SG178795A1

SG178795A1 - Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof

Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof Download PDF

Info

Publication number: SG178795A1
Authority: SG; Singapore
Prior art keywords: cancer; angiopoietin; compound; benzoyl; angeloyl
Prior art date: 2007-02-16

Application number

SG2012011029A

Other languages

English (en)

Inventor

Pui-Kwong Chan

May Sung Mak

Original Assignee

Pacific Arrow Ltd

Priority date

2007-02-16

Filing date

2008-02-15

Publication date

2012-03-29

2007-03-07 Priority claimed from US11/683,198 external-priority patent/US8614197B2/en

2007-08-30 Priority claimed from PCT/US2007/077273 external-priority patent/WO2008028060A2/fr

2008-02-15 Application filed by Pacific Arrow Ltd filed Critical Pacific Arrow Ltd

2012-03-29 Publication of SG178795A1 publication Critical patent/SG178795A1/en

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 232
206010028980 Neoplasm Diseases 0.000 title claims abstract description 158
108090000623 proteins and genes Proteins 0.000 title claims abstract description 127
201000011510 cancer Diseases 0.000 title claims abstract description 117
102000004169 proteins and genes Human genes 0.000 title claims abstract description 101
206010027476 Metastases Diseases 0.000 title claims abstract description 53
230000009401 metastasis Effects 0.000 title claims abstract description 53
230000005012 migration Effects 0.000 title abstract description 33
238000013508 migration Methods 0.000 title abstract description 33
230000000903 blocking effect Effects 0.000 title description 14
210000004027 cell Anatomy 0.000 claims abstract description 251
108010067306 Fibronectins Proteins 0.000 claims abstract description 167
238000000034 method Methods 0.000 claims abstract description 160
-1 polyglycans Proteins 0.000 claims abstract description 149
230000002401 inhibitory effect Effects 0.000 claims abstract description 92
230000014509 gene expression Effects 0.000 claims abstract description 79
239000000203 mixture Substances 0.000 claims abstract description 68
102000006495 integrins Human genes 0.000 claims abstract description 49
108010044426 integrins Proteins 0.000 claims abstract description 49
102000008186 Collagen Human genes 0.000 claims abstract description 39
108010035532 Collagen Proteins 0.000 claims abstract description 39
229920001436 collagen Polymers 0.000 claims abstract description 39
108010008125 Tenascin Proteins 0.000 claims abstract description 38
108010031318 Vitronectin Proteins 0.000 claims abstract description 37
102100035140 Vitronectin Human genes 0.000 claims abstract description 37
102000000905 Cadherin Human genes 0.000 claims abstract description 36
108050007957 Cadherin Proteins 0.000 claims abstract description 36
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 35
108010085895 Laminin Proteins 0.000 claims abstract description 35
102000007547 Laminin Human genes 0.000 claims abstract description 35
102000003505 Myosin Human genes 0.000 claims abstract description 34
108060008487 Myosin Proteins 0.000 claims abstract description 34
230000005907 cancer growth Effects 0.000 claims abstract description 34
229920000669 heparin Polymers 0.000 claims abstract description 32
229960002897 heparin Drugs 0.000 claims abstract description 32
206010033128 Ovarian cancer Diseases 0.000 claims abstract description 28
230000001105 regulatory effect Effects 0.000 claims abstract description 27
206010061535 Ovarian neoplasm Diseases 0.000 claims abstract description 23
208000032839 leukemia Diseases 0.000 claims abstract description 22
201000001441 melanoma Diseases 0.000 claims abstract description 22
208000008839 Kidney Neoplasms Diseases 0.000 claims abstract description 21
206010038389 Renal cancer Diseases 0.000 claims abstract description 21
201000010982 kidney cancer Diseases 0.000 claims abstract description 21
210000000265 leukocyte Anatomy 0.000 claims abstract description 19
206010058467 Lung neoplasm malignant Diseases 0.000 claims abstract description 16
208000000453 Skin Neoplasms Diseases 0.000 claims abstract description 16
201000000849 skin cancer Diseases 0.000 claims abstract description 16
206010005949 Bone cancer Diseases 0.000 claims abstract description 15
208000018084 Bone neoplasm Diseases 0.000 claims abstract description 15
208000003174 Brain Neoplasms Diseases 0.000 claims abstract description 15
206010006187 Breast cancer Diseases 0.000 claims abstract description 15
208000026310 Breast neoplasm Diseases 0.000 claims abstract description 15
201000007270 liver cancer Diseases 0.000 claims abstract description 15
208000014018 liver neoplasm Diseases 0.000 claims abstract description 15
206010009944 Colon cancer Diseases 0.000 claims abstract description 14
206010060862 Prostate cancer Diseases 0.000 claims abstract description 14
208000000236 Prostatic Neoplasms Diseases 0.000 claims abstract description 14
201000007455 central nervous system cancer Diseases 0.000 claims abstract description 14
208000029742 colonic neoplasm Diseases 0.000 claims abstract description 14
201000005202 lung cancer Diseases 0.000 claims abstract description 14
208000020816 lung neoplasm Diseases 0.000 claims abstract description 14
230000008569 process Effects 0.000 claims abstract description 14
102100037362 Fibronectin Human genes 0.000 claims description 172
125000002252 acyl group Chemical group 0.000 claims description 137
235000000346 sugar Nutrition 0.000 claims description 115
125000005601 angeloyl group Chemical group 0.000 claims description 80
230000001603 reducing effect Effects 0.000 claims description 72
239000003814 drug Substances 0.000 claims description 65
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 57
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 56
125000005607 tigloyl group Chemical group 0.000 claims description 53
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 52
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 52
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 49
125000003118 aryl group Chemical group 0.000 claims description 44
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 39
239000002253 acid Substances 0.000 claims description 39
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 37
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 36
239000008103 glucose Substances 0.000 claims description 35
PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims description 33
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 32
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 32
229930182830 galactose Natural products 0.000 claims description 32
239000000126 substance Substances 0.000 claims description 30
102000009840 Angiopoietins Human genes 0.000 claims description 27
108010009906 Angiopoietins Proteins 0.000 claims description 27
IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims description 26
229940097043 glucuronic acid Drugs 0.000 claims description 26
IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 claims description 25
125000000217 alkyl group Chemical group 0.000 claims description 25
WURBFLDFSFBTLW-UHFFFAOYSA-N benzil Chemical group C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 WURBFLDFSFBTLW-UHFFFAOYSA-N 0.000 claims description 25
150000003839 salts Chemical class 0.000 claims description 23
102100034608 Angiopoietin-2 Human genes 0.000 claims description 22
PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 22
150000002148 esters Chemical class 0.000 claims description 21
SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 20
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
108010048036 Angiopoietin-2 Proteins 0.000 claims description 19
229910052739 hydrogen Inorganic materials 0.000 claims description 19
239000001257 hydrogen Substances 0.000 claims description 19
206010005003 Bladder cancer Diseases 0.000 claims description 17
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 17
208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 15
201000005112 urinary bladder cancer Diseases 0.000 claims description 15
WQZGKKKJIJFFOK-CBPJZXOFSA-N D-Gulose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O WQZGKKKJIJFFOK-CBPJZXOFSA-N 0.000 claims description 14
WQZGKKKJIJFFOK-IVMDWMLBSA-N D-allopyranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@@H]1O WQZGKKKJIJFFOK-IVMDWMLBSA-N 0.000 claims description 14
LKDRXBCSQODPBY-JDJSBBGDSA-N D-allulose Chemical compound OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O LKDRXBCSQODPBY-JDJSBBGDSA-N 0.000 claims description 14
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 14
229930091371 Fructose Natural products 0.000 claims description 14
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 14
239000005715 Fructose Substances 0.000 claims description 14
PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims description 14
LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 claims description 14
WQZGKKKJIJFFOK-VSOAQEOCSA-N L-altropyranose Chemical compound OC[C@@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-VSOAQEOCSA-N 0.000 claims description 14
SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 14
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 14
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 14
SRBFZHDQGSBBOR-STGXQOJASA-N alpha-D-lyxopyranose Chemical compound O[C@@H]1CO[C@H](O)[C@@H](O)[C@H]1O SRBFZHDQGSBBOR-STGXQOJASA-N 0.000 claims description 14
125000002951 idosyl group Chemical class C1([C@@H](O)[C@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims description 14
WQZGKKKJIJFFOK-WHZQZERISA-N D-aldose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-WHZQZERISA-N 0.000 claims description 13
102100022337 Integrin alpha-V Human genes 0.000 claims description 13
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
210000004556 brain Anatomy 0.000 claims description 12
210000004185 liver Anatomy 0.000 claims description 12
210000004072 lung Anatomy 0.000 claims description 12
210000003932 urinary bladder Anatomy 0.000 claims description 12
210000003491 skin Anatomy 0.000 claims description 11
102100025665 Angiopoietin-related protein 1 Human genes 0.000 claims description 10
101001027128 Homo sapiens Fibronectin Proteins 0.000 claims description 10
210000000988 bone and bone Anatomy 0.000 claims description 10
108010048154 Angiopoietin-1 Proteins 0.000 claims description 9
102000009088 Angiopoietin-1 Human genes 0.000 claims description 9
101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 claims description 9
101000740400 Homo sapiens Secretory carrier-associated membrane protein 1 Proteins 0.000 claims description 9
102100037230 Secretory carrier-associated membrane protein 1 Human genes 0.000 claims description 9
210000000481 breast Anatomy 0.000 claims description 9
210000001072 colon Anatomy 0.000 claims description 9
210000002307 prostate Anatomy 0.000 claims description 9
102100028003 Catenin alpha-1 Human genes 0.000 claims description 8
102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 8
102100035820 Unconventional myosin-Ie Human genes 0.000 claims description 8
210000003169 central nervous system Anatomy 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 8
102100025674 Angiopoietin-related protein 4 Human genes 0.000 claims description 7
101000693093 Homo sapiens Angiopoietin-related protein 1 Proteins 0.000 claims description 7
101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 claims description 7
101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 7
101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims description 7
102100032818 Integrin alpha-4 Human genes 0.000 claims description 7
230000033115 angiogenesis Effects 0.000 claims description 7
