SG11202102271WA - Tricyclic compound acting on crbn protein - Google Patents
Tricyclic compound acting on crbn proteinInfo
- Publication number
- SG11202102271WA SG11202102271WA SG11202102271WA SG11202102271WA SG11202102271WA SG 11202102271W A SG11202102271W A SG 11202102271WA SG 11202102271W A SG11202102271W A SG 11202102271WA SG 11202102271W A SG11202102271W A SG 11202102271WA SG 11202102271W A SG11202102271W A SG 11202102271WA
- Authority
- SG
- Singapore
- Prior art keywords
- tricyclic compound
- compound acting
- crbn protein
- crbn
- protein
- Prior art date
Links
- 101150013999 CRBN gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 101150016677 ohgt gene Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811045941 | 2018-09-07 | ||
| CN201811354986 | 2018-11-14 | ||
| CN201910222597 | 2019-03-22 | ||
| PCT/CN2019/104996 WO2020048548A1 (zh) | 2018-09-07 | 2019-09-09 | 一种作用于crbn蛋白的三并环类化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202102271WA true SG11202102271WA (en) | 2021-04-29 |
Family
ID=69721960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202102271WA SG11202102271WA (en) | 2018-09-07 | 2019-09-09 | Tricyclic compound acting on crbn protein |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220119376A1 (zh) |
| EP (1) | EP3848367A4 (zh) |
| JP (1) | JP7422139B2 (zh) |
| KR (1) | KR20210057767A (zh) |
| CN (2) | CN112533916B (zh) |
| AU (1) | AU2019334065A1 (zh) |
| BR (1) | BR112021004269A2 (zh) |
| CA (1) | CA3111649A1 (zh) |
| IL (1) | IL281296B2 (zh) |
| SG (1) | SG11202102271WA (zh) |
| WO (1) | WO2020048548A1 (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020048546A1 (zh) * | 2018-09-07 | 2020-03-12 | 南京明德新药研发有限公司 | 三环取代哌啶二酮类化合物 |
| KR102605291B1 (ko) * | 2018-09-07 | 2023-11-23 | 메드샤인 디스커버리 아이엔씨. | 트리사이클릭 퓨란에 의해 치환된 피페리디온 화합물 |
| JP7209897B2 (ja) * | 2019-09-12 | 2023-01-20 | メッドシャイン ディスカバリー インコーポレイテッド | Ｃｒｂｎタンパク質モジュレーターとしての二環式化合物 |
| CA3170620A1 (en) * | 2020-03-06 | 2021-09-10 | Maoyi LEI | Crystal of tricyclic compound acting on crbn protein and preparation method therefor |
| WO2021185291A1 (zh) * | 2020-03-17 | 2021-09-23 | 南京明德新药研发有限公司 | 蛋白降解调节剂与其使用方法 |
| CN117580575A (zh) * | 2021-06-17 | 2024-02-20 | 南京明德新药研发有限公司 | 戊二酰亚胺取代的异噁唑稠环化合物及其应用 |
| EP4375281A1 (en) * | 2021-07-19 | 2024-05-29 | Medshine Discovery Inc. | Heteroaryl-3-piperidinedione compound and use thereof |
| CA3228411A1 (en) * | 2021-08-10 | 2023-02-16 | Xiaomin Zhang | Sulfonamide derivative, preparation method therefor and medical use thereof |
| KR20240107324A (ko) * | 2021-11-18 | 2024-07-09 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 융합 이미드 유도체 |
| TW202409025A (zh) * | 2022-08-19 | 2024-03-01 | 大陸商正大天晴藥業集團股份有限公司 | 包含環己基的化合物、包含其的藥物組合物及其用途 |
| WO2024199146A1 (zh) * | 2023-03-24 | 2024-10-03 | 漳州片仔癀药业股份有限公司 | 萘并异噁唑类化合物的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101223168A (zh) * | 2005-07-14 | 2008-07-16 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
| US8163767B2 (en) * | 2005-07-14 | 2012-04-24 | Astellas Pharma Inc. | Heterocyclic Janus Kinase 3 inhibitors |
| JP2010530421A (ja) * | 2007-06-18 | 2010-09-09 | シェーリング コーポレイション | 複素環化合物およびｅｒｋ阻害剤としてのそれらの使用 |
| US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| TWI701249B (zh) * | 2015-03-13 | 2020-08-11 | 德商４Ｓｃ製藥公司 | Ｋv１.３抑制劑及其醫學應用 |
| CN109153643B (zh) * | 2016-03-04 | 2022-06-21 | 范德比尔特大学 | 取代的吲哚mcl-1抑制剂 |
| WO2017197055A1 (en) * | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| WO2019060693A1 (en) * | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| WO2020048546A1 (zh) * | 2018-09-07 | 2020-03-12 | 南京明德新药研发有限公司 | 三环取代哌啶二酮类化合物 |
| KR102605291B1 (ko) * | 2018-09-07 | 2023-11-23 | 메드샤인 디스커버리 아이엔씨. | 트리사이클릭 퓨란에 의해 치환된 피페리디온 화합물 |
-
2019
- 2019-09-09 WO PCT/CN2019/104996 patent/WO2020048548A1/zh unknown
- 2019-09-09 US US17/273,997 patent/US20220119376A1/en not_active Abandoned
- 2019-09-09 SG SG11202102271WA patent/SG11202102271WA/en unknown
- 2019-09-09 IL IL281296A patent/IL281296B2/en unknown
- 2019-09-09 JP JP2021512786A patent/JP7422139B2/ja active Active
- 2019-09-09 EP EP19857378.4A patent/EP3848367A4/en not_active Withdrawn
- 2019-09-09 CN CN201980052516.1A patent/CN112533916B/zh active Active
- 2019-09-09 BR BR112021004269-5A patent/BR112021004269A2/pt unknown
- 2019-09-09 KR KR1020217010320A patent/KR20210057767A/ko not_active Application Discontinuation
- 2019-09-09 AU AU2019334065A patent/AU2019334065A1/en active Pending
- 2019-09-09 CN CN202210606710.3A patent/CN115109074A/zh active Pending
- 2019-09-09 CA CA3111649A patent/CA3111649A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3848367A4 (en) | 2022-06-08 |
| CN112533916B (zh) | 2022-05-20 |
| CN115109074A (zh) | 2022-09-27 |
| US20220119376A1 (en) | 2022-04-21 |
| CN112533916A (zh) | 2021-03-19 |
| IL281296B1 (en) | 2024-04-01 |
| AU2019334065A1 (en) | 2021-04-15 |
| BR112021004269A2 (pt) | 2021-05-25 |
| CA3111649A1 (en) | 2020-03-12 |
| IL281296A (en) | 2021-04-29 |
| WO2020048548A1 (zh) | 2020-03-12 |
| KR20210057767A (ko) | 2021-05-21 |
| JP2021536480A (ja) | 2021-12-27 |
| EP3848367A1 (en) | 2021-07-14 |
| IL281296B2 (en) | 2024-08-01 |
| JP7422139B2 (ja) | 2024-01-25 |
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