수 있는 한 극미량으로 첨가되어 사용되는 것이 바람직하다. "극미량"이란 수치적으로 표현할 때 식품 조성물 전체 중량을 기준으로 할 때 0.0005중량％ 내지 약 0.5중량％ 범위를 의미한다.Such preservatives, emulsifiers and the like are preferably added in a very small amount as long as they can attain an application to which they are added. By "trace amount" is meant numerically the range of from 0.0005% to about 0.5% by weight based on the total weight of the food composition.
사용될 수 있는 보존제로서는 소듐 소르브산칼슘, 소르브산나트륨, 소르브산칼륨, 벤조산칼슘, 벤조산나트륨, 벤조산칼륨, EDTA(에틸렌디아민테트라아세트산) 등을 들 수 있다. Examples of the preservative which can be used include calcium sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate and EDTA (ethylenediaminetetraacetic acid).
사용될 수 있는 유화제로서는 아카시아검, 카르복시메틸셀룰로스, 잔탄검, 펙틴 등을 들 수 있다.Examples of the emulsifier which can be used include acacia gum, carboxymethyl cellulose, xanthan gum, pectin and the like.
사용될 수 있는 산미료로서는 연산, 말산, 푸마르산, 아디프산, 인산, 글루콘산, 타르타르산, 아스코르브산, 아세트산, 인산 등을 들 수 있다. 이러한 산미료는 맛을 증진시키는 목적 이외에 미생물의 증식을 억제할 목적으로 식품 조성물이 적정 산도로 되도록 첨가될 수 있다.Examples of the acidulant that can be used include acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, and phosphoric acid. Such an acidulant may be added so that the food composition has a proper acidity for the purpose of inhibiting the growth of microorganisms other than the purpose of enhancing the taste.
사용될 수 있는 점증제로서는 현탁화 구현제, 침강제, 겔형성제, 팽화제 등을 들 수 있다. Agents that may be used include suspending agents, sedimentation agents, gel formers, bulking agents and the like.
이하, 본 발명의 일 실시형태에 따라 실시예를 통하여 본 발명을 보다 구체적으로 설명하나, 이들이 본 발명의 범위를 제한하는 것은 아니다.BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail with reference to the following examples, but they should not be construed as limiting the scope of the present invention.
[제조예 1] 감국 뿌리 추출물의 제조 [Preparation Example 1] Preparation of Root Extract
건조하여 준비된 감국뿌리를 고형분 기준 10%에 대해 정제수와 유기용매로써 저급 에탄올을 30:70의 부피비(70%)로 혼합 첨가하여 열수 추출 또는 초음파 추출 방법을 사용하여 교반하여 추출액을 회수하고 이를 농축하여 1차 정제하였다. 더욱 정제하고자 할 때는 4℃에서 분자량 10kD의 막 필터를 이용한 투석을 통해 저분자량의 물질을 제거하였다. 추출용매(70% 에탄올) ml당 감국뿌리 고형분이 0, 10, 50, 100ug/ml이 되도록 농도를 맞추어 실험을 진행하였다. The dried rootstock was mixed with purified water at a ratio of 10% based on the solids content and low ethanol as an organic solvent at a volume ratio (70%) of 30:70, and the mixture was stirred using hot water extraction or ultrasonic extraction to recover the extract. And then subjected to primary purification. For further purification, low molecular weight substances were removed by dialysis using a membrane filter with a molecular weight of 10 kD at 4 ° C. Experiments were carried out at concentrations of 0, 10, 50, and 100 ug / ml per ml of extraction solvent (70% ethanol).