230000002611 ovarian Effects 0.000 claims description 7
230000004936 stimulating effect Effects 0.000 claims description 7
102100025668 Angiopoietin-related protein 3 Human genes 0.000 claims description 6
101000693085 Homo sapiens Angiopoietin-related protein 3 Proteins 0.000 claims description 6
101001008568 Homo sapiens Laminin subunit beta-1 Proteins 0.000 claims description 6
101001022780 Homo sapiens Myosin light chain kinase, smooth muscle Proteins 0.000 claims description 6
101001072202 Homo sapiens Protein disulfide-isomerase Proteins 0.000 claims description 6
101000585623 Homo sapiens Unconventional myosin-X Proteins 0.000 claims description 6
102100027448 Laminin subunit beta-1 Human genes 0.000 claims description 6
102100034710 Laminin subunit gamma-1 Human genes 0.000 claims description 6
101700049202 MYO1C Proteins 0.000 claims description 6
241000124008 Mammalia Species 0.000 claims description 6
102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 claims description 6
102100036352 Protein disulfide-isomerase Human genes 0.000 claims description 6
102100029827 Unconventional myosin-X Human genes 0.000 claims description 6
108010069801 angiopoietin 4 Proteins 0.000 claims description 6
102100036364 Cadherin-2 Human genes 0.000 claims description 5
102100028906 Catenin delta-1 Human genes 0.000 claims description 5
102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims description 5
102100031502 Collagen alpha-2(V) chain Human genes 0.000 claims description 5
101000714537 Homo sapiens Cadherin-2 Proteins 0.000 claims description 5
101000859063 Homo sapiens Catenin alpha-1 Proteins 0.000 claims description 5
101000916264 Homo sapiens Catenin delta-1 Proteins 0.000 claims description 5
101000940068 Homo sapiens Collagen alpha-1(XVIII) chain Proteins 0.000 claims description 5
101000710876 Homo sapiens Collagen alpha-2(IV) chain Proteins 0.000 claims description 5
101000941594 Homo sapiens Collagen alpha-2(V) chain Proteins 0.000 claims description 5
101000976713 Homo sapiens Integrin beta-like protein 1 Proteins 0.000 claims description 5
101000595904 Homo sapiens Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Proteins 0.000 claims description 5
101000595907 Homo sapiens Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 Proteins 0.000 claims description 5
101000614345 Homo sapiens Prolyl 4-hydroxylase subunit alpha-1 Proteins 0.000 claims description 5
101000583031 Homo sapiens Unconventional myosin-Va Proteins 0.000 claims description 5
102100023481 Integrin beta-like protein 1 Human genes 0.000 claims description 5
102100022743 Laminin subunit alpha-4 Human genes 0.000 claims description 5
102100035202 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Human genes 0.000 claims description 5
102100035198 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 Human genes 0.000 claims description 5
102100031834 Unconventional myosin-VI Human genes 0.000 claims description 5
102100030409 Unconventional myosin-Va Human genes 0.000 claims description 5
108010049787 myosin VI Proteins 0.000 claims description 5
108010088547 ARNTL Transcription Factors Proteins 0.000 claims description 4
102000008867 ARNTL Transcription Factors Human genes 0.000 claims description 4
102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 claims description 4
102100021251 Beclin-1 Human genes 0.000 claims description 4
102100024154 Cadherin-13 Human genes 0.000 claims description 4
102100025232 Calcium/calmodulin-dependent protein kinase type II subunit beta Human genes 0.000 claims description 4
102100033781 Collagen alpha-2(IV) chain Human genes 0.000 claims description 4
102100037569 Dual specificity protein phosphatase 10 Human genes 0.000 claims description 4
102100030673 Histone H2A.V Human genes 0.000 claims description 4
101000894649 Homo sapiens Beclin-1 Proteins 0.000 claims description 4
101000762243 Homo sapiens Cadherin-13 Proteins 0.000 claims description 4
101001077352 Homo sapiens Calcium/calmodulin-dependent protein kinase type II subunit beta Proteins 0.000 claims description 4
101000749004 Homo sapiens Collagen alpha-1(XIII) chain Proteins 0.000 claims description 4
101000881127 Homo sapiens Dual specificity protein phosphatase 10 Proteins 0.000 claims description 4
101001084711 Homo sapiens Histone H2A.V Proteins 0.000 claims description 4
101000972488 Homo sapiens Laminin subunit alpha-4 Proteins 0.000 claims description 4
101001028827 Homo sapiens Myosin phosphatase Rho-interacting protein Proteins 0.000 claims description 4
101001000109 Homo sapiens Myosin-10 Proteins 0.000 claims description 4
101001030232 Homo sapiens Myosin-9 Proteins 0.000 claims description 4
101000611643 Homo sapiens Protein phosphatase 1 regulatory subunit 15A Proteins 0.000 claims description 4
101000988232 Homo sapiens Protocadherin gamma-A10 Proteins 0.000 claims description 4
101000988230 Homo sapiens Protocadherin gamma-A11 Proteins 0.000 claims description 4
101000988229 Homo sapiens Protocadherin gamma-A12 Proteins 0.000 claims description 4
101000602015 Homo sapiens Protocadherin gamma-B4 Proteins 0.000 claims description 4
101001069710 Homo sapiens Serine protease 23 Proteins 0.000 claims description 4
101000835083 Homo sapiens Tissue factor pathway inhibitor 2 Proteins 0.000 claims description 4
101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims description 4
101000850794 Homo sapiens Tropomyosin alpha-3 chain Proteins 0.000 claims description 4
101000982054 Homo sapiens Unconventional myosin-Ib Proteins 0.000 claims description 4
101000982047 Homo sapiens Unconventional myosin-XIX Proteins 0.000 claims description 4
101000775709 Homo sapiens V-type proton ATPase subunit C 1 Proteins 0.000 claims description 4
102100037183 Myosin phosphatase Rho-interacting protein Human genes 0.000 claims description 4
102100036640 Myosin-10 Human genes 0.000 claims description 4
102100038938 Myosin-9 Human genes 0.000 claims description 4
102100040477 Prolyl 4-hydroxylase subunit alpha-1 Human genes 0.000 claims description 4
102100040714 Protein phosphatase 1 regulatory subunit 15A Human genes 0.000 claims description 4
102100029258 Protocadherin gamma-A10 Human genes 0.000 claims description 4
102100029263 Protocadherin gamma-A11 Human genes 0.000 claims description 4
102100029264 Protocadherin gamma-A12 Human genes 0.000 claims description 4
102100037554 Protocadherin gamma-B4 Human genes 0.000 claims description 4
102100033835 Serine protease 23 Human genes 0.000 claims description 4
102100038126 Tenascin Human genes 0.000 claims description 4
102100026134 Tissue factor pathway inhibitor 2 Human genes 0.000 claims description 4
102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims description 4
102100033080 Tropomyosin alpha-3 chain Human genes 0.000 claims description 4
102100026776 Unconventional myosin-Ib Human genes 0.000 claims description 4
102100026769 Unconventional myosin-XIX Human genes 0.000 claims description 4
102100032189 V-type proton ATPase subunit C 1 Human genes 0.000 claims description 4
108010090909 laminin gamma 1 Proteins 0.000 claims description 4
229920002791 poly-4-hydroxybutyrate Polymers 0.000 claims description 4
DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 claims description 4
102100033402 Angiopoietin-4 Human genes 0.000 claims description 3
102100025672 Angiopoietin-related protein 2 Human genes 0.000 claims description 3
102100034567 Angiopoietin-related protein 5 Human genes 0.000 claims description 3
102100034598 Angiopoietin-related protein 7 Human genes 0.000 claims description 3
102100024156 Cadherin-12 Human genes 0.000 claims description 3
102100029761 Cadherin-5 Human genes 0.000 claims description 3
102100033471 Cbp/p300-interacting transactivator 2 Human genes 0.000 claims description 3
102100022145 Collagen alpha-1(IV) chain Human genes 0.000 claims description 3
102100031457 Collagen alpha-1(V) chain Human genes 0.000 claims description 3
102100040993 Collagen alpha-1(XIII) chain Human genes 0.000 claims description 3
102100033775 Collagen alpha-5(IV) chain Human genes 0.000 claims description 3
102100033773 Collagen alpha-6(IV) chain Human genes 0.000 claims description 3
101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 claims description 3
101000693081 Homo sapiens Angiopoietin-related protein 2 Proteins 0.000 claims description 3
101000924346 Homo sapiens Angiopoietin-related protein 5 Proteins 0.000 claims description 3
101000924546 Homo sapiens Angiopoietin-related protein 7 Proteins 0.000 claims description 3
101000762238 Homo sapiens Cadherin-12 Proteins 0.000 claims description 3
101000944098 Homo sapiens Cbp/p300-interacting transactivator 2 Proteins 0.000 claims description 3
101000901150 Homo sapiens Collagen alpha-1(IV) chain Proteins 0.000 claims description 3
101000941708 Homo sapiens Collagen alpha-1(V) chain Proteins 0.000 claims description 3
101000710886 Homo sapiens Collagen alpha-5(IV) chain Proteins 0.000 claims description 3
101000710885 Homo sapiens Collagen alpha-6(IV) chain Proteins 0.000 claims description 3
101000612134 Homo sapiens Procollagen C-endopeptidase enhancer 1 Proteins 0.000 claims description 3
101000595913 Homo sapiens Procollagen glycosyltransferase Proteins 0.000 claims description 3
101000614347 Homo sapiens Prolyl 4-hydroxylase subunit alpha-2 Proteins 0.000 claims description 3
101000613336 Homo sapiens Protocadherin gamma-A3 Proteins 0.000 claims description 3
102100041026 Procollagen C-endopeptidase enhancer 1 Human genes 0.000 claims description 3
102100035199 Procollagen glycosyltransferase Human genes 0.000 claims description 3
102100040922 Protocadherin gamma-A3 Human genes 0.000 claims description 3
125000000328 arabinofuranosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 3
PJOHVEQSYPOERL-SHEAVXILSA-N (e)-n-[(4r,4as,7ar,12br)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N[C@]1(CCC(=O)[C@@H]2O3)[C@H]4CC5=CC=C(O)C3=C5[C@]12CCN4CC1CC1 PJOHVEQSYPOERL-SHEAVXILSA-N 0.000 claims description 2
102100040973 26S proteasome non-ATPase regulatory subunit 1 Human genes 0.000 claims description 2
102100024419 28S ribosomal protein S31, mitochondrial Human genes 0.000 claims description 2
102100024420 39S ribosomal protein S30, mitochondrial Human genes 0.000 claims description 2
102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims description 2
102100027398 A disintegrin and metalloproteinase with thrombospondin motifs 1 Human genes 0.000 claims description 2
108091005660 ADAMTS1 Proteins 0.000 claims description 2
102100028357 ADP-ribosylation factor-like protein 8B Human genes 0.000 claims description 2
102100033347 AP-2 complex subunit beta Human genes 0.000 claims description 2
108010075348 Activated-Leukocyte Cell Adhesion Molecule Proteins 0.000 claims description 2
102100032488 Acylamino-acid-releasing enzyme Human genes 0.000 claims description 2
102000004602 Aldo-Keto Reductase Family 1 Member C3 Human genes 0.000 claims description 2
102100031317 Alpha-N-acetylgalactosaminidase Human genes 0.000 claims description 2
102100031090 Alpha-catulin Human genes 0.000 claims description 2
102100032126 Aminopeptidase B Human genes 0.000 claims description 2
102100032040 Amphoterin-induced protein 2 Human genes 0.000 claims description 2
102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 claims description 2
102100034599 Angiopoietin-related protein 6 Human genes 0.000 claims description 2
101000798762 Anguilla anguilla Troponin C, skeletal muscle Proteins 0.000 claims description 2
102100034614 Ankyrin repeat domain-containing protein 11 Human genes 0.000 claims description 2
102100034225 Armadillo repeat-containing X-linked protein 1 Human genes 0.000 claims description 2
