SG11202108311RA - Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies - Google Patents
Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodiesInfo
- Publication number
- SG11202108311RA SG11202108311RA SG11202108311RA SG11202108311RA SG11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA
- Authority
- SG
- Singapore
- Prior art keywords
- egfr
- cancer
- met
- seq
- subject
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962810716P | 2019-02-26 | 2019-02-26 | |
| US201962930190P | 2019-11-04 | 2019-11-04 | |
| PCT/IB2020/051559 WO2020174370A2 (en) | 2019-02-26 | 2020-02-24 | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202108311RA true SG11202108311RA (en) | 2021-09-29 |
Family
ID=72142314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202108311RA SG11202108311RA (en) | 2019-02-26 | 2020-02-24 | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
Country Status (16)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021010265A (es) | 2019-02-26 | 2021-09-23 | Janssen Biotech Inc | Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos. |
| US12629375B2 (en) | 2019-03-29 | 2026-05-19 | Board Of Regents, The University Of Texas System | Compounds with anti-tumor activity against cancer cells bearing HER2 exon 21 insertions |
| JP7709384B2 (ja) * | 2019-04-17 | 2025-07-16 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがんに対する化合物 |
| BR112021022828A2 (pt) * | 2019-05-14 | 2022-04-12 | Janssen Biotech Inc | Terapias combinadas com anticorpos biespecíficos anti-egfr/c-met e inibidores de egfr tirosina-quinase de terceira geração |
| MY208668A (en) | 2019-05-14 | 2025-05-23 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| BR112022015140A2 (pt) | 2020-02-12 | 2022-10-11 | Janssen Biotech Inc | Tratamento de pacientes que têm mutações de salto do éxon 14 de c-met |
| EP4204455A4 (en) | 2020-08-25 | 2024-10-16 | Janssen Biotech, Inc. | Treatment of non-small cell lung cancer with egfr mutations |
| IL305700A (en) * | 2021-03-09 | 2023-11-01 | Janssen Biotech Inc | Treatment of cancers lacking EFGR-activating mutations |
| EP4372001A4 (en) * | 2021-07-14 | 2025-02-12 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | ANTIGEN-BINDING MOLECULE SPECIFICALLY BINDING TO HGFR AND EGFR, AND PHARMACEUTICAL USE THEREOF |
| KR20240051145A (ko) * | 2021-07-29 | 2024-04-19 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Kras 돌연변이 암의 치료를 위한 방법 및 조성물 |
| KR102793991B1 (ko) | 2021-10-06 | 2025-04-09 | 주식회사 엘지에너지솔루션 | 태양광 시스템과 연계하는 에너지 저장 시스템 및 에너지 저장 시스템의 제어 방법 |
| US20230183360A1 (en) * | 2021-12-09 | 2023-06-15 | Janssen Biotech, Inc. | Use of Amivantamab to Treat Colorectal Cancer |
| AU2024236678A1 (en) * | 2023-03-13 | 2025-10-30 | Janssen Biotech, Inc. | Combination therapies with bi-specific anti-egfr/c-met antibodies and anti-pd-1 antibodies |
| JP2026513451A (ja) * | 2023-04-24 | 2026-04-27 | 正大天晴▲藥▼▲業▼集▲団▼股▲フン▼有限公司 | ｃ－Ｍｅｔを標的とする多重特異性抗体 |
| WO2025067492A1 (zh) * | 2023-09-28 | 2025-04-03 | 上海翰森生物医药科技有限公司 | 一种双特异性抗体在制备治疗癌症的药物中的用途 |
| WO2026086844A1 (zh) * | 2024-10-23 | 2026-04-30 | 正大天晴药业集团股份有限公司 | 靶向EGFR和c-Met的抗体药物偶联物 |
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| MX2021010265A (es) | 2019-02-26 | 2021-09-23 | Janssen Biotech Inc | Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos. |
| US20220143023A1 (en) | 2019-03-29 | 2022-05-12 | Board Of Regents, The University Of Texas System | Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 insertions |
| JP7709384B2 (ja) | 2019-04-17 | 2025-07-16 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがんに対する化合物 |
| JP7822597B2 (ja) | 2019-04-17 | 2026-03-03 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがん細胞に対する抗腫瘍活性を有する化合物 |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| MY208668A (en) | 2019-05-14 | 2025-05-23 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors |
| TW202309094A (zh) * | 2021-05-18 | 2023-03-01 | 美商健生生物科技公司 | 用於識別癌症患者以進行組合治療之方法 |
-
2020
- 2020-02-24 MX MX2021010265A patent/MX2021010265A/es unknown
- 2020-02-24 WO PCT/IB2020/051559 patent/WO2020174370A2/en not_active Ceased
- 2020-02-24 CA CA3131654A patent/CA3131654A1/en active Pending
- 2020-02-24 EP EP20763439.5A patent/EP3931224A4/en active Pending
- 2020-02-24 CN CN202080017112.1A patent/CN113840842A/zh active Pending
- 2020-02-24 NZ NZ778579A patent/NZ778579A/en unknown
- 2020-02-24 US US16/798,662 patent/US11459391B2/en active Active
- 2020-02-24 MA MA055089A patent/MA55089A/fr unknown
- 2020-02-24 SG SG11202108311RA patent/SG11202108311RA/en unknown
- 2020-02-24 BR BR112021016149-0A patent/BR112021016149A2/pt unknown
- 2020-02-24 KR KR1020217030301A patent/KR20210132117A/ko active Pending
- 2020-02-24 AU AU2020229467A patent/AU2020229467A1/en active Pending
- 2020-02-24 PH PH1/2021/552030A patent/PH12021552030A1/en unknown
- 2020-02-24 JP JP2021549746A patent/JP7703448B2/ja active Active
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2021
- 2021-08-18 IL IL285718A patent/IL285718A/en unknown
- 2021-08-23 JO JOP/2021/0233A patent/JOP20210233A1/ar unknown
-
2022
- 2022-08-03 US US17/817,295 patent/US12215161B2/en active Active
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2024
- 2024-07-04 JP JP2024108371A patent/JP2024153659A/ja active Pending
- 2024-12-20 US US18/990,769 patent/US20250236675A1/en active Pending
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2025
- 2025-01-30 JP JP2025014414A patent/JP2025084739A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024153659A (ja) | 2024-10-29 |
| BR112021016149A2 (pt) | 2021-10-13 |
| US20230130600A1 (en) | 2023-04-27 |
| CA3131654A1 (en) | 2020-09-03 |
| WO2020174370A2 (en) | 2020-09-03 |
| US20200270351A1 (en) | 2020-08-27 |
| MX2021010265A (es) | 2021-09-23 |
| JOP20210233A1 (ar) | 2023-01-30 |
| CN113840842A (zh) | 2021-12-24 |
| WO2020174370A3 (en) | 2020-12-03 |
| NZ778579A (en) | 2026-03-27 |
| PH12021552030A1 (en) | 2022-08-15 |
| JP2022521610A (ja) | 2022-04-11 |
| IL285718A (en) | 2021-10-31 |
| JP7703448B2 (ja) | 2025-07-07 |
| KR20210132117A (ko) | 2021-11-03 |
| US20250236675A1 (en) | 2025-07-24 |
| US11459391B2 (en) | 2022-10-04 |
| AU2020229467A1 (en) | 2021-08-12 |
| EP3931224A2 (en) | 2022-01-05 |
| JP2025084739A (ja) | 2025-06-03 |
| MA55089A (fr) | 2022-01-05 |
| US12215161B2 (en) | 2025-02-04 |
| EP3931224A4 (en) | 2023-03-01 |
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