SG11202106986VA - L718 and/or l792 mutant treatment-resistant egfr inhibitor - Google Patents

L718 and/or l792 mutant treatment-resistant egfr inhibitor

Info

Publication number
SG11202106986VA
SG11202106986VA SG11202106986VA SG11202106986VA SG11202106986VA SG 11202106986V A SG11202106986V A SG 11202106986VA SG 11202106986V A SG11202106986V A SG 11202106986VA SG 11202106986V A SG11202106986V A SG 11202106986VA SG 11202106986V A SG11202106986V A SG 11202106986VA
Authority
SG
Singapore
Prior art keywords
egfr inhibitor
resistant egfr
mutant treatment
mutant
treatment
Prior art date
Application number
SG11202106986VA
Other languages
English (en)
Inventor
Shinichi Hasako
Takao Uno
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of SG11202106986VA publication Critical patent/SG11202106986VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11202106986VA 2018-12-28 2019-12-27 L718 and/or l792 mutant treatment-resistant egfr inhibitor SG11202106986VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018247131 2018-12-28
PCT/JP2019/051377 WO2020138400A1 (en) 2018-12-28 2019-12-27 L718 and/or l792 mutant treatment-resistant egfr inhibitor

Publications (1)

Publication Number Publication Date
SG11202106986VA true SG11202106986VA (en) 2021-07-29

Family

ID=69174561

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106986VA SG11202106986VA (en) 2018-12-28 2019-12-27 L718 and/or l792 mutant treatment-resistant egfr inhibitor

Country Status (13)

Country Link
US (1) US20220072000A1 (ja)
EP (1) EP3902548A1 (ja)
JP (1) JP7303303B2 (ja)
KR (1) KR20210110329A (ja)
CN (1) CN113423403A (ja)
AU (1) AU2019417691A1 (ja)
BR (1) BR112021012687A2 (ja)
CA (1) CA3124750A1 (ja)
IL (1) IL284330A (ja)
MX (1) MX2021007852A (ja)
SG (1) SG11202106986VA (ja)
WO (1) WO2020138400A1 (ja)
ZA (1) ZA202104679B (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022007841A1 (zh) * 2020-07-09 2022-01-13 上海和誉生物医药科技有限公司 一种egfr抑制剂、其制备方法和在药学上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014309788B2 (en) 2013-08-22 2017-02-16 Taiho Pharmaceutical Co., Ltd. Novel quinoline-substituted compound
US20170166598A1 (en) * 2014-05-13 2017-06-15 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
JOP20190073A1 (ar) * 2016-10-31 2019-04-07 Taiho Pharmaceutical Co Ltd مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20
AU2018325819B2 (en) * 2017-09-01 2024-02-01 Taiho Pharmaceutical Co., Ltd. Exon 18 and/or exon 21 mutant EGFR selective inhibitor

Also Published As

Publication number Publication date
BR112021012687A2 (pt) 2021-09-28
KR20210110329A (ko) 2021-09-07
EP3902548A1 (en) 2021-11-03
ZA202104679B (en) 2023-12-20
AU2019417691A1 (en) 2021-07-22
CA3124750A1 (en) 2020-07-02
JP2022522573A (ja) 2022-04-20
CN113423403A (zh) 2021-09-21
IL284330A (en) 2021-08-31
WO2020138400A1 (en) 2020-07-02
US20220072000A1 (en) 2022-03-10
TW202038965A (zh) 2020-11-01
JP7303303B2 (ja) 2023-07-04
MX2021007852A (es) 2021-08-11

Similar Documents

Publication Publication Date Title
IL290399A (en) kras g12c inhibitors and methods of using them
IL272512A (en) KRAS G12C inhibitors and methods of using them
IL276095B1 (en) gcn2 inhibitors and their uses
IL276147A (en) GCN2 inhibitors and uses thereof
ZA202002172B (en) Pde9 inhibitor and use thereof
IL276489A (en) ATR inhibitor and its application
IL282350A (en) Bernani-RGMC inhibitors and their use
FI3677266T3 (fi) Eksoni 18- ja/tai eksoni 21 -egfr-mutantille selektiivinen inhibiittori
GB2591554B (en) Composiitons and methods and uses relating thereto
ZA202102192B (en) Fgfr4 inhibitor and use thereof
IL286485A (en) pi4-kinase inhibitors and methods of using them
EP3744722A4 (en) Ss-LACTAMASE INHIBITOR AND ITS USE
IL284330A (en) Treatment-resistant EGFR inhibitor mutant L718 and/or L792
IL280408A (en) CDK inhibitors and uses thereof
GB2589437B (en) Circuitry and methods
GB201908884D0 (en) Inhibitors and use
GB201902266D0 (en) New methods and uses