102100037546 BEN domain-containing protein 6 Human genes 0.000 claims description 2
102100021334 Bcl-2-related protein A1 Human genes 0.000 claims description 2
102100026031 Beta-glucuronidase Human genes 0.000 claims description 2
102100036848 C-C motif chemokine 20 Human genes 0.000 claims description 2
102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims description 2
102100034798 CCAAT/enhancer-binding protein beta Human genes 0.000 claims description 2
102100024210 CD166 antigen Human genes 0.000 claims description 2
102100035680 Cadherin EGF LAG seven-pass G-type receptor 2 Human genes 0.000 claims description 2
102100022527 Cadherin-18 Human genes 0.000 claims description 2
102100022509 Cadherin-23 Human genes 0.000 claims description 2
102100032216 Calcium and integrin-binding protein 1 Human genes 0.000 claims description 2
102100039319 Calcium release-activated calcium channel protein 1 Human genes 0.000 claims description 2
102100033089 Calcium/calmodulin-dependent protein kinase type 1G Human genes 0.000 claims description 2
102100025228 Calcium/calmodulin-dependent protein kinase type II subunit delta Human genes 0.000 claims description 2
102100025227 Calcium/calmodulin-dependent protein kinase type II subunit gamma Human genes 0.000 claims description 2
102100022789 Calcium/calmodulin-dependent protein kinase type IV Human genes 0.000 claims description 2
102100033561 Calmodulin-binding transcription activator 1 Human genes 0.000 claims description 2
102100025592 Calmodulin-regulated spectrin-associated protein 1 Human genes 0.000 claims description 2
102100038710 Capping protein-inhibiting regulator of actin dynamics Human genes 0.000 claims description 2
102100032936 Carboxypeptidase M Human genes 0.000 claims description 2
108090000007 Carboxypeptidase M Proteins 0.000 claims description 2
102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 claims description 2
102100031118 Catenin delta-2 Human genes 0.000 claims description 2
102100035888 Caveolin-1 Human genes 0.000 claims description 2
102100024495 Cdc42 effector protein 4 Human genes 0.000 claims description 2
102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims description 2
102100039219 Centrosome-associated protein CEP250 Human genes 0.000 claims description 2
101710082464 Cis-aconitate decarboxylase Proteins 0.000 claims description 2
102100034467 Clathrin light chain A Human genes 0.000 claims description 2
102100039537 Claudin-14 Human genes 0.000 claims description 2
102100038641 Cleavage and polyadenylation specificity factor subunit 1 Human genes 0.000 claims description 2
102100037290 Coatomer subunit gamma-1 Human genes 0.000 claims description 2
102100023708 Coiled-coil domain-containing protein 80 Human genes 0.000 claims description 2
102100033601 Collagen alpha-1(I) chain Human genes 0.000 claims description 2
102100036217 Collagen alpha-1(X) chain Human genes 0.000 claims description 2
102100027442 Collagen alpha-1(XII) chain Human genes 0.000 claims description 2
102100040995 Collagen alpha-1(XXI) chain Human genes 0.000 claims description 2
102100035432 Complement factor H Human genes 0.000 claims description 2
102100040132 Complement factor H-related protein 1 Human genes 0.000 claims description 2
102100040998 Conserved oligomeric Golgi complex subunit 6 Human genes 0.000 claims description 2
102100032648 Copine-3 Human genes 0.000 claims description 2
102100026891 Cystatin-B Human genes 0.000 claims description 2
102100021784 Cysteine-rich protein 2-binding protein Human genes 0.000 claims description 2
102100031089 Cystinosin Human genes 0.000 claims description 2
102000012698 DDB1 Human genes 0.000 claims description 2
102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 claims description 2
108010060424 DEAD Box Protein 20 Proteins 0.000 claims description 2
102100031868 DNA excision repair protein ERCC-8 Human genes 0.000 claims description 2
101710147299 DNA fragmentation factor subunit beta Proteins 0.000 claims description 2
102100022204 DNA-dependent protein kinase catalytic subunit Human genes 0.000 claims description 2
101100170004 Dictyostelium discoideum repE gene Proteins 0.000 claims description 2
101100170005 Drosophila melanogaster pic gene Proteins 0.000 claims description 2
102100030370 E3 ubiquitin-protein ligase Hakai Human genes 0.000 claims description 2
102100039495 E3 ubiquitin-protein ligase RNF25 Human genes 0.000 claims description 2
102100031814 EGF-containing fibulin-like extracellular matrix protein 1 Human genes 0.000 claims description 2
102100032059 EMILIN-1 Human genes 0.000 claims description 2
102100037074 Ellis-van Creveld syndrome protein Human genes 0.000 claims description 2
102100039246 Elongator complex protein 1 Human genes 0.000 claims description 2
102100033183 Epithelial membrane protein 1 Human genes 0.000 claims description 2
102100021808 Eukaryotic elongation factor 2 kinase Human genes 0.000 claims description 2
102100029074 Exostosin-2 Human genes 0.000 claims description 2
102100026561 Filamin-A Human genes 0.000 claims description 2
102100025626 GTP-binding protein GEM Human genes 0.000 claims description 2
102100041034 Glucosamine-6-phosphate isomerase 1 Human genes 0.000 claims description 2
102100023122 Glycylpeptide N-tetradecanoyltransferase 2 Human genes 0.000 claims description 2
102100040896 Growth/differentiation factor 15 Human genes 0.000 claims description 2
102100030373 HSPB1-associated protein 1 Human genes 0.000 claims description 2
102100029977 Helicase SKI2W Human genes 0.000 claims description 2
102100028006 Heme oxygenase 1 Human genes 0.000 claims description 2
102100024025 Heparanase Human genes 0.000 claims description 2
101000612655 Homo sapiens 26S proteasome non-ATPase regulatory subunit 1 Proteins 0.000 claims description 2
101000689847 Homo sapiens 28S ribosomal protein S31, mitochondrial Proteins 0.000 claims description 2
101000689854 Homo sapiens 39S ribosomal protein S30, mitochondrial Proteins 0.000 claims description 2
101000769042 Homo sapiens ADP-ribosylation factor-like protein 8B Proteins 0.000 claims description 2
101000732341 Homo sapiens AP-2 complex subunit beta Proteins 0.000 claims description 2
101000798584 Homo sapiens Acylamino-acid-releasing enzyme Proteins 0.000 claims description 2
101000588435 Homo sapiens Alpha-N-acetylgalactosaminidase Proteins 0.000 claims description 2
101000922043 Homo sapiens Alpha-catulin Proteins 0.000 claims description 2
101000775829 Homo sapiens Aminopeptidase B Proteins 0.000 claims description 2
101000776165 Homo sapiens Amphoterin-induced protein 2 Proteins 0.000 claims description 2
101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 claims description 2
101000924549 Homo sapiens Angiopoietin-related protein 6 Proteins 0.000 claims description 2
101000924476 Homo sapiens Ankyrin repeat domain-containing protein 11 Proteins 0.000 claims description 2
101000925943 Homo sapiens Armadillo repeat-containing X-linked protein 1 Proteins 0.000 claims description 2
101000739794 Homo sapiens BEN domain-containing protein 6 Proteins 0.000 claims description 2
101001000001 Homo sapiens Basement membrane-specific heparan sulfate proteoglycan core protein Proteins 0.000 claims description 2
101000894929 Homo sapiens Bcl-2-related protein A1 Proteins 0.000 claims description 2
101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 claims description 2
101000933364 Homo sapiens Brain protein I3 Proteins 0.000 claims description 2
101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 claims description 2
101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims description 2
101000945963 Homo sapiens CCAAT/enhancer-binding protein beta Proteins 0.000 claims description 2
101000715674 Homo sapiens Cadherin EGF LAG seven-pass G-type receptor 2 Proteins 0.000 claims description 2
101000899405 Homo sapiens Cadherin-18 Proteins 0.000 claims description 2
101000899459 Homo sapiens Cadherin-20 Proteins 0.000 claims description 2
101000899442 Homo sapiens Cadherin-23 Proteins 0.000 claims description 2
101000794587 Homo sapiens Cadherin-5 Proteins 0.000 claims description 2
101000943475 Homo sapiens Calcium and integrin-binding protein 1 Proteins 0.000 claims description 2
101000745520 Homo sapiens Calcium release-activated calcium channel protein 1 Proteins 0.000 claims description 2
101000944259 Homo sapiens Calcium/calmodulin-dependent protein kinase type 1G Proteins 0.000 claims description 2
101001077338 Homo sapiens Calcium/calmodulin-dependent protein kinase type II subunit delta Proteins 0.000 claims description 2
101001077334 Homo sapiens Calcium/calmodulin-dependent protein kinase type II subunit gamma Proteins 0.000 claims description 2
101000974816 Homo sapiens Calcium/calmodulin-dependent protein kinase type IV Proteins 0.000 claims description 2
101000945309 Homo sapiens Calmodulin-binding transcription activator 1 Proteins 0.000 claims description 2
101000932956 Homo sapiens Calmodulin-regulated spectrin-associated protein 1 Proteins 0.000 claims description 2
101000957909 Homo sapiens Capping protein-inhibiting regulator of actin dynamics Proteins 0.000 claims description 2
101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims description 2
101000922056 Homo sapiens Catenin delta-2 Proteins 0.000 claims description 2
101000715467 Homo sapiens Caveolin-1 Proteins 0.000 claims description 2
101000762421 Homo sapiens Cdc42 effector protein 4 Proteins 0.000 claims description 2
101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims description 2
101000957426 Homo sapiens Centrosomal protein of 135 kDa Proteins 0.000 claims description 2
101000710244 Homo sapiens Clathrin light chain A Proteins 0.000 claims description 2
101000888570 Homo sapiens Claudin-14 Proteins 0.000 claims description 2
101000957603 Homo sapiens Cleavage and polyadenylation specificity factor subunit 1 Proteins 0.000 claims description 2
101000952964 Homo sapiens Coatomer subunit gamma-1 Proteins 0.000 claims description 2
101000978383 Homo sapiens Coiled-coil domain-containing protein 80 Proteins 0.000 claims description 2
101000875027 Homo sapiens Collagen alpha-1(X) chain Proteins 0.000 claims description 2
101000861874 Homo sapiens Collagen alpha-1(XII) chain Proteins 0.000 claims description 2
101000748976 Homo sapiens Collagen alpha-1(XXI) chain Proteins 0.000 claims description 2
101000737574 Homo sapiens Complement factor H Proteins 0.000 claims description 2
101000890732 Homo sapiens Complement factor H-related protein 1 Proteins 0.000 claims description 2
101000710846 Homo sapiens Condensin complex subunit 1 Proteins 0.000 claims description 2
101000748957 Homo sapiens Conserved oligomeric Golgi complex subunit 6 Proteins 0.000 claims description 2
101000941769 Homo sapiens Copine-3 Proteins 0.000 claims description 2
101000912191 Homo sapiens Cystatin-B Proteins 0.000 claims description 2
101000895916 Homo sapiens Cysteine-rich protein 2-binding protein Proteins 0.000 claims description 2
101000922034 Homo sapiens Cystinosin Proteins 0.000 claims description 2
101000920778 Homo sapiens DNA excision repair protein ERCC-8 Proteins 0.000 claims description 2
101000619536 Homo sapiens DNA-dependent protein kinase catalytic subunit Proteins 0.000 claims description 2
101001083405 Homo sapiens E3 ubiquitin-protein ligase Hakai Proteins 0.000 claims description 2
101001103592 Homo sapiens E3 ubiquitin-protein ligase RNF25 Proteins 0.000 claims description 2
101001065272 Homo sapiens EGF-containing fibulin-like extracellular matrix protein 1 Proteins 0.000 claims description 2
101000921280 Homo sapiens EMILIN-1 Proteins 0.000 claims description 2
101000881890 Homo sapiens Ellis-van Creveld syndrome protein Proteins 0.000 claims description 2
