SG156613A1 - Use of mitochondrially targeted antioxidant in the treatment of liver diseases and epithelial cancers - Google Patents

Use of mitochondrially targeted antioxidant in the treatment of liver diseases and epithelial cancers

Info

Publication number
SG156613A1
SG156613A1 SG200906579-8A SG2009065798A SG156613A1 SG 156613 A1 SG156613 A1 SG 156613A1 SG 2009065798 A SG2009065798 A SG 2009065798A SG 156613 A1 SG156613 A1 SG 156613A1
Authority
SG
Singapore
Prior art keywords
treatment
liver diseases
epithelial cancers
antioxidant
mitochondrially targeted
Prior art date
Application number
SG200906579-8A
Other languages
English (en)
Inventor
Eleonore Froehlich
Ivica Kvietikova
Kurt Zatloukal
Gottfried Schatz
Helmut Denk
Cornelia Stumptner
Charles Buck
Original Assignee
Oridis Biomed Forschungs Und E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oridis Biomed Forschungs Und E filed Critical Oridis Biomed Forschungs Und E
Publication of SG156613A1 publication Critical patent/SG156613A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
SG200906579-8A 2004-07-13 2005-07-12 Use of mitochondrially targeted antioxidant in the treatment of liver diseases and epithelial cancers SG156613A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04103318 2004-07-13

Publications (1)

Publication Number Publication Date
SG156613A1 true SG156613A1 (en) 2009-11-26

Family

ID=34929318

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200906579-8A SG156613A1 (en) 2004-07-13 2005-07-12 Use of mitochondrially targeted antioxidant in the treatment of liver diseases and epithelial cancers

Country Status (11)

Country Link
US (1) US20070225255A1 (zh)
EP (1) EP1765413A2 (zh)
JP (1) JP2008506667A (zh)
CN (1) CN1997403A (zh)
AU (1) AU2005261654A1 (zh)
CA (1) CA2573456A1 (zh)
IL (1) IL179738A0 (zh)
RU (1) RU2007105138A (zh)
SG (1) SG156613A1 (zh)
WO (1) WO2006005759A2 (zh)
ZA (1) ZA200609635B (zh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8147825B2 (en) 2004-01-22 2012-04-03 University Of Miami Topical co-enzyme Q10 formulations and methods of use
US20080032940A1 (en) * 2006-08-07 2008-02-07 Balaraman Kalyanaraman Methods for reducing anthracycline-induced toxicity
WO2008048135A1 (fr) 2006-10-20 2008-04-24 Limited Liability Company 'mitotechnology' Composition destinée à la régénération, la stimulation de la croissance et l'adaptation de plantes à tous types de facteurs de stress
US8658624B2 (en) 2006-10-20 2014-02-25 Mitotech Sa Pharmaceutical compositions for preventing and treating eye pathologies
WO2008094061A1 (fr) * 2007-01-29 2008-08-07 Limited Liability Company 'mitotechnology' Compositions pharmaceutiques et cosmétiques servant à accélérer le processus de cicatrisation de plaies et autres lésions superficielles
US8349902B2 (en) * 2007-01-29 2013-01-08 Mitotech Sa Pharmaceutical compositions useful for preventing and treating oncological diseases
WO2008127138A1 (fr) 2007-04-11 2008-10-23 Limited Liability Company 'mitotechnology' Composition visant à ralentir le vieillissement et à allonger la durée de vie de l'organisme et utilisation de cette composition
US8518915B2 (en) 2007-06-29 2013-08-27 Mitotech Sa Use of mitochondrially-addressed compounds for preventing and treating cardiovascular diseases
WO2009033130A1 (en) * 2007-09-07 2009-03-12 Gencia Corporation Mitochondrial compositions and uses thereof
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
US8388931B2 (en) * 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
CN102083424B (zh) 2008-04-11 2013-08-28 细胞研究有限公司 诱导癌细胞凋亡的方法和应用
US9308214B2 (en) 2008-11-12 2016-04-12 Mitotech S.A. Method for moderately increasing the proton conductivity of biological membranes with the aid of mitochondria-targeted delocalized cations
CN102438615A (zh) * 2009-04-17 2012-05-02 科尔比制药公司 包含氧化应激调节剂(osm)的药学活性组合物、新的化学实体、组合物和用途
SG10201402288RA (en) 2009-05-11 2014-07-30 Berg Llc Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
AU2009347921B8 (en) 2009-06-10 2014-07-24 Mitotech Sa Pharmaceutical composition for use in medical and veterinary ophthalmology
CA3068007C (en) 2009-11-13 2022-08-23 Mitotech S.A. Pharmaceutical substances on the basis of mitochondria-addressed antioxidants
CN103608323B (zh) 2011-04-04 2016-08-17 博格有限责任公司 治疗中枢神经系统肿瘤的方法
EP2714024B1 (en) 2011-06-03 2018-10-03 Mitotech SA Oral formulations of mitochondrially-targeted antioxidants and their preparation and use
JP2014527969A (ja) * 2011-09-19 2014-10-23 ジェンシア コーポレイション 改変クレアチン化合物
CN113797343A (zh) 2013-04-08 2021-12-17 博格有限责任公司 使用辅酶q10联合疗法治疗癌症
EP2989110B1 (en) * 2013-04-24 2018-08-08 Smart Brain s.r.o. Tamoxifen derivatives for treatment of neoplastic diseases, especially with high her2 protein level
HUE050060T2 (hu) 2013-09-04 2020-11-30 Berg Llc Eljárások rák kezelésére koenzim Q10 folyamatos infúziójával
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
KR101773404B1 (ko) 2015-08-25 2017-08-31 (주) 씨유스킨 자외선에 의한 피부 손상의 예방 또는 개선을 위한 화장료 조성물
CN107510848A (zh) * 2016-06-15 2017-12-26 常州莱道斯生物医药科技有限公司 线粒体靶向制剂MitoPBN在防治糖尿病中的应用
CN108201543A (zh) * 2016-12-19 2018-06-26 北京福纳康生物技术有限公司 水溶性富勒烯结构在制备治疗脂肪肝的药物中的应用
CN115381804B (zh) * 2022-08-10 2024-06-21 华南师大(清远)科技创新研究院有限公司 癸基泛醌在制备治疗肝纤维化药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722361D0 (en) * 1997-10-24 1997-12-17 Pharma Nord Uk Ltd Pharmaceutical formulation for treating liver disorders
US6331532B1 (en) * 1998-11-25 2001-12-18 University Of Otago Mitochondrially targeted antioxidants
CA2354743A1 (en) * 2001-08-07 2003-02-07 University Of Otago Mitochondrially targeted antioxidants
NZ513547A (en) * 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)
AU2004266988B2 (en) * 2003-08-22 2011-05-26 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants

Also Published As

Publication number Publication date
WO2006005759A3 (en) 2006-05-11
JP2008506667A (ja) 2008-03-06
RU2007105138A (ru) 2008-08-20
ZA200609635B (en) 2008-08-27
US20070225255A1 (en) 2007-09-27
IL179738A0 (en) 2007-05-15
WO2006005759A2 (en) 2006-01-19
CA2573456A1 (en) 2006-01-19
CN1997403A (zh) 2007-07-11
EP1765413A2 (en) 2007-03-28
AU2005261654A1 (en) 2006-01-19

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