SG152923A1 - Biochemical methods for measuring metabolic fitness of tissues or whole organisms - Google Patents

Biochemical methods for measuring metabolic fitness of tissues or whole organisms

Info

Publication number
SG152923A1
SG152923A1 SG200706374-6A SG2007063746A SG152923A1 SG 152923 A1 SG152923 A1 SG 152923A1 SG 2007063746 A SG2007063746 A SG 2007063746A SG 152923 A1 SG152923 A1 SG 152923A1
Authority
SG
Singapore
Prior art keywords
aerobic
metabolic fitness
tissues
biochemical methods
fitness
Prior art date
Application number
SG200706374-6A
Other languages
English (en)
Inventor
Marc K Hellerstein
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of SG152923A1 publication Critical patent/SG152923A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G01N33/5079—Mitochondria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
SG200706374-6A 2002-09-16 2003-09-16 Biochemical methods for measuring metabolic fitness of tissues or whole organisms SG152923A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41102902P 2002-09-16 2002-09-16

Publications (1)

Publication Number Publication Date
SG152923A1 true SG152923A1 (en) 2009-06-29

Family

ID=31994237

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200706374-6A SG152923A1 (en) 2002-09-16 2003-09-16 Biochemical methods for measuring metabolic fitness of tissues or whole organisms

Country Status (9)

Country Link
US (1) US20040081994A1 (ja)
EP (1) EP1545628A4 (ja)
JP (1) JP2005539069A (ja)
AU (1) AU2003275037A1 (ja)
CA (1) CA2498583A1 (ja)
HK (1) HK1079707A1 (ja)
SG (1) SG152923A1 (ja)
TW (1) TW200502394A (ja)
WO (1) WO2004024941A2 (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
JP2005515452A (ja) * 2001-10-24 2005-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アイソトープで標識された水を用いるヒトおよび実験系におけるタンパク質合成速度の測定
WO2003068919A2 (en) * 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
AU2003234688A1 (en) * 2002-04-05 2003-10-27 The Regents Of The University Of California Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
EP1546364A4 (en) 2002-07-30 2006-09-06 Univ California METHOD FOR THE LARGE-SCALE AUTOMATIC MEASUREMENT OF PROTEOMIC OR ORGANOMOMIC MOLECULAR FLOW RATES BY MASS SPECTROMETRY
US20060105339A1 (en) * 2002-09-04 2006-05-18 Marc Hellerstein Methods for measuring the rates of replication and death of microbial infectious agents in an infected
DE60324950D1 (de) * 2002-09-13 2009-01-08 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
CA2504313C (en) 2002-11-04 2012-01-17 Marc K. Hellerstein Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
ATE554391T1 (de) * 2003-12-19 2012-05-15 Max Planck Gesellschaft Verfahren zur analyse von metaboliten
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
US20050238577A1 (en) * 2004-03-29 2005-10-27 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
JP2006053100A (ja) * 2004-08-13 2006-02-23 Institute Of Physical & Chemical Research 動物の代謝解析方法、ラベル動物の製造方法、ラベル動物、および、動物のｎｍｒ測定方法
JP4488852B2 (ja) * 2004-09-17 2010-06-23 味の素ゼネラルフーヅ株式会社 体内脂肪低減作用を有する組成物
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
WO2007086100A1 (ja) * 2006-01-24 2007-08-02 Ajinomoto General Foods, Inc. 血圧の降下作用及び／または上昇抑制作用を有する組成物およびこれを含有する飲食物
JP4771882B2 (ja) * 2006-07-21 2011-09-14 味の素ゼネラルフーヅ株式会社 糖尿病または糖尿病性合併症の治療、予防、または改善作用を有する組成物およびこれを含有する飲料
KR100940511B1 (ko) 2007-08-20 2010-03-08 미토테크 주식회사 미토콘드리아 기반 대사진단 시스템 및 대사진단 방법
JP5526379B2 (ja) * 2009-06-25 2014-06-18 独立行政法人製品評価技術基盤機構 新規化合物の同定法
US9110008B2 (en) 2010-07-26 2015-08-18 Los Gatos Research Method for isotopic analysis of water in bodily fluids
US10386371B2 (en) 2011-09-08 2019-08-20 The Regents Of The University Of California Metabolic flux measurement, imaging and microscopy
JP5821447B2 (ja) * 2011-09-13 2015-11-24 大正製薬株式会社 カルジオリピンを用いた疲労の判定方法
JP6024939B2 (ja) * 2011-10-12 2016-11-16 国立大学法人金沢大学 薬物代謝機能測定方法
CA2858368A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
US11754478B2 (en) 2018-08-16 2023-09-12 Abb Schweiz Ag Rapid equilibrator for water isotope analysis