101000813117 Homo sapiens Elongator complex protein 1 Proteins 0.000 claims description 2
101000850989 Homo sapiens Epithelial membrane protein 1 Proteins 0.000 claims description 2
101000895759 Homo sapiens Eukaryotic elongation factor 2 kinase Proteins 0.000 claims description 2
101000918275 Homo sapiens Exostosin-2 Proteins 0.000 claims description 2
101000913549 Homo sapiens Filamin-A Proteins 0.000 claims description 2
101000856606 Homo sapiens GTP-binding protein GEM Proteins 0.000 claims description 2
101001039324 Homo sapiens Glucosamine-6-phosphate isomerase 1 Proteins 0.000 claims description 2
101000979544 Homo sapiens Glycylpeptide N-tetradecanoyltransferase 2 Proteins 0.000 claims description 2
101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims description 2
101000843045 Homo sapiens HSPB1-associated protein 1 Proteins 0.000 claims description 2
101000863680 Homo sapiens Helicase SKI2W Proteins 0.000 claims description 2
101001079623 Homo sapiens Heme oxygenase 1 Proteins 0.000 claims description 2
101001047819 Homo sapiens Heparanase Proteins 0.000 claims description 2
101001042781 Homo sapiens Hydroxysteroid dehydrogenase-like protein 2 Proteins 0.000 claims description 2
101000840540 Homo sapiens Iduronate 2-sulfatase Proteins 0.000 claims description 2
101000903806 Homo sapiens Inactive glycosyltransferase 25 family member 3 Proteins 0.000 claims description 2
101000993959 Homo sapiens Inositol 1,4,5-trisphosphate receptor-interacting protein Proteins 0.000 claims description 2
101001077600 Homo sapiens Insulin receptor substrate 2 Proteins 0.000 claims description 2
101001076680 Homo sapiens Insulin-induced gene 1 protein Proteins 0.000 claims description 2
101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 claims description 2
101001056814 Homo sapiens Integral membrane protein 2C Proteins 0.000 claims description 2
101001053790 Homo sapiens Integrator complex subunit 1 Proteins 0.000 claims description 2
101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 2
101000997642 Homo sapiens Integrin beta-1-binding protein 1 Proteins 0.000 claims description 2
101000960337 Homo sapiens Intercellular adhesion molecule 5 Proteins 0.000 claims description 2
101000975512 Homo sapiens Junctional protein associated with coronary artery disease Proteins 0.000 claims description 2
101000998020 Homo sapiens Keratin, type I cytoskeletal 18 Proteins 0.000 claims description 2
101000975502 Homo sapiens Keratin, type II cytoskeletal 7 Proteins 0.000 claims description 2
101001007046 Homo sapiens Keratin-associated protein 4-7 Proteins 0.000 claims description 2
101000972491 Homo sapiens Laminin subunit alpha-2 Proteins 0.000 claims description 2
101001008558 Homo sapiens Laminin subunit beta-2 Proteins 0.000 claims description 2
101000946306 Homo sapiens Laminin subunit gamma-1 Proteins 0.000 claims description 2
101001055427 Homo sapiens Mediator of RNA polymerase II transcription subunit 13 Proteins 0.000 claims description 2
101001057154 Homo sapiens Melanoma-associated antigen D2 Proteins 0.000 claims description 2
101001039757 Homo sapiens Multiple C2 and transmembrane domain-containing protein 1 Proteins 0.000 claims description 2
101000589016 Homo sapiens Myomegalin Proteins 0.000 claims description 2
101001128460 Homo sapiens Myosin light polypeptide 6 Proteins 0.000 claims description 2
101000635840 Homo sapiens Myosin regulatory light chain 10 Proteins 0.000 claims description 2
101001000104 Homo sapiens Myosin-11 Proteins 0.000 claims description 2
101000651201 Homo sapiens N-sulphoglucosamine sulphohydrolase Proteins 0.000 claims description 2
101001076431 Homo sapiens NF-kappa-B inhibitor zeta Proteins 0.000 claims description 2
101001109579 Homo sapiens NPC intracellular cholesterol transporter 2 Proteins 0.000 claims description 2
101000604463 Homo sapiens Netrin-G1 Proteins 0.000 claims description 2
101000604469 Homo sapiens Netrin-G2 Proteins 0.000 claims description 2
101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 2
101000582002 Homo sapiens Neuron navigator 2 Proteins 0.000 claims description 2
101001072765 Homo sapiens Neutral alpha-glucosidase AB Proteins 0.000 claims description 2
101000578062 Homo sapiens Nicastrin Proteins 0.000 claims description 2
101001108862 Homo sapiens Nucleoporin NUP188 Proteins 0.000 claims description 2
101001137510 Homo sapiens Outer dynein arm-docking complex subunit 2 Proteins 0.000 claims description 2
101001071236 Homo sapiens PHD finger protein 19 Proteins 0.000 claims description 2
101001072590 Homo sapiens POZ-, AT hook-, and zinc finger-containing protein 1 Proteins 0.000 claims description 2
101000786356 Homo sapiens Palmitoyltransferase ZDHHC20 Proteins 0.000 claims description 2
101001001516 Homo sapiens Phosphatidylinositol 4-kinase alpha Proteins 0.000 claims description 2
101000609261 Homo sapiens Plasminogen activator inhibitor 2 Proteins 0.000 claims description 2
101000583178 Homo sapiens Pleckstrin homology domain-containing family M member 1 Proteins 0.000 claims description 2
101000610110 Homo sapiens Pre-B-cell leukemia transcription factor 2 Proteins 0.000 claims description 2
101000702560 Homo sapiens Probable global transcription activator SNF2L1 Proteins 0.000 claims description 2
101000612139 Homo sapiens Procollagen C-endopeptidase enhancer 2 Proteins 0.000 claims description 2
101001133936 Homo sapiens Prolyl 3-hydroxylase 2 Proteins 0.000 claims description 2
101000612320 Homo sapiens Prostate collagen triple helix protein Proteins 0.000 claims description 2
101000710213 Homo sapiens Protein CLN8 Proteins 0.000 claims description 2
101001057166 Homo sapiens Protein EVI2A Proteins 0.000 claims description 2
101001135375 Homo sapiens Protein PET117 homolog, mitochondrial Proteins 0.000 claims description 2
101001098824 Homo sapiens Protein disulfide-isomerase A4 Proteins 0.000 claims description 2
101000994437 Homo sapiens Protein jagged-1 Proteins 0.000 claims description 2
101000822459 Homo sapiens Protein transport protein Sec31A Proteins 0.000 claims description 2
101000666171 Homo sapiens Protein-glutamine gamma-glutamyltransferase 2 Proteins 0.000 claims description 2
101000610013 Homo sapiens Protocadherin beta-10 Proteins 0.000 claims description 2
101000610017 Homo sapiens Protocadherin beta-12 Proteins 0.000 claims description 2
101000613391 Homo sapiens Protocadherin beta-16 Proteins 0.000 claims description 2
101000610006 Homo sapiens Protocadherin beta-7 Proteins 0.000 claims description 2
101000613332 Homo sapiens Protocadherin gamma-A1 Proteins 0.000 claims description 2
101000613330 Homo sapiens Protocadherin gamma-A2 Proteins 0.000 claims description 2
101000988245 Homo sapiens Protocadherin gamma-A4 Proteins 0.000 claims description 2
101000988240 Homo sapiens Protocadherin gamma-A7 Proteins 0.000 claims description 2
101000602014 Homo sapiens Protocadherin gamma-B1 Proteins 0.000 claims description 2
101000602018 Homo sapiens Protocadherin gamma-B3 Proteins 0.000 claims description 2
101000601991 Homo sapiens Protocadherin gamma-B6 Proteins 0.000 claims description 2
101000601995 Homo sapiens Protocadherin gamma-B7 Proteins 0.000 claims description 2
101000601993 Homo sapiens Protocadherin gamma-C3 Proteins 0.000 claims description 2
101000601999 Homo sapiens Protocadherin gamma-C4 Proteins 0.000 claims description 2
101001072227 Homo sapiens Protocadherin-18 Proteins 0.000 claims description 2
101000735368 Homo sapiens Protocadherin-9 Proteins 0.000 claims description 2
101000734537 Homo sapiens Pyridoxal-dependent decarboxylase domain-containing protein 1 Proteins 0.000 claims description 2
101000686231 Homo sapiens Ras-related GTP-binding protein C Proteins 0.000 claims description 2
101001060859 Homo sapiens Ras-related protein Rab-32 Proteins 0.000 claims description 2
101000606545 Homo sapiens Receptor-type tyrosine-protein phosphatase F Proteins 0.000 claims description 2
101000606506 Homo sapiens Receptor-type tyrosine-protein phosphatase eta Proteins 0.000 claims description 2
101001073409 Homo sapiens Retrotransposon-derived protein PEG10 Proteins 0.000 claims description 2
101000731737 Homo sapiens Rho guanine nucleotide exchange factor 26 Proteins 0.000 claims description 2
101000666657 Homo sapiens Rho-related GTP-binding protein RhoQ Proteins 0.000 claims description 2
101000682954 Homo sapiens Ribosome biogenesis regulatory protein homolog Proteins 0.000 claims description 2
101000650590 Homo sapiens Roundabout homolog 4 Proteins 0.000 claims description 2
101000868747 Homo sapiens SPOC domain-containing protein 1 Proteins 0.000 claims description 2
101000709099 Homo sapiens Schlafen family member 5 Proteins 0.000 claims description 2
101000644537 Homo sapiens Sequestosome-1 Proteins 0.000 claims description 2
101000885387 Homo sapiens Serine/threonine-protein kinase DCLK2 Proteins 0.000 claims description 2
101000709238 Homo sapiens Serine/threonine-protein kinase SIK1 Proteins 0.000 claims description 2
101000836084 Homo sapiens Serpin B7 Proteins 0.000 claims description 2
101000739905 Homo sapiens Sestrin-2 Proteins 0.000 claims description 2
101000709472 Homo sapiens Sialic acid-binding Ig-like lectin 15 Proteins 0.000 claims description 2
101001123859 Homo sapiens Sialidase-1 Proteins 0.000 claims description 2
101000704203 Homo sapiens Spectrin alpha chain, non-erythrocytic 1 Proteins 0.000 claims description 2
101000692109 Homo sapiens Syndecan-2 Proteins 0.000 claims description 2
101000642688 Homo sapiens Syntaxin-3 Proteins 0.000 claims description 2
101000595554 Homo sapiens TIR domain-containing adapter molecule 2 Proteins 0.000 claims description 2
101000598025 Homo sapiens Talin-1 Proteins 0.000 claims description 2
101000666340 Homo sapiens Tenascin Proteins 0.000 claims description 2
101000962473 Homo sapiens Transcription factor MafG Proteins 0.000 claims description 2
101000594296 Homo sapiens Transcription termination factor 2, mitochondrial Proteins 0.000 claims description 2
101000894525 Homo sapiens Transforming growth factor-beta-induced protein ig-h3 Proteins 0.000 claims description 2
101000763456 Homo sapiens Transmembrane protein 138 Proteins 0.000 claims description 2
101000766345 Homo sapiens Tribbles homolog 3 Proteins 0.000 claims description 2
101000649014 Homo sapiens Triple functional domain protein Proteins 0.000 claims description 2
101000830781 Homo sapiens Tropomyosin alpha-4 chain Proteins 0.000 claims description 2
101000795659 Homo sapiens Tuberin Proteins 0.000 claims description 2
101000823271 Homo sapiens Tyrosine-protein kinase ABL2 Proteins 0.000 claims description 2
101000662004 Homo sapiens UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 Proteins 0.000 claims description 2
101000809261 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 11 Proteins 0.000 claims description 2
101000643890 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 5 Proteins 0.000 claims description 2
101000808753 Homo sapiens Ubiquitin-conjugating enzyme E2 variant 1 Proteins 0.000 claims description 2
101000958733 Homo sapiens Unconventional myosin-IXb Proteins 0.000 claims description 2
101001000122 Homo sapiens Unconventional myosin-Ie Proteins 0.000 claims description 2
101001030254 Homo sapiens Unconventional myosin-XVB Proteins 0.000 claims description 2
101000644174 Homo sapiens Uridine phosphorylase 1 Proteins 0.000 claims description 2
101000850434 Homo sapiens V-type proton ATPase subunit B, brain isoform Proteins 0.000 claims description 2
101000805481 Homo sapiens Vigilin Proteins 0.000 claims description 2
101000941898 Homo sapiens Volume-regulated anion channel subunit LRRC8E Proteins 0.000 claims description 2
