ZA200609635B - Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers - Google Patents

Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers

Info

Publication number
ZA200609635B
ZA200609635B ZA200609635A ZA200609635A ZA200609635B ZA 200609635 B ZA200609635 B ZA 200609635B ZA 200609635 A ZA200609635 A ZA 200609635A ZA 200609635 A ZA200609635 A ZA 200609635A ZA 200609635 B ZA200609635 B ZA 200609635B
Authority
ZA
South Africa
Prior art keywords
treatment
liver diseases
epithelial cancers
mitochondrially targeted
targeted antioxidants
Prior art date
Application number
ZA200609635A
Other languages
English (en)
Inventor
Froehlich Eleonore
Kvietikova Ivica
Zatloukal Kurt
Schatz Gottfried
Denk Helmut
Stumptner Cornelia
Buck Charles
Original Assignee
Oridis Biomed Forschungs Und E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oridis Biomed Forschungs Und E filed Critical Oridis Biomed Forschungs Und E
Publication of ZA200609635B publication Critical patent/ZA200609635B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA200609635A 2004-07-13 2006-11-20 Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers ZA200609635B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04103318 2004-07-13

Publications (1)

Publication Number Publication Date
ZA200609635B true ZA200609635B (en) 2008-08-27

Family

ID=34929318

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200609635A ZA200609635B (en) 2004-07-13 2006-11-20 Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers

Country Status (11)

Country Link
US (1) US20070225255A1 (xx)
EP (1) EP1765413A2 (xx)
JP (1) JP2008506667A (xx)
CN (1) CN1997403A (xx)
AU (1) AU2005261654A1 (xx)
CA (1) CA2573456A1 (xx)
IL (1) IL179738A0 (xx)
RU (1) RU2007105138A (xx)
SG (1) SG156613A1 (xx)
WO (1) WO2006005759A2 (xx)
ZA (1) ZA200609635B (xx)

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ES2410587T3 (es) 2004-01-22 2013-07-02 University Of Miami Formulaciones tópicas de coenzima Q10 y métodos de uso
US20080032940A1 (en) * 2006-08-07 2008-02-07 Balaraman Kalyanaraman Methods for reducing anthracycline-induced toxicity
WO2008048135A1 (fr) 2006-10-20 2008-04-24 Limited Liability Company 'mitotechnology' Composition destinée à la régénération, la stimulation de la croissance et l'adaptation de plantes à tous types de facteurs de stress
US8658624B2 (en) 2006-10-20 2014-02-25 Mitotech Sa Pharmaceutical compositions for preventing and treating eye pathologies
WO2008094062A1 (fr) * 2007-01-29 2008-08-07 Limited Liability Company 'mitotechnology' Compositions pharmaceutiques servant à la prévention et au traitement de maladies oncologiques
US9427444B2 (en) 2007-01-29 2016-08-30 Mitotech Sa Pharmaceutical and cosmetic compositions for accelerated healing of wounds and other surface damages
WO2008127138A1 (fr) 2007-04-11 2008-10-23 Limited Liability Company 'mitotechnology' Composition visant à ralentir le vieillissement et à allonger la durée de vie de l'organisme et utilisation de cette composition
WO2009005386A1 (fr) 2007-06-29 2009-01-08 Limited Liability Company 'mitotechnology' Utilisation de compositions à adressage mitochondrial dans la prévention et le traitement de maldies cardio-vasculaires
CN101848918A (zh) * 2007-09-07 2010-09-29 吉奇亚公司 线粒体组合物及其用途
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
US8388931B2 (en) * 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
CN103462896A (zh) 2008-04-11 2013-12-25 细胞研究有限公司 诱导癌细胞凋亡的方法和应用
WO2010056145A1 (ru) 2008-11-12 2010-05-20 Общество С Ограниченной Ответственностью "Митотехнология" Способ умеренного повышения протонной проводимости биологических мембран при помощи митохондриально- адресованных делокализованных катионов
MX2011010956A (es) * 2009-04-17 2012-01-27 Colby Pharmaceutical Company Composiciones farmaceuticamente activas que comprenden moduladores de estres oxidativo (osm por sus siglas en inglés), nuevas entidades quimicas, composiciones y usos.
WO2010132479A2 (en) 2009-05-11 2010-11-18 Cytotech Labs, Llc Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
MX2011013150A (es) 2009-06-10 2012-03-14 Ltd Liability Company Mitotech Composicion farmaceutica para uso en oftalmologia medica y veterinaria.
CA2789846C (en) 2009-11-13 2020-02-25 Obschestvo S Ogranichennoi Otvetstvennostyu "Mitotekh" Pharmaceutical substances on the basis of mitochondria-addressed antioxidants
CA2832324C (en) 2011-04-04 2022-03-15 Berg Llc Methods of treating central nervous system tumors
CN103764132B (zh) 2011-06-03 2017-04-12 米托特克公司 线粒体靶向的抗氧化剂的口服制剂及其制备和用途
EP2758411A2 (en) 2011-09-19 2014-07-30 Gencia Corporation Modified creatine compounds
KR102279451B1 (ko) 2013-04-08 2021-07-19 버그 엘엘씨 코엔자임 q10 병용 요법을 이용한 암 치료
CN105452265B (zh) * 2013-04-24 2017-05-10 智脑公司 用于治疗肿瘤性疾病尤其具有高her2蛋白水平的肿瘤性疾病的他莫昔芬衍生物
KR102370843B1 (ko) 2013-09-04 2022-03-04 버그 엘엘씨 코엔자임 q10의 연속주입에 의한 암치료 방법
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
KR101773404B1 (ko) 2015-08-25 2017-08-31 (주) 씨유스킨 자외선에 의한 피부 손상의 예방 또는 개선을 위한 화장료 조성물
CN107510848A (zh) * 2016-06-15 2017-12-26 常州莱道斯生物医药科技有限公司 线粒体靶向制剂MitoPBN在防治糖尿病中的应用
CN108201543A (zh) * 2016-12-19 2018-06-26 北京福纳康生物技术有限公司 水溶性富勒烯结构在制备治疗脂肪肝的药物中的应用
CN115381804B (zh) * 2022-08-10 2024-06-21 华南师大(清远)科技创新研究院有限公司 癸基泛醌在制备治疗肝纤维化药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722361D0 (en) * 1997-10-24 1997-12-17 Pharma Nord Uk Ltd Pharmaceutical formulation for treating liver disorders
US6331532B1 (en) * 1998-11-25 2001-12-18 University Of Otago Mitochondrially targeted antioxidants
CA2354743A1 (en) * 2001-08-07 2003-02-07 University Of Otago Mitochondrially targeted antioxidants
NZ513547A (en) * 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)
AU2004266988B2 (en) * 2003-08-22 2011-05-26 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants

Also Published As

Publication number Publication date
WO2006005759A3 (en) 2006-05-11
JP2008506667A (ja) 2008-03-06
SG156613A1 (en) 2009-11-26
EP1765413A2 (en) 2007-03-28
US20070225255A1 (en) 2007-09-27
CA2573456A1 (en) 2006-01-19
AU2005261654A1 (en) 2006-01-19
CN1997403A (zh) 2007-07-11
WO2006005759A2 (en) 2006-01-19
IL179738A0 (en) 2007-05-15
RU2007105138A (ru) 2008-08-20

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