[실험예 1] 콜라겐 생성효능 [Experimental Example 1] Effect of collagen production
감국 뿌리 추출물의 콜라겐 생합성 촉진효과를 알아보기 위해, 인체 정상 섬유아세포(fibroblast)를 96-웰 마이크로 플레이트(96-wellmicroplate)의 각 웰(well)에 1X104 세포가 되도록 접종하여 디엠이엠(DMEM) 배지에서 24시간 배양한다. 배양 후 상기에서 제조한 실시예 1 의 감국 뿌리 추출물을 최종농도 ___㎍/ml가 되도록 조정한 혈청이 없는 디엠이엠 배지로 교체한 후 48시간 더 배양한다. 배양 마지막 24시간 전에 아스코르빅산 50㎍/ml를 첨가하여 콜라겐 합성을 촉진시킨다. 배양 후 각 웰을 세척하고 혈청이 함유되지 않은 디엠이엠 배지로 교체한 후 24시간 더 배양한다. 배양 후 각 웰의 상층액을 모아 프로콜라겐 타입 아이씨-펩타이드(PICP, Type-IC-peptide)양을 키트(Kit, Takara, Kyoto, Japan)를 이용하여 새로 합성된 콜라겐 양을 PICP 양으로 측정하였으며 PICP 양은 ng/2X104세포로 환산하여 콜라겐의 합성효과를 하기 표 2에 나타내었다. To examine collagen biosynthesis promoting effect of root rot root extract, human normal fibroblast was inoculated into each well of a 96-well microplate to be 1 × 10 4 cells and cultured in DMEM, And cultured in a medium for 24 hours. After cultivation, the Gamma root extract of Example 1 prepared above is replaced with serum-free DM medium adjusted to have a final concentration of ___ g / ml, and then cultured for another 48 hours. 50 μg / ml of ascorbic acid is added 24 hours prior to incubation to promote collagen synthesis. After incubation, each well is washed and replaced with DMEM medium containing no serum, followed by further incubation for 24 hours. After the incubation, the supernatant of each well was collected and the amount of collagen type IIC-peptide (PICP, Type-IC-peptide) was measured using a kit (Kit, Takara, Kyoto, Japan) The amount of PICP in terms of ng / 2 × 10 4 cells and the effect of collagen synthesis are shown in Table 2 below.
감국뿌리의 경우 시험농도에 비례하여 콜라겐 생성증가를 보였으며, 시험 최고 농도인 100ug/ml에서 18%의 콜라겐 생성능 향상을 보였다. In the case of rootstock, the collagen production was increased in proportion to the test concentration, and the collagen production was improved by 18% at the maximum concentration of 100 ug / ml.
[제형예 1] 밀크로션의 제조[Formulation Example 1] Production of Milk Lotion
상기 실시예 1에서 제조한 감국 뿌리 추출물을 함유하는 밀크로션을 하기 표 1의 조성에 따라 제조하였다. Milk lotions containing the root rot root extract prepared in Example 1 were prepared according to the composition shown in Table 1 below.
[제형예 2] 영양크림의 제조[Formulation Example 2] Preparation of nutritional cream
상기 실시예 1에서 제조한 감국 뿌리 추출물을 함유하는 영양크림을 하기 표 2의 조성에 따라 제조하였다.Nutritive creams containing the root rot root extract prepared in Example 1 were prepared according to the composition shown in Table 2 below.
본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자는 본 발명이 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 변형된 형태로 구현될 수 있음을 이해할 수 있을 것이다. 그러므로 개시된 실시예들은 한정적인 관점이 아니라 설명적인 관점에서 고려되어야 한다. 본 발명의 범위는 전술한 설명이 아니라 특허청구범위에 나타나 있으며, 그와 동등한 범위 내에 있는 모든 차이점은 본 발명에 포함된 것으로 해석되어야 할 것이다. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.
Claims (7)
Gamguk (Chrysanthemum indicum) for purified water and ethanol at the root 50: Mixture in a volume ratio of 50 to 10: 90 to gamguk obtained by hot-water extraction method (Chrysanthemum indicum) root extract to, collagen production promoting cosmetic composition comprising as an active ingredient.
상기 감국 뿌리 추출물은 용매 ml 당 감국 뿌리 고형분 농도가 90~150 ug/ml 이 되게 하여 얻은 것을 특징으로 하는 콜라겐 생성 촉진용 화장료 조성물.
The method according to claim 1,
The cosmetic composition for accelerating collagen production according to any one of claims 1 to 5, wherein the root root extract of the rootstock is obtained by allowing the solid root concentration of root root to be 90-150 ug / ml per ml of solvent.
A functional cosmetic composition for improving wrinkles comprising the composition according to claim 1 as an active ingredient.
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