SG155214A1 - Process for the synthesis c-2, c-3 substituted n-alkylated indoles useful as cpla2 inhibitors - Google Patents

Process for the synthesis c-2, c-3 substituted n-alkylated indoles useful as cpla2 inhibitors

Info

Publication number
SG155214A1
SG155214A1 SG200905383-6A SG2009053836A SG155214A1 SG 155214 A1 SG155214 A1 SG 155214A1 SG 2009053836 A SG2009053836 A SG 2009053836A SG 155214 A1 SG155214 A1 SG 155214A1
Authority
SG
Singapore
Prior art keywords
synthesis
substituted
cpla2 inhibitors
indoles useful
alkylated indoles
Prior art date
Application number
SG200905383-6A
Other languages
English (en)
Inventor
Ronald S Michalak
Mahmut Levent
Frederick J Vyverberg
Ara R Boyajian
Panolil Raveendranath
Michel Cantin
Alan Stockton
Michael W Winkley
Mousumi Ghosh
Christoph Dehnhardt
Charles Guinosso
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of SG155214A1 publication Critical patent/SG155214A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG200905383-6A 2004-08-19 2005-08-18 Process for the synthesis c-2, c-3 substituted n-alkylated indoles useful as cpla2 inhibitors SG155214A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60312404P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
SG155214A1 true SG155214A1 (en) 2009-09-30

Family

ID=35219553

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200905383-6A SG155214A1 (en) 2004-08-19 2005-08-18 Process for the synthesis c-2, c-3 substituted n-alkylated indoles useful as cpla2 inhibitors

Country Status (24)

Country Link
US (3) US7582772B2 (fr)
EP (1) EP1778629B1 (fr)
JP (1) JP2008510707A (fr)
KR (1) KR20070043036A (fr)
CN (2) CN101006048B (fr)
AR (1) AR053410A1 (fr)
AT (1) ATE517084T1 (fr)
AU (1) AU2005277392A1 (fr)
BR (1) BRPI0514431A (fr)
CA (1) CA2576008A1 (fr)
CR (1) CR8936A (fr)
EC (1) ECSP077244A (fr)
GT (1) GT200500224A (fr)
HN (1) HN2005000474A (fr)
IL (1) IL181364A0 (fr)
MX (1) MX2007002042A (fr)
NO (1) NO20071253L (fr)
PE (1) PE20060628A1 (fr)
RU (1) RU2401829C2 (fr)
SG (1) SG155214A1 (fr)
SV (1) SV2006002200A (fr)
TW (1) TW200609214A (fr)
UA (1) UA85428C2 (fr)
WO (1) WO2006023611A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7605156B2 (en) * 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
GT200600228A (es) * 2005-05-27 2006-12-26 Inhibidores de la fosfolipasa a2 citosolica
TW200826932A (en) * 2006-10-31 2008-07-01 Wyeth Corp Semi-solid formulations of phospholipase enzyme inhibitors
EP2104498A2 (fr) * 2006-10-31 2009-09-30 Wyeth Inhibiteurs de l'enzyme phospholipase sous forme de préparations liquides

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02115157A (ja) * 1988-10-24 1990-04-27 Hokko Chem Ind Co Ltd スルホニルグリシン誘導体および除草剤
US6797708B2 (en) * 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7101875B2 (en) * 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6984735B2 (en) * 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
TWI334778B (en) * 2001-12-03 2010-12-21 Wyeth Corp Inhibitors of cytosolic phospholipase a2
US6635771B2 (en) * 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US7713964B2 (en) * 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
TW200510305A (en) * 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
EP1651177A1 (fr) 2003-07-29 2006-05-03 Ciba SC Holding AG Derives de l'acide 3-aryle-2-cyano-3-hydroxy-acrylique
US7582771B2 (en) * 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) * 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

Also Published As

Publication number Publication date
HN2005000474A (es) 2009-04-07
RU2401829C2 (ru) 2010-10-20
WO2006023611A1 (fr) 2006-03-02
KR20070043036A (ko) 2007-04-24
US20090306428A1 (en) 2009-12-10
IL181364A0 (en) 2007-07-04
JP2008510707A (ja) 2008-04-10
CN101006048B (zh) 2011-07-06
ECSP077244A (es) 2007-03-29
CN101006048A (zh) 2007-07-25
CN101830837A (zh) 2010-09-15
NO20071253L (no) 2007-05-15
US7582772B2 (en) 2009-09-01
CA2576008A1 (fr) 2006-03-02
PE20060628A1 (es) 2006-08-14
AR053410A1 (es) 2007-05-09
ATE517084T1 (de) 2011-08-15
EP1778629B1 (fr) 2011-07-20
US20060041005A1 (en) 2006-02-23
US7842837B2 (en) 2010-11-30
AU2005277392A1 (en) 2006-03-02
BRPI0514431A (pt) 2008-06-10
US20110054189A1 (en) 2011-03-03
EP1778629A1 (fr) 2007-05-02
US8034960B2 (en) 2011-10-11
UA85428C2 (ru) 2009-01-26
RU2007105231A (ru) 2008-09-27
TW200609214A (en) 2006-03-16
MX2007002042A (es) 2007-03-29
GT200500224A (es) 2006-03-21
SV2006002200A (es) 2006-05-09
CR8936A (es) 2007-04-26

Similar Documents

Publication Publication Date Title
EP1931632A4 (fr) Composes indoles utiles
IL185419A0 (en) Improved process for the synthesis of enantiomeric indanylamine derivatives
HK1078075A1 (en) Process for preparing indolinone derivatives
TWI318626B (en) Indole derivatives exhibiting pgd2 receptor antagonism
IL188039A0 (en) Oxindole derivatives
SG152287A1 (en) Acetylene derivatives
IL213799A0 (en) Process for preparing 2,3-disubstituted indoles
ZA200804301B (en) 1,5-substituted indol-2-yl amide derivatives
EP1935890A4 (fr) Dérivé indole substitué en position 2 par un groupe hétéroaryle
IL183568A (en) Process for making 7,8-dihydro-5 h-patridine-6-onh
GB2431927A9 (en) 1,2-Disubstituted indoles & derivatives thereof astherapeutic 5-iipoxygenase-activating protein (fl ap) inhibitors
EP1915372A4 (fr) Derives d'indole en tant qu'antagonistes du recepteur crth2
PT1720832E (pt) Processo de preparação de derivados de 4-cetoprolina n-protegidos
IL178233A0 (en) Process for producing 5-hydroxy-4-thiomethylpyrazole derivatives
ZA200804508B (en) Process for humidifying synthesis gas
ZA200709717B (en) Imidazolone phenylalanine derivatives as VLA-4 antagonists
SI1807395T1 (sl) Proces za sintezo N-alkoksiaminov
HK1100410A1 (en) Indole derivatives having piperidine rings
ZA200705130B (en) Process for the synthesis of azetidinones
IL181364A0 (en) Process for the synthesis c-2,c-3 substituted n-alkylated indoles useful as cpla2 inhibitors
ZA200705216B (en) Novel process for the preparation of substituted indoles
ZA200710389B (en) Process for the copolymerization of propylene
IL177936A0 (en) Process for cross coupling indoles
EP1876170A4 (fr) Appareil pour la synthèse d'urée
PL374461A1 (pl) Sposób otrzymywania pochodnych 13,14-dihydro-PGF