SG11202104460UA - Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as atr kinase inhibitors - Google Patents
Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as atr kinase inhibitorsInfo
- Publication number
- SG11202104460UA SG11202104460UA SG11202104460UA SG11202104460UA SG11202104460UA SG 11202104460U A SG11202104460U A SG 11202104460UA SG 11202104460U A SG11202104460U A SG 11202104460UA SG 11202104460U A SG11202104460U A SG 11202104460UA SG 11202104460U A SG11202104460U A SG 11202104460UA
- Authority
- SG
- Singapore
- Prior art keywords
- compounds
- methods
- pharmaceutical compositions
- kinase inhibitors
- atr kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862752873P | 2018-10-30 | 2018-10-30 | |
| US201962877177P | 2019-07-22 | 2019-07-22 | |
| PCT/CA2019/051539 WO2020087170A1 (en) | 2018-10-30 | 2019-10-30 | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as atr kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202104460UA true SG11202104460UA (en) | 2021-05-28 |
Family
ID=70461742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202104460UA SG11202104460UA (en) | 2018-10-30 | 2019-10-30 | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as atr kinase inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20210277002A1 (zh) |
| EP (1) | EP3873905A4 (zh) |
| JP (2) | JP2022510501A (zh) |
| KR (1) | KR20210097124A (zh) |
| CN (1) | CN113454080A (zh) |
| AU (1) | AU2019373416A1 (zh) |
| BR (1) | BR112021008336A2 (zh) |
| CA (1) | CA3118218A1 (zh) |
| CR (1) | CR20210281A (zh) |
| EC (1) | ECSP21038390A (zh) |
| IL (1) | IL282801A (zh) |
| MA (1) | MA54091A (zh) |
| MX (1) | MX2021005012A (zh) |
| PH (1) | PH12021550992A1 (zh) |
| SG (1) | SG11202104460UA (zh) |
| WO (1) | WO2020087170A1 (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022541825A (ja) * | 2019-07-22 | 2022-09-27 | リペア セラピューティクス インコーポレイテッド | Ａｔｒキナーゼ阻害剤としての置換２－モルホリノピリジン誘導体 |
| EP4072551A4 (en) * | 2019-12-11 | 2023-11-15 | Repare Therapeutics Inc. | USE OF ATR INHIBITORS IN COMBINATION WITH PARP INHIBITORS |
| TW202214642A (zh) * | 2020-07-02 | 2022-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 咪唑并嘧啶類衍生物、其製備方法及其在醫藥上的應用 |
| CN116507337A (zh) * | 2020-08-07 | 2023-07-28 | 上海德琪医药科技有限公司 | Atr抑制剂及其用途 |
| US20240043419A1 (en) * | 2020-09-27 | 2024-02-08 | Medshine Discovery Inc. | Class of 1,7-naphthyridine compounds and application thereof |
| JP2024516821A (ja) * | 2021-04-28 | 2024-04-17 | リペア セラピューティクス インコーポレイテッド | 両アレル機能喪失型変異または遺伝子過剰発現変異を有するがんを治療する方法 |
| MX2023014300A (es) * | 2021-06-16 | 2024-02-27 | Repare Therapeutics Inc | Uso de inhibidores de atr en combinacion con inhibidores de parp. |
| CN115677730A (zh) | 2021-07-27 | 2023-02-03 | 上海辉启生物医药科技有限公司 | 8-氧-3-氮杂二环[3.2.1]辛烷类化合物或其盐及其制备方法和用途 |
| AU2022325376A1 (en) * | 2021-08-11 | 2024-02-22 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Naphthyridine derivative as atr inhibitor and method for preparing same |
| CN116262749A (zh) * | 2021-12-15 | 2023-06-16 | 上海翊石医药科技有限公司 | 一类芳杂环取代的化合物及其制备方法和用途 |
