SG11202105227QA - C10-alkylene substituted 13-membered macrolides and uses thereof - Google Patents

C10-alkylene substituted 13-membered macrolides and uses thereof

Info

Publication number
SG11202105227QA
SG11202105227QA SG11202105227QA SG11202105227QA SG11202105227QA SG 11202105227Q A SG11202105227Q A SG 11202105227QA SG 11202105227Q A SG11202105227Q A SG 11202105227QA SG 11202105227Q A SG11202105227Q A SG 11202105227QA SG 11202105227Q A SG11202105227Q A SG 11202105227QA
Authority
SG
Singapore
Prior art keywords
alkylene substituted
membered macrolides
macrolides
membered
alkylene
Prior art date
Application number
SG11202105227QA
Other languages
English (en)
Inventor
Roger B Clark
Richard Alm
Wesley Francis Austin
Philip Hogan
Ivan Jewett
Sushmita D Lahiri
Jonathan F Lawrence
Xiben Li
Shuhao Shi
Wenying Wang
Yoshitaka Ichikawa
Andrew G Myers
Ziyang Zhang
Peter Niels Carlsen
Andre Sanchez
Ganapathy Dhandapani
Thrimurtulu Neetipalli
Md Ataur Rahman
Thomas Lepitre
Original Assignee
Zikani Therapeutics Inc
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zikani Therapeutics Inc, Harvard College filed Critical Zikani Therapeutics Inc
Publication of SG11202105227QA publication Critical patent/SG11202105227QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SG11202105227QA 2018-11-19 2019-11-18 C10-alkylene substituted 13-membered macrolides and uses thereof SG11202105227QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862769383P 2018-11-19 2018-11-19
PCT/US2019/062030 WO2020106627A1 (en) 2018-11-19 2019-11-18 C10-alkylene substituted 13-membered macrolides and uses thereof

Publications (1)

Publication Number Publication Date
SG11202105227QA true SG11202105227QA (en) 2021-06-29

Family

ID=68916562

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105227QA SG11202105227QA (en) 2018-11-19 2019-11-18 C10-alkylene substituted 13-membered macrolides and uses thereof

Country Status (12)

Country Link
US (1) US20230093692A1 (ja)
EP (1) EP3883647A1 (ja)
JP (1) JP2022507776A (ja)
KR (1) KR20210133950A (ja)
CN (1) CN113573779A (ja)
AU (1) AU2019385333A1 (ja)
BR (1) BR112021009624A2 (ja)
CA (1) CA3120148A1 (ja)
IL (1) IL283194A (ja)
MX (1) MX2021005423A (ja)
SG (1) SG11202105227QA (ja)
WO (1) WO2020106627A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313065A (zh) * 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023250513A1 (en) * 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
NZ526120A (en) * 1999-11-09 2005-02-25 Pfizer Prod Inc 13-membered azalides and their use as antibiotic agents
BR0110382A (pt) * 2000-04-27 2003-06-24 Pfizer Prod Inc Utilização de composições antibióticas azalida para o tratamento ou prevenção de uma infecção causada por bactérias ou protozoários em mamìferos
HRP20030381B1 (en) * 2003-05-14 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
CN101228171A (zh) * 2005-07-26 2008-07-23 默克勒有限公司 作为5-脂氧化酶和环加氧酶抑制剂的吡咯里嗪和中氮茚化合物的大环内酯偶联物
EP1985620A4 (en) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd COMPOUND 10a-AZALIDE
EP2588084B1 (en) * 2010-07-01 2023-11-22 Elanco Tiergesundheit AG Antibiotic compositions comprising tulathromycin
WO2013004116A1 (zh) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
CA3000709A1 (en) * 2015-10-01 2017-04-06 Memorial Sloan-Kettering Cancer Center Inhibitors of menaquinone biosynthesis
US11673910B2 (en) * 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof

Also Published As

Publication number Publication date
WO2020106627A1 (en) 2020-05-28
MX2021005423A (es) 2021-09-08
CN113573779A (zh) 2021-10-29
JP2022507776A (ja) 2022-01-18
EP3883647A1 (en) 2021-09-29
CA3120148A1 (en) 2020-05-28
AU2019385333A1 (en) 2021-07-01
BR112021009624A2 (pt) 2021-08-10
IL283194A (en) 2021-06-30
KR20210133950A (ko) 2021-11-08
US20230093692A1 (en) 2023-03-23

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