101000744745 Homo sapiens YTH domain-containing family protein 2 Proteins 0.000 claims description 2
101000788819 Homo sapiens Zinc finger CCHC domain-containing protein 9 Proteins 0.000 claims description 2
101000723833 Homo sapiens Zinc finger E-box-binding homeobox 2 Proteins 0.000 claims description 2
101000785561 Homo sapiens Zinc finger and SCAN domain-containing protein 29 Proteins 0.000 claims description 2
101000744882 Homo sapiens Zinc finger protein 185 Proteins 0.000 claims description 2
101000723645 Homo sapiens Zinc finger protein 697 Proteins 0.000 claims description 2
101000687642 Homo sapiens snRNA-activating protein complex subunit 1 Proteins 0.000 claims description 2
101000814246 Homo sapiens tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 Proteins 0.000 claims description 2
102100021656 Hydroxysteroid dehydrogenase-like protein 2 Human genes 0.000 claims description 2
102100029199 Iduronate 2-sulfatase Human genes 0.000 claims description 2
102100022966 Inactive glycosyltransferase 25 family member 3 Human genes 0.000 claims description 2
102100031533 Inositol 1,4,5-trisphosphate receptor-interacting protein Human genes 0.000 claims description 2
102100025092 Insulin receptor substrate 2 Human genes 0.000 claims description 2
102100025887 Insulin-induced gene 1 protein Human genes 0.000 claims description 2
102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 claims description 2
102100025464 Integral membrane protein 2C Human genes 0.000 claims description 2
102100024061 Integrator complex subunit 1 Human genes 0.000 claims description 2
102100025304 Integrin beta-1 Human genes 0.000 claims description 2
102100033335 Integrin beta-1-binding protein 1 Human genes 0.000 claims description 2
102100020944 Integrin-linked protein kinase Human genes 0.000 claims description 2
108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 claims description 2
102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims description 2
102100039919 Intercellular adhesion molecule 5 Human genes 0.000 claims description 2
208000028257 Joubert syndrome with oculorenal defect Diseases 0.000 claims description 2
102100023957 Junctional protein associated with coronary artery disease Human genes 0.000 claims description 2
101710036322 KIAA0586 Proteins 0.000 claims description 2
102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 claims description 2
102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 claims description 2
102100028332 Keratin-associated protein 4-7 Human genes 0.000 claims description 2
102100022745 Laminin subunit alpha-2 Human genes 0.000 claims description 2
102100031775 Leptin receptor Human genes 0.000 claims description 2
108010009491 Lysosomal-Associated Membrane Protein 2 Proteins 0.000 claims description 2
102100038225 Lysosome-associated membrane glycoprotein 2 Human genes 0.000 claims description 2
101700028140 MYO1D Proteins 0.000 claims description 2
102100026161 Mediator of RNA polymerase II transcription subunit 13 Human genes 0.000 claims description 2
102100027251 Melanoma-associated antigen D2 Human genes 0.000 claims description 2
102100040889 Multiple C2 and transmembrane domain-containing protein 1 Human genes 0.000 claims description 2
102100032966 Myomegalin Human genes 0.000 claims description 2
102100031829 Myosin light polypeptide 6 Human genes 0.000 claims description 2
102100030857 Myosin regulatory light chain 10 Human genes 0.000 claims description 2
102100036639 Myosin-11 Human genes 0.000 claims description 2
102100027661 N-sulphoglucosamine sulphohydrolase Human genes 0.000 claims description 2
102100026009 NF-kappa-B inhibitor zeta Human genes 0.000 claims description 2
102100022737 NPC intracellular cholesterol transporter 2 Human genes 0.000 claims description 2
102100038699 Netrin-G2 Human genes 0.000 claims description 2
102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 2
102100030465 Neuron navigator 2 Human genes 0.000 claims description 2
102100036592 Neutral alpha-glucosidase AB Human genes 0.000 claims description 2
102100028056 Nicastrin Human genes 0.000 claims description 2
102100021530 Nucleoporin NUP188 Human genes 0.000 claims description 2
102100035706 Outer dynein arm-docking complex subunit 2 Human genes 0.000 claims description 2
102100036870 PHD finger protein 19 Human genes 0.000 claims description 2
102100036665 POZ-, AT hook-, and zinc finger-containing protein 1 Human genes 0.000 claims description 2
102100025789 Palmitoyltransferase ZDHHC20 Human genes 0.000 claims description 2
102100036161 Phosphatidylinositol 4-kinase alpha Human genes 0.000 claims description 2
102100039419 Plasminogen activator inhibitor 2 Human genes 0.000 claims description 2
102100030349 Pleckstrin homology domain-containing family M member 1 Human genes 0.000 claims description 2
102100040168 Pre-B-cell leukemia transcription factor 2 Human genes 0.000 claims description 2
102100026091 Probable ATP-dependent RNA helicase DDX20 Human genes 0.000 claims description 2
101710145525 Probable cinnamyl alcohol dehydrogenase Proteins 0.000 claims description 2
102100031031 Probable global transcription activator SNF2L1 Human genes 0.000 claims description 2
102100041027 Procollagen C-endopeptidase enhancer 2 Human genes 0.000 claims description 2
102100034015 Prolyl 3-hydroxylase 2 Human genes 0.000 claims description 2
108010065942 Prostaglandin-F synthase Proteins 0.000 claims description 2
102100041009 Prostate collagen triple helix protein Human genes 0.000 claims description 2
102100034479 Protein CLN8 Human genes 0.000 claims description 2
102100027246 Protein EVI2A Human genes 0.000 claims description 2
102100028545 Protein TALPID3 Human genes 0.000 claims description 2
102100037089 Protein disulfide-isomerase A4 Human genes 0.000 claims description 2
102100032702 Protein jagged-1 Human genes 0.000 claims description 2
102100022484 Protein transport protein Sec31A Human genes 0.000 claims description 2
102100038095 Protein-glutamine gamma-glutamyltransferase 2 Human genes 0.000 claims description 2
102100040146 Protocadherin beta-10 Human genes 0.000 claims description 2
102100040145 Protocadherin beta-12 Human genes 0.000 claims description 2
102100040927 Protocadherin beta-16 Human genes 0.000 claims description 2
102100039150 Protocadherin beta-7 Human genes 0.000 claims description 2
102100040876 Protocadherin gamma-A1 Human genes 0.000 claims description 2
102100040875 Protocadherin gamma-A2 Human genes 0.000 claims description 2
102100029260 Protocadherin gamma-A4 Human genes 0.000 claims description 2
102100029255 Protocadherin gamma-A7 Human genes 0.000 claims description 2
102100037555 Protocadherin gamma-B1 Human genes 0.000 claims description 2
102100037605 Protocadherin gamma-B3 Human genes 0.000 claims description 2
102100037542 Protocadherin gamma-B6 Human genes 0.000 claims description 2
102100037559 Protocadherin gamma-B7 Human genes 0.000 claims description 2
102100037560 Protocadherin gamma-C3 Human genes 0.000 claims description 2
102100037557 Protocadherin gamma-C4 Human genes 0.000 claims description 2
102100036397 Protocadherin-18 Human genes 0.000 claims description 2
102100034957 Protocadherin-9 Human genes 0.000 claims description 2
102100034759 Pyridoxal-dependent decarboxylase domain-containing protein 1 Human genes 0.000 claims description 2
102100025009 Ras-related GTP-binding protein C Human genes 0.000 claims description 2
102100027915 Ras-related protein Rab-32 Human genes 0.000 claims description 2
102100039663 Receptor-type tyrosine-protein phosphatase F Human genes 0.000 claims description 2
102100039808 Receptor-type tyrosine-protein phosphatase eta Human genes 0.000 claims description 2
102100037420 Regulator of G-protein signaling 4 Human genes 0.000 claims description 2
101710140404 Regulator of G-protein signaling 4 Proteins 0.000 claims description 2
102100035844 Retrotransposon-derived protein PEG10 Human genes 0.000 claims description 2
102100032447 Rho guanine nucleotide exchange factor 26 Human genes 0.000 claims description 2
102100038339 Rho-related GTP-binding protein RhoQ Human genes 0.000 claims description 2
102100023902 Ribosome biogenesis regulatory protein homolog Human genes 0.000 claims description 2
102100027701 Roundabout homolog 4 Human genes 0.000 claims description 2
108091006542 SLC35A3 Proteins 0.000 claims description 2
108091006313 SLC3A2 Proteins 0.000 claims description 2
102100032395 SPOC domain-containing protein 1 Human genes 0.000 claims description 2
102100032668 Schlafen family member 5 Human genes 0.000 claims description 2
102100020814 Sequestosome-1 Human genes 0.000 claims description 2
102100039775 Serine/threonine-protein kinase DCLK2 Human genes 0.000 claims description 2
102100032771 Serine/threonine-protein kinase SIK1 Human genes 0.000 claims description 2
102100025521 Serpin B7 Human genes 0.000 claims description 2
102100037576 Sestrin-2 Human genes 0.000 claims description 2
102100034361 Sialic acid-binding Ig-like lectin 15 Human genes 0.000 claims description 2
102100028760 Sialidase-1 Human genes 0.000 claims description 2
102100031874 Spectrin alpha chain, non-erythrocytic 1 Human genes 0.000 claims description 2
102100026087 Syndecan-2 Human genes 0.000 claims description 2
102100035937 Syntaxin-3 Human genes 0.000 claims description 2
102100036074 TIR domain-containing adapter molecule 2 Human genes 0.000 claims description 2
102100036977 Talin-1 Human genes 0.000 claims description 2
108010057666 Transcription Factor CHOP Proteins 0.000 claims description 2
102100039188 Transcription factor MafG Human genes 0.000 claims description 2
102100035550 Transcription termination factor 2, mitochondrial Human genes 0.000 claims description 2
102100021398 Transforming growth factor-beta-induced protein ig-h3 Human genes 0.000 claims description 2
102100027026 Transmembrane protein 138 Human genes 0.000 claims description 2
102100026390 Tribbles homolog 3 Human genes 0.000 claims description 2
102100028101 Triple functional domain protein Human genes 0.000 claims description 2
102100024944 Tropomyosin alpha-4 chain Human genes 0.000 claims description 2
102100031638 Tuberin Human genes 0.000 claims description 2
102100022651 Tyrosine-protein kinase ABL2 Human genes 0.000 claims description 2
102100033778 UDP-N-acetylglucosamine transporter Human genes 0.000 claims description 2
102100037918 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 Human genes 0.000 claims description 2
102100038462 Ubiquitin carboxyl-terminal hydrolase 11 Human genes 0.000 claims description 2
102100021017 Ubiquitin carboxyl-terminal hydrolase 5 Human genes 0.000 claims description 2
102100038467 Ubiquitin-conjugating enzyme E2 variant 1 Human genes 0.000 claims description 2
102100038325 Unconventional myosin-IXb Human genes 0.000 claims description 2
102100036638 Unconventional myosin-Id Human genes 0.000 claims description 2
102100038933 Unconventional myosin-XVB Human genes 0.000 claims description 2
102100020892 Uridine phosphorylase 1 Human genes 0.000 claims description 2
102100033476 V-type proton ATPase subunit B, brain isoform Human genes 0.000 claims description 2
102100037814 Vigilin Human genes 0.000 claims description 2
102100032675 Volume-regulated anion channel subunit LRRC8E Human genes 0.000 claims description 2
102100039644 YTH domain-containing family protein 2 Human genes 0.000 claims description 2
102100025362 Zinc finger CCHC domain-containing protein 9 Human genes 0.000 claims description 2
102100028458 Zinc finger E-box-binding homeobox 2 Human genes 0.000 claims description 2
102100026581 Zinc finger and SCAN domain-containing protein 29 Human genes 0.000 claims description 2