| WO2023193114A1 (en) * | 2022-04-07 | 2023-10-12 | Repare Therapeutics Inc. | Methods of using atr inhibitors |
| WO2024123932A1 (en) | 2022-12-07 | 2024-06-13 | F. Hoffmann-La Roche Ag | Crystalline salt form of atr inhibitor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040048866A1 (en) * | 2002-03-08 | 2004-03-11 | Teodozyj Kolasa | Indazole derivatives that are activators of soluble guanylate cyclase |
| KR101905350B1 (ko) * | 2009-12-31 | 2018-11-30 | 허치슨 메디파르마 리미티드 | 특정 트리아졸로피리딘 및 트리아졸로피라진, 이들의 조성물 및 이들의 사용 방법 |
| EP2755962B1 (en) * | 2011-09-13 | 2017-03-01 | Glaxosmithkline LLC | Azaindazoles |
| WO2013067302A1 (en) * | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
| US8906910B2 (en) * | 2011-12-20 | 2014-12-09 | Glaxosmithkline Llc | Imidazopyridine derivatives as PI3 kinase |
| TWI656121B (zh) * | 2014-08-04 | 2019-04-11 | 德商拜耳製藥公司 | ２－（嗎啉－４－基）－１，７－萘啶 |
| CN107835814B (zh) * | 2015-04-29 | 2021-07-23 | 詹森药业有限公司 | 氮杂苯并咪唑及其作为ampa受体调节剂的用途 |
| CA3011189C (en) * | 2016-01-14 | 2024-02-20 | Bayer Pharma Aktiengesellschaft | 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines |
-
2019
- 2019-10-30 SG SG11202104460UA patent/SG11202104460UA/en unknown
- 2019-10-30 CN CN201980087223.7A patent/CN113454080A/zh active Pending
- 2019-10-30 EP EP19878747.5A patent/EP3873905A4/en active Pending
- 2019-10-30 WO PCT/CA2019/051539 patent/WO2020087170A1/en unknown
- 2019-10-30 CA CA3118218A patent/CA3118218A1/en active Pending
- 2019-10-30 BR BR112021008336-7A patent/BR112021008336A2/pt unknown
- 2019-10-30 MA MA054091A patent/MA54091A/fr unknown
- 2019-10-30 MX MX2021005012A patent/MX2021005012A/es unknown
- 2019-10-30 AU AU2019373416A patent/AU2019373416A1/en active Pending
- 2019-10-30 CR CR20210281A patent/CR20210281A/es unknown
- 2019-10-30 KR KR1020217016338A patent/KR20210097124A/ko not_active Application Discontinuation
- 2019-10-30 JP JP2021547609A patent/JP2022510501A/ja active Pending
-
2021
- 2021-04-29 IL IL282801A patent/IL282801A/en unknown
- 2021-04-30 US US17/245,574 patent/US20210277002A1/en active Pending
- 2021-04-30 PH PH12021550992A patent/PH12021550992A1/en unknown
- 2021-05-28 EC ECSENADI202138390A patent/ECSP21038390A/es unknown
-
2024
- 2024-04-24 JP JP2024070493A patent/JP2024105340A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021008336A2 (pt) | 2021-08-03 |
| EP3873905A4 (en) | 2022-08-17 |
| EP3873905A1 (en) | 2021-09-08 |
| US20210277002A1 (en) | 2021-09-09 |
| CN113454080A (zh) | 2021-09-28 |
| MX2021005012A (es) | 2021-07-21 |
| JP2024105340A (ja) | 2024-08-06 |
| CA3118218A1 (en) | 2020-05-07 |
| PH12021550992A1 (en) | 2021-10-04 |
| WO2020087170A1 (en) | 2020-05-07 |
| JP2022510501A (ja) | 2022-01-26 |
| MA54091A (fr) | 2021-09-15 |
| CR20210281A (es) | 2021-10-25 |
| AU2019373416A1 (en) | 2021-06-10 |
| IL282801A (en) | 2021-06-30 |
| ECSP21038390A (es) | 2021-08-31 |
| KR20210097124A (ko) | 2021-08-06 |
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