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065552A (en) * 1975-05-05 1977-12-27 Giovanni Giacomo Costa Method of detecting malignant neoplasms
US4332784A (en) * 1979-02-06 1982-06-01 The Radiochemical Centre Limited Dual isotope assays
US5317098A (en) * 1986-03-17 1994-05-31 Hiroaki Shizuya Non-radioisotope tagging of fragments
EP0248924B1 (en) * 1986-06-09 1989-11-23 Bruker Analytische Messtechnik GmbH Method for determining the turnover of organic material in living tissue and nmr spectrometer for performing this method
US4940658A (en) * 1986-11-20 1990-07-10 University Patents, Inc. Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency
EP0335918A1 (en) * 1987-08-07 1989-10-11 Mallinckrodt Diagnostica (Holland) B.V. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US5042488A (en) * 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
US5217903A (en) * 1990-05-15 1993-06-08 Trustees Of Boston University Measuring connective tissue breakdown products in body fluids
CA2027714C (en) * 1990-07-13 2003-01-28 Kenneth W. Turtletaub Method of measurement in biological systems
US5209919A (en) * 1990-07-13 1993-05-11 Regents Of The University Of California Method of measurement in biological systems
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
US5394236A (en) * 1992-02-03 1995-02-28 Rutgers, The State University Methods and apparatus for isotopic analysis
US5338686A (en) * 1992-04-29 1994-08-16 Hellerstein Marc K Method for measuring in vivo synthesis of biopolymers
US5506147A (en) * 1993-04-15 1996-04-09 Kolhouse; J. Fred Non-invasive evaluation of maldigestion and malaborption
US5439803A (en) * 1993-08-13 1995-08-08 The Regents Of The University Of Michigan Isotope and assay for glycolysis and the pentose phosphate pathway
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
US5961470A (en) * 1997-07-09 1999-10-05 Wagner; David A. Breath test for assessing hepatic function
US6329208B1 (en) * 1997-07-16 2001-12-11 Board Of Regents, The University Of Texas System Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling
CA2249173C (en) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Diagnostic agent for liver function
US6461870B2 (en) * 1998-05-06 2002-10-08 Isotechnika Inc. 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
AU3725199A (en) * 1998-05-06 1999-11-23 Isotechnika Inc. 13c glucose breath test for the diagnosis of diabetic indications andmonitoring glycemic control
US6284219B1 (en) * 1998-06-30 2001-09-04 Phenome Sciences Inc. In vivo determination of metabolic function for use in therapy management
US6625547B1 (en) * 1998-08-05 2003-09-23 Washington State University Research Foundation Relative rates of cytochrome p450 metabolism
DE19839491A1 (de) * 1998-08-29 2000-03-02 Hermann Heumann Verfahren zur Markierung von Biopolymeren mit Isotopen
CA2341157A1 (en) * 1998-08-31 2000-03-09 University Of Washington Stable isotope metabolic labeling for analysis of biopolymers
US6887712B1 (en) * 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6764817B1 (en) * 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6653090B1 (en) * 1999-11-05 2003-11-25 University Of Alberta Methods for measuring the metabolism of and screening for drugs in isolated hearts
WO2001086306A2 (en) * 2000-05-05 2001-11-15 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
GB0106923D0 (en) * 2001-03-20 2001-05-09 Univ Dundee Liver function test
US7256047B2 (en) * 2001-05-01 2007-08-14 Board Of Regents, The University Of Texas System Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
CA2451795A1 (en) * 2001-06-26 2003-01-09 Paul M. Mathews Cell-based high-throughput screening methods
JP2005515452A (ja) * 2001-10-24 2005-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アイソトープで標識された水を用いるヒトおよび実験系におけるタンパク質合成速度の測定
WO2003068919A2 (en) * 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
US20030180710A1 (en) * 2002-03-22 2003-09-25 Lee Wai-Nang Paul Method of enhancing the efficiency of a pharmaceutical business
US20030180800A1 (en) * 2002-03-22 2003-09-25 Lee Wai-Nang Paul Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development
AU2003234688A1 (en) * 2002-04-05 2003-10-27 The Regents Of The University Of California Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
CA2504313C (en) * 2002-11-04 2012-01-17 Marc K. Hellerstein Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL EFFECTS OF IRRADIATED SUCROSE SOLUTIONS IN THE RAT *
ISOTOPIC LABELLING OF HEART MITOCHNONDRIA AS A FUNCTION OF RESPIRATORY STATE *
PENETRATION OF AMINO ACIDS INTO ISOLATED MITOCHONDRIA *
SYNTHESIS OF I *