102100040032 Zinc finger protein 185 Human genes 0.000 claims description 2
102100028373 Zinc finger protein 697 Human genes 0.000 claims description 2
108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 claims description 2
101150077768 ddb1 gene Proteins 0.000 claims description 2
DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims description 2
238000000249 far-infrared magnetic resonance spectroscopy Methods 0.000 claims description 2
108010019813 leptin receptors Proteins 0.000 claims description 2
102100024840 snRNA-activating protein complex subunit 1 Human genes 0.000 claims description 2
102100039415 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 Human genes 0.000 claims description 2
102000009310 vitamin D receptors Human genes 0.000 claims description 2
108050000156 vitamin D receptors Proteins 0.000 claims description 2
239000000243 solution Substances 0.000 claims 10
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 5
238000001990 intravenous administration Methods 0.000 claims 4
238000010253 intravenous injection Methods 0.000 claims 4
239000007928 intraperitoneal injection Substances 0.000 claims 3
FWXLVXABZRYLST-UHFFFAOYSA-N ACH-Y Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)C(O)C(O)C5(CO)C(OC(=O)C(C)=CC)C(OC(=O)C(C)=CC)C(C)(C)CC5C4=CCC3C21C FWXLVXABZRYLST-UHFFFAOYSA-N 0.000 claims 2
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims 2
BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 claims 2
102100034604 Angiopoietin-like protein 8 Human genes 0.000 claims 1
102100024436 Caldesmon Human genes 0.000 claims 1
102100038909 Caveolin-2 Human genes 0.000 claims 1
102100040512 Collagen alpha-1(IX) chain Human genes 0.000 claims 1
102100021194 Glypican-6 Human genes 0.000 claims 1
102000049982 HMGA2 Human genes 0.000 claims 1
108700039143 HMGA2 Proteins 0.000 claims 1
102100029001 Heparan sulfate 2-O-sulfotransferase 1 Human genes 0.000 claims 1
102100038720 Histone deacetylase 9 Human genes 0.000 claims 1
101150073387 Hmga2 gene Proteins 0.000 claims 1
101000924544 Homo sapiens Angiopoietin-like protein 8 Proteins 0.000 claims 1
101000740981 Homo sapiens Caveolin-2 Proteins 0.000 claims 1
101000749901 Homo sapiens Collagen alpha-1(IX) chain Proteins 0.000 claims 1
101001040704 Homo sapiens Glypican-6 Proteins 0.000 claims 1
101000838692 Homo sapiens Heparan sulfate 2-O-sulfotransferase 1 Proteins 0.000 claims 1
101001032092 Homo sapiens Histone deacetylase 9 Proteins 0.000 claims 1
101000852543 Homo sapiens Importin-4 Proteins 0.000 claims 1
101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 claims 1
101100073788 Homo sapiens KIF21A gene Proteins 0.000 claims 1
101001004313 Homo sapiens LHFPL tetraspan subfamily member 2 protein Proteins 0.000 claims 1
101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 1
101000617546 Homo sapiens Presenilin-2 Proteins 0.000 claims 1
101000752520 Homo sapiens Protein ARMCX6 Proteins 0.000 claims 1
101000602012 Homo sapiens Protocadherin gamma-B2 Proteins 0.000 claims 1
101000613375 Homo sapiens Protocadherin-11 Y-linked Proteins 0.000 claims 1
101000979900 Homo sapiens Putative methyltransferase NSUN5C Proteins 0.000 claims 1
101001132549 Homo sapiens Ras-related protein Rab-9A Proteins 0.000 claims 1
101000588553 Homo sapiens Serine/threonine-protein kinase Nek9 Proteins 0.000 claims 1
101000701446 Homo sapiens Stanniocalcin-2 Proteins 0.000 claims 1
102100036341 Importin-4 Human genes 0.000 claims 1
102100025305 Integrin alpha-2 Human genes 0.000 claims 1
102100037688 Kinesin-like protein KIF21A Human genes 0.000 claims 1
125000003264 L-arabinofuranosyl group Chemical group [H]OC([H])([H])[C@]1([H])OC([H])(*)[C@]([H])(O[H])[C@@]1([H])O[H] 0.000 claims 1
102100025687 LHFPL tetraspan subfamily member 2 protein Human genes 0.000 claims 1
102100032352 Leukemia inhibitory factor Human genes 0.000 claims 1
108090000581 Leukemia inhibitory factor Proteins 0.000 claims 1
102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
102100022036 Presenilin-2 Human genes 0.000 claims 1
102100040478 Prolyl 4-hydroxylase subunit alpha-2 Human genes 0.000 claims 1
102100022029 Protein ARMCX6 Human genes 0.000 claims 1
102100037552 Protocadherin gamma-B2 Human genes 0.000 claims 1
102100040932 Protocadherin-11 Y-linked Human genes 0.000 claims 1
102100024551 Putative methyltransferase NSUN5C Human genes 0.000 claims 1
102100033966 Ras-related protein Rab-9A Human genes 0.000 claims 1
102100039640 Rho-related GTP-binding protein RhoE Human genes 0.000 claims 1
108050007494 Rho-related GTP-binding protein RhoE Proteins 0.000 claims 1
102100031398 Serine/threonine-protein kinase Nek9 Human genes 0.000 claims 1
102100030510 Stanniocalcin-2 Human genes 0.000 claims 1
230000028327 secretion Effects 0.000 abstract description 80
102000007000 Tenascin Human genes 0.000 abstract description 36
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 31
102000018697 Membrane Proteins Human genes 0.000 abstract description 30
108010052285 Membrane Proteins Proteins 0.000 abstract description 30
230000013595 glycosylation Effects 0.000 abstract description 30
238000006206 glycosylation reaction Methods 0.000 abstract description 30
108010014258 Elastin Proteins 0.000 abstract description 29
102000016942 Elastin Human genes 0.000 abstract description 29
229920002549 elastin Polymers 0.000 abstract description 29
208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract description 20
201000010881 cervical cancer Diseases 0.000 abstract description 20
201000010099 disease Diseases 0.000 abstract description 14
102000005962 receptors Human genes 0.000 abstract description 14
108020003175 receptors Proteins 0.000 abstract description 14
230000003527 anti-angiogenesis Effects 0.000 abstract description 11
102000016359 Fibronectins Human genes 0.000 abstract 1
238000002474 experimental method Methods 0.000 description 95
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 78
238000011282 treatment Methods 0.000 description 75
229940079593 drug Drugs 0.000 description 54
230000005764 inhibitory process Effects 0.000 description 51
230000000694 effects Effects 0.000 description 46
102000016289 Cell Adhesion Molecules Human genes 0.000 description 37
108010067225 Cell Adhesion Molecules Proteins 0.000 description 37
102100037813 Focal adhesion kinase 1 Human genes 0.000 description 29
101000878536 Homo sapiens Focal adhesion kinase 1 Proteins 0.000 description 29
238000001262 western blot Methods 0.000 description 28
238000002493 microarray Methods 0.000 description 23
208000024891 symptom Diseases 0.000 description 22
201000002282 venous insufficiency Diseases 0.000 description 22
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 21
229910052799 carbon Inorganic materials 0.000 description 21
238000000134 MTT assay Methods 0.000 description 19
231100000002 MTT assay Toxicity 0.000 description 19
229930182490 saponin Natural products 0.000 description 17
235000017709 saponins Nutrition 0.000 description 17
206010030124 Oedema peripheral Diseases 0.000 description 16
230000015572 biosynthetic process Effects 0.000 description 16
239000001963 growth medium Substances 0.000 description 16
239000002207 metabolite Substances 0.000 description 16
150000007949 saponins Chemical class 0.000 description 16
SRBFZHDQGSBBOR-SOOFDHNKSA-N D-ribopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@@H]1O SRBFZHDQGSBBOR-SOOFDHNKSA-N 0.000 description 15
241000699670 Mus sp. Species 0.000 description 15
230000009467 reduction Effects 0.000 description 15
239000000284 extract Substances 0.000 description 14
230000012010 growth Effects 0.000 description 14
208000014617 hemorrhoid Diseases 0.000 description 14
239000012528 membrane Substances 0.000 description 14
AXNVHPCVMSNXNP-GKTCLTPXSA-N Aescin Natural products O=C(O[C@H]1[C@@H](OC(=O)C)[C@]2(CO)[C@@H](O)C[C@@]3(C)[C@@]4(C)[C@@H]([C@]5(C)[C@H]([C@](CO)(C)[C@@H](O[C@@H]6[C@@H](O[C@H]7[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O7)[C@@H](C(=O)O)O6)CC5)CC4)CC=C3[C@@H]2CC1(C)C)/C(=C/C)/C AXNVHPCVMSNXNP-GKTCLTPXSA-N 0.000 description 12
LKDRXBCSQODPBY-OEXCPVAWSA-N D-tagatose Chemical compound OCC1(O)OC[C@@H](O)[C@H](O)[C@@H]1O LKDRXBCSQODPBY-OEXCPVAWSA-N 0.000 description 12
150000003648 triterpenes Chemical group 0.000 description 12
239000012979 RPMI medium Substances 0.000 description 11
208000010729 leg swelling Diseases 0.000 description 11
208000011580 syndromic disease Diseases 0.000 description 11
241001465754 Metazoa Species 0.000 description 10
206010046996 Varicose vein Diseases 0.000 description 10
230000001413 cellular effect Effects 0.000 description 10
239000000499 gel Substances 0.000 description 10
239000002609 medium Substances 0.000 description 10
210000004379 membrane Anatomy 0.000 description 10
239000000523 sample Substances 0.000 description 10
239000000020 Nitrocellulose Substances 0.000 description 9
239000012980 RPMI-1640 medium Substances 0.000 description 9
206010042674 Swelling Diseases 0.000 description 9
230000010261 cell growth Effects 0.000 description 9
230000002490 cerebral effect Effects 0.000 description 9
208000037998 chronic venous disease Diseases 0.000 description 9
229920001220 nitrocellulos Polymers 0.000 description 9
230000008961 swelling Effects 0.000 description 9
WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 8
206010048962 Brain oedema Diseases 0.000 description 8
208000018262 Peripheral vascular disease Diseases 0.000 description 8
208000007536 Thrombosis Diseases 0.000 description 8
230000002402 anti-lipaemic effect Effects 0.000 description 8
208000006752 brain edema Diseases 0.000 description 8
239000003172 expectorant agent Substances 0.000 description 8
230000003419 expectorant effect Effects 0.000 description 8
230000006870 function Effects 0.000 description 8
229920001184 polypeptide Polymers 0.000 description 8
230000002980 postoperative effect Effects 0.000 description 8
102000004196 processed proteins & peptides Human genes 0.000 description 8
108090000765 processed proteins & peptides Proteins 0.000 description 8
KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 7
206010010904 Convulsion Diseases 0.000 description 7
229930012538 Paclitaxel Natural products 0.000 description 7
208000002193 Pain Diseases 0.000 description 7
206010033425 Pain in extremity Diseases 0.000 description 7
208000003251 Pruritus Diseases 0.000 description 7
208000028017 Psychotic disease Diseases 0.000 description 7
208000007107 Stomach Ulcer Diseases 0.000 description 7
238000004458 analytical method Methods 0.000 description 7
230000000975 bioactive effect Effects 0.000 description 7
230000036461 convulsion Effects 0.000 description 7
238000011161 development Methods 0.000 description 7
230000018109 developmental process Effects 0.000 description 7
208000035475 disorder Diseases 0.000 description 7
125000000524 functional group Chemical group 0.000 description 7
229960001592 paclitaxel Drugs 0.000 description 7
239000001397 quillaja saponaria molina bark Substances 0.000 description 7
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 7
150000008130 triterpenoid saponins Chemical class 0.000 description 7
YFESOSRPNPYODN-RSMWSHJLSA-N (2s,3s,4s,5r,6r)-6-[[(4s,6ar,6bs,8r,8ar,9r,10r,14br)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2s,3r,4s, Chemical compound O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)OC1CC[C@]2(C)C3CC=C4[C@@]([C@@]3(CCC2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(CC14)(C)C)OC(=O)C(\C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O.O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)OC1CC[C@]2(C)C3CC=C4[C@@]([C@@]3(CCC2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(CC14)(C)C)OC(=O)C(/C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YFESOSRPNPYODN-RSMWSHJLSA-N 0.000 description 6
