WO2006128120A3 - Novel lapachone compounds and methods of use thereof - Google Patents

Novel lapachone compounds and methods of use thereof Download PDF

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Publication number
WO2006128120A3
WO2006128120A3 PCT/US2006/020780 US2006020780W WO2006128120A3 WO 2006128120 A3 WO2006128120 A3 WO 2006128120A3 US 2006020780 W US2006020780 W US 2006020780W WO 2006128120 A3 WO2006128120 A3 WO 2006128120A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compounds
lapachone compounds
novel
novel lapachone
Prior art date
Application number
PCT/US2006/020780
Other languages
French (fr)
Other versions
WO2006128120A2 (en
Inventor
Mark Ashwell
Manish Tandon
Jean-Marc Lapierre
Syed Ali
Yanbin Liu
Chiang J Li
Original Assignee
Arqule Inc
Mark Ashwell
Manish Tandon
Jean-Marc Lapierre
Syed Ali
Yanbin Liu
Chiang J Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc, Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, Yanbin Liu, Chiang J Li filed Critical Arqule Inc
Publication of WO2006128120A2 publication Critical patent/WO2006128120A2/en
Publication of WO2006128120A3 publication Critical patent/WO2006128120A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of cancer or precancerous conditions.
PCT/US2006/020780 2005-05-26 2006-05-26 Novel lapachone compounds and methods of use thereof WO2006128120A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68504505P 2005-05-26 2005-05-26
US60/685,045 2005-05-26

Publications (2)

Publication Number Publication Date
WO2006128120A2 WO2006128120A2 (en) 2006-11-30
WO2006128120A3 true WO2006128120A3 (en) 2007-01-18

Family

ID=37076320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/020780 WO2006128120A2 (en) 2005-05-26 2006-05-26 Novel lapachone compounds and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2006128120A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
EP1877097B1 (en) 2004-08-11 2012-06-20 Arqule, Inc. Aminoacid conjugates of beta-lapachone for tumor targeting
EP2035435A1 (en) * 2006-05-26 2009-03-18 Arqule, Inc. Novel lapachone compounds and methods of use thereof
ES2532656T3 (en) 2007-04-30 2015-03-30 Arqule, Inc. Quinone hydroxy sulfonate compounds and their uses
WO2017106624A1 (en) 2015-12-18 2017-06-22 The Board Of Regents Of The University Of Texas System Napthoquinones, pro-drugs, and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045557A2 (en) * 2002-11-18 2004-06-03 Arqule, Inc. Novel lapachone compounds and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045557A2 (en) * 2002-11-18 2004-06-03 Arqule, Inc. Novel lapachone compounds and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUGIYAMA K ET AL: "ALDOSE REDUCTASE CATALYZES THE OXIDATION OF NAPHTHALENE-1,2- DIHYDRODIOL FOR THE FORMATION OF ORTHO-NAPHTHOQUINONE", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS., BALTIMORE, MD, US, vol. 27, no. 1, 1999, pages 60 - 67, XP002948478, ISSN: 0090-9556 *

Also Published As

Publication number Publication date
WO2006128120A2 (en) 2006-11-30

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