Also Published As

Publication number Publication date
US20040081994A1 (en) 2004-04-29
JP2005539069A (ja) 2005-12-22
AU2003275037A1 (en) 2004-04-30
TW200502394A (en) 2005-01-16
EP1545628A4 (en) 2010-07-28
HK1079707A1 (zh) 2006-04-13
EP1545628A2 (en) 2005-06-29
CA2498583A1 (en) 2004-03-25
WO2004024941A2 (en) 2004-03-25
WO2004024941A3 (en) 2004-11-11

Similar Documents

Publication Publication Date Title
SG152923A1 (en) Biochemical methods for measuring metabolic fitness of tissues or whole organisms
Meyskens Jr et al. Cancer prevention: obstacles, challenges, and the road ahead
Neufer et al. Understanding the cellular and molecular mechanisms of physical activity-induced health benefits
Libby et al. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment
Sung et al. Effects of a regular walking exercise program on behavioral and biochemical aspects in elderly people with type II diabetes
Joyner et al. Ten questions about systems biology
Jaggers et al. Metabolic syndrome and risk of cancer mortality in men
Armstrong et al. Cardiopulmonary fitness, physical activity patterns, and selected coronary risk factor variables in 11-to 16-year-olds
Milne et al. Fluctuating asymmetry and physical health among young adults
Hordern et al. Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes
Somani et al. Acute response to a 2-minute isometric exercise test predicts the blood pressure-lowering efficacy of isometric resistance training in young adults
Wiskemann et al. Physical Exercise Training versus Relaxation in Allogeneic stem cell transplantation (PETRA Study)–Rationale and design of a randomized trial to evaluate a yearlong exercise intervention on overall survival and side-effects after allogeneic stem cell transplantation
Georges et al. Impact of pain in health related quality of life of patients with systemic sclerosis
Agboola et al. The future of Connected Health in preventive medicine
Maharaj et al. Rebound exercise: A beneficial adjuvant for sedentary non‐insulin‐dependent type 2 diabetic individuals in a rural environment
Parini et al. Taking action: European Atherosclerosis Society targets the United Nations Sustainable Development Goals 2030 agenda to fight atherosclerotic cardiovascular disease in Europe
Espinoza et al. An individualized low-intensity walking clinic leads to improvement in frailty characteristics in older veterans
Pawłowska et al. The effect of submaximal exercise followed by short-term cold-water immersion on the inflammatory state in healthy recreational athletes: A cross-over study
Gupta et al. Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis
Al Asoom et al. Functional DNA variations associated with Saudi female with low VO2max: A pilot microarray study
Lee et al. The role of cardiopulmonary fitness and its genetic influences on surgical outcomes
Rosenthal et al. Motor ability, function, and health-related quality of life as correlates of symptom burden in patients with sclerotic chronic graft-versus-host disease receiving imatinib mesylate
Natalucci et al. A Mixed-apprOach program To help women wIth breast cancer stay actiVE (MOTIVE program): A pilot-controlled study
US20130041239A1 (en) Immune and oxygen system measuring and drug screening method and apparatus
Taphoorn et al. Evaluation of cognitive functions and quality of life