AXNVHPCVMSNXNP-OXPBSUTMSA-N Aescin Chemical compound O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(C[C@H]14)(C)C)OC(=O)C(\C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O AXNVHPCVMSNXNP-OXPBSUTMSA-N 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
239000012722 SDS sample buffer Substances 0.000 description 6
241000700605 Viruses Species 0.000 description 6
229940093314 beta-escin Drugs 0.000 description 6
AXNVHPCVMSNXNP-BEJCRFBNSA-N beta-escin Natural products CC=C(/C)C(=O)O[C@H]1[C@H](OC(=O)C)[C@]2(CO)[C@H](O)C[C@@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@H]6O[C@@H]([C@H](O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@@H]6O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(=O)O)[C@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2CC1(C)C AXNVHPCVMSNXNP-BEJCRFBNSA-N 0.000 description 6
238000004113 cell culture Methods 0.000 description 6
201000002816 chronic venous insufficiency Diseases 0.000 description 6
229930186222 escin Natural products 0.000 description 6
229940011399 escin Drugs 0.000 description 6
230000002829 reductive effect Effects 0.000 description 6
QRXMUCSWCMTJGU-UHFFFAOYSA-N 5-bromo-4-chloro-3-indolyl phosphate Chemical compound C1=C(Br)C(Cl)=C2C(OP(O)(=O)O)=CNC2=C1 QRXMUCSWCMTJGU-UHFFFAOYSA-N 0.000 description 5
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 5
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 5
150000007513 acids Chemical class 0.000 description 5
239000000853 adhesive Substances 0.000 description 5
230000001070 adhesive effect Effects 0.000 description 5
230000003833 cell viability Effects 0.000 description 5
238000001962 electrophoresis Methods 0.000 description 5
125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 5
102200082402 rs751610198 Human genes 0.000 description 5
238000003786 synthesis reaction Methods 0.000 description 5
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
RIHFRRZHVHNGFQ-PTEMOXQYSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4as,6ar,6bs,7r,8s,8ar,9r,10r,12as,14ar,14bs)-7,8-dihydroxy-8a-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-9,10-bis[[(z)-2-methylbut-2-enoyl]oxy]-2,3,4,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydro-1h-picen-3-yl]oxy]-4-[(2s,3r,4 Chemical class O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@H]1C)C)(C)[C@@H](O)[C@@H](O)[C@@]1(CO)[C@@H](OC(=O)C(\C)=C/C)[C@@H](C(C[C@H]14)(C)C)OC(=O)C(\C)=C/C)C(O)=O)[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O RIHFRRZHVHNGFQ-PTEMOXQYSA-N 0.000 description 4
206010000087 Abdominal pain upper Diseases 0.000 description 4
229940126062 Compound A Drugs 0.000 description 4
101150097493 D gene Proteins 0.000 description 4
108010028143 Dioxygenases Proteins 0.000 description 4
102000016680 Dioxygenases Human genes 0.000 description 4
241000196324 Embryophyta Species 0.000 description 4
229920002971 Heparan sulfate Polymers 0.000 description 4
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 4
239000004472 Lysine Substances 0.000 description 4
241000699666 Mus <mouse, genus> Species 0.000 description 4
238000002123 RNA extraction Methods 0.000 description 4
108010048673 Vitronectin Receptors Proteins 0.000 description 4
230000012292 cell migration Effects 0.000 description 4
230000008859 change Effects 0.000 description 4
239000002299 complementary DNA Substances 0.000 description 4
239000000287 crude extract Substances 0.000 description 4
238000007405 data analysis Methods 0.000 description 4
238000012217 deletion Methods 0.000 description 4
230000037430 deletion Effects 0.000 description 4
WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 description 4
238000004128 high performance liquid chromatography Methods 0.000 description 4
238000009396 hybridization Methods 0.000 description 4
VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 4
BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 4
NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 4
230000018448 secretion by cell Effects 0.000 description 4
238000006467 substitution reaction Methods 0.000 description 4
150000008163 sugars Chemical class 0.000 description 4
108010085238 Actins Proteins 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
101710106619 Catenin alpha-3 Proteins 0.000 description 3
102000016362 Catenins Human genes 0.000 description 3
108010067316 Catenins Proteins 0.000 description 3
102000003886 Glycoproteins Human genes 0.000 description 3
108090000288 Glycoproteins Proteins 0.000 description 3
101100118545 Holotrichia diomphalia EGF-like gene Proteins 0.000 description 3
101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 3
108010041012 Integrin alpha4 Proteins 0.000 description 3
108010008212 Integrin alpha4beta1 Proteins 0.000 description 3
102100025390 Integrin beta-2 Human genes 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
230000010933 acylation Effects 0.000 description 3
238000005917 acylation reaction Methods 0.000 description 3
PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 description 3
125000003342 alkenyl group Chemical group 0.000 description 3
239000000427 antigen Substances 0.000 description 3
102000036639 antigens Human genes 0.000 description 3
108091007433 antigens Proteins 0.000 description 3
210000004204 blood vessel Anatomy 0.000 description 3
210000000170 cell membrane Anatomy 0.000 description 3
238000001647 drug administration Methods 0.000 description 3
235000013861 fat-free Nutrition 0.000 description 3
125000000623 heterocyclic group Chemical group 0.000 description 3
238000011081 inoculation Methods 0.000 description 3
238000011068 loading method Methods 0.000 description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
235000013336 milk Nutrition 0.000 description 3
239000008267 milk Substances 0.000 description 3
210000004080 milk Anatomy 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
210000004881 tumor cell Anatomy 0.000 description 3
230000004565 tumor cell growth Effects 0.000 description 3
230000003827 upregulation Effects 0.000 description 3
XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 2
101000983256 Acanthamoeba polyphaga mimivirus Putative prolyl 4-hydroxylase Proteins 0.000 description 2
102100022900 Actin, cytoplasmic 1 Human genes 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
241000283707 Capra Species 0.000 description 2
102100028914 Catenin beta-1 Human genes 0.000 description 2
102000012432 Collagen Type V Human genes 0.000 description 2
108010022514 Collagen Type V Proteins 0.000 description 2
AEMOLEFTQBMNLQ-DTEWXJGMSA-N D-Galacturonic acid Natural products O[C@@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-DTEWXJGMSA-N 0.000 description 2
241000283074 Equus asinus Species 0.000 description 2
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 description 2
101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 description 2
101100501790 Mus musculus Esd gene Proteins 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 2
108010090804 Streptavidin Proteins 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
150000007854 aminals Chemical class 0.000 description 2
230000003321 amplification Effects 0.000 description 2
239000002246 antineoplastic agent Substances 0.000 description 2
229940041181 antineoplastic drug Drugs 0.000 description 2
238000003491 array Methods 0.000 description 2
230000008901 benefit Effects 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 2
230000008827 biological function Effects 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
235000020958 biotin Nutrition 0.000 description 2
239000011616 biotin Substances 0.000 description 2
201000001531 bladder carcinoma Diseases 0.000 description 2
125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
108010018828 cadherin 5 Proteins 0.000 description 2
230000009400 cancer invasion Effects 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
210000003679 cervix uteri Anatomy 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
230000007423 decrease Effects 0.000 description 2
239000002934 diuretic Substances 0.000 description 2
230000003828 downregulation Effects 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
239000012737 fresh medium Substances 0.000 description 2
125000005842 heteroatom Chemical group 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
238000011534 incubation Methods 0.000 description 2
238000002372 labelling Methods 0.000 description 2
201000005296 lung carcinoma Diseases 0.000 description 2
239000000463 material Substances 0.000 description 2
238000003199 nucleic acid amplification method Methods 0.000 description 2
238000002966 oligonucleotide array Methods 0.000 description 2
210000000056 organ Anatomy 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
108010049224 perlecan Proteins 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
239000000419 plant extract Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
238000000746 purification Methods 0.000 description 2
238000003908 quality control method Methods 0.000 description 2
230000000241 respiratory effect Effects 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
238000013179 statistical model Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
238000013518 transcription Methods 0.000 description 2
230000035897 transcription Effects 0.000 description 2
230000004614 tumor growth Effects 0.000 description 2
208000010570 urinary bladder carcinoma Diseases 0.000 description 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
102000007469 Actins Human genes 0.000 description 1
208000024985 Alport syndrome Diseases 0.000 description 1
208000024827 Alzheimer disease Diseases 0.000 description 1
206010002383 Angina Pectoris Diseases 0.000 description 1
101710145634 Antigen 1 Proteins 0.000 description 1
101000702760 Arabidopsis thaliana Cytosolic sulfotransferase 12 Proteins 0.000 description 1
101100481030 Arabidopsis thaliana TGA4 gene Proteins 0.000 description 1
206010003210 Arteriosclerosis Diseases 0.000 description 1
206010003805 Autism Diseases 0.000 description 1
208000020706 Autistic disease Diseases 0.000 description 1
102100021631 B-cell lymphoma 6 protein Human genes 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
102100026044 Biotinidase Human genes 0.000 description 1
108010059108 CD18 Antigens Proteins 0.000 description 1
102100032912 CD44 antigen Human genes 0.000 description 1
102100029756 Cadherin-6 Human genes 0.000 description 1
101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 description 1
101100420946 Caenorhabditis elegans sea-2 gene Proteins 0.000 description 1
108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
208000020446 Cardiac disease Diseases 0.000 description 1
102000000844 Cell Surface Receptors Human genes 0.000 description 1
108010001857 Cell Surface Receptors Proteins 0.000 description 1
102100032765 Chordin-like protein 1 Human genes 0.000 description 1
102100038248 Cis-aconitate decarboxylase Human genes 0.000 description 1
102100031519 Collagen alpha-1(VI) chain Human genes 0.000 description 1
102100024338 Collagen alpha-3(VI) chain Human genes 0.000 description 1
OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 description 1
101800000414 Corticotropin Proteins 0.000 description 1
230000006820 DNA synthesis Effects 0.000 description 1
206010011906 Death Diseases 0.000 description 1
206010012289 Dementia Diseases 0.000 description 1
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
102100023114 Dual specificity tyrosine-phosphorylation-regulated kinase 3 Human genes 0.000 description 1
102100034675 E3 ubiquitin-protein ligase HECW2 Human genes 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
