SG11202108033TA - Native microfluidic ce-ms analysis of antibody charge heterogeneity - Google Patents
Native microfluidic ce-ms analysis of antibody charge heterogeneityInfo
- Publication number
- SG11202108033TA SG11202108033TA SG11202108033TA SG11202108033TA SG11202108033TA SG 11202108033T A SG11202108033T A SG 11202108033TA SG 11202108033T A SG11202108033T A SG 11202108033TA SG 11202108033T A SG11202108033T A SG 11202108033TA SG 11202108033T A SG11202108033T A SG 11202108033TA
- Authority
- SG
- Singapore
- Prior art keywords
- antibody
- interest
- sample
- post
- antibody fragments
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4044—Concentrating samples by chemical techniques; Digestion; Chemical decomposition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799331P | 2019-01-31 | 2019-01-31 | |
| US201962851365P | 2019-05-22 | 2019-05-22 | |
| PCT/US2020/015875 WO2020160266A1 (en) | 2019-01-31 | 2020-01-30 | Native microfluidic ce-ms analysis of antibody charge heterogeneity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202108033TA true SG11202108033TA (en) | 2021-08-30 |
Family
ID=69811860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202108033TA SG11202108033TA (en) | 2019-01-31 | 2020-01-30 | Native microfluidic ce-ms analysis of antibody charge heterogeneity |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12169203B2 (enExample) |
| EP (1) | EP3918339A1 (enExample) |
| JP (1) | JP2022519246A (enExample) |
| KR (1) | KR20210122803A (enExample) |
| CN (1) | CN113646638B (enExample) |
| AU (1) | AU2020216172A1 (enExample) |
| BR (1) | BR112021013716A2 (enExample) |
| CA (1) | CA3126712A1 (enExample) |
| IL (1) | IL284929A (enExample) |
| MX (1) | MX2021009267A (enExample) |
| SG (1) | SG11202108033TA (enExample) |
| WO (1) | WO2020160266A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114544839B (zh) * | 2022-01-20 | 2024-08-20 | 未名生物医药有限公司 | 一种抗人神经生长因子抗体的电荷变异体检测方法 |
| EP4493921A1 (en) * | 2022-03-18 | 2025-01-22 | Regeneron Pharmaceuticals, Inc. | Methods and systems for analyzing polypeptide variants |
| WO2024020199A1 (en) * | 2022-07-21 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Native microfluidic ce-ms analysis of antibody charge heterogeneity |
| WO2025022284A1 (en) * | 2023-07-25 | 2025-01-30 | Dh Technologies Development Pte. Ltd. | Method for in-capillary dissociation and analysis of mass spectral data |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000063683A1 (en) * | 1999-04-20 | 2000-10-26 | Target Discovery, Inc. | Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database |
| FR2862134B1 (fr) * | 2003-11-12 | 2007-07-27 | Sebia Sa | Analyse et typage de proteines monoclonales par electrophorese capillaire et immunodeplacement |
| CN101201355A (zh) * | 2006-12-15 | 2008-06-18 | 许洋 | 免疫组质谱检测个体化肿瘤生物标志及疗效试剂盒和方法 |
| US20100187113A1 (en) * | 2009-01-26 | 2010-07-29 | Vladislav Dolnik | Capillary sieving electrophoresis with a cationic surfactant for size separation of proteins |
| LT2975051T (lt) | 2009-06-26 | 2021-07-12 | Regeneron Pharmaceuticals, Inc. | Lengvai išskiriami bispecifiniai antikūnai su natyvios formos imunoglobulinu |
| CN103033628A (zh) * | 2012-12-18 | 2013-04-10 | 北京科技大学 | 制备个体全蛋白质组芯片的方法及其应用 |
| WO2016183222A1 (en) * | 2015-05-12 | 2016-11-17 | Regeneron Pharmaceuticals, Inc. | Multimeric protein purity determination |
| GB201603291D0 (en) * | 2016-02-25 | 2016-04-13 | Binding Site Group The Ltd | Antibodies |
| WO2018183622A1 (en) * | 2017-03-30 | 2018-10-04 | 908 Devices Inc. | Microfluidic analysis of biological samples |
-
2020
- 2020-01-30 CA CA3126712A patent/CA3126712A1/en active Pending
- 2020-01-30 US US16/777,230 patent/US12169203B2/en active Active
- 2020-01-30 BR BR112021013716-5A patent/BR112021013716A2/pt not_active IP Right Cessation
- 2020-01-30 EP EP20711357.2A patent/EP3918339A1/en not_active Withdrawn
- 2020-01-30 JP JP2021544511A patent/JP2022519246A/ja active Pending
- 2020-01-30 CN CN202080009967.XA patent/CN113646638B/zh not_active Expired - Fee Related
- 2020-01-30 WO PCT/US2020/015875 patent/WO2020160266A1/en not_active Ceased
- 2020-01-30 MX MX2021009267A patent/MX2021009267A/es unknown
- 2020-01-30 SG SG11202108033TA patent/SG11202108033TA/en unknown
- 2020-01-30 KR KR1020217026598A patent/KR20210122803A/ko not_active Withdrawn
- 2020-01-30 AU AU2020216172A patent/AU2020216172A1/en not_active Abandoned
-
2021
- 2021-07-18 IL IL284929A patent/IL284929A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113646638A (zh) | 2021-11-12 |
| AU2020216172A1 (en) | 2021-08-05 |
| CA3126712A1 (en) | 2020-08-06 |
| BR112021013716A2 (pt) | 2021-09-21 |
| US20200249241A1 (en) | 2020-08-06 |
| US12169203B2 (en) | 2024-12-17 |
| IL284929A (en) | 2021-09-30 |
| MX2021009267A (es) | 2021-09-10 |
| KR20210122803A (ko) | 2021-10-12 |
| CN113646638B (zh) | 2024-05-24 |
| EP3918339A1 (en) | 2021-12-08 |
| JP2022519246A (ja) | 2022-03-22 |
| WO2020160266A1 (en) | 2020-08-06 |
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