102100021558 ER lumen protein-retaining receptor 3 Human genes 0.000 description 1
102100031362 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 Human genes 0.000 description 1
208000008967 Enuresis Diseases 0.000 description 1
102100036763 Extended synaptotagmin-1 Human genes 0.000 description 1
108010073385 Fibrin Proteins 0.000 description 1
102000009123 Fibrin Human genes 0.000 description 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
102100036716 Glycosylphosphatidylinositol anchor attachment 1 protein Human genes 0.000 description 1
206010019233 Headaches Diseases 0.000 description 1
101000971234 Homo sapiens B-cell lymphoma 6 protein Proteins 0.000 description 1
101000933545 Homo sapiens Biotinidase Proteins 0.000 description 1
101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
101000794604 Homo sapiens Cadherin-6 Proteins 0.000 description 1
101000941971 Homo sapiens Chordin-like protein 1 Proteins 0.000 description 1
101000941581 Homo sapiens Collagen alpha-1(VI) chain Proteins 0.000 description 1
101000941585 Homo sapiens Collagen alpha-2(VI) chain Proteins 0.000 description 1
101000909506 Homo sapiens Collagen alpha-3(VI) chain Proteins 0.000 description 1
101001049991 Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 3 Proteins 0.000 description 1
101000872871 Homo sapiens E3 ubiquitin-protein ligase HECW2 Proteins 0.000 description 1
101000898776 Homo sapiens ER lumen protein-retaining receptor 3 Proteins 0.000 description 1
101000866794 Homo sapiens Endonuclease/exonuclease/phosphatase family domain-containing protein 1 Proteins 0.000 description 1
101000851525 Homo sapiens Extended synaptotagmin-1 Proteins 0.000 description 1
101001072432 Homo sapiens Glycosylphosphatidylinositol anchor attachment 1 protein Proteins 0.000 description 1
101001003102 Homo sapiens Hypoxia up-regulated protein 1 Proteins 0.000 description 1
101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 description 1
101001015059 Homo sapiens Integrin beta-5 Proteins 0.000 description 1
101001002695 Homo sapiens Integrin-linked protein kinase Proteins 0.000 description 1
101000957316 Homo sapiens Lysophospholipid acyltransferase 2 Proteins 0.000 description 1
101001023037 Homo sapiens Myoferlin Proteins 0.000 description 1
101000904181 Homo sapiens Probable gluconokinase Proteins 0.000 description 1
101000610001 Homo sapiens Protocadherin beta-6 Proteins 0.000 description 1
101000988236 Homo sapiens Protocadherin gamma-A8 Proteins 0.000 description 1
101000988234 Homo sapiens Protocadherin gamma-A9 Proteins 0.000 description 1
101000735377 Homo sapiens Protocadherin-7 Proteins 0.000 description 1
101000939460 Homo sapiens Ubiquitin-associated protein 2-like Proteins 0.000 description 1
229940122393 Hyaluronidase inhibitor Drugs 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
102100020755 Hypoxia up-regulated protein 1 Human genes 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
102100032819 Integrin alpha-3 Human genes 0.000 description 1
108010072255 Integrin alpha3beta1 Proteins 0.000 description 1
102000000426 Integrin alpha6 Human genes 0.000 description 1
108010041100 Integrin alpha6 Proteins 0.000 description 1
102100033010 Integrin beta-5 Human genes 0.000 description 1
108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
WQZGKKKJIJFFOK-ZZWDRFIYSA-N L-glucose Chemical compound OC[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@H]1O WQZGKKKJIJFFOK-ZZWDRFIYSA-N 0.000 description 1
102100032913 Leukocyte surface antigen CD47 Human genes 0.000 description 1
108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 1
102100038805 Lysophospholipid acyltransferase 2 Human genes 0.000 description 1
230000027311 M phase Effects 0.000 description 1
102100030129 Mitochondrial 2-oxodicarboxylate carrier Human genes 0.000 description 1
102100035083 Myoferlin Human genes 0.000 description 1
108010057466 NF-kappa B Proteins 0.000 description 1
102000003945 NF-kappa B Human genes 0.000 description 1
208000012902 Nervous system disease Diseases 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 description 1
208000018737 Parkinson disease Diseases 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
102100024009 Probable gluconokinase Human genes 0.000 description 1
102220492136 Protein Flattop_F33A_mutation Human genes 0.000 description 1
102100039152 Protocadherin beta-6 Human genes 0.000 description 1
102100029256 Protocadherin gamma-A8 Human genes 0.000 description 1
102100029257 Protocadherin gamma-A9 Human genes 0.000 description 1
102100034941 Protocadherin-7 Human genes 0.000 description 1
208000003782 Raynaud disease Diseases 0.000 description 1
208000012322 Raynaud phenomenon Diseases 0.000 description 1
239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
108091006427 SLC25A21 Proteins 0.000 description 1
241001093760 Sapindaceae Species 0.000 description 1
102000003800 Selectins Human genes 0.000 description 1
108090000184 Selectins Proteins 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
208000030886 Traumatic Brain injury Diseases 0.000 description 1
GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
108010047933 Tumor Necrosis Factor alpha-Induced Protein 3 Proteins 0.000 description 1
102100024596 Tumor necrosis factor alpha-induced protein 3 Human genes 0.000 description 1
102100029817 Ubiquitin-associated protein 2-like Human genes 0.000 description 1
206010046543 Urinary incontinence Diseases 0.000 description 1
102000008790 VE-cadherin Human genes 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
125000002723 alicyclic group Chemical group 0.000 description 1
125000005090 alkenylcarbonyl group Chemical group 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000001088 anti-asthma Effects 0.000 description 1
230000001093 anti-cancer Effects 0.000 description 1
230000003501 anti-edematous effect Effects 0.000 description 1
230000002322 anti-exudative effect Effects 0.000 description 1
230000002968 anti-fracture Effects 0.000 description 1
230000003602 anti-herpes Effects 0.000 description 1
230000001387 anti-histamine Effects 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000000767 anti-ulcer Effects 0.000 description 1
239000000924 antiasthmatic agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
230000003078 antioxidant effect Effects 0.000 description 1
150000001491 aromatic compounds Chemical class 0.000 description 1
208000011775 arteriosclerosis disease Diseases 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
238000003556 assay Methods 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
210000002469 basement membrane Anatomy 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
125000002619 bicyclic group Chemical group 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
238000001815 biotherapy Methods 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
208000024055 brain glioblastoma Diseases 0.000 description 1
201000011609 brain glioblastoma multiforme Diseases 0.000 description 1
125000004369 butenyl group Chemical group C(=CCC)* 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
230000004712 cancer cell adhesion Effects 0.000 description 1
230000003327 cancerostatic effect Effects 0.000 description 1
125000002837 carbocyclic group Chemical group 0.000 description 1
230000022131 cell cycle Effects 0.000 description 1
210000002390 cell membrane structure Anatomy 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
229960005188 collagen Drugs 0.000 description 1
230000002301 combined effect Effects 0.000 description 1
208000029078 coronary artery disease Diseases 0.000 description 1
OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 description 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
229960000258 corticotropin Drugs 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
231100000433 cytotoxic Toxicity 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
108700041286 delta Proteins 0.000 description 1
230000001882 diuretic effect Effects 0.000 description 1
208000002173 dizziness Diseases 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
238000001035 drying Methods 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
210000002744 extracellular matrix Anatomy 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000012091 fetal bovine serum Substances 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
229950003499 fibrin Drugs 0.000 description 1
230000000855 fungicidal effect Effects 0.000 description 1
239000000417 fungicide Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
231100000869 headache Toxicity 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
230000002949 hemolytic effect Effects 0.000 description 1
230000023597 hemostasis Effects 0.000 description 1
125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
208000003215 hereditary nephritis Diseases 0.000 description 1
150000002390 heteroarenes Chemical class 0.000 description 1
125000001072 heteroaryl group Chemical group 0.000 description 1
150000002391 heterocyclic compounds Chemical class 0.000 description 1
125000006038 hexenyl group Chemical group 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
238000001794 hormone therapy Methods 0.000 description 1
239000010903 husk Substances 0.000 description 1
125000002636 imidazolinyl group Chemical group 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
108010008094 laminin alpha 3 Proteins 0.000 description 1
210000005265 lung cell Anatomy 0.000 description 1
210000004324 lymphatic system Anatomy 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
210000005033 mesothelial cell Anatomy 0.000 description 1
208000015625 metaphyseal chondrodysplasia Diseases 0.000 description 1
208000037819 metastatic cancer Diseases 0.000 description 1
208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
230000027939 micturition Effects 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
125000002757 morpholinyl group Chemical group 0.000 description 1
125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
230000001452 natriuretic effect Effects 0.000 description 1
230000023578 negative regulation of cell adhesion Effects 0.000 description 1
229910052754 neon Inorganic materials 0.000 description 1
GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
125000006574 non-aromatic ring group Chemical group 0.000 description 1
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
210000003200 peritoneal cavity Anatomy 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
238000007747 plating Methods 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
238000002673 radiosurgery Methods 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 description 1
238000010992 reflux Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
125000006413 ring segment Chemical group 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
108091006024 signal transducing proteins Proteins 0.000 description 1
102000034285 signal transducing proteins Human genes 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
230000000153 supplemental effect Effects 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
125000004568 thiomorpholinyl group Chemical group 0.000 description 1
230000003096 thymolvtic effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
230000017105 transposition Effects 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229930182493 triterpene saponin Natural products 0.000 description 1
230000010415 tropism Effects 0.000 description 1
125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000002666 vasoprotective effect Effects 0.000 description 1
230000001643 venotonic effect Effects 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
230000003612 virological effect Effects 